ACER2 (alkaline ceramidase 2) - Rat Genome Database

Name: ACER2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: ACER2 (alkaline ceramidase 2) Chlorocebus sabaeus

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Symbol:

ACER2

Name:

alkaline ceramidase 2

RGD ID:

18526610

Description:

ENCODES a protein that exhibits hydrolase activity (inferred); hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (inferred); N-acylsphingosine amidohydrolase activity (inferred); INVOLVED IN cellular response to xenobiotic stimulus (inferred); ceramide catabolic process (inferred); ceramide metabolic process (inferred); FOUND IN Golgi apparatus (inferred); Golgi membrane (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ACER2 (alkaline ceramidase 2)	NCBI	Ortholog
Mus musculus (house mouse):	Acer2 (alkaline ceramidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Acer2 (alkaline ceramidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Acer2 (alkaline ceramidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ACER2 (alkaline ceramidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ACER2 (alkaline ceramidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Acer2 (alkaline ceramidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ACER2 (alkaline ceramidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Acer2 (alkaline ceramidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	60,286,802 - 60,323,359 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	60,283,174 - 60,321,817 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	48,397,984 - 48,467,119 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to xenobiotic stimulus (IEA)

ceramide catabolic process (IEA)

ceramide metabolic process (IEA)

DNA damage response (IEA)

DNA damage response, signal transduction by p53 class mediator (IEA)

negative regulation of cell adhesion mediated by integrin (IEA)

negative regulation of cell-matrix adhesion (IEA)

positive regulation of cell population proliferation (IEA)

regulation of apoptotic process (IEA)

regulation of autophagy (IEA)

regulation of protein glycosylation (IEA)

response to retinoic acid (IEA)

sphingolipid metabolic process (IEA)

sphingosine biosynthetic process (IEA)

Cellular Component

Golgi apparatus (IEA)

Golgi membrane (IEA)

membrane (IEA)

Molecular Function

hydrolase activity (IEA)

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA)

N-acylsphingosine amidohydrolase activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ACER2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	60,286,802 - 60,323,359 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	60,283,174 - 60,321,817 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	48,397,984 - 48,467,119 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

ACER2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	19,409,009 - 19,452,505 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	19,409,009 - 19,452,505 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	19,409,007 - 19,452,503 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	19,398,925 - 19,442,500 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	9	19,335,075 - 19,378,570 (+)	NCBI		Celera
Cytogenetic Map	9	p22.1	NCBI
HuRef	9	19,370,525 - 19,414,024 (+)	NCBI		HuRef
CHM1_1	9	19,408,778 - 19,452,327 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	19,421,828 - 19,465,242 (+)	NCBI		T2T-CHM13v2.0

Acer2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	86,792,585 - 86,853,059 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	86,792,633 - 86,853,059 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	86,874,348 - 86,932,524 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	86,874,396 - 86,934,822 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	86,520,318 - 86,566,785 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	86,345,695 - 86,392,106 (+)	NCBI		MGSCv36	mm8
Celera	4	85,395,108 - 85,439,689 (+)	NCBI		Celera
Cytogenetic Map	4	C4	NCBI
cM Map	4	40.69	NCBI

Acer2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	106,437,773 - 106,488,572 (+)	NCBI		GRCr8
mRatBN7.2	5	101,391,830 - 101,442,615 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	101,391,885 - 101,442,614 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	103,772,875 - 103,817,891 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	105,563,430 - 105,608,446 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	105,596,792 - 105,641,922 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	105,230,540 - 105,279,732 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	105,230,580 - 105,279,731 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	109,217,448 - 109,266,600 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	106,185,779 - 106,237,588 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	106,185,877 - 106,412,446 (+)	NCBI
Celera	5	101,644,752 - 101,692,910 (-)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI

Acer2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955434	21,786,856 - 21,810,648 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955434	21,786,857 - 21,810,648 (+)	NCBI	ChiLan1.0	ChiLan1.0

ACER2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	105,092,977 - 105,139,449 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	105,098,921 - 105,145,396 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	19,216,891 - 19,262,477 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	19,706,716 - 19,751,057 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	19,709,402 - 19,750,896 (+)	Ensembl	panpan1.1		panPan2

ACER2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	39,190,873 - 39,223,590 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	39,190,115 - 39,219,776 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	37,848,571 - 37,881,294 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	40,124,209 - 40,156,941 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	40,124,252 - 40,156,909 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	38,816,668 - 38,849,382 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	38,614,132 - 38,646,861 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	39,248,101 - 39,280,836 (+)	NCBI		UU_Cfam_GSD_1.0

Acer2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	153,619,937 - 153,659,729 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936652	1,289,382 - 1,329,409 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936652	1,289,445 - 1,329,236 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACER2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	203,386,791 - 203,414,972 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	203,387,669 - 203,415,018 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	227,035,770 - 227,065,826 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Acer2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	23,363,983 - 23,411,100 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624736	23,363,806 - 23,556,247 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007969130	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007969131	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037998359	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000007481 ⟹ ENSCSAP00000005661

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	12	60,283,174 - 60,321,817 (-)	Ensembl

RefSeq Acc Id:

XM_007969130 ⟹ XP_007967321

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	12	60,286,802 - 60,320,414 (-)	NCBI
Vero_WHO_p1.0	NW_023666038	48,397,984 - 48,432,305 (-)	NCBI

