FMO3 (flavin containing dimethylaniline monoxygenase 3) - Rat Genome Database

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Gene: FMO3 (flavin containing dimethylaniline monoxygenase 3) Chlorocebus sabaeus
Analyze
Symbol: FMO3
Name: flavin containing dimethylaniline monoxygenase 3
RGD ID: 18341127
Description: ENCODES a protein that exhibits amino acid binding (ortholog); N,N-dimethylaniline monooxygenase activity (ortholog); NADP binding (ortholog); INVOLVED IN xenobiotic metabolic process (ortholog); PARTICIPATES IN nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; tamoxifen pharmacodynamics pathway; ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); autism spectrum disorder (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dimethylaniline monooxygenase [N-oxide-forming] 3; flavin containing monooxygenase 3
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12557,971,737 - 57,995,850 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2557,969,234 - 57,995,613 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605559,615,621 - 59,640,759 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FMO3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12557,971,737 - 57,995,850 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2557,969,234 - 57,995,613 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605559,615,621 - 59,640,759 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
FMO3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381171,090,905 - 171,117,819 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1171,090,901 - 171,117,819 (+)EnsemblGRCh38hg38GRCh38
GRCh371171,060,046 - 171,086,959 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,326,660 - 169,353,583 (+)NCBINCBI36Build 36hg18NCBI36
Build 341167,791,693 - 167,818,617NCBI
Celera1144,169,885 - 144,196,864 (+)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1142,283,384 - 142,310,544 (+)NCBIHuRef
CHM1_11172,482,298 - 172,509,155 (+)NCBICHM1_1
T2T-CHM13v2.01170,447,248 - 170,474,197 (+)NCBIT2T-CHM13v2.0
Fmo3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,781,368 - 162,812,097 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,781,369 - 162,812,097 (-)EnsemblGRCm39 Ensembl
GRCm381162,953,799 - 162,984,528 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,953,800 - 162,984,528 (-)EnsemblGRCm38mm10GRCm38
MGSCv371164,883,931 - 164,914,622 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361164,790,475 - 164,821,166 (-)NCBIMGSCv36mm8
Celera1165,392,349 - 165,424,291 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.34NCBI
Fmo3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,838,899 - 77,868,869 (-)NCBIGRCr8
mRatBN7.21375,309,367 - 75,334,915 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1375,309,374 - 75,328,028 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1377,887,467 - 77,905,768 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01379,188,007 - 79,206,312 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01376,447,880 - 76,466,015 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,837,418 - 80,856,214 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,837,420 - 80,862,963 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01385,732,370 - 85,750,452 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41378,659,513 - 78,678,524 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11378,673,154 - 78,692,556 (-)NCBI
Celera1375,050,485 - 75,068,979 (-)NCBICelera
Cytogenetic Map13q22NCBI
FMO3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2178,639,381 - 78,665,636 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1178,313,659 - 78,339,132 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,583,570 - 146,611,720 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11150,298,957 - 150,325,850 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1150,298,957 - 150,325,850 (+)Ensemblpanpan1.1panPan2
FMO3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1727,720,420 - 27,745,522 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl727,720,420 - 27,845,626 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha727,247,890 - 27,272,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0727,522,170 - 27,547,286 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl727,522,170 - 27,547,286 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1727,372,307 - 27,397,410 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0727,407,132 - 27,432,265 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0727,649,342 - 27,674,458 (-)NCBIUU_Cfam_GSD_1.0
FMO3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl963,757,964 - 63,777,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1963,757,928 - 63,777,075 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2970,033,981 - 70,053,802 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in FMO3
787 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000009685   ⟹   ENSCSAP00000007798
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2557,969,234 - 57,995,613 (-)Ensembl
RefSeq Acc Id: XM_007989532   ⟹   XP_007987723
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12557,971,737 - 57,995,849 (-)NCBI
Vero_WHO_p1.0NW_02366605559,615,621 - 59,640,759 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007987723 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000007798.1
RefSeq Acc Id: XP_007987723   ⟸   XM_007989532
- UniProtKB: A0A0D9RGQ9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000007798   ⟸   ENSCSAT00000009685


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000011600 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000009685.1 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
  Flavin_mOase UniProtKB/TrEMBL
  Flavin_mOase-like UniProtKB/TrEMBL
  Flavin_mOase_3 UniProtKB/TrEMBL
  FMO UniProtKB/TrEMBL
KEGG Report csab:103230599 UniProtKB/TrEMBL
NCBI Gene FMO3 ENTREZGENE
PANTHER DIMETHYLANILINE MONOOXYGENASE UniProtKB/TrEMBL
  DIMETHYLANILINE MONOOXYGENASE [N-OXIDE-FORMING] 3 UniProtKB/TrEMBL
Pfam FMO-like UniProtKB/TrEMBL
PIRSF FMO UniProtKB/TrEMBL
PRINTS FMOXYGENASE UniProtKB/TrEMBL
  FMOXYGENASE3 UniProtKB/TrEMBL
Superfamily-SCOP SSF51905 UniProtKB/TrEMBL
UniProt A0A0D9RGQ9 ENTREZGENE, UniProtKB/TrEMBL