Lzts1 (leucine zipper, putative tumor suppressor 1) - Rat Genome Database
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Gene: Lzts1 (leucine zipper, putative tumor suppressor 1) Mus musculus
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Symbol: Lzts1
Name: leucine zipper, putative tumor suppressor 1
RGD ID: 1331874
MGI Page MGI
Description: Predicted to have microtubule binding activity. Predicted to be involved in negative regulation of macroautophagy; regulation of dendrite morphogenesis; and regulation of synaptic plasticity. Predicted to localize to several cellular components, including apical plasma membrane; dendrite; and postsynaptic density. Is expressed in several structures, including brain and metanephros. Human ortholog(s) of this gene implicated in esophageal cancer and squamous cell carcinoma. Orthologous to human LZTS1 (leucine zipper tumor suppressor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: F37; F37 esophageal cancer-related leucine zipper motif 1; F37/Esophageal cancer-related gene-coding leucine-zipper motif; FEZ1; Gm7677; leucine zipper putative tumor suppressor 1; leucine-zipper protein FEZ1; predicted gene 7677; PSD-Z; PSD-Zip70
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39869,585,311 - 69,636,901 (-)NCBIGRCm39mm39
GRCm38869,132,659 - 69,184,249 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl869,132,669 - 69,184,225 (-)EnsemblGRCm38mm10GRCm38
MGSCv37871,659,402 - 71,664,852 (-)NCBIGRCm37mm9NCBIm37
MGSCv36872,064,492 - 72,069,942 (-)NCBImm8
Celera871,685,839 - 71,691,289 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:17349584   PMID:17419986   PMID:18192690   PMID:21267068  
PMID:21873635   PMID:21949185   PMID:22419569   PMID:26490870   PMID:26516211   PