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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of macroautophagy
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Accession:GO:0016242 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.
Synonyms:exact_synonym: down regulation of macroautophagy;   downregulation of macroautophagy;   negative regulation of starvation-induced autophagy
 narrow_synonym: inhibition of macroautophagy



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negative regulation of macroautophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 acts_upstream_of_or_within IMP (PMID:20705711) MGI PMID:20705711 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO GO_Central GO_REF:0000119 NCBI chr15:91,556,994...91,700,327
Ensembl chr15:91,557,378...91,700,323
JBrowse link
G Lzts1 leucine zipper, putative tumor suppressor 1 involved_in ISO
IEA
GO_Central
Ensembl
GO_REF:0000107 GO_REF:0000119 NCBI chr 8:69,585,311...69,636,901
Ensembl chr 8:69,585,321...69,636,877
JBrowse link
G Mtor mechanistic target of rapamycin kinase acts_upstream_of_or_within
involved_in
IMP
IBA
ISO
(PMID:16714284), (PMID:23274896)
(PMID:25327288)
MGI
GO_Central
PMID:16714284 PMID:23274896 PMID:25327288 GO_REF:0000033 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 acts_upstream_of_or_within IGI
IMP
(PMID:17468177) MGI PMID:17468177 NCBI chr18:12,322,751...12,369,851
Ensembl chr18:12,322,749...12,369,457
JBrowse link
G Nrbp2 nuclear receptor binding protein 2 involved_in ISO
IEA
GO_Central
Ensembl
GO_REF:0000107 GO_REF:0000119 NCBI chr15:75,957,364...75,963,539
Ensembl chr15:75,957,367...75,963,476
JBrowse link
G Pink1 PTEN induced putative kinase 1 involved_in ISO GO_Central GO_REF:0000119 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618
JBrowse link
G Poldip2 polymerase (DNA-directed), delta interacting protein 2 acts_upstream_of_or_within IMP (PMID:24797518) MGI PMID:24797518 NCBI chr11:78,403,105...78,413,562
Ensembl chr11:78,403,019...78,413,562
JBrowse link
G Qsox1 quiescin Q6 sulfhydryl oxidase 1 involved_in ISO
IEA
GO_Central
Ensembl
GO_REF:0000107 GO_REF:0000119 NCBI chr 1:155,653,901...155,688,645
Ensembl chr 1:155,651,775...155,688,635
JBrowse link
G Smcr8 Smith-Magenis syndrome chromosome region, candidate 8 homolog (human) involved_in ISO
ISS
GO_Central
UniProt
GO_REF:0000024 GO_REF:0000119 NCBI chr11:60,668,351...60,679,113
Ensembl chr11:60,668,350...60,679,113
JBrowse link
G Tsc1 TSC complex subunit 1 involved_in ISS
ISO
ParkinsonsUK-UCL
GO_Central
GO_REF:0000024 GO_REF:0000096 NCBI chr 2:28,531,005...28,581,183
Ensembl chr 2:28,531,240...28,581,179
JBrowse link
G Tsc2 TSC complex subunit 2 involved_in ISO RGD
GO_Central
PMID:24599401 GO_REF:0000096 RGD:11568679 NCBI chr17:24,814,788...24,851,607
Ensembl chr17:24,814,790...24,851,604
JBrowse link
G Usp36 ubiquitin specific peptidase 36 involved_in ISS
ISO
UniProt
GO_Central
GO_REF:0000024 GO_REF:0000119 NCBI chr11:118,150,477...118,181,086
Ensembl chr11:118,150,477...118,181,070
JBrowse link
negative regulation of aggrephagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac6 histone deacetylase 6 involved_in ISO
IEA
GO_Central
Ensembl
GO_REF:0000107 GO_REF:0000119 NCBI chr  X:7,796,355...7,814,284
Ensembl chr  X:7,796,359...7,814,128
JBrowse link
G Lypla1 lysophospholipase 1 involved_in ISO
IEA
GO_Central
Ensembl
GO_REF:0000107 GO_REF:0000119 NCBI chr 1:4,878,046...4,916,958
Ensembl chr 1:4,878,011...4,918,633
JBrowse link
