Gjb6 (gap junction protein, beta 6) - Rat Genome Database

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Gene: Gjb6 (gap junction protein, beta 6) Rattus norvegicus
Analyze
Symbol: Gjb6
Name: gap junction protein, beta 6
RGD ID: 621830
Description: Predicted to enable cytoskeletal protein binding activity and gap junction channel activity involved in cell communication by electrical coupling. Involved in several processes, including aging; cellular response to glucose stimulus; and response to lipopolysaccharide. Located in apical plasma membrane; cytosol; and gap junction. Biomarker of borna disease; status epilepticus; transient cerebral ischemia; ureteral obstruction; and visual epilepsy. Human ortholog(s) of this gene implicated in Clouston syndrome; autosomal dominant nonsyndromic deafness 3B; autosomal recessive nonsyndromic deafness 1A; autosomal recessive nonsyndromic deafness 1B; and ectodermal dysplasia. Orthologous to human GJB6 (gap junction protein beta 6); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: connexin f; Cx30; Cxnf; gap junction beta-6 protein; gap junction membrane channel protein beta 6; gap junction protein, beta 6 (connexin 30)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21531,284,562 - 31,295,010 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1531,284,419 - 31,294,582 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1533,275,886 - 33,285,877 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01534,426,541 - 34,436,532 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01532,684,670 - 32,694,661 (-)NCBIRnor_WKY
Rnor_6.01537,400,888 - 37,411,656 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1537,400,889 - 37,410,848 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01541,248,072 - 41,258,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41536,177,736 - 36,186,513 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11536,193,435 - 36,202,213 (-)NCBI
Celera1530,996,679 - 31,005,456 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Upregulation of connexins 30 and 32 gap junctions in rat hippocampus at transcription level by chronic central injection of lipopolysaccharide. Abbasian M, etal., Iran Biomed J. 2012;16(3):127-32. doi: 10.6091/ibj.1099.2012.
2. Expression of connexin 30 and connexin 32 in hippocampus of rat during epileptogenesis in a kindling model of epilepsy. Akbarpour B, etal., Neurosci Bull. 2012 Dec;28(6):729-36. doi: 10.1007/s12264-012-1279-6. Epub 2012 Nov 12.
3. Reduced gap junctional communication among astrocytes in experimental diabetes: contributions of altered connexin protein levels and oxidative-nitrosative modifications. Ball KK, etal., J Neurosci Res. 2011 Dec;89(12):2052-67. doi: 10.1002/jnr.22663. Epub 2011 May 2.
4. Absence of GJB6 mutations in Indian patients with non-syndromic hearing loss. Bhalla S, etal., Int J Pediatr Otorhinolaryngol. 2011 Mar;75(3):356-9. doi: 10.1016/j.ijporl.2010.12.003. Epub 2011 Jan 11.
5. Hearing loss features in GJB2 biallelic mutations and GJB2/GJB6 digenic inheritance in a large Italian cohort. Cama E, etal., Int J Audiol. 2009 Jan;48(1):12-7. doi: 10.1080/14992020802400654.
6. Prevalence of GJB6 mutations in Chinese patients with non-syndromic hearing loss. Chen P, etal., Int J Pediatr Otorhinolaryngol. 2012 Feb;76(2):265-7. doi: 10.1016/j.ijporl.2011.11.018. Epub 2011 Dec 18.
7. Connexin-30 mRNA is up-regulated in astrocytes and expressed in apoptotic neuronal cells of rat brain following kainate-induced seizures. Condorelli DF, etal., Mol Cell Neurosci 2002 Sep;21(1):94-113.
8. Expression of multiple connexins in the rat epididymis indicates a complex regulation of gap junctional communication. Dufresne J, etal., Am J Physiol Cell Physiol 2003 Jan;284(1):C33-43.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Prevalence of DFNB1 mutations in Argentinean children with non-syndromic deafness. Report of a novel mutation in GJB2. Gravina LP, etal., Int J Pediatr Otorhinolaryngol. 2010 Mar;74(3):250-4. doi: 10.1016/j.ijporl.2009.11.014. Epub 2009 Dec 22.
11. Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. Hugyecz M, etal., Brain Res. 2011 Aug 2;1404:31-8. Epub 2011 Jun 12.
12. Layer specific changes of astroglial gap junctions in the rat cerebellar cortex by persistent Borna Disease Virus infection. Koster-Patzlaff C, etal., Brain Res. 2008 Jul 11;1219:143-58. doi: 10.1016/j.brainres.2008.04.062. Epub 2008 Apr 30.
13. Mutations in GJB6 cause hidrotic ectodermal dysplasia. Lamartine J, etal., Nat Genet. 2000 Oct;26(2):142-4.
14. Developmental expression patterns of connexin26 and -30 in the rat cochlea. Lautermann J, etal., Dev Genet. 1999;25(4):306-11.
15. Molecular screening of patients with nonsyndromic hearing loss from Nanjing city of China. Lu Y, etal., J Biomed Res. 2011 Sep;25(5):309-18. doi: 10.1016/S1674-8301(11)60042-0.
16. High glucose-induced downregulation of connexin 30.2 promotes retinal vascular lesions: implications for diabetic retinopathy. Manasson J, etal., Invest Ophthalmol Vis Sci. 2013 Mar 28;54(3):2361-6. doi: 10.1167/iovs.12-10815.
17. Connexin 30 expression and frequency of connexin heterogeneity in astrocyte gap junction plaques increase with age in the rat retina. Mansour H, etal., PLoS One. 2013;8(3):e57038. doi: 10.1371/journal.pone.0057038. Epub 2013 Mar 14.
18. Spectrum and frequency of GJB2 mutations in a cohort of 264 Portuguese nonsyndromic sensorineural hearing loss patients. Matos TD, etal., Int J Audiol. 2013 Jul;52(7):466-71. doi: 10.3109/14992027.2013.783719. Epub 2013 May 13.
19. Localization of connexin 30 in the luminal membrane of cells in the distal nephron. McCulloch F, etal., Am J Physiol Renal Physiol. 2005 Dec;289(6):F1304-12. Epub 2005 Aug 2.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Connexin30 in rodent, cat and human brain: selective expression in gray matter astrocytes, co-localization with connexin43 at gap junctions and late developmental appearance. Nagy JI, etal., Neuroscience. 1999 Jan;88(2):447-68.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Rat gap junction connexin-30 inhibits proliferation of glioma cell lines. Princen F, etal., Carcinogenesis. 2001 Mar;22(3):507-13.
25. Identification of cells expressing Cx43, Cx30, Cx26, Cx32 and Cx36 in gap junctions of rat brain and spinal cord. Rash JE, etal., Cell Commun Adhes 2001;8(4-6):315-20.
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Comprehensive gene review and curation RGD comprehensive gene curation
30. The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice. Schutz M, etal., Hum Mol Genet. 2010 Dec 15;19(24):4759-73. doi: 10.1093/hmg/ddq402. Epub 2010 Sep 21.
31. Expression of connexins in the normal and obstructed developing kidney. Silverstein DM, etal., Pediatr Nephrol. 2003 Mar;18(3):216-24. Epub 2003 Feb 7.
32. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
33. Connexin30 (Gjb6)-deficiency causes severe hearing impairment and lack of endocochlear potential. Teubner B, etal., Hum Mol Genet. 2003 Jan 1;12(1):13-21.
34. Differential expression of hippocampal connexins after acute hypoxia in the developing brain. Zeinieh MP, etal., Brain Dev. 2010 Nov;32(10):810-7. doi: 10.1016/j.braindev.2009.11.003. Epub 2010 Jan 19.
