RGD Reference Report - Relationship between glutathione S-transferase M1, T1, and P1 polymorphisms and chronic lymphocytic leukemia. - Rat Genome Database

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Relationship between glutathione S-transferase M1, T1, and P1 polymorphisms and chronic lymphocytic leukemia.

Authors: Yuille, M  Condie, A  Hudson, C  Kote-Jarai, Z  Stone, E  Eeles, R  Matutes, E  Catovsky, D  Houlston, R 
Citation: Yuille M, etal., Blood. 2002 Jun 1;99(11):4216-8.
RGD ID: 10755404
Pubmed: PMID:12010828   (View Abstract at PubMed)

Interindividual differences in susceptibility to hematologic malignancies may be mediated in part through polymorphic variability in the bioactivation and detoxification of carcinogens. The glutathione S-transferases (GSTs) have been implicated as susceptibility genes in this context for a number of cancers. The aim of this study was to examine whether polymorphic variation in GSTs confers susceptibility to chronic lymphocytic leukemia (CLL). GSTM1, GSTT1, and GSTP1 genotypes were determined in 138 patients and 280 healthy individuals. The frequency of both GSTM1 and GSTT1 null genotypes and the GSTP1-Ile allele was higher in cases than in controls. There was evidence of a trend in increasing risk with the number of putative "high-risk" alleles of the GST family carried (P =.04). The risk of CLL associated with possession of all 3 "high-risk" genotypes was increased 2.8-fold (OR = 2.8, 95% confidence interval: 1.1-6.9). Our findings suggest that heritable GST status may influence the risk of developing CLL.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
lymphoid leukemia susceptibilityIAGP 10755404DNA:polymorphism:cds:p.I105V(human)RGD 
lymphoid leukemia susceptibilityISOGSTP1 (Homo sapiens)10755404; 10755404DNA:polymorphism:cds:p.I105V(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gstp1  (glutathione S-transferase pi 1)

Genes (Mus musculus)
Gstp1  (glutathione S-transferase, pi 1)

Genes (Homo sapiens)
GSTP1  (glutathione S-transferase pi 1)


Additional Information