Gje1 (gap junction protein, epsilon 1) - Rat Genome Database

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Gene: Gje1 (gap junction protein, epsilon 1) Rattus norvegicus
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Symbol: Gje1
Name: gap junction protein, epsilon 1
RGD ID: 1598009
Description: Predicted to enable gap junction channel activity. Predicted to be involved in cell-cell signaling. Predicted to act upstream of or within cell morphogenesis; lens development in camera-type eye; and organ growth. Predicted to be part of connexin complex. Orthologous to human GJE1 (gap junction protein epsilon 1); INTERACTS WITH bisphenol A; furan; trichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: connexin t; Cxnt; gap junction epsilon-1 protein; LOC308377; LOC681263; RGD1308189; similar to connexin 39; similar to connexin 62
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8110,905,890 - 10,911,800 (-)NCBIGRCr8
mRatBN7.219,085,789 - 9,088,204 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl19,086,348 - 9,088,138 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx18,805,690 - 8,807,403 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0114,807,600 - 14,809,313 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.019,060,816 - 9,062,538 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.018,883,767 - 8,887,721 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18,883,961 - 8,885,967 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0110,501,325 - 10,503,331 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.419,565,845 - 9,567,558 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera17,563,059 - 7,564,781 (-)NCBICelera
Cytogenetic Map1p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18385072  


Genomics

Comparative Map Data
Gje1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8110,905,890 - 10,911,800 (-)NCBIGRCr8
mRatBN7.219,085,789 - 9,088,204 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl19,086,348 - 9,088,138 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx18,805,690 - 8,807,403 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0114,807,600 - 14,809,313 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.019,060,816 - 9,062,538 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.018,883,767 - 8,887,721 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18,883,961 - 8,885,967 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0110,501,325 - 10,503,331 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.419,565,845 - 9,567,558 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera17,563,059 - 7,564,781 (-)NCBICelera
Cytogenetic Map1p13NCBI
GJE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386142,132,925 - 142,135,358 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6142,132,925 - 142,135,358 (+)EnsemblGRCh38hg38GRCh38
GRCh376142,454,062 - 142,456,495 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map6q24.1NCBI
CHM1_16142,716,548 - 142,718,311 (+)NCBICHM1_1
T2T-CHM13v2.06143,325,015 - 143,327,448 (+)NCBIT2T-CHM13v2.0
Gje1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391014,591,365 - 14,593,958 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1014,591,367 - 14,593,958 (-)EnsemblGRCm39 Ensembl
GRCm381014,715,626 - 14,718,214 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1014,715,623 - 14,718,214 (-)EnsemblGRCm38mm10GRCm38
MGSCv371014,435,432 - 14,438,020 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361014,405,824 - 14,408,412 (-)NCBIMGSCv36mm8
Celera1014,618,111 - 14,620,696 (-)NCBICelera
Cytogenetic Map10A2NCBI
cM Map105.5NCBI
GJE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25162,099,947 - 162,109,714 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16159,994,590 - 160,004,356 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06139,901,021 - 139,902,784 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16143,974,781 - 143,976,543 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6143,974,781 - 143,976,543 (+)Ensemblpanpan1.1panPan2
GJE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha134,718,461 - 34,720,290 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0133,994,678 - 33,996,507 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl133,994,678 - 33,996,507 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1133,865,197 - 33,867,024 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0133,747,011 - 33,748,840 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0134,057,924 - 34,059,753 (+)NCBIUU_Cfam_GSD_1.0
Gje1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946128,795,413 - 128,797,787 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366253,837,700 - 3,840,234 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366253,838,128 - 3,840,159 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl122,933,885 - 22,935,121 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1122,933,885 - 22,936,167 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GJE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_0236660403,256,343 - 3,258,108 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gje1
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:99
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000016102
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1416280711481482Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 7 4 25 19 20 4 12 4 1 40 20 20 8 21 16

Sequence


Ensembl Acc Id: ENSRNOT00000016102   ⟹   ENSRNOP00000016102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl19,086,348 - 9,088,138 (-)Ensembl
Rnor_6.0 Ensembl18,883,961 - 8,885,967 (-)Ensembl
RefSeq Acc Id: NM_001197092   ⟹   NP_001184021
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8110,905,890 - 10,908,305 (-)NCBI
mRatBN7.219,085,789 - 9,088,204 (-)NCBI
Rnor_6.018,883,961 - 8,885,967 (-)NCBI
Rnor_5.0110,501,325 - 10,503,331 (-)NCBI
Celera17,563,059 - 7,564,781 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063273748   ⟹   XP_063129818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8110,905,890 - 10,911,800 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001184021 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129818 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAZ38711 (Get FASTA)   NCBI Sequence Viewer  
  EDL93747 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016102.2
GenBank Protein VZP20211 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001184021   ⟸   NM_001197092
- UniProtKB: G3V7K4 (UniProtKB/TrEMBL),   A6JP74 (UniProtKB/TrEMBL),   A0A654ICF1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016102   ⟸   ENSRNOT00000016102
RefSeq Acc Id: XP_063129818   ⟸   XM_063273748
- Peptide Label: isoform X1
- UniProtKB: A0A654ICF1 (UniProtKB/TrEMBL),   G3V7K4 (UniProtKB/TrEMBL),   A6JP74 (UniProtKB/TrEMBL)
Protein Domains
Connexin N-terminal   Gap junction protein cysteine-rich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7K4-F1-model_v2 AlphaFold G3V7K4 1-205 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598009 AgrOrtholog
BioCyc Gene G2FUF-62340 BioCyc
Ensembl Genes ENSRNOG00000012092 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016102.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.80 UniProtKB/TrEMBL
InterPro Connexin UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/TrEMBL
  Connexin_N UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/TrEMBL
KEGG Report rno:681263 UniProtKB/TrEMBL
NCBI Gene 681263 ENTREZGENE
PANTHER Connexin UniProtKB/TrEMBL
  GAP JUNCTION EPSILON-1 PROTEIN-RELATED UniProtKB/TrEMBL
Pfam Connexin UniProtKB/TrEMBL
PhenoGen Gje1 PhenoGen
PRINTS CONNEXIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012092 RatGTEx
SMART Connexin_CCC UniProtKB/TrEMBL
UniProt A0A654ICF1 ENTREZGENE, UniProtKB/TrEMBL
  A6JP74 ENTREZGENE, UniProtKB/TrEMBL
  G3V7K4 ENTREZGENE, UniProtKB/TrEMBL
  Q45KZ1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Gje1  gap junction protein, epsilon 1  LOC684664  similar to connexin 39  Data merged from RGD:1587910 1643240 APPROVED
2008-10-30 Gje1  gap junction protein, epsilon 1   LOC681263  similar to connexin 39  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 LOC681263  similar to connexin 39  RGD1308189  similar to connexin 62   Data merged from RGD:1308189 1643240 APPROVED
2008-04-30 RGD1308189  similar to connexin 62   RGD1308189_predicted  similar to connexin 62 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC681263  similar to connexin 39      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684664  similar to connexin 39      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 RGD1308189_predicted  similar to connexin 62 (predicted)  LOC308377_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC308377_predicted  similar to connexin 62 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL