ONTOLOGY REPORT - ANNOTATIONS
Term: translesion synthesis
Accession: GO:0019985
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Definition: The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.
Synonyms: exact_synonym: bypass DNA synthesis
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Dtl
denticleless E3 ubiquitin protein ligase homolog
involved_in
ISO
(PMID:20129063)
RGD
PMID:20129063
NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890
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Faap20
FA core complex associated protein 20
involved_in
ISO ISS
(PMID:22266823) GO_REF:0000024
RGD UniProt
PMID:22266823
GO_REF:0000024
NCBI chr 5:165,808,370...165,815,291
Ensembl chr 5:165,808,657...165,815,333
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Parp10
poly (ADP-ribose) polymerase family, member 10
involved_in
ISO
(PMID:24695737)
RGD
PMID:24695737
NCBI chr 7:107,949,031...107,958,377
Ensembl chr 7:107,949,043...107,958,304
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Pclaf
PCNA clamp associated factor
involved_in
ISO IBA ISS
(PMID:23000965) GO_REF:0000033 GO_REF:0000024
RGD GO_Central UniProt
PMID:23000965
GO_REF:0000024 GO_REF:0000033
NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994 Ensembl chr 8:66,420,587...66,432,994
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Pcna
proliferating cell nuclear antigen
involved_in
ISO ISS IBA
(PMID:20129063) GO_REF:0000024 GO_REF:0000033
RGD UniProt GO_Central
PMID:20129063
GO_REF:0000024 GO_REF:0000033
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Poli
DNA polymerase iota
involved_in acts_upstream_of_or_within
IBA ISO
GO_REF:0000033 MGI:3055735 (PMID:17114294)
GO_Central RGD
PMID:17114294
GO_REF:0000033
NCBI chr18:64,116,774...64,134,373
Ensembl chr18:64,116,774...64,163,418
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Poln
DNA polymerase nu
involved_in
ISO
(PMID:19908865), (PMID:20102227)
RGD
PMID:19908865 PMID:20102227
NCBI chr14:76,579,983...76,752,460
Ensembl chr14:76,580,546...76,752,463
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Primpol
primase and DNA directed polymerase
involved_in
ISO IBA
(PMID:24240614), (PMID:24267451) GO_REF:0000033
RGD GO_Central
PMID:24240614 PMID:24267451
GO_REF:0000033
NCBI chr16:45,681,252...45,715,758
Ensembl chr16:45,681,326...45,715,565
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Sprtn
SprT-like N-terminal domain
involved_in
IEA ISS ISO
GO_REF:0000107 GO_REF:0000024 (PMID:22681887), (PMID:22902628), (PMID:23042605), (PMID:23042607)
Ensembl UniProt RGD
PMID:22681887 PMID:22902628 PMID:23042605 PMID:23042607
GO_REF:0000024 GO_REF:0000107
NCBI chr19:52,857,612...52,864,864
Ensembl chr19:52,857,866...52,864,864
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Vcp
valosin-containing protein
involved_in
ISO ISS
(PMID:23042605) GO_REF:0000024
RGD UniProt
PMID:23042605
GO_REF:0000024
NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
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Zbtb1
zinc finger and BTB domain containing 1
involved_in
ISO
(PMID:24657165)
RGD
PMID:24657165
NCBI chr 6:95,096,838...95,125,811
Ensembl chr 6:95,096,387...95,118,996
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Pold1
DNA polymerase delta 1, catalytic subunit
involved_in
ISO ISS IEA
(PMID:24191025) GO_REF:0000024 GO_REF:0000107
RGD UniProt Ensembl
PMID:24191025
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465
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Poldip2
DNA polymerase delta interacting protein 2
involved_in
ISO IBA
(PMID:24191025) GO_REF:0000033
RGD GO_Central
PMID:24191025
GO_REF:0000033
NCBI chr10:63,407,237...63,417,605
Ensembl chr10:63,407,213...63,417,605
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Rev1
REV1, DNA directed polymerase
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 9:40,278,100...40,351,764
Ensembl chr 9:40,278,101...40,351,576
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Mad2l2
mitotic arrest deficient 2 like 2
involved_in
ISO
(PMID:24449906)
RGD
PMID:24449906
NCBI chr 5:158,563,545...158,576,698
Ensembl chr 5:158,563,567...158,576,693
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Pold2
DNA polymerase delta 2, accessory subunit
involved_in
ISO IEA
(PMID:24449906) GO_REF:0000107
RGD Ensembl
PMID:24449906
GO_REF:0000107
NCBI chr14:80,748,971...80,755,188
Ensembl chr14:80,748,974...80,755,160
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Pold3
DNA polymerase delta 3, accessory subunit
involved_in
ISO
(PMID:24449906)
RGD
PMID:24449906
NCBI chr 1:154,417,893...154,456,687
Ensembl chr 1:154,418,084...154,456,665
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Pole2
DNA polymerase epsilon 2, accessory subunit
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 6:87,674,702...87,712,723
Ensembl chr 6:87,674,702...87,699,305
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Polh
DNA polymerase eta
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723
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Polk
DNA polymerase kappa
involved_in
ISO IBA
(PMID:28297716) GO_REF:0000033
RGD GO_Central
PMID:28297716
GO_REF:0000033
NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313
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Polq
DNA polymerase theta
involved_in
ISO
(PMID:30655289)
RGD
PMID:30655289
NCBI chr11:63,673,796...63,775,905
Ensembl chr11:63,673,816...63,775,878
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Primpol
primase and DNA directed polymerase
involved_in
ISO
(PMID:24682820), (PMID:25746449), (PMID:28534480)
RGD
PMID:24682820 PMID:25746449 PMID:28534480
NCBI chr16:45,681,252...45,715,758
Ensembl chr16:45,681,326...45,715,565
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Rev1
REV1, DNA directed polymerase
involved_in acts_upstream_of_or_within
IBA ISO
GO_REF:0000033 (PMID:11711549)
GO_Central RGD
PMID:11711549
GO_REF:0000033
NCBI chr 9:40,278,100...40,351,764
Ensembl chr 9:40,278,101...40,351,576
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Rev3l
REV3 like, DNA directed polymerase zeta catalytic subunit
involved_in
ISO IBA
(PMID:24449906) GO_REF:0000033
RGD GO_Central
PMID:24449906
GO_REF:0000033
NCBI chr20:43,131,841...43,290,102
Ensembl chr20:43,132,363...43,290,099
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