GSTP1 (glutathione S-transferase pi 1) - Rat Genome Database

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Gene: GSTP1 (glutathione S-transferase pi 1) Canis lupus familiaris
Analyze
Symbol: GSTP1
Name: glutathione S-transferase pi 1
RGD ID: 12322688
Description: ENCODES a protein that exhibits dinitrosyl-iron complex binding (ortholog); fatty acid binding (ortholog); glutathione peroxidase activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); cellular response to cell-matrix adhesion (ortholog); cellular response to epidermal growth factor stimulus (ortholog); PARTICIPATES IN glutathione conjugation pathway; paracetamol pharmacokinetics pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute kidney failure (ortholog); acute myeloid leukemia (ortholog); FOUND IN protein-containing complex (ortholog); TRAF2-GSTP1 complex (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutathione S-transferase P
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC475191  
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,905,161 - 49,908,182 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,905,161 - 49,908,182 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,515,700 - 48,518,722 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01850,827,487 - 50,830,507 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1850,827,046 - 50,830,507 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11850,040,622 - 50,043,638 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,615,622 - 49,618,639 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,409,350 - 50,412,373 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
Aicardi-Goutieres Syndrome 3  (ISO)
Airway Obstruction  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
amyotrophic lateral sclerosis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bone marrow disease  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
bronchopulmonary dysplasia  (ISO)
bronchus carcinoma  (ISO)
carcinoma  (ISO)
carotid artery disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
cholangiocarcinoma  (ISO)
Cholangiofibrosis  (ISO)
cholestasis  (ISO)
Chromosome Aberrations  (ISO)
Chronic Cerebral Hypoperfusion  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
clear cell renal cell carcinoma  (ISO)
colorectal adenoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
conjunctivochalasis  (ISO)
contact dermatitis  (ISO)
Cough  (ISO)
diffuse large B-cell lymphoma  (ISO)
Disease Progression  (ISO)
drug allergy  (ISO)
Drug-Induced Leukopenia  (ISO)
Drug-induced Neutropenia  (ISO)
esophagus squamous cell carcinoma  (ISO)
essential tremor  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Seizures  (ISO)
Focal Nodular Hyperplasia  (ISO)
Gallbladder Neoplasms  (ISO)
genetic disease  (ISO)
Graves' disease  (ISO)
hematopoietic system disease  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Hodgkin's lymphoma  (ISO)
hypertension  (ISO)
intellectual disability  (ISO)
Kidney Calculi  (ISO)
kidney disease  (ISO)
Kuhnt-Junius degeneration  (ISO)
Laryngeal Neoplasms  (ISO)
late onset Parkinson's disease  (ISO)
liver disease  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lymphoid leukemia  (ISO)
malignant astrocytoma  (ISO)
melanoma  (ISO)
meningitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
mitochondrial metabolism disease  (ISO)
movement disease  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myelodysplastic syndrome  (ISO)
myeloid leukemia  (ISO)
Myocardial Ischemia  (ISO)
Necrosis  (ISO)
oral squamous cell carcinoma  (ISO)
osteoporosis  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
Perennial Allergic Rhinitis  (ISO)
peripheral nervous system disease  (ISO)
peritonitis  (ISO)
Plasmodium falciparum malaria  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Respiratory Sounds  (ISO)
respiratory system disease  (ISO)
sarcoma  (ISO)
senile cataract  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
substance-induced psychosis  (ISO)
testicular cancer  (ISO)
toxic encephalopathy  (ISO)
type 2 diabetes mellitus  (ISO)
Ureteral Calculi  (ISO)
urinary bladder cancer  (ISO)
vestibular disease  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
cellular response to cell-matrix adhesion  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
common myeloid progenitor cell proliferation  (ISO)
glutathione derivative biosynthetic process  (ISO)
glutathione metabolic process  (IEA,ISO)
hepoxilin biosynthetic process  (ISO)
linoleic acid metabolic process  (ISO)
negative regulation of biosynthetic process  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of leukocyte proliferation  (ISO)
negative regulation of monocyte chemotactic protein-1 production  (ISO)
negative regulation of nitric-oxide synthase biosynthetic process  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of smooth muscle cell chemotaxis  (ISO)
negative regulation of stress-activated MAPK cascade  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
oligodendrocyte development  (ISO)
positive regulation of superoxide anion generation  (ISO)
prostaglandin metabolic process  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of stress-activated MAPK cascade  (ISO)
response to amino acid  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to L-ascorbic acid  (ISO)
response to nutrient levels  (ISO)
response to reactive oxygen species  (ISO)
response to toxic substance  (ISO)
xenobiotic metabolic process  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:24565113   PMID:30032202   PMID:33920860   PMID:36808425  


Genomics

Comparative Map Data
GSTP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,905,161 - 49,908,182 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,905,161 - 49,908,182 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,515,700 - 48,518,722 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01850,827,487 - 50,830,507 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1850,827,046 - 50,830,507 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11850,040,622 - 50,043,638 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,615,622 - 49,618,639 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,409,350 - 50,412,373 (-)NCBIUU_Cfam_GSD_1.0
GSTP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,583,812 - 67,586,653 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1167,583,742 - 67,586,656 (+)EnsemblGRCh38hg38GRCh38
GRCh371167,351,283 - 67,354,124 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,107,862 - 67,110,699 (+)NCBINCBI36Build 36hg18NCBI36
Build 341167,107,861 - 67,110,699NCBI
Celera1164,685,527 - 64,688,585 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1163,680,236 - 63,683,230 (+)NCBIHuRef
CHM1_11167,234,118 - 67,237,177 (+)NCBICHM1_1
T2T-CHM13v2.01167,578,501 - 67,581,343 (+)NCBIT2T-CHM13v2.0
Gstp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,085,411 - 4,087,912 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl194,085,407 - 4,087,985 (-)EnsemblGRCm39 Ensembl
GRCm38194,035,411 - 4,037,912 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,035,407 - 4,037,985 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,035,411 - 4,037,912 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,035,411 - 4,037,912 (-)NCBIMGSCv36mm8
Celera193,906,327 - 3,908,828 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.75NCBI
Gstp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,767,237 - 210,770,242 (-)NCBIGRCr8
mRatBN7.21201,337,762 - 201,340,230 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,321,672 - 201,340,226 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,690,040 - 209,692,503 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,783,226 - 216,785,696 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,474,253 - 209,476,723 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,291,679 - 219,294,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,291,679 - 219,294,147 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,162,330 - 226,164,798 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,627,398 - 206,629,866 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11206,780,853 - 206,783,288 (-)NCBI
Celera1198,882,807 - 198,885,275 (-)NCBICelera
Cytogenetic Map1q43NCBI
Gstp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,914,305 - 17,917,428 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,914,228 - 17,916,918 (-)NCBIChiLan1.0ChiLan1.0
GSTP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2968,811,099 - 68,814,237 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,853,927 - 69,856,897 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,942,756 - 62,945,701 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,253,421 - 66,256,472 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,253,421 - 66,256,472 (+)Ensemblpanpan1.1panPan2
