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ONTOLOGY REPORT - ANNOTATIONS

Term:cerebellar Purkinje cell layer formation
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Accession:GO:0021694 term browser browse the term
Definition:The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.


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cerebellar Purkinje cell layer formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gba1 glucosylceramidase beta 1 acts_upstream_of_or_within ISO (PMID:17954912) RGD PMID:17954912 NCBI chr 2:174,609,437...174,615,457 JBrowse link
G Whrn whirlin involved_in IEA
ISO		 GO_REF:0000107
(PMID:24011083)		 Ensembl
RGD		 PMID:24011083 GO_REF:0000107 NCBI chr 5:76,828,308...76,911,945 JBrowse link
cerebellar Purkinje cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtpbp1 ATP/GTP binding carboxypeptidase 1 acts_upstream_of_or_within
involved_in		 ISO MGI:1856535|MGI:1857523|MGI:2443047|MGI:6270378 (PMID:10630211), (PMID:30420556)
(PMID:11884758), (PMID:16465590), (PMID:21074048)		 RGD PMID:10630211 PMID:11884758 PMID:16465590 PMID:21074048 PMID:30420556 NCBI chr17:5,120,540...5,238,874 JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO MGI:1857876 (PMID:9668038) RGD PMID:9668038 NCBI chr 4:146,894,602...147,208,060 JBrowse link
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856466 (PMID:2473662) RGD PMID:2473662 NCBI chr  X:71,094,144...71,201,550 JBrowse link
G Atxn2 ataxin 2 acts_upstream_of_or_within ISO MGI:3505741 (PMID:10973246) RGD PMID:10973246 NCBI chr12:34,754,132...34,851,175 JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:1856209|MGI:1856210 (PMID:10630211), (PMID:1306163), (PMID:7834360) RGD PMID:1306163 PMID:7834360 PMID:10630211 NCBI chr19:40,425,560...40,724,810 JBrowse link
G Cend1 cell cycle exit and neuronal differentiation 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:4831137 (PMID:20153830)		 GO_Central
RGD		 PMID:20153830 GO_REF:0000033 NCBI chr 1:196,525,153...196,528,152 JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:21957071)		 UniProt
Ensembl
RGD		 PMID:21957071 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:130,632,368...130,659,353 JBrowse link
G Foxp2 forkhead box P2 involved_in ISO MGI:3778383 (PMID:22133810) RGD PMID:22133810 NCBI chr 4:43,133,827...43,712,442 JBrowse link
G Herc1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 acts_upstream_of_or_within ISO MGI:3613033 (PMID:20041218) RGD PMID:20041218 NCBI chr 8:66,857,169...67,070,318 JBrowse link
G Ldb1 LIM domain binding 1 acts_upstream_of_or_within ISO MGI:3719683 (PMID:17664423) RGD PMID:17664423 NCBI chr 1:244,864,168...244,890,007 JBrowse link
G Lhx1 LIM homeobox 1 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:107792 (PMID:17664423)		 UniProt
RGD		 PMID:17664423 GO_REF:0000024 NCBI chr10:69,396,829...69,403,617 JBrowse link
G Lhx5 LIM homeobox 5 acts_upstream_of_or_within ISO MGI:99783 (PMID:17664423) RGD PMID:17664423 NCBI chr12:36,126,186...36,134,625 JBrowse link
G Psap prosaposin acts_upstream_of_or_within ISO MGI:3521746 (PMID:15345707) RGD PMID:15345707 NCBI chr20:28,214,229...28,240,501 JBrowse link
G Rora RAR-related orphan receptor A acts_upstream_of_or_within ISO MGI:1857035 (PMID:8996814) RGD PMID:8996814 NCBI chr 8:69,301,635...70,034,741 JBrowse link
G Skor2 SKI family transcriptional corepressor 2 acts_upstream_of_or_within ISO MGI:5300464 (PMID:21937600), (PMID:24491816) RGD PMID:21937600 PMID:24491816 NCBI chr18:70,404,431...70,446,330 JBrowse link
G Slc25a46 solute carrier family 25, member 46 acts_upstream_of_or_within ISO MGI:6358090 (PMID:28934388) RGD PMID:28934388 NCBI chr18:23,215,954...23,244,917 JBrowse link
G Top2a DNA topoisomerase II alpha IEP RGD PMID:11170002 RGD:8693630 NCBI chr10:83,945,731...83,976,874 JBrowse link
G Ttc21b tetratricopeptide repeat domain 21B acts_upstream_of_or_within ISO MGI:2137515|MGI:2152544|MGI:2179048|MGI:5587034 (PMID:29615573) RGD PMID:29615573 NCBI chr 3:50,861,367...50,935,880 JBrowse link
G Ttll1 TTL family tubulin polyglutamylase complex subunit L1 acts_upstream_of_or_within ISO MGI:1918244 (PMID:30420556) RGD PMID:30420556 NCBI chr 7:114,619,509...114,648,850 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    developmental process 7109
      anatomical structure formation involved in morphogenesis 1379
        cerebellar Purkinje cell layer formation 21
          candelabrum cell differentiation 0
          cerebellar Purkinje cell differentiation 19
Path 2
Term Annotations click to browse term
  biological_process 20536
    developmental process 7109
      anatomical structure development 6611
        multicellular organism development 5330
          system development 4612
            nervous system development 2862
              central nervous system development 1216
                brain development 903
                  hindbrain development 229
                    metencephalon development 175
                      cerebellum development 161
                        cerebellar cortex development 71
                          cerebellar Purkinje cell layer development 40
                            cerebellar Purkinje cell layer morphogenesis 26
                              cerebellar Purkinje cell layer formation 21
                                candelabrum cell differentiation 0
                                cerebellar Purkinje cell differentiation 19
paths to the root