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Gene: Gja8 (gap junction protein, alpha 8) Rattus norvegicus
Symbol: Gja8
Name: gap junction protein, alpha 8
Description: Exhibits identical protein binding activity. Contributes to gap junction channel activity. Involved in cell-cell signaling. Localizes to connexin complex and integral component of membrane. Used to study cataract; cataract 1 multiple types; and microphthalmia. Human ortholog(s) of this gene implicated in cataract and cataract 1 multiple types. Orthologous to human GJA8 (gap junction protein alpha 8); INTERACTS WITH bisphenol A; manganese(II) chloride; (+)-catechin (ortholog).
Type: protein-coding
Also known as: connexin 50; connexin l; connexin-50; Cx50; Cxnl; gap junction alpha-8 protein; gap junction membrane channel protein alpha 8
Homo sapiens (human) : GJA8 (gap junction protein alpha 8)  HGNC  Alliance
Mus musculus (house mouse) : Gja8 (gap junction protein, alpha 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gja8 (gap junction protein alpha 8)
Pan paniscus (bonobo/pygmy chimpanzee) : GJA8 (gap junction protein alpha 8)
Canis lupus familiaris (dog) : GJA8 (gap junction protein alpha 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gja8 (gap junction protein alpha 8)
Sus scrofa (pig) : GJA8 (gap junction protein alpha 8)
Chlorocebus sabaeus (African green monkey) : GJA8 (gap junction protein alpha 8)
Heterocephalus glaber (naked mole-rat) : Gja8 (gap junction protein alpha 8)
more info ...
Allele / Splice: Gja8m1Cub   Gja8m1Cas  
Is Marker For: Strains:   SHR-Gja8m1Cub  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02199,050,854 - 199,052,470 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,050,854 - 199,052,470 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,536,831 - 218,538,447 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2176,986,507 - 176,988,123 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gja8
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628890
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.