Additional References at PubMed
PMID:12767933   PMID:14595769   PMID:19285977   PMID:20089884   PMID:22871113   PMID:24301293   PMID:24590285   PMID:27130897   PMID:28875331   PMID:32462383  


Genomics

Comparative Map Data
Gjb6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21531,284,562 - 31,295,010 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1531,284,419 - 31,294,582 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1533,275,886 - 33,285,877 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01534,426,541 - 34,436,532 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01532,684,670 - 32,694,661 (-)NCBIRnor_WKY
Rnor_6.01537,400,888 - 37,411,656 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1537,400,889 - 37,410,848 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01541,248,072 - 41,258,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41536,177,736 - 36,186,513 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11536,193,435 - 36,202,213 (-)NCBI
Celera1530,996,679 - 31,005,456 (-)NCBICelera
Cytogenetic Map15p12NCBI
GJB6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381320,221,962 - 20,232,319 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1320,221,962 - 20,232,365 (-)EnsemblGRCh38hg38GRCh38
GRCh371320,796,101 - 20,806,458 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361319,694,101 - 19,703,067 (-)NCBINCBI36Build 36hg18NCBI36
Build 341319,694,101 - 19,703,067NCBI
Celera131,857,920 - 1,868,353 (-)NCBICelera
Cytogenetic Map13q12.11NCBI
HuRef131,601,586 - 1,612,019 (-)NCBIHuRef
CHM1_11320,764,612 - 20,775,034 (-)NCBICHM1_1
T2T-CHM13v2.01319,418,446 - 19,428,785 (-)NCBIT2T-CHM13v2.0
Gjb6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391457,360,758 - 57,371,068 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1457,360,760 - 57,371,068 (-)EnsemblGRCm39 Ensembl
GRCm381457,123,301 - 57,133,611 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1457,123,303 - 57,133,611 (-)EnsemblGRCm38mm10GRCm38
MGSCv371457,742,140 - 57,752,414 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361456,077,413 - 56,087,687 (-)NCBIMGSCv36mm8
Celera1454,913,863 - 54,924,132 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1430.1NCBI
Gjb6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554971,018,610 - 1,027,360 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554971,018,610 - 1,027,593 (-)NCBIChiLan1.0ChiLan1.0
GJB6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11319,864,208 - 19,874,385 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1319,864,939 - 19,865,724 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0131,549,089 - 1,559,452 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GJB6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12517,912,036 - 17,922,310 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2517,911,262 - 17,921,605 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2517,942,707 - 17,952,942 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02518,049,941 - 18,060,202 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2518,049,939 - 18,062,858 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12517,916,508 - 17,926,768 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02517,928,188 - 17,938,444 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02517,984,771 - 17,995,017 (+)NCBIUU_Cfam_GSD_1.0
Gjb6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945119,938,223 - 119,947,042 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367201,493,733 - 1,494,518 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049367201,485,895 - 1,494,673 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJB6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl11793,280 - 800,046 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.111793,276 - 800,109 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GJB6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.13775,410 - 783,770 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl3782,251 - 783,036 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605743,801,650 - 43,810,335 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gjb6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477617,477,966 - 17,487,303 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477617,477,947 - 17,487,304 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:102
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000011742
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
RH131114  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21531,284,567 - 31,284,749 (+)MAPPERmRatBN7.2
Rnor_6.01537,400,894 - 37,401,075NCBIRnor6.0