Gstp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,755,332 - 5,758,293 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,197,634 - 2,201,050 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365992,197,681 - 2,200,642 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100739163
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.124,978,761 - 4,982,233 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,618,596 - 3,620,933 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSTP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,676,897 - 6,679,936 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038103,955,106 - 103,991,379 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in GSTP1
49 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 5 5
Medium 5 5 17 6 6 6 6 6 12 2 5 6
Low 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000018035   ⟹   ENSCAFP00000016702
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1849,905,161 - 49,908,182 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000079280   ⟹   ENSCAFP00000053483
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1849,905,243 - 49,908,182 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845016270   ⟹   ENSCAFP00845012657
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1850,827,046 - 50,830,438 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845016308   ⟹   ENSCAFP00845012688
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1850,827,569 - 50,830,507 (-)Ensembl
RefSeq Acc Id: NM_001252167   ⟹   NP_001239096
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11849,905,161 - 49,908,182 (-)NCBI
Dog10K_Boxer_Tasha1848,515,700 - 48,518,722 (-)NCBI
ROS_Cfam_1.01850,827,487 - 50,830,507 (-)NCBI
UMICH_Zoey_3.11850,040,622 - 50,043,638 (-)NCBI
UNSW_CanFamBas_1.01849,615,622 - 49,618,639 (-)NCBI
UU_Cfam_GSD_1.01850,409,350 - 50,412,373 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038423403   ⟹   XP_038279331
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01850,827,492 - 50,830,435 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001239096   ⟸   NM_001252167
- UniProtKB: A0A8C0S5S6 (UniProtKB/TrEMBL),   A0A8I3QRM6 (UniProtKB/TrEMBL),   A0A8C0JL73 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000053483   ⟸   ENSCAFT00000079280
RefSeq Acc Id: ENSCAFP00000016702   ⟸   ENSCAFT00000018035
RefSeq Acc Id: XP_038279331   ⟸   XM_038423403
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845012657   ⟸   ENSCAFT00845016270
RefSeq Acc Id: ENSCAFP00845012688   ⟸   ENSCAFT00845016308
Protein Domains
GST C-terminal   GST N-terminal

Promoters
RGD ID:13686561
Promoter ID:EPDNEW_C4629
Type:multiple initiation site
Name:GSTP1_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11849,908,171 - 49,908,231EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011349 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00000011827 UniProtKB/TrEMBL
  ENSCAFG00030022002 UniProtKB/TrEMBL
  ENSCAFG00040010120 UniProtKB/TrEMBL
  ENSCAFG00845009240 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFG00845029100 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000018035.4 UniProtKB/TrEMBL
  ENSCAFT00000018769.5 UniProtKB/TrEMBL
  ENSCAFT00000079280.2 UniProtKB/TrEMBL
  ENSCAFT00030040462.1 UniProtKB/TrEMBL
  ENSCAFT00030040483.1 UniProtKB/TrEMBL
  ENSCAFT00040018739.1 UniProtKB/TrEMBL
  ENSCAFT00040018792.1 UniProtKB/TrEMBL
  ENSCAFT00845016270 ENTREZGENE
  ENSCAFT00845016270.1 UniProtKB/TrEMBL
  ENSCAFT00845016308 ENTREZGENE
  ENSCAFT00845016308.1 UniProtKB/TrEMBL
  ENSCAFT00845051479.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.10 UniProtKB/TrEMBL
  1.20.1050.130 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
InterPro Glutathione-S-Trfase_C-like UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/TrEMBL
  GST_C UniProtKB/TrEMBL
  GST_pi UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
KEGG Report cfa:476005 UniProtKB/TrEMBL
NCBI Gene GSTP1 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/TrEMBL
  GLUTATHIONE S-TRANSFERASE P UniProtKB/TrEMBL
Pfam GST_C UniProtKB/TrEMBL
  GST_C_3 UniProtKB/TrEMBL
  GST_N UniProtKB/TrEMBL
PRINTS GSTRNSFRASEP UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/TrEMBL
  GST_NTER UniProtKB/TrEMBL
Superfamily-SCOP SSF47616 UniProtKB/TrEMBL
  SSF52833 UniProtKB/TrEMBL
UniProt A0A8C0JL73 ENTREZGENE
  A0A8C0S5R9_CANLF UniProtKB/TrEMBL
  A0A8C0S5S6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N6E9_CANLF UniProtKB/TrEMBL
  A0A8I3NBB4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3QRM6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SG78 ENTREZGENE, UniProtKB/TrEMBL