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ONTOLOGY REPORT - ANNOTATIONS

Term:wide pore channel activity
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Accession:GO:0022829 term browser browse the term
Definition:Enables the energy-independent facilitated diffusion of propanediol through a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts.
Synonyms:exact_synonym: non-gated, wide pore channel activity
 narrow_synonym: gap junction activity


show annotations for term's descendants           Sort by:
wide pore channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsdma gasdermin A enables ISO (PMID:35110732), (PMID:35545676) RGD PMID:35110732 PMID:35545676 NCBI chr10:83,614,336...83,639,543
Ensembl chr10:83,627,051...83,639,543 		JBrowse link
G Gsdmc gasdermin C enables ISO (PMID:32929201), (PMID:34012073) RGD PMID:32929201 PMID:34012073 NCBI chr 7:95,594,015...95,606,106
Ensembl chr 7:95,594,015...95,611,344 		JBrowse link
G Gsdmd gasdermin D enables ISO (PMID:32109412)
(PMID:35749514), (PMID:35794369)
(PMID:32820063), (PMID:38538834)
(PMID:27339137), (PMID:38632402)
(PMID:27383986), (PMID:29195811), (PMID:29274245), (PMID:33883744), (PMID:35705808)
(PMID:32820063), (PMID:38040708), (PMID:38530158), (PMID:38599239)
(PMID:35794369)
(PMID:33883744)		 RGD PMID:27339137 PMID:27383986 PMID:29195811 PMID:29274245 PMID:32109412 More... NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsdme gasdermin E enables ISO (PMID:28459430)
(PMID:32188940), (PMID:33852854), (PMID:35594856)		 RGD PMID:28459430 PMID:32188940 PMID:33852854 PMID:35594856 NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806 		JBrowse link
G Mpeg1 macrophage expressed 1 enables ISS
ISO		 GO_REF:0000024
(PMID:32064340), (PMID:36245269), (PMID:37347855)
(PMID:31537793)		 UniProt
RGD		 PMID:31537793 PMID:32064340 PMID:36245269 PMID:37347855 GO_REF:0000024 NCBI chr 1:209,452,176...209,456,692
Ensembl chr 1:209,452,133...209,458,855 		JBrowse link
G Panx1 Pannexin 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774 		JBrowse link
G Panx2 pannexin 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:120,139,259...120,153,056
Ensembl chr 7:120,139,294...120,152,361 		JBrowse link
G Panx3 pannexin 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:37,366,758...37,377,640
Ensembl chr 8:37,366,862...37,377,640 		JBrowse link
G Prf1 perforin 1 enables ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:21037563), (PMID:26306037), (PMID:35148176), (PMID:35705808)
GO_REF:0000033
(PMID:20038786), (PMID:20889983), (PMID:24558045)
GO_REF:0000107		 UniProt
RGD
GO_Central
Ensembl		 PMID:20038786 PMID:20889983 PMID:21037563 PMID:24558045 PMID:26306037 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701 		JBrowse link
gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 enables IDA
ISO
IBA		 (PMID:11397787), (PMID:15084279), (PMID:29366904)
GO_REF:0000033
(PMID:29366904)
(PMID:16790700), (PMID:1696265), (PMID:23348765)
PMID:15284189		 RGD
GO_Central		 PMID:1696265 PMID:11397787 PMID:15084279 PMID:16790700 PMID:23348765 More... GO_REF:0000033, RGD:1580399, RGD:1582674, RGD:12793029 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gja10 gap junction protein, alpha 10 enables IBA
ISO		 GO_REF:0000033
(PMID:10329667)		 GO_Central
RGD		 PMID:10329667 GO_REF:0000033 NCBI chr 5:46,991,051...47,002,902
Ensembl chr 5:46,992,946...46,996,570 		JBrowse link
G Gja3 gap junction protein, alpha 3 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:1659572 GO_REF:0000033, RGD:728416 NCBI chr15:31,181,360...31,206,820
Ensembl chr15:31,181,369...31,206,810 		JBrowse link
G Gja4 gap junction protein, alpha 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:139,633,324...139,635,857
Ensembl chr 5:139,633,287...139,635,925 		JBrowse link
G Gja5 gap junction protein, alpha 5 IDA RGD PMID:1328644 RGD:728713 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
