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ONTOLOGY REPORT - ANNOTATIONS

Term:cerebellar Purkinje cell layer development
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Accession:GO:0021680 term browser browse the term
Definition:The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.


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cerebellar Purkinje cell layer development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 acts_upstream_of_or_within ISO MGI:3618596 (MGI:3640843|PMID:16906134) RGD PMID:16906134 MGI:3640843 NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147 		JBrowse link
G Agtpbp1 ATP/GTP binding carboxypeptidase 1 acts_upstream_of_or_within ISO (MGI:4849309|PMID:21052544) RGD PMID:21052544 MGI:4849309 NCBI chr17:5,120,540...5,238,874
Ensembl chr17:5,120,609...5,238,869 		JBrowse link
G Atg7 autophagy related 7 acts_upstream_of_or_within ISO MGI:2386545|MGI:3587769 (MGI:3630371|PMID:16625205), (MGI:4829568|PMID:20577052) RGD PMID:16625205 PMID:20577052 MGI:3630371 MGI:4829568 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G B4galt2 beta-1,4-galactosyltransferase 2 acts_upstream_of_or_within ISO MGI:3849305 (MGI:3849110|PMID:19265195) RGD PMID:19265195 MGI:3849110 NCBI chr 5:131,412,541...131,422,573
Ensembl chr 5:131,412,541...131,421,013 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:1856209|MGI:1856210 (MGI:62667|PMID:1306163) RGD PMID:1306163 MGI:62667 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225 		JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5295128|PMID:21957071)		 UniProt
RGD		 PMID:21957071 GO_REF:0000024 MGI:5295128 NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISO (MGI:4437543|PMID:19816510) RGD PMID:19816510 MGI:4437543 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Klhl1 kelch-like family member 1 acts_upstream_of_or_within ISO MGI:3664534|MGI:3664543 (MGI:3664006|PMID:17005861) RGD PMID:17005861 MGI:3664006 NCBI chr15:72,698,188...73,142,707
Ensembl chr15:72,699,094...73,142,594 		JBrowse link
G Myh10 myosin heavy chain 10 acts_upstream_of_or_within ISO MGI:3664765 (MGI:3656460|PMID:16481398) RGD PMID:16481398 MGI:3656460 NCBI chr10:53,393,901...53,525,174
Ensembl chr10:53,394,389...53,525,165 		JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase acts_upstream_of_or_within ISO MGI:1934018 (MGI:3769195|PMID:17712420) RGD PMID:17712420 MGI:3769195 NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972 		JBrowse link
G Nfix nuclear factor I X acts_upstream_of_or_within ISO MGI:3802571 (MGI:5436217|PMID:21800304) RGD PMID:21800304 MGI:5436217 NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265 		JBrowse link
G Sez6 seizure related 6 homolog acts_upstream_of_or_within ISO MGI:1935121|MGI:2385295 (MGI:3654399|PMID:16814779) RGD PMID:16814779 MGI:3654399 NCBI chr10:62,818,931...62,868,686
Ensembl chr10:62,819,069...62,868,671 		JBrowse link
G Sez6l seizure related 6 homolog like acts_upstream_of_or_within ISO MGI:104745|MGI:2385295 (MGI:3654399|PMID:16814779) RGD PMID:16814779 MGI:3654399 NCBI chr12:44,064,628...44,221,815
Ensembl chr12:44,064,935...44,219,663 		JBrowse link
G Sez6l2 seizure related 6 homolog like 2 acts_upstream_of_or_within ISO MGI:104745|MGI:1935121 (MGI:3654399|PMID:16814779) RGD PMID:16814779 MGI:3654399 NCBI chr 1:181,557,109...181,577,456
Ensembl chr 1:181,557,109...181,577,456 		JBrowse link
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII involved_in ISO (MGI:3662936|PMID:16901643) RGD PMID:16901643 MGI:3662936 NCBI chr10:37,585,864...37,589,328
Ensembl chr10:37,586,888...37,589,169 		JBrowse link
cerebellar Purkinje cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtpbp1 ATP/GTP binding carboxypeptidase 1 involved_in
acts_upstream_of_or_within		 ISO (MGI:2159417|PMID:11884758), (MGI:3614720|PMID:16465590), (MGI:4849873|PMID:21074048)
MGI:1856535|MGI:1857523|MGI:2443047|MGI:6270378 (MGI:1347769|PMID:10630211), (MGI:6269036|PMID:30420556)		 RGD PMID:10630211 PMID:11884758 PMID:16465590 PMID:21074048 PMID:30420556 MGI:1347769 MGI:2159417 MGI:3614720 MGI:4849873 MGI:6269036 NCBI chr17:5,120,540...5,238,874
Ensembl chr17:5,120,609...5,238,869 		JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO MGI:1857876 (MGI:1275896|PMID:9668038) RGD PMID:9668038 MGI:1275896 NCBI chr 4:146,896,332...147,140,665
Ensembl chr 4:146,896,332...147,140,665 		JBrowse link
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856466 (MGI:71790|PMID:2473662) RGD PMID:2473662 MGI:71790 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Atxn2 ataxin 2 acts_upstream_of_or_within ISO MGI:3505741 (MGI:3510013|PMID:10973246) RGD PMID:10973246 MGI:3510013 NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:1856209|MGI:1856210 (MGI:1347769|PMID:10630211), (MGI:62667|PMID:1306163), (MGI:68980|PMID:7834360) RGD PMID:1306163 PMID:7834360 PMID:10630211 MGI:1347769 MGI:62667 MGI:68980 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225 		JBrowse link
G Cend1 cell cycle exit and neuronal differentiation 1 acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:4831137 (MGI:4830814|PMID:20153830)
PMID:21873635		 RGD PMID:20153830 PMID:21873635 MGI:4830814, RGD:13792537 NCBI chr 1:196,525,153...196,528,152
Ensembl chr 1:196,523,920...196,528,302 		JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:5295128|PMID:21957071)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:21957071 GO_REF:0000024 GO_REF:0000107 MGI:5295128 NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168 		JBrowse link
G Foxp2 forkhead box P2 involved_in ISO MGI:3778383 (MGI:5306536|PMID:22133810) RGD PMID:22133810 MGI:5306536 NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683 		JBrowse link
G Herc1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 acts_upstream_of_or_within ISO MGI:3613033 (MGI:4461108|PMID:20041218) RGD PMID:20041218 MGI:4461108 NCBI chr 8:66,857,169...67,070,318
Ensembl chr 8:66,856,935...67,070,312 		JBrowse link
G Ldb1 LIM domain binding 1 acts_upstream_of_or_within ISO MGI:3719683 (MGI:3718715|PMID:17664423) RGD PMID:17664423 MGI:3718715 NCBI chr 1:244,864,168...244,890,007
Ensembl chr 1:244,877,173...244,890,013 		JBrowse link
G Lhx1 LIM homeobox 1 acts_upstream_of_or_within
involved_in		 ISO
ISS		 MGI:107792 (MGI:3718715|PMID:17664423)
GO_REF:0000024		 RGD
UniProt		 PMID:17664423 GO_REF:0000024 MGI:3718715 NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617 		JBrowse link
G Lhx5 LIM homeobox 5 acts_upstream_of_or_within ISO MGI:99783 (MGI:3718715|PMID:17664423) RGD PMID:17664423 MGI:3718715 NCBI chr12:36,126,186...36,134,625
Ensembl chr12:36,126,186...36,134,625 		JBrowse link
G Psap prosaposin acts_upstream_of_or_within ISO MGI:3521746 (MGI:3512714|PMID:15345707) RGD PMID:15345707 MGI:3512714 NCBI chr20:28,214,229...28,240,501
Ensembl chr20:28,214,271...28,240,498 		JBrowse link
G Rora RAR-related orphan receptor A acts_upstream_of_or_within ISO MGI:1857035 (MGI:86446|PMID:8996814) RGD PMID:8996814 MGI:86446 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
G Skor2 SKI family transcriptional corepressor 2 acts_upstream_of_or_within ISO MGI:5300464 (MGI:5300220|PMID:21937600), (MGI:5565016|PMID:24491816) RGD PMID:21937600 PMID:24491816 MGI:5300220 MGI:5565016 NCBI chr18:70,404,431...70,446,330
Ensembl chr18:70,404,489...70,440,342 		JBrowse link
G Slc25a46 solute carrier family 25, member 46 acts_upstream_of_or_within ISO MGI:6358090 (MGI:5921109|PMID:28934388) RGD PMID:28934388 MGI:5921109 NCBI chr18:23,215,954...23,244,917
Ensembl chr18:23,215,962...23,244,314 		JBrowse link
G Top2a DNA topoisomerase II alpha IEP RGD PMID:11170002 RGD:8693630 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Ttc21b tetratricopeptide repeat domain 21B acts_upstream_of_or_within ISO MGI:2137515|MGI:2152544|MGI:2179048|MGI:5587034 (MGI:6152587|PMID:29615573) RGD PMID:29615573 MGI:6152587 NCBI chr 3:50,861,367...50,935,782
Ensembl chr 3:50,861,367...50,935,903 		JBrowse link
G Ttll1 TTL family tubulin polyglutamylase complex subunit L1 acts_upstream_of_or_within ISO MGI:1918244 (MGI:6269036|PMID:30420556) RGD PMID:30420556 MGI:6269036 NCBI chr 7:114,619,509...114,648,850
Ensembl chr 7:114,619,508...114,648,761 		JBrowse link
cerebellar Purkinje cell layer formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gba glucosylceramidase beta acts_upstream_of_or_within ISO (MGI:3762988|PMID:17954912) RGD PMID:17954912 MGI:3762988 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G Whrn whirlin involved_in ISO
IEA		 (MGI:5516521|PMID:24011083)
GO_REF:0000107		 RGD
Ensembl		 PMID:24011083 GO_REF:0000107 MGI:5516521 NCBI chr 5:76,828,308...76,911,945
Ensembl chr 5:76,828,301...76,912,223 		JBrowse link
cerebellar Purkinje cell layer maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arcn1 archain 1 acts_upstream_of_or_within ISO MGI:2671790 (MGI:4454933|PMID:20502676) RGD PMID:20502676 MGI:4454933 NCBI chr 8:45,057,617...45,082,224
Ensembl chr 8:45,057,619...45,082,247 		JBrowse link
G Rere arginine-glutamic acid dipeptide repeats acts_upstream_of_or_within ISO MGI:3577419 (MGI:5582020|PMID:24466353) RGD PMID:24466353 MGI:5582020 NCBI chr 5:160,765,855...161,097,678
Ensembl chr 5:160,765,934...161,097,677 		JBrowse link
cerebellar Purkinje cell layer morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO MGI:1857876 (MGI:3709537|PMID:17409239) RGD PMID:17409239 MGI:3709537 NCBI chr 4:146,896,332...147,140,665
Ensembl chr 4:146,896,332...147,140,665 		JBrowse link
G Cntnap2 contactin associated protein 2 involved_in ISO (MGI:6477849|PMID:32675284) RGD PMID:32675284 MGI:6477849 NCBI chr 4:74,109,455...76,366,434
Ensembl chr 4:74,109,472...76,362,027 		JBrowse link
G Coq8b coenzyme Q8B involved_in ISS
ISO		 GO_REF:0000024
(PMID:27499294)		 UniProt
RGD		 PMID:27499294 GO_REF:0000024 NCBI chr 1:82,525,578...82,549,182
Ensembl chr 1:82,526,568...82,549,180 		JBrowse link
G Sptbn2 spectrin, beta, non-erythrocytic 2 acts_upstream_of_or_within ISO MGI:4127354 (MGI:4438955|PMID:20231455) RGD PMID:20231455 MGI:4438955 NCBI chr 1:202,002,970...202,045,343
Ensembl chr 1:202,002,970...202,044,283 		JBrowse link
cerebellar Purkinje cell layer structural organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:5504540|PMID:23688253)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:23688253 GO_REF:0000024 GO_REF:0000107 MGI:5504540 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179 		JBrowse link
G Kif14 kinesin family member 14 involved_in ISO (MGI:5485315|PMID:23308235) RGD PMID:23308235 MGI:5485315 NCBI chr13:47,926,975...47,990,598
Ensembl chr13:47,927,044...47,989,164 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19746
    developmental process 6931
      anatomical structure development 6386
        cerebellar Purkinje cell layer development 40
          cerebellar Purkinje cell layer maturation 2
          cerebellar Purkinje cell layer morphogenesis + 26
Path 2
Term Annotations click to browse term
  biological_process 19746
    developmental process 6931
      anatomical structure development 6386
        multicellular organism development 5165
          system development 4438
            nervous system development 2706
              central nervous system development 1190
                brain development 890
                  hindbrain development 227
                    metencephalon development 173
                      cerebellum development 159
                        cerebellar cortex development 72
                          cerebellar Purkinje cell layer development 40
                            cerebellar Purkinje cell layer maturation 2
                            cerebellar Purkinje cell layer morphogenesis + 26
paths to the root