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ONTOLOGY REPORT - ANNOTATIONS


Term:error-prone translesion synthesis
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Accession:GO:0042276 term browser browse the term
Definition:The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.
Synonyms:exact_synonym: mutagenic PRR
 related_synonym: error-prone postreplication DNA repair;   mutagenic postreplication DNA repair


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error-prone translesion synthesis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pole2 DNA polymerase epsilon 2, accessory subunit JBrowse link 6 91,494,348 91,532,355 RGD:13792537
G Polh DNA polymerase eta JBrowse link 9 17,163,354 17,198,006 RGD:13792537
G Polk DNA polymerase kappa JBrowse link 2 27,305,718 27,364,906 RGD:1624291
RGD:13792537
G Rev1 REV1, DNA directed polymerase JBrowse link 9 44,714,137 44,786,330 RGD:1624291
RGD:13792537
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit JBrowse link 20 44,803,664 44,961,362 RGD:13792537

Term paths to the root
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Term Annotations click to browse term
  biological_process 19336
    metabolic process 11555
      cellular metabolic process 10567
        cellular macromolecule metabolic process 8127
          DNA metabolic process 877
            DNA repair 470
              DNA synthesis involved in DNA repair 30
                translesion synthesis 16
                  error-prone translesion synthesis 5
                    negative regulation of error-prone translesion synthesis 0
                    positive regulation of error-prone translesion synthesis 0
                    regulation of error-prone translesion synthesis + 0
Path 2
Term Annotations click to browse term
  biological_process 19336
    metabolic process 11555
      cellular metabolic process 10567
        cellular aromatic compound metabolic process 5484
          nucleobase-containing compound metabolic process 5258
            nucleic acid metabolic process 4770
              DNA metabolic process 877
                DNA repair 470
                  DNA synthesis involved in DNA repair 30
                    translesion synthesis 16
                      error-prone translesion synthesis 5
                        negative regulation of error-prone translesion synthesis 0
                        positive regulation of error-prone translesion synthesis 0
                        regulation of error-prone translesion synthesis + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.