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ONTOLOGY REPORT - ANNOTATIONS


Term:gap junction channel activity
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Accession:GO:0005243 term browser browse the term
Definition:A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
Synonyms:exact_synonym: innexin channel activity
 narrow_synonym: innexin
 broad_synonym: intercellular channel
 related_synonym: connexin
 alt_id: GO:0015285;   GO:0015286
 xref: reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane";   reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication";   reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication";   reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication";   reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication"


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gap junction channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 IDA
IBA
ISO
PMID:21873635
(PMID:16790700), (PMID:1696265), (PMID:23348765), (PMID:29366904)
(MGI:MGI:2157676|PMID:11397787), (MGI:MGI:3042529|PMID:15084279), (MGI:MGI:6271573|PMID:29366904)
PMID:15284189
RGD PMID:1696265, PMID:11397787, PMID:15084279, PMID:16790700, PMID:23348765, PMID:29366904, PMID:15048573, PMID:21873635, PMID:15284189, PMID:16731531 MGI:MGI:2157676, MGI:MGI:3042529, MGI:MGI:6271573, RGD:1580399, RGD:13792537, RGD:12793029, RGD:1582674 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gja10 gap junction protein, alpha 10 ISO
IBA
(MGI:MGI:1336986|PMID:10329667)
PMID:21873635
RGD PMID:10329667, PMID:21873635 MGI:MGI:1336986, RGD:13792537 NCBI chr 5:47,819,484...47,841,138
Ensembl chr 5:47,835,066...47,836,586
JBrowse link
G Gja3 gap junction protein, alpha 3 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:1659572, PMID:21873635 RGD:728416, RGD:13792537 NCBI chr15:37,298,607...37,325,370
Ensembl chr15:37,299,738...37,325,178
JBrowse link
G Gja4 gap junction protein, alpha 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:145,374,688...145,377,221
Ensembl chr 5:145,374,690...145,377,221
JBrowse link
G Gja5 gap junction protein, alpha 5 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:1328644, PMID:21873635 RGD:728713, RGD:13792537 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
G Gja6 gap junction protein, alpha 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:35,621,805...35,622,665 JBrowse link
G Gja8 gap junction protein, alpha 8 contributes_to IDA
ISO
(PMID:19756179) RGD PMID:19756179, PMID:16123426 RGD:1598965 NCBI chr 2:199,050,854...199,052,470
Ensembl chr 2:199,050,854...199,052,470
JBrowse link
G Gjb1 gap junction protein, beta 1 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:12119284, PMID:21873635 RGD:728476, RGD:13792537 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977
JBrowse link
G Gjb2 gap junction protein, beta 2 TAS
IBA
ISO
ISS
IMP
PMID:21873635
(PMID:12767933), (PMID:21094651)
(MGI:MGI:3603482|PMID:15692151)
GO_REF:0000024
RGD
UniProt
PMID:12767933, PMID:15692151, PMID:21094651, PMID:12064607, PMID:21873635, PMID:23232329 GO_REF:0000024, MGI:MGI:3603482, RGD:1299562, RGD:13792537, RGD:7349364 NCBI chr15:37,377,313...37,394,494
Ensembl chr15:37,377,316...37,383,277
JBrowse link
G Gjb3 gap junction protein, beta 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:145,390,590...145,397,271
Ensembl chr 5:145,391,311...145,392,123
JBrowse link
G Gjb4 gap junction protein, beta 4 ISS
IBA
ISO
IEA
GO_REF:0000024
PMID:21873635
(MGI:MGI:3603482|PMID:15692151)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:15692151, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3603482, RGD:13792537 NCBI chr 5:145,416,343...145,421,122
Ensembl chr 5:145,416,343...145,418,992
JBrowse link
G Gjb5 gap junction protein, beta 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:145,422,034...145,440,558
Ensembl chr 5:145,422,357...145,423,172
JBrowse link
G Gjb6 gap junction protein, beta 6 ISO
IBA
(PMID:12767933)
PMID:21873635
RGD PMID:12767933, PMID:21873635 RGD:13792537 NCBI chr15:37,400,888...37,411,656
Ensembl chr15:37,400,889...37,410,848
JBrowse link
G Gjc1 gap junction protein, gamma 1 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:11668048, PMID:21873635 RGD:628534, RGD:13792537 NCBI chr10:90,781,408...90,912,440
Ensembl chr10:90,781,402...90,912,287
JBrowse link
G Gjc2 gap junction protein, gamma 2 ISO
IBA
(MGI:MGI:2153053|PMID:11160382)
PMID:21873635
RGD PMID:11160382, PMID:21873635 MGI:MGI:2153053, RGD:13792537 NCBI chr10:45,526,740...45,535,520
Ensembl chr10:45,526,745...45,534,570
JBrowse link