negative regulation of autophagosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1, autophagy related acts_upstream_of_or_within IMP (PMID:27994061) MGI PMID:27994061 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112
JBrowse link
G Ehmt2 euchromatic histone lysine N-methyltransferase 2 acts_upstream_of_or_within IMP (PMID:23918802) MGI PMID:23918802 NCBI chr17:35,117,427...35,133,049
Ensembl chr17:35,117,445...35,133,028
JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 involved_in ISS GO_Central GO_REF:0000024 NCBI chr 9:36,732,694...36,790,220
Ensembl chr 9:36,733,160...36,790,220
JBrowse link
G Fez2 fasciculation and elongation protein zeta 2 involved_in ISS GO_Central GO_REF:0000024 NCBI chr17:78,676,641...78,725,581
Ensembl chr17:78,676,641...78,725,581
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO
IEA
GO_Central
Ensembl
GO_REF:0000107 GO_REF:0000119 NCBI chr15:91,556,994...91,700,327
Ensembl chr15:91,557,378...91,700,323
JBrowse link
G Mtm1 X-linked myotubular myopathy gene 1 involved_in
acts_upstream_of_or_within
IBA
IMP
(PMID:23695157) GO_Central
MGI
PMID:23695157 GO_REF:0000033 NCBI chr  X:70,254,373...70,359,019
Ensembl chr  X:70,254,373...70,359,297
JBrowse link
G Nupr1 nuclear protein transcription regulator 1 involved_in ISO
ISS
GO_Central
UniProt
GO_REF:0000024 GO_REF:0000119 NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033
JBrowse link
G Phf23 PHD finger protein 23 involved_in IBA
ISS
GO_Central GO_REF:0000024 GO_REF:0000033 NCBI chr11:69,886,592...69,890,837
Ensembl chr11:69,886,603...69,890,835
JBrowse link
G Pink1 PTEN induced putative kinase 1 involved_in IEA
ISO
Ensembl
GO_Central
GO_REF:0000107 GO_REF:0000119 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618
JBrowse link
G Scfd1 Sec1 family domain containing 1 involved_in IEA
ISO
Ensembl
GO_Central
GO_REF:0000107 GO_REF:0000119 NCBI chr12:51,424,296...51,496,887
Ensembl chr12:51,424,293...51,496,884
JBrowse link
G Sec22b SEC22 homolog B, vesicle trafficking protein involved_in ISO
IEA
GO_Central
Ensembl
GO_REF:0000107 GO_REF:0000119 NCBI chr 3:97,808,543...97,829,634
Ensembl chr 3:97,808,506...97,830,592
JBrowse link
G Smcr8 Smith-Magenis syndrome chromosome region, candidate 8 homolog (human) involved_in ISS
ISO
UniProt
GO_Central
GO_REF:0000024 GO_REF:0000119 NCBI chr11:60,668,351...60,679,113
Ensembl chr11:60,668,350...60,679,113
JBrowse link
G Tmem39a transmembrane protein 39a involved_in IBA
ISS
ISO
GO_Central
UniProt
GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr16:38,379,060...38,412,524
Ensembl chr16:38,379,060...38,412,524
JBrowse link
negative regulation of autophagosome maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec16a C-type lectin domain family 16, member A involved_in ISO GO_Central GO_REF:0000119 NCBI chr16:10,363,173...10,562,742
Ensembl chr16:10,363,203...10,562,742
JBrowse link
G Phf23 PHD finger protein 23 involved_in IBA
ISS
GO_Central GO_REF:0000024 GO_REF:0000033 NCBI chr11:69,886,592...69,890,837
Ensembl chr11:69,886,603...69,890,835
JBrowse link
G Rubcn RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein involved_in IBA
IEA
ISO
GO_Central
Ensembl
GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr16:32,642,072...32,698,121
Ensembl chr16:32,642,073...32,698,136
JBrowse link
G Tmem39a transmembrane protein 39a involved_in IBA
ISO
ISS
GO_Central
UniProt
GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr16:38,379,060...38,412,524
Ensembl chr16:38,379,060...38,412,524
JBrowse link
G Ubqln4 ubiquilin 4 involved_in ISO
IEA
GO_Central
Ensembl
GO_REF:0000107 GO_REF:0000119 NCBI chr 3:88,460,984...88,477,032
Ensembl chr 3:88,461,065...88,477,032
JBrowse link
negative regulation of mitophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec16a C-type lectin domain family 16, member A acts_upstream_of_or_within IMP (PMID:24949970) MGI PMID:24949970 NCBI chr16:10,363,173...10,562,742
Ensembl chr16:10,363,203...10,562,742
JBrowse link
G Pink1 PTEN induced putative kinase 1 involved_in ISO
IEA
GO_Central
Ensembl
GO_REF:0000107 GO_REF:0000119 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618
JBrowse link
G Rnf41 ring finger protein 41 acts_upstream_of_or_within IGI (PMID:24949970) MGI PMID:24949970 NCBI chr10:128,247,485...128,277,310
Ensembl chr10:128,247,526...128,277,310
JBrowse link
G Tigar Trp53 induced glycolysis regulatory phosphatase acts_upstream_of_or_within IMP (PMID:22044588) MGI PMID:22044588 NCBI chr 6:127,062,079...127,086,564
Ensembl chr 6:127,062,079...127,086,520
JBrowse link
G Trp53 transformation related protein 53 acts_upstream_of_or_within IMP (PMID:22044588) MGI PMID:22044588 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Tspo translocator protein involved_in IMP (PMID:25470454) ParkinsonsUK-UCL PMID:25470454 NCBI chr15:83,447,774...83,458,404
Ensembl chr15:83,447,793...83,458,404
JBrowse link
G Usp30 ubiquitin specific peptidase 30 involved_in ISO
IEA
RGD
Ensembl
GO_Central
PMID:24896179 GO_REF:0000096 GO_REF:0000107 RGD:13208875 NCBI chr 5:114,238,395...114,261,571
Ensembl chr 5:114,203,522...114,262,781
JBrowse link
negative regulation of type 2 mitophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htra2 HtrA serine peptidase 2 involved_in IMP (PMID:24709290) ParkinsonsUK-UCL PMID:24709290 NCBI chr 6:83,028,247...83,031,552
Ensembl chr 6:83,028,247...83,032,254
JBrowse link
G Vps13c vacuolar protein sorting 13C involved_in ISO
ISS
GO_Central
ParkinsonsUK-UCL
GO_REF:0000024 GO_REF:0000119 NCBI chr 9:67,747,594...67,905,026
Ensembl chr 9:67,747,678...67,902,920
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28635
    cellular process 18389
      process utilizing autophagic mechanism 560
        autophagy 560
          macroautophagy 333
            negative regulation of macroautophagy 35
              negative regulation of aggrephagy 2
              negative regulation of autophagosome assembly 13
              negative regulation of autophagosome maturation 5
              negative regulation of lipophagy 0
              negative regulation of mitophagy + 9
              negative regulation of xenophagy 0
Path 2
Term Annotations click to browse term
  biological_process 28635
    biological regulation 13440
      regulation of biological process 13004
        negative regulation of biological process 6094
          negative regulation of cellular process 5841
            negative regulation of metabolic process 3395
              negative regulation of catabolic process 383
                negative regulation of autophagy 91
                  negative regulation of macroautophagy 35
                    negative regulation of aggrephagy 2
                    negative regulation of autophagosome assembly 13
                    negative regulation of autophagosome maturation 5
                    negative regulation of lipophagy 0
                    negative regulation of mitophagy + 9
                    negative regulation of xenophagy 0
paths to the root