Rnor_5.01541,248,078 - 41,248,259UniSTSRnor5.0
RGSC_v3.41536,177,739 - 36,177,920UniSTSRGSC3.4
Celera1530,996,682 - 30,996,863UniSTS
RH 3.4 Map15260.89UniSTS
Cytogenetic Map15p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 6 38
Low 2 2 2 26 1 20 8
Below cutoff 1 22 18 15 5 15 8 9 10 28 19 2 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011742   ⟹   ENSRNOP00000011828
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1531,284,419 - 31,293,653 (-)Ensembl
Rnor_6.0 Ensembl1537,400,889 - 37,409,668 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081757   ⟹   ENSRNOP00000071038
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1531,284,419 - 31,294,582 (-)Ensembl
Rnor_6.0 Ensembl1537,400,889 - 37,410,848 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094969   ⟹   ENSRNOP00000097059
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1531,284,566 - 31,293,255 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099568   ⟹   ENSRNOP00000086326
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1531,284,566 - 31,293,255 (-)Ensembl
RefSeq Acc Id: NM_053388   ⟹   NP_445840
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21531,284,565 - 31,293,342 (-)NCBI
Rnor_6.01537,400,891 - 37,409,668 (-)NCBI
Rnor_5.01541,248,072 - 41,258,522 (-)NCBI
RGSC_v3.41536,177,736 - 36,186,513 (-)RGD
Celera1530,996,679 - 31,005,456 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252079   ⟹   XP_006252141
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21531,284,562 - 31,295,010 (-)NCBI
Rnor_6.01537,400,888 - 37,411,656 (-)NCBI
Rnor_5.01541,248,072 - 41,258,522 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006252080   ⟹   XP_006252142
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21531,284,562 - 31,293,481 (-)NCBI
Rnor_6.01537,400,888 - 37,410,546 (-)NCBI
Rnor_5.01541,248,072 - 41,258,522 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_445840   ⟸   NM_053388
- UniProtKB: Q6AZ42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252141   ⟸   XM_006252079
- Peptide Label: isoform X1
- UniProtKB: Q6AZ42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252142   ⟸   XM_006252080
- Peptide Label: isoform X1
- UniProtKB: Q6AZ42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011828   ⟸   ENSRNOT00000011742
RefSeq Acc Id: ENSRNOP00000071038   ⟸   ENSRNOT00000081757
RefSeq Acc Id: ENSRNOP00000097059   ⟸   ENSRNOT00000094969
RefSeq Acc Id: ENSRNOP00000086326   ⟸   ENSRNOT00000099568
Protein Domains
CNX   Connexin_CCC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AZ42-F1-model_v2 AlphaFold Q6AZ42 1-261 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621830 AgrOrtholog
BioCyc Gene G2FUF-13608 BioCyc
Ensembl Genes ENSRNOG00000022116 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000011828 ENTREZGENE
  ENSRNOP00000011828.2 UniProtKB/TrEMBL
  ENSRNOP00000071038 ENTREZGENE
  ENSRNOP00000071038.1 UniProtKB/TrEMBL
  ENSRNOP00000086326.1 UniProtKB/TrEMBL
  ENSRNOP00000097059 ENTREZGENE
  ENSRNOP00000097059.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011742 ENTREZGENE
  ENSRNOT00000011742.4 UniProtKB/TrEMBL
  ENSRNOT00000081757 ENTREZGENE
  ENSRNOT00000081757.2 UniProtKB/TrEMBL
  ENSRNOT00000094969 ENTREZGENE
  ENSRNOT00000094969.1 UniProtKB/TrEMBL
  ENSRNOT00000099568.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.80 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132296 IMAGE-MGC_LOAD
InterPro Connexin UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/TrEMBL
  Connexin_CS UniProtKB/TrEMBL
  Connexin_N UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/TrEMBL
KEGG Report rno:84403 UniProtKB/TrEMBL
MGC_CLONE MGC:93246 IMAGE-MGC_LOAD
NCBI Gene 84403 ENTREZGENE
PANTHER Connexin UniProtKB/TrEMBL
Pfam Connexin UniProtKB/TrEMBL
PhenoGen Gjb6 PhenoGen
PRINTS CONNEXIN UniProtKB/TrEMBL
PROSITE CONNEXINS_1 UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/TrEMBL
SMART CNX UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/TrEMBL
UniProt Q6AZ42 ENTREZGENE, UniProtKB/TrEMBL
  Q9R140_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-20 Gjb6  gap junction protein, beta 6  Gjb6  gap junction membrane channel protein beta 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gjb6  gap junction membrane channel protein beta 6    gap junction protein, beta 6 (connexin 30)  Name updated 1299863 APPROVED
2002-08-07 Gjb6  gap junction protein, beta 6 (connexin 30)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in grey matter astrocytes of the brain 632751
gene_expression expressed in adult epididymis 628541
gene_regulation enhanced expression in neuronal cells undergoing cell death by kainate-induced seizures 632751