G Gjc3 gap junction protein, gamma 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:19,166,074...19,177,701
Ensembl chr12:19,166,239...19,167,015
JBrowse link
G Gjd2 gap junction protein, delta 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:105,467,480...105,470,475
Ensembl chr 3:105,467,480...105,470,475
JBrowse link
G Gjd3 gap junction protein, delta 3 IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:23385797, PMID:21873635 RGD:7364769, RGD:13792537 NCBI chr10:86,888,982...86,891,915
Ensembl chr10:86,889,421...86,890,257
JBrowse link
G Gjd4 gap junction protein, delta 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:62,297,086...62,299,655
Ensembl chr17:62,297,086...62,299,655
JBrowse link
G Gje1 gap junction protein, epsilon 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:8,883,767...8,887,721
Ensembl chr 1:8,883,961...8,885,967
JBrowse link
G Panx1 Pannexin 1 IMP RGD PMID:14597722 RGD:1299639 NCBI chr 8:13,567,185...13,606,040
Ensembl chr 8:13,566,739...13,606,040
JBrowse link
G Panx2 pannexin 2 IMP RGD PMID:14597722 RGD:1299639 NCBI chr 7:130,042,948...130,053,034
Ensembl chr 7:130,042,947...130,053,032
JBrowse link
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 ISO (PMID:16790700), (PMID:20606116), (PMID:23348765) RGD PMID:16790700, PMID:20606116, PMID:23348765 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 ISO (PMID:22247482) RGD PMID:22247482 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
G Gjc1 gap junction protein, gamma 1 ISO (MGI:MGI:5544102|PMID:22982984) RGD PMID:22982984 MGI:MGI:5544102 NCBI chr10:90,781,408...90,912,440
Ensembl chr10:90,781,402...90,912,287
JBrowse link
G Gjd3 gap junction protein, delta 3 ISO (MGI:MGI:5544102|PMID:22982984) RGD PMID:22982984 MGI:MGI:5544102 NCBI chr10:86,888,982...86,891,915
Ensembl chr10:86,889,421...86,890,257
JBrowse link
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 ISO (PMID:22247482) RGD PMID:22247482 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
gap junction channel activity involved in cardiac conduction electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja5 gap junction protein, alpha 5 ISO (PMID:16790700), (PMID:23348765) RGD PMID:16790700, PMID:23348765 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
gap junction channel activity involved in cell communication by electrical coupling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 ISO (PMID:1696265) RGD PMID:1696265 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gjb2 gap junction protein, beta 2 ISO (PMID:12767933) RGD PMID:12767933 NCBI chr15:37,377,313...37,394,494
Ensembl chr15:37,377,316...37,383,277
JBrowse link
G Gjb6 gap junction protein, beta 6 ISO (PMID:12767933) RGD PMID:12767933 NCBI chr15:37,400,888...37,411,656
Ensembl chr15:37,400,889...37,410,848
JBrowse link
G Gjc2 gap junction protein, gamma 2 ISO (PMID:17344063) RGD PMID:17344063 NCBI chr10:45,526,740...45,535,520
Ensembl chr10:45,526,745...45,534,570
JBrowse link
gap junction hemi-channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja1 gap junction protein, alpha 1 ISS
ISO
GO_REF:0000024
(PMID:29366904)
UniProt
RGD
PMID:29366904 GO_REF:0000024 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gja3 gap junction protein, alpha 3 ISS
IDA
ISO
IEA
GO_REF:0000024
PMID:17715132
(PMID:30044662)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:30044662, PMID:17715132 GO_REF:0000024, GO_REF:0000107, RGD:15090844 NCBI chr15:37,298,607...37,325,370
Ensembl chr15:37,299,738...37,325,178
JBrowse link
G Gja5 gap junction protein, alpha 5 ISO (PMID:23348765) RGD PMID:23348765 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
G Panx1 Pannexin 1 NOT IDA PMID:17715132 UniProt PMID:17715132 RGD:15090844 NCBI chr 8:13,567,185...13,606,040
Ensembl chr 8:13,566,739...13,606,040
JBrowse link
G Panx2 pannexin 2 NOT ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 7:130,042,948...130,053,034
Ensembl chr 7:130,042,947...130,053,032
JBrowse link
G Panx3 pannexin 3 NOT ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 8:40,126,379...40,137,390
Ensembl chr 8:40,126,342...40,137,390
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  molecular_function 20467
    transporter activity 1204
      transmembrane transporter activity 1114
        passive transmembrane transporter activity 494
          channel activity 494
            wide pore channel activity 42
              gap junction channel activity 23
                gap junction channel activity involved in cell communication by electrical coupling + 7
                gap junction hemi-channel activity 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.