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ONTOLOGY REPORT - ANNOTATIONS

Term:cerebellar Purkinje cell differentiation
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Accession:GO:0021702 term browser browse the term
Definition:The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem.


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cerebellar Purkinje cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtpbp1 ATP/GTP binding carboxypeptidase 1 acts_upstream_of_or_within
involved_in 		ISO MGI:1856535|MGI:1857523|MGI:2443047|MGI:6270378 (PMID:10630211), (PMID:30420556)
(PMID:11884758), (PMID:16465590), (PMID:21074048) 		RGD PMID:10630211 PMID:11884758 PMID:16465590 PMID:21074048 PMID:30420556 NCBI chr17:5,120,540...5,238,874
Ensembl chr17:5,120,609...5,238,869 		JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO MGI:1857876 (PMID:9668038) RGD PMID:9668038 NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665 		JBrowse link
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856466 (PMID:2473662) RGD PMID:2473662 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Atxn2 ataxin 2 acts_upstream_of_or_within ISO MGI:3505741 (PMID:10973246) RGD PMID:10973246 NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:1856209|MGI:1856210 (PMID:10630211), (PMID:1306163), (PMID:7834360) RGD PMID:1306163 PMID:7834360 PMID:10630211 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225 		JBrowse link
G Cend1 cell cycle exit and neuronal differentiation 1 involved_in
acts_upstream_of_or_within 		IBA
ISO
IEA 		GO_REF:0000033
MGI:4831137 (PMID:20153830)
GO_REF:0000107 		GO_Central
RGD
Ensembl		 PMID:20153830 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:196,525,153...196,528,152
Ensembl chr 1:196,523,920...196,528,302 		JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:21957071)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:21957071 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168 		JBrowse link
G Foxp2 forkhead box P2 involved_in ISO
IEA 		MGI:3778383 (PMID:22133810)
GO_REF:0000107 		RGD
Ensembl		 PMID:22133810 GO_REF:0000107 NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683 		JBrowse link
G Herc1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 acts_upstream_of_or_within ISO
IEA 		MGI:3613033 (PMID:20041218)
GO_REF:0000107 		RGD
Ensembl		 PMID:20041218 GO_REF:0000107 NCBI chr 8:75,796,347...75,965,347
Ensembl chr 8:66,856,935...67,070,312 		JBrowse link
G Ldb1 LIM domain binding 1 acts_upstream_of_or_within ISO
IEA 		MGI:3719683 (PMID:17664423)
GO_REF:0000107 		RGD
Ensembl		 PMID:17664423 GO_REF:0000107 NCBI chr 1:244,864,168...244,890,007
Ensembl chr 1:244,877,173...244,890,013 		JBrowse link
G Lhx1 LIM homeobox 1 involved_in
acts_upstream_of_or_within 		ISS
ISO
IEA 		GO_REF:0000024
MGI:107792 (PMID:17664423)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:17664423 GO_REF:0000024 GO_REF:0000107 NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617 		JBrowse link
G Lhx5 LIM homeobox 5 acts_upstream_of_or_within ISO
IEA 		MGI:99783 (PMID:17664423)
GO_REF:0000107 		RGD
Ensembl		 PMID:17664423 GO_REF:0000107 NCBI chr12:36,126,186...36,134,625
Ensembl chr12:36,126,186...36,134,625 		JBrowse link
G Psap prosaposin acts_upstream_of_or_within ISO MGI:3521746 (PMID:15345707) RGD PMID:15345707 NCBI chr20:28,214,229...28,240,501
Ensembl chr20:28,214,271...28,240,498 		JBrowse link
G Rora RAR-related orphan receptor A acts_upstream_of_or_within ISO
IEA 		MGI:1857035 (PMID:8996814)
GO_REF:0000107 		RGD
Ensembl		 PMID:8996814 GO_REF:0000107 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
G Skor2 SKI family transcriptional corepressor 2 acts_upstream_of_or_within ISO
IEA 		MGI:5300464 (PMID:21937600), (PMID:24491816)
GO_REF:0000107 		RGD
Ensembl		 PMID:21937600 PMID:24491816 GO_REF:0000107 NCBI chr18:70,404,431...70,446,330
Ensembl chr18:70,404,489...70,440,342 		JBrowse link
G Slc25a46 solute carrier family 25, member 46 acts_upstream_of_or_within ISO
IEA 		MGI:6358090 (PMID:28934388)
GO_REF:0000107 		RGD
Ensembl		 PMID:28934388 GO_REF:0000107 NCBI chr18:23,215,954...23,244,917
Ensembl chr18:23,215,962...23,244,314 		JBrowse link
G Top2a DNA topoisomerase II alpha IEP RGD PMID:11170002 RGD:8693630 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Ttc21b tetratricopeptide repeat domain 21B acts_upstream_of_or_within ISO
IEA 		MGI:2137515|MGI:2152544|MGI:2179048|MGI:5587034 (PMID:29615573)
GO_REF:0000107 		RGD
Ensembl		 PMID:29615573 GO_REF:0000107 NCBI chr 3:50,861,367...50,935,880
Ensembl chr 3:50,861,367...50,935,903 		JBrowse link
G Ttll1 TTL family tubulin polyglutamylase complex subunit L1 acts_upstream_of_or_within ISO
IEA 		MGI:1918244 (PMID:30420556)
GO_REF:0000107 		RGD
Ensembl		 PMID:30420556 GO_REF:0000107 NCBI chr 7:114,619,509...114,648,850
Ensembl chr 7:114,619,508...114,648,761 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    developmental process 7160
      anatomical structure formation involved in morphogenesis 1384
        cerebellar Purkinje cell layer formation 21
          cerebellar Purkinje cell differentiation 19
Path 2
Term Annotations click to browse term
  biological_process 20543
    developmental process 7160
      anatomical structure development 6656
        multicellular organism development 5362
          system development 4644
            nervous system development 2881
              central nervous system development 1238
                brain development 912
                  hindbrain development 228
                    metencephalon development 174
                      cerebellum development 160
                        cerebellar cortex development 71
                          cerebellar Purkinje cell layer development 40
                            cerebellar Purkinje cell layer morphogenesis 26
                              cerebellar Purkinje cell layer formation 21
                                cerebellar Purkinje cell differentiation 19
paths to the root