KCNQ2 (potassium voltage-gated channel subfamily Q member 2) - Rat Genome Database

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Gene: KCNQ2 (potassium voltage-gated channel subfamily Q member 2) Chlorocebus sabaeus
Analyze
Symbol: KCNQ2
Name: potassium voltage-gated channel subfamily Q member 2
RGD ID: 18449914
Description: ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity (ortholog); INVOLVED IN action potential (ortholog); action potential initiation (ortholog); apoptosome assembly (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); autosomal dominant nocturnal frontal lobe epilepsy (ortholog); FOUND IN axon initial segment (ortholog); cell surface (ortholog); node of Ranvier (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: potassium voltage-gated channel subfamily KQT member 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12739,965 - 803,575 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2761,952 - 802,999 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605048,302,539 - 48,404,899 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (ISO)
action potential initiation  (ISO)
apoptosome assembly  (ISO)
brain development  (ISO)
cellular response to calcium ion  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cognition  (ISO)
dentate gyrus development  (ISO)
determination of adult lifespan  (ISO)
endocytosis  (ISO)
establishment of cell polarity  (ISO)
excitatory chemical synaptic transmission  (ISO)
exocytosis  (ISO)
exploration behavior  (ISO)
gene expression  (ISO)
grooming behavior  (ISO)
hippocampal pyramidal neuron differentiation  (ISO)
hippocampus development  (ISO)
inhibitory chemical synaptic transmission  (ISO)
learning  (ISO)
membrane hyperpolarization  (ISO)
memory  (ISO)
mitochondrial depolarization  (ISO)
monoatomic ion transmembrane transport  (ISO)
motor behavior  (ISO)
nerve development  (ISO)
neuron apoptotic process  (ISO)
neuron differentiation  (ISO)
neuron remodeling  (ISO)
neuronal action potential  (ISO)
potassium ion transmembrane transport  (IEA)
potassium ion transport  (IEA)
protein import into nucleus  (ISO)
protein phosphorylation  (ISO)
protein transport  (ISO)
psychomotor behavior  (ISO)
regulation of action potential firing threshold  (ISO)
regulation of membrane potential  (ISO)
regulation of synaptic plasticity  (ISO)
response to auditory stimulus  (ISO)
response to mechanical stimulus  (ISO)
response to organic cyclic compound  (ISO)
response to temperature stimulus  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of sound  (ISO)
social behavior  (ISO)
sodium ion transmembrane transport  (ISO)
substantia propria of cornea development  (ISO)
transmembrane transport  (IEA)
transmission of nerve impulse  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNQ2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12739,965 - 803,575 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2761,952 - 802,999 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605048,302,539 - 48,404,899 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
KCNQ2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,400,208 - 63,472,655 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2063,400,208 - 63,472,677 (-)EnsemblGRCh38hg38GRCh38
GRCh372062,031,561 - 62,104,008 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,507,986 - 61,574,437 (-)NCBINCBI36Build 36hg18NCBI36
Build 342061,535,475 - 61,574,437NCBI
Celera2058,714,783 - 58,784,129 (-)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2058,763,581 - 58,832,303 (-)NCBIHuRef
CHM1_12061,938,421 - 62,005,028 (-)NCBICHM1_1
T2T-CHM13v2.02065,207,872 - 65,283,534 (-)NCBIT2T-CHM13v2.0
Kcnq2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,717,372 - 180,777,368 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,717,372 - 180,777,093 (-)EnsemblGRCm39 Ensembl
GRCm382181,075,579 - 181,135,580 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,075,579 - 181,135,300 (-)EnsemblGRCm38mm10GRCm38
MGSCv372180,810,284 - 180,869,930 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362181,004,987 - 181,064,633 (-)NCBIMGSCv36mm8
Celera2185,162,036 - 185,221,619 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.57NCBI
Kcnq2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,572,345 - 188,631,391 (-)NCBIGRCr8
mRatBN7.23168,194,776 - 168,253,831 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,195,357 - 168,275,071 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,579,283 - 172,633,822 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,538,370 - 181,592,919 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,199,749 - 178,254,694 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,585,897 - 176,645,029 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,589,906 - 176,644,951 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,295,948 - 180,355,064 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,227,938 - 170,282,887 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,133,973 - 170,188,923 (-)NCBI
Celera3164,332,108 - 164,387,022 (+)NCBICelera
Cytogenetic Map3q43NCBI
Kcnq2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528737,416 - 791,321 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955528737,416 - 792,885 (+)NCBIChiLan1.0ChiLan1.0
KCNQ2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22169,200,455 - 69,274,058 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12069,192,461 - 69,266,056 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl2061,325,365 - 61,395,266 (-)Ensemblpanpan1.1panPan2
KCNQ2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12447,060,527 - 47,089,077 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2447,060,245 - 47,089,711 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2446,239,964 - 46,285,184 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02448,009,941 - 48,055,221 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2448,013,499 - 48,211,383 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12447,025,196 - 47,070,380 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02447,149,830 - 47,195,058 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02447,905,637 - 47,933,777 (-)NCBIUU_Cfam_GSD_1.0
Kcnq2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,281,604 - 195,334,016 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651410,735,809 - 10,787,678 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651410,735,247 - 10,787,682 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNQ2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,459,281 - 62,506,424 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11762,459,277 - 62,506,403 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Kcnq2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474129,091,119 - 29,143,589 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474129,089,894 - 29,143,681 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 17 33 33 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000014465   ⟹   ENSCSAP00000012437
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2761,952 - 802,999 (+)Ensembl
RefSeq Acc Id: XM_037983059   ⟹   XP_037838987
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605048,302,539 - 48,404,899 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037838987 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000012437.1
Ensembl Acc Id: ENSCSAP00000012437   ⟸   ENSCSAT00000014465
RefSeq Acc Id: XP_037838987   ⟸   XM_037983059
- UniProtKB: A0A0D9RUZ8 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000016373 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000014465.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  6.10.140.1910 UniProtKB/TrEMBL
InterPro Ankyrin-G_BS UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ2 UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ_C UniProtKB/TrEMBL
NCBI Gene KCNQ2 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2 UniProtKB/TrEMBL
  POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  KCNQ2_u3 UniProtKB/TrEMBL
  KCNQ_channel UniProtKB/TrEMBL
  KCNQC3-Ank-G_bd UniProtKB/TrEMBL
PRINTS KCHANNEL UniProtKB/TrEMBL
  KCNQ2CHANNEL UniProtKB/TrEMBL
  KCNQCHANNEL UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A0D9RUZ8 ENTREZGENE, UniProtKB/TrEMBL