Sequence:

show sequence

CAAGGCGAGGCGGGGCGGAGCGCGGGAGGCCGGCTGGGAGGCGCACATCCGGCGGCTGCCCGGT
ACTTCATAAAGCCGCTGTCGCCGCGGGCTGTCGCCGCGGTTTGCCTCTGCAGCAGCTCTGGGCT
CTTCTCGGCTGCGGGAGCAGCTGCTCCAATGCTCCAGGGTGGCCATGGGCGCCCCGCACTGGTG
GGACCAGTTGCAGGCTGGCAGCTCGGAGGTGGACTGGTGCGAGGACAACTACACCATCGTGCCT
GCTATCGCCGAGTTCTACAACACGATCAGCAATGTCTTATTTTTCATTTTACCGCCCATCTGCA
TGTGCTTGTTTCGTCAGTATGCAACATGCTTCAACAGCGGCATCTACTTAATCTGGACTCTTTT
AGTTGTAGTGGGAATTGGATCCGTCTACTTCCATGCAACCCTTAGTTTCCTGGGTCAGATGCTT
GATGAACTTGCAATCCTTTGGGTTCTGATGTGTGCTTTGGCCATGTGGTTCCCCAGAAGGTATC
TACCAAAGATCTTTCGGAATGACCGGGGCAGGTTCAAGGTGGTGGTCTGTGTCCTGTCTGCAGT
TACGACGTGCCTGGCATTTGTCAAGCCTGCCATCAACAACATCTCTCTGATGACCCTGGGAGTT
CCTTGCACTGCACTGCTCATCGCAGAGCTAAAGAGATGTGACAACGTGCGTGTGTTTAAGCTGG
GCCTCTTCTCGGGCCTCTGGTGGACCCTGGCCCTGTTCTGCTGGATCAGTGACCGAGCTTTCTG
CGAGCTGCTGTCGTCCTTCAACTTCCCCTACCTGCACTGTGTGTGGCACATCCTCATCTGCCTT
GCTGCCTACCTGGGCTGTGTATGCTTTGCCTACTTTGATGCTGCCTCAGAGATTCCTGAGCAAG
GCCCTGTCATCAAGTTCTGGCCCAGCGAGAAATGGGCCTTCATTGGTGTCCCCTACGTGTCCCT
TCTGTGTGCCAACAAGAAATCATCAGTCAAAATCACGTGATGGCAAGGTGGTGGCTGGCTTCTC
TGCTTATTGCCCCTCATGCAGTGGGCTTCCTTTGCTAGGAAGACAGCCAAGGGATTTCGAAGAG
TTGGGATGTGGGCTATCTTTTCAAAAATCTGTTTGCTGAGGCTCTCACTAATATGTCTGTGGAC
CACCAGGATTCCCCTGTGCAAGGGGAAAAGTGTCTTTTCCTTTCCCAAAGACGGAAAATGGAGG
GCTTAGGGACACTAGATGCATCTTTCTCAGCATCGCTTCCAGATGCAGTGACTTGTTGAGCTGC
GTCCTTAATGGCCATGGCAGAGCAGTCCCTTGGGGGATCCAGCCCTGTACAATGCATCTCATCC
TGGAGAAAGCTGGCCTGCTCCAGACCCCACCATTCCCAGGCACCCTTGGAGTGGACTCTACTGA
TGACAGACAGACCCTCTGACCGACAAGACTCTCTGACTCTCTGATGGAAGATGCCAGAGATTTT
CCTTTGGGGTAATTGTCCTTAAACAAAACCAAACAGATGAAACACACACAGGACTTGTGGCTAA
AAAGGCTAGTTTTTCACTTGCATTTCTCAACTAACATGCATCTGTGAATCCTTTTACTACTACC
TCTGTGGAGAGATGGAGAGACTTCAGATAAAGGTGAAGCTAATGAGTAAAACCCTCTCTGCCAA
AACCTACACTCCACTGTAGGCCATTCTTGAAGATGAGCACAGTTTTTAAATACTGACATCATTT
CCGCTTCCCCCTCCCACCCCAGCTCAGCAGCCTCAAATCCACAGAGAAGAAGAATTATGGCATG
AACATTCCCACAGACCCACCATCTTTAAGACTTGACCTCCGTAAGTTTACCAAAGGGCTCCTCA
CAATTGTGGTGGGGGTTCTGGTTCAAAATTTGGAGCACACATGAAGTTTTTGGAAACTTTTTCT
CATTTAAAGTCTCCAATATGCTGTACTATTCTGGAAATTACCTTCAAGAATCTCACTTGTTGTT
T

hide sequence

RefSeq Acc Id:

XM_037998359 ⟹ XP_037854287

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666038	48,399,677 - 48,467,119 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_007967321	(Get FASTA)	NCBI Sequence Viewer
	XP_037854287	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000005661.1

RefSeq Acc Id:	XP_007967321 ⟸ XM_007969130
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSCSAP00000005661 ⟸ ENSCSAT00000007481

RefSeq Acc Id:	XP_037854287 ⟸ XM_037998359
- Peptide Label:	isoform X2
- UniProtKB:	A0A0D9RAM2 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000009413	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000007481.1	UniProtKB/TrEMBL
InterPro	ACER	UniProtKB/TrEMBL
NCBI Gene	ACER2	ENTREZGENE
PANTHER	ALKALINE CERAMIDASE 2	UniProtKB/TrEMBL
	PTHR46139	UniProtKB/TrEMBL
Pfam	Ceramidase	UniProtKB/TrEMBL
UniProt	A0A0D9RAM2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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