FMO3 (flavin containing dimethylaniline monoxygenase 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: FMO3 (flavin containing dimethylaniline monoxygenase 3) Canis lupus familiaris
Analyze
Symbol: FMO3
Name: flavin containing dimethylaniline monoxygenase 3
RGD ID: 12168763
Description: ENCODES a protein that exhibits amino acid binding (ortholog); N,N-dimethylaniline monooxygenase activity (ortholog); NADP binding (ortholog); INVOLVED IN taurine biosynthetic process (ortholog); xenobiotic metabolic process (ortholog); PARTICIPATES IN nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; tamoxifen pharmacodynamics pathway; ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); autism spectrum disorder (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dimethylaniline monooxygenase [N-oxide-forming] 3; dimethylaniline oxidase 3; flavin containing monooxygenase 3; flavin-containing monooxygenase 3; hepatic flavin-containing monooxygenase 3; trimethylamine monooxygenase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1727,720,420 - 27,745,522 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl727,720,420 - 27,845,626 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha727,247,890 - 27,272,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0727,522,170 - 27,547,286 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl727,522,170 - 27,547,286 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1727,372,307 - 27,397,410 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0727,407,132 - 27,432,265 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0727,649,342 - 27,674,458 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:11792679   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FMO3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1727,720,420 - 27,745,522 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl727,720,420 - 27,845,626 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha727,247,890 - 27,272,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0727,522,170 - 27,547,286 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl727,522,170 - 27,547,286 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1727,372,307 - 27,397,410 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0727,407,132 - 27,432,265 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0727,649,342 - 27,674,458 (-)NCBIUU_Cfam_GSD_1.0
FMO3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381171,090,905 - 171,117,819 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1171,090,901 - 171,117,819 (+)EnsemblGRCh38hg38GRCh38
GRCh371171,060,046 - 171,086,959 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,326,660 - 169,353,583 (+)NCBINCBI36Build 36hg18NCBI36
Build 341167,791,693 - 167,818,617NCBI
Celera1144,169,885 - 144,196,864 (+)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1142,283,384 - 142,310,544 (+)NCBIHuRef
CHM1_11172,482,298 - 172,509,155 (+)NCBICHM1_1
T2T-CHM13v2.01170,447,248 - 170,474,197 (+)NCBIT2T-CHM13v2.0
Fmo3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,781,368 - 162,812,097 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,781,369 - 162,812,097 (-)EnsemblGRCm39 Ensembl
GRCm381162,953,799 - 162,984,528 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,953,800 - 162,984,528 (-)EnsemblGRCm38mm10GRCm38
MGSCv371164,883,931 - 164,914,622 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361164,790,475 - 164,821,166 (-)NCBIMGSCv36mm8
Celera1165,392,349 - 165,424,291 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.34NCBI
Fmo3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,838,899 - 77,868,869 (-)NCBIGRCr8
mRatBN7.21375,309,367 - 75,334,915 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1375,309,374 - 75,328,028 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1377,887,467 - 77,905,768 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01379,188,007 - 79,206,312 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01376,447,880 - 76,466,015 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,837,418 - 80,856,214 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,837,420 - 80,862,963 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01385,732,370 - 85,750,452 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41378,659,513 - 78,678,524 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11378,673,154 - 78,692,556 (-)NCBI
Celera1375,050,485 - 75,068,979 (-)NCBICelera
Cytogenetic Map13q22NCBI
FMO3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2178,639,381 - 78,665,636 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1178,313,659 - 78,339,132 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,583,570 - 146,611,720 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11150,298,957 - 150,325,850 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1150,298,957 - 150,325,850 (+)Ensemblpanpan1.1panPan2
FMO3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl963,757,964 - 63,777,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1963,757,928 - 63,777,075 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2970,033,981 - 70,053,802 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FMO3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12557,971,737 - 57,995,850 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2557,969,234 - 57,995,613 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605559,615,621 - 59,640,759 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in FMO3
307 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 8 6 6 7 5
Low 4 5 14 6 6 5 8 3 1
Below cutoff 1 4 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000023776   ⟹   ENSCAFP00000022069
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl727,720,420 - 27,845,626 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845002507   ⟹   ENSCAFP00845001992
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl727,522,170 - 27,547,286 (-)Ensembl
RefSeq Acc Id: NM_001003060   ⟹   NP_001003060
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1727,720,420 - 27,745,522 (-)NCBI
Dog10K_Boxer_Tasha727,247,890 - 27,272,992 (-)NCBI
ROS_Cfam_1.0727,522,170 - 27,547,286 (-)NCBI
UMICH_Zoey_3.1727,372,307 - 27,397,410 (-)NCBI
UNSW_CanFamBas_1.0727,407,132 - 27,432,265 (-)NCBI
UU_Cfam_GSD_1.0727,649,342 - 27,674,458 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001003060 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK97434 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000022069.1
  ENSCAFP00030000165.1
  ENSCAFP00040000106.1
  ENSCAFP00805013467
  ENSCAFP00845001992
  ENSCAFP00845001992.1
GenBank Protein Q95LA1 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001003060   ⟸   NM_001003060
- UniProtKB: Q95LA1 (UniProtKB/Swiss-Prot),   A0A8C0R5N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000022069   ⟸   ENSCAFT00000023776
RefSeq Acc Id: ENSCAFP00845001992   ⟸   ENSCAFT00845002507

Promoters
RGD ID:13683948
Promoter ID:EPDNEW_C2016
Type:multiple initiation site
Name:FMO3_1
Description:flavin containing monooxygenase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1727,745,536 - 27,745,596EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014992 Ensembl, UniProtKB/Swiss-Prot
  ENSCAFG00030000129 UniProtKB/Swiss-Prot
  ENSCAFG00040000102 UniProtKB/Swiss-Prot
  ENSCAFG00805009377 UniProtKB/Swiss-Prot
  ENSCAFG00845001467 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000023776.2 UniProtKB/Swiss-Prot
  ENSCAFT00030000196.1 UniProtKB/Swiss-Prot
  ENSCAFT00040000143.1 UniProtKB/Swiss-Prot
  ENSCAFT00805017157 UniProtKB/Swiss-Prot
  ENSCAFT00845002507 ENTREZGENE
  ENSCAFT00845002507.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot
  Flavin_mOase UniProtKB/Swiss-Prot
  Flavin_mOase-like UniProtKB/Swiss-Prot
  Flavin_mOase_3 UniProtKB/Swiss-Prot
KEGG Report cfa:403603 UniProtKB/Swiss-Prot
NCBI Gene FMO3 ENTREZGENE
PANTHER DIMETHYLANILINE MONOOXYGENASE UniProtKB/Swiss-Prot
  DIMETHYLANILINE MONOOXYGENASE [N-OXIDE-FORMING] 3 UniProtKB/Swiss-Prot
Pfam FMO-like UniProtKB/Swiss-Prot
PIRSF FMO UniProtKB/Swiss-Prot
PRINTS FMOXYGENASE UniProtKB/Swiss-Prot
  FMOXYGENASE3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot
UniProt A0A8C0R5N1 ENTREZGENE
  FMO3_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:40918 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-06 FMO3  flavin containing dimethylaniline monoxygenase 3  FMO3  flavin containing monooxygenase 3  Symbol and/or name change 5135510 APPROVED