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ONTOLOGY REPORT - ANNOTATIONS

Term:cerebellar Purkinje cell layer morphogenesis
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Accession:GO:0021692 term browser browse the term
Definition:The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.


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cerebellar Purkinje cell layer morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO MGI:1857876 (MGI:3709537|PMID:17409239) RGD PMID:17409239 MGI:3709537 NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665 		JBrowse link
G Cntnap2 contactin associated protein 2 involved_in ISO (MGI:6477849|PMID:32675284) RGD PMID:32675284 MGI:6477849 NCBI chr 4:74,109,455...76,366,434
Ensembl chr 4:74,109,472...76,362,027 		JBrowse link
G Coq8b coenzyme Q8B involved_in ISS
ISO		 GO_REF:0000024
(PMID:27499294)		 UniProt
RGD		 PMID:27499294 GO_REF:0000024 NCBI chr 1:82,525,578...82,549,182
Ensembl chr 1:82,526,568...82,549,180 		JBrowse link
G Sptbn2 spectrin, beta, non-erythrocytic 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:4127354 (MGI:4438955|PMID:20231455)
GO_REF:0000107		 RGD
Ensembl		 PMID:20231455 GO_REF:0000107 MGI:4438955 NCBI chr 1:202,002,970...202,045,343
Ensembl chr 1:202,002,970...202,044,283 		JBrowse link
cerebellar Purkinje cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtpbp1 ATP/GTP binding carboxypeptidase 1 acts_upstream_of_or_within
involved_in		 ISO MGI:1856535|MGI:1857523|MGI:2443047|MGI:6270378 (MGI:1347769|PMID:10630211), (MGI:6269036|PMID:30420556)
(MGI:2159417|PMID:11884758), (MGI:3614720|PMID:16465590), (MGI:4849873|PMID:21074048)		 RGD PMID:10630211 PMID:11884758 PMID:16465590 PMID:21074048 PMID:30420556 MGI:1347769 MGI:2159417 MGI:3614720 MGI:4849873 MGI:6269036 NCBI chr17:5,120,540...5,238,874
Ensembl chr17:5,120,609...5,238,869 		JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO MGI:1857876 (MGI:1275896|PMID:9668038) RGD PMID:9668038 MGI:1275896 NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665 		JBrowse link
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856466 (MGI:71790|PMID:2473662) RGD PMID:2473662 MGI:71790 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Atxn2 ataxin 2 acts_upstream_of_or_within ISO MGI:3505741 (MGI:3510013|PMID:10973246) RGD PMID:10973246 MGI:3510013 NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:1856209|MGI:1856210 (MGI:1347769|PMID:10630211), (MGI:62667|PMID:1306163), (MGI:68980|PMID:7834360) RGD PMID:1306163 PMID:7834360 PMID:10630211 MGI:1347769 MGI:62667 MGI:68980 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225 		JBrowse link
G Cend1 cell cycle exit and neuronal differentiation 1 acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:4831137 (MGI:4830814|PMID:20153830)
PMID:21873635		 RGD PMID:20153830 PMID:21873635 MGI:4830814, RGD:13792537 NCBI chr 1:196,525,153...196,528,152
Ensembl chr 1:196,523,920...196,528,302 		JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5295128|PMID:21957071)		 UniProt
RGD		 PMID:21957071 GO_REF:0000024 MGI:5295128 NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168 		JBrowse link
G Foxp2 forkhead box P2 involved_in ISO MGI:3778383 (MGI:5306536|PMID:22133810) RGD PMID:22133810 MGI:5306536 NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683 		JBrowse link
G Herc1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 acts_upstream_of_or_within ISO MGI:3613033 (MGI:4461108|PMID:20041218) RGD PMID:20041218 MGI:4461108 NCBI chr 8:66,857,169...67,070,318
Ensembl chr 8:66,856,935...67,070,312 		JBrowse link
G Ldb1 LIM domain binding 1 acts_upstream_of_or_within ISO MGI:3719683 (MGI:3718715|PMID:17664423) RGD PMID:17664423 MGI:3718715 NCBI chr 1:244,864,168...244,890,007
Ensembl chr 1:244,877,173...244,890,013 		JBrowse link
G Lhx1 LIM homeobox 1 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:107792 (MGI:3718715|PMID:17664423)		 UniProt
RGD		 PMID:17664423 GO_REF:0000024 MGI:3718715 NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617 		JBrowse link
