RGD Reference Report - The enhancing effect of ethanol on the development of glutatione S-transferase placental form-positive foci induced by diethylnitrosamine in F344 rat. - Rat Genome Database

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The enhancing effect of ethanol on the development of glutatione S-transferase placental form-positive foci induced by diethylnitrosamine in F344 rat.

Authors: Cho, KJ  Myong, NH  Jang, JJ 
Citation: Cho KJ, etal., J Korean Med Sci. 1990 Mar;5(1):13-7.
RGD ID: 2317846
Pubmed: PMID:2206462   (View Abstract at PubMed)
PMCID: PMC3053722   (View Article at PubMed Central)
DOI: DOI:10.3346/jkms.1990.5.1.13   (Journal Full-text)

The effects of ethyl alcohol and pig serum administration on the development of preneoplastic hepatic enzyme-altered foci were examined in an in vivo mid-term assay system. Rats were initially given a single dose (200 mg/Kg) intraperitoneal injection of diethylnitrosamine (DEN). Two weeks later, treatment was started with 10% ethanol + 10% sucrose solution, 10% sucrose solution, or tap water as drinking water for 6 weeks with or without intraperitoneal injection of porcine serum twice a week. All rats were subjected to a two-thirds partial hepatectomy at week 3. The modification potentials were evaluated by comparing the number and area per cm2 of glutathione S-transferase placental form-positive (GST-P+) foci in the liver of each group. As a result, ethanol significantly enhanced the development of GST-P+ foci. Unfortunately, the porcine serum injection produced no hepatic fibrosis and no significant alteration in GST-P+ foci.




Biological Process

  
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Original Reference(s)
Gstp1Ratresponse to ethanol  IEP  RGD 


Genes (Rattus norvegicus)
Gstp1  (glutathione S-transferase pi 1)