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Gene: Lzts1 (leucine zipper, putative tumor suppressor 1) Mus musculus
Symbol: Lzts1
Name: leucine zipper, putative tumor suppressor 1
Description: Predicted to have microtubule binding activity. Predicted to be involved in negative regulation of macroautophagy; regulation of dendrite morphogenesis; and regulation of synaptic plasticity. Predicted to localize to several cellular components, including the apical plasma membrane; dendrite; and postsynaptic density. Human ortholog(s) of this gene implicated in esophageal cancer and squamous cell carcinoma. Is expressed in several structures, including brain and metanephros. Orthologous to human LZTS1 (leucine zipper tumor suppressor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: F37; F37 esophageal cancer-related leucine zipper motif 1; F37/Esophageal cancer-related gene-coding leucine-zipper motif; FEZ1; Gm7677; leucine zipper putative tumor suppressor 1; leucine-zipper protein FEZ1; predicted gene 7677; PSD-Zip70
Homo sapiens (human) : LZTS1 (leucine zipper tumor suppressor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lzts1 (leucine zipper tumor suppressor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lzts1 (leucine zipper tumor suppressor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LZTS1 (leucine zipper tumor suppressor 1)
Canis lupus familiaris (dog) : LZTS1 (leucine zipper tumor suppressor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lzts1 (leucine zipper tumor suppressor 1)
Sus scrofa (pig) : LZTS1 (leucine zipper tumor suppressor 1)
Chlorocebus sabaeus (green monkey) : LZTS1 (leucine zipper tumor suppressor 1)
Heterocephalus glaber (naked mole-rat) : Lzts1 (leucine zipper tumor suppressor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl869,132,669 - 69,184,225 (-)Ensembl
GRCm38869,132,659 - 69,184,249 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37871,659,402 - 71,664,852 (-)NCBIGRCm37mm9NCBIm37
MGSCv36872,064,492 - 72,069,942 (-)NCBImm8
Celera871,685,839 - 71,691,289 (-)NCBICelera
Cytogenetic Map8 B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Lzts1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1331874
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.