G Lhx5 LIM homeobox 5 acts_upstream_of_or_within ISO MGI:99783 (MGI:3718715|PMID:17664423) RGD PMID:17664423 MGI:3718715 NCBI chr12:36,126,186...36,134,625
Ensembl chr12:36,126,186...36,134,625 		JBrowse link
G Psap prosaposin acts_upstream_of_or_within ISO MGI:3521746 (MGI:3512714|PMID:15345707) RGD PMID:15345707 MGI:3512714 NCBI chr20:28,214,229...28,240,501
Ensembl chr20:28,214,271...28,240,498 		JBrowse link
G Rora RAR-related orphan receptor A acts_upstream_of_or_within ISO MGI:1857035 (MGI:86446|PMID:8996814) RGD PMID:8996814 MGI:86446 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
G Skor2 SKI family transcriptional corepressor 2 acts_upstream_of_or_within ISO MGI:5300464 (MGI:5300220|PMID:21937600), (MGI:5565016|PMID:24491816) RGD PMID:21937600 PMID:24491816 MGI:5300220 MGI:5565016 NCBI chr18:70,404,431...70,446,330
Ensembl chr18:70,404,489...70,440,342 		JBrowse link
G Slc25a46 solute carrier family 25, member 46 acts_upstream_of_or_within ISO MGI:6358090 (MGI:5921109|PMID:28934388) RGD PMID:28934388 MGI:5921109 NCBI chr18:23,215,954...23,244,917
Ensembl chr18:23,215,962...23,244,314 		JBrowse link
G Top2a DNA topoisomerase II alpha IEP RGD PMID:11170002 RGD:8693630 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Ttc21b tetratricopeptide repeat domain 21B acts_upstream_of_or_within ISO MGI:2137515|MGI:2152544|MGI:2179048|MGI:5587034 (MGI:6152587|PMID:29615573) RGD PMID:29615573 MGI:6152587 NCBI chr 3:50,861,367...50,935,880
Ensembl chr 3:50,861,367...50,935,903 		JBrowse link
G Ttll1 TTL family tubulin polyglutamylase complex subunit L1 acts_upstream_of_or_within ISO MGI:1918244 (MGI:6269036|PMID:30420556) RGD PMID:30420556 MGI:6269036 NCBI chr 7:114,619,509...114,648,850
Ensembl chr 7:114,619,508...114,648,761 		JBrowse link
cerebellar Purkinje cell layer formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gba1 glucosylceramidase beta 1 acts_upstream_of_or_within ISO (MGI:3762988|PMID:17954912) RGD PMID:17954912 MGI:3762988 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G Whrn whirlin involved_in IEA
ISO		 GO_REF:0000107
(MGI:5516521|PMID:24011083)		 Ensembl
RGD		 PMID:24011083 GO_REF:0000107 MGI:5516521 NCBI chr 5:76,828,308...76,911,945
Ensembl chr 5:76,828,301...76,912,223 		JBrowse link
cerebellar Purkinje cell layer structural organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:5504540|PMID:23688253)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:23688253 GO_REF:0000024 GO_REF:0000107 MGI:5504540 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179 		JBrowse link
G Kif14 kinesin family member 14 involved_in ISO (MGI:5485315|PMID:23308235) RGD PMID:23308235 MGI:5485315 NCBI chr13:47,926,975...47,990,598
Ensembl chr13:47,927,044...47,989,164 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19553
    developmental process 6909
      anatomical structure morphogenesis 2939
        cerebellar Purkinje cell layer morphogenesis 26
          cerebellar Purkinje cell layer formation + 21
          cerebellar Purkinje cell layer structural organization 2
Path 2
Term Annotations click to browse term
  biological_process 19553
    developmental process 6909
      anatomical structure development 6435
        multicellular organism development 5184
          system development 4463
            nervous system development 2734
              central nervous system development 1189
                brain development 885
                  hindbrain development 228
                    metencephalon development 174
                      cerebellum development 160
                        cerebellar cortex development 73
                          cerebellar Purkinje cell layer development 40
                            cerebellar Purkinje cell layer morphogenesis 26
                              cerebellar Purkinje cell layer formation + 21
                              cerebellar Purkinje cell layer structural organization 2
paths to the root