RGD Reference Report - GSTM1, GSTP1, and NQO1 polymorphisms and susceptibility to atopy and airway hyperresponsiveness among South African schoolchildren. - Rat Genome Database

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GSTM1, GSTP1, and NQO1 polymorphisms and susceptibility to atopy and airway hyperresponsiveness among South African schoolchildren.

Authors: Reddy, P  Naidoo, RN  Robins, TG  Mentz, G  London, SJ  Li, H  Naidoo, R 
Citation: Reddy P, etal., Lung. 2010 Oct;188(5):409-14. Epub 2010 Jun 5.
RGD ID: 5133266
Pubmed: PMID:20526719   (View Abstract at PubMed)
PMCID: PMC3611889   (View Article at PubMed Central)
DOI: DOI:10.1007/s00408-010-9246-3   (Journal Full-text)

Glutathione-S-transferases (GSTM1 and GSTP1) and nicotinamide quinone oxidoreductase (NQO1) genes play an important role in cellular protection against oxidative stress which has been linked to asthma pathogenesis. We investigated whether common, functional polymorphisms in GSTM1, GSTP1 and NQO1 influence airway hyperreactivity (AHR) and atopy among schoolchildren in South Africa. Genomic DNA was extracted from 317 primary schoolchildren, aged 9-11 years, from urban, low socioeconomic communities of Durban, South Africa. GSTM1 (null vs. present genotype), GSTP1 (Ile105Val; AA --> AG + GG), and NQO1 (Pro/187Ser; CC --> CT/TT) genotypes were determined using polymerase chain reaction (PCR) methods. Atopy was defined as a positive skin-prick test to any of several common allergens. Airway hyperreactivity (AHR) was evaluated by pulmonary function testing before and after methacholine challenge. Among the children, 30% were GSTM1 null, 65% carried the G allele for GSTP1, and 36% carried the C allele for NQO1. The frequency of GSTM1, GSTP1, and NQO1 variants among our South African sample was similar to frequencies found in similar ethnic groups worldwide. Marked airway reactivity (PC(20)

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
allergic disease susceptibilityIAGP 5133266DNA:polymorphism:exon:p.I105V (rs1695) (human)RGD 
allergic disease susceptibilityISOGSTP1 (Homo sapiens)5133266; 5133266DNA:polymorphism:exon:p.I105V (rs1695) (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gstp1  (glutathione S-transferase pi 1)

Genes (Mus musculus)
Gstp1  (glutathione S-transferase, pi 1)

Genes (Homo sapiens)
GSTP1  (glutathione S-transferase pi 1)


Additional Information