G Gja6 gap junction protein, alpha 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:33,840,689...33,845,585
Ensembl chr  X:33,840,549...33,845,614 		JBrowse link
G Gja8 gap junction protein, alpha 8 contributes_to
enables		 IDA
ISO		 (PMID:19756179) RGD PMID:19756179 PMID:16123426 RGD:1598965 NCBI chr 2:184,490,840...184,492,456
Ensembl chr 2:184,490,840...184,492,456 		JBrowse link
G Gjb1 gap junction protein, beta 1 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:12119284 GO_REF:0000033, RGD:728476 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925 		JBrowse link
G Gjb2 gap junction protein, beta 2 enables TAS
ISO
IBA
ISS
IMP		 (PMID:15692151)
GO_REF:0000033
GO_REF:0000024
(PMID:12767933), (PMID:21094651)		 RGD
GO_Central
UniProt		 PMID:12767933 PMID:15692151 PMID:21094651 PMID:12064607 PMID:23232329 GO_REF:0000024 GO_REF:0000033, RGD:1299562, RGD:7349364 NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177 		JBrowse link
G Gjb3 gap junction protein, beta 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:139,649,227...139,654,970
Ensembl chr 5:139,649,195...139,654,980 		JBrowse link
G Gjb4 gap junction protein, beta 4 enables ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:15692151)
GO_REF:0000033
GO_REF:0000107		 UniProt
RGD
GO_Central
Ensembl		 PMID:15692151 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:139,675,776...139,679,551
Ensembl chr 5:139,675,780...139,679,667 		JBrowse link
G Gjb5 gap junction protein, beta 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:139,680,670...139,683,588
Ensembl chr 5:139,680,671...139,683,583 		JBrowse link
G Gjb6 gap junction protein, beta 6 enables ISO
IBA		 (PMID:12767933)
GO_REF:0000033		 RGD
GO_Central		 PMID:12767933 GO_REF:0000033 NCBI chr15:31,284,561...31,294,552
Ensembl chr15:31,284,419...31,294,582 		JBrowse link
G Gjc1 gap junction protein, gamma 1 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:11668048 GO_REF:0000033, RGD:628534 NCBI chr10:87,758,192...87,785,443
Ensembl chr10:87,760,528...87,785,867 		JBrowse link
G Gjc2 gap junction protein, gamma 2 enables IBA
ISO		 GO_REF:0000033
(PMID:11160382)		 GO_Central
RGD		 PMID:11160382 GO_REF:0000033 NCBI chr10:43,962,642...43,971,358
Ensembl chr10:43,962,642...43,970,467 		JBrowse link
G Gjc3 gap junction protein, gamma 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:16,899,846...16,912,309
Ensembl chr12:16,896,813...16,964,246 		JBrowse link
G Gjd2 gap junction protein, delta 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:100,771,450...100,776,134
Ensembl chr 3:100,772,062...100,775,061 		JBrowse link
G Gjd3 gap junction protein, delta 3 IMP RGD PMID:23385797 RGD:7364769 NCBI chr10:83,933,694...83,935,759
Ensembl chr10:83,934,135...83,934,971 		JBrowse link
G Gjd4 gap junction protein, delta 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:57,348,844...57,352,601
Ensembl chr17:57,349,877...57,352,446 		JBrowse link
G Gje1 gap junction protein, epsilon 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:9,085,789...9,088,204
Ensembl chr 1:9,086,348...9,088,138 		JBrowse link
G Panx1 Pannexin 1 IMP RGD PMID:14597722 RGD:1299639 NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774 		JBrowse link
G Panx2 pannexin 2 IMP RGD PMID:14597722 RGD:1299639 NCBI chr 7:120,139,259...120,153,056
Ensembl chr 7:120,139,294...120,152,361 		JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 enables ISO
IBA		 (PMID:16790700), (PMID:20606116), (PMID:23348765)
GO_REF:0000033		 RGD
GO_Central		 PMID:16790700 PMID:20606116 PMID:23348765 GO_REF:0000033 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 enables ISO (PMID:22247482) RGD PMID:22247482 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
G Gjc1 gap junction protein, gamma 1 enables ISO (PMID:22982984) RGD PMID:22982984 NCBI chr10:87,758,192...87,785,443
Ensembl chr10:87,760,528...87,785,867 		JBrowse link
G Gjd3 gap junction protein, delta 3 enables IBA
ISO		 GO_REF:0000033
(PMID:22982984)		 GO_Central
RGD		 PMID:22982984 GO_REF:0000033 NCBI chr10:83,933,694...83,935,759
Ensembl chr10:83,934,135...83,934,971 		JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 enables ISO (PMID:22247482)
(PMID:26786475)		 RGD PMID:22247482 PMID:26786475 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 enables ISO (PMID:16790700), (PMID:23348765) RGD PMID:16790700 PMID:23348765 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 enables ISO (PMID:1696265) RGD PMID:1696265 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gjb2 gap junction protein, beta 2 enables ISO (PMID:12767933) RGD PMID:12767933 NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177 		JBrowse link
G Gjb6 gap junction protein, beta 6 enables ISO (PMID:12767933) RGD PMID:12767933 NCBI chr15:31,284,561...31,294,552
Ensembl chr15:31,284,419...31,294,582 		JBrowse link
G Gjc2 gap junction protein, gamma 2 enables ISO (PMID:17344063) RGD PMID:17344063 NCBI chr10:43,962,642...43,971,358
Ensembl chr10:43,962,642...43,970,467 		JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 enables ISS
ISO		 GO_REF:0000024
(PMID:29366904)		 UniProt
RGD		 PMID:29366904 GO_REF:0000024 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gja3 gap junction protein, alpha 3 enables ISS
IDA
IEA
ISO		 GO_REF:0000024
PMID:17715132
GO_REF:0000107
(PMID:30044662)		 UniProt
Ensembl
RGD		 PMID:30044662 PMID:17715132 GO_REF:0000024 GO_REF:0000107, RGD:15090844 NCBI chr15:31,181,360...31,206,820
Ensembl chr15:31,181,369...31,206,810 		JBrowse link
G Gja5 gap junction protein, alpha 5 enables ISO (PMID:23348765) RGD PMID:23348765 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
G Panx1 Pannexin 1 NOT|enables IDA PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774 		JBrowse link
G Panx2 pannexin 2 NOT|enables ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 7:120,139,259...120,153,056
Ensembl chr 7:120,139,294...120,152,361 		JBrowse link
G Panx3 pannexin 3 NOT|enables ISS
ISO		 GO_REF:0000024
(PMID:21690309)		 UniProt
RGD		 PMID:21690309 GO_REF:0000024 NCBI chr 8:37,366,758...37,377,640
Ensembl chr 8:37,366,862...37,377,640 		JBrowse link
porin activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07051831.1 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr 3:23,215,541...23,222,588 JBrowse link
G Bak1 BCL2-antagonist/killer 1 enables ISO (PMID:22006182) RGD PMID:22006182 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G ENSRNOG00000063023 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr 2:246,631,795...246,632,409 JBrowse link
G ENSRNOG00000067316 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr13:2,022,739...2,023,266 JBrowse link
G ENSRNOG00000069396 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr  X:146,383,480...146,384,468 JBrowse link
G ENSRNOG00000069999 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr 6:83,278,344...83,279,351 JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:79,358,781...79,370,882
Ensembl chr 1:79,358,786...79,370,915 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
G Vdac2 voltage-dependent anion channel 2 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553 		JBrowse link
G Vdac3 voltage-dependent anion channel 3 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr16:69,434,982...69,451,473
Ensembl chr16:69,435,005...69,451,471 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20634
    transporter activity 1253
      transmembrane transporter activity 1153
        passive transmembrane transporter activity 511
          channel activity 511
            wide pore channel activity 39
              gap junction channel activity + 23
              gap junction hemi-channel activity 6
              porin activity + 10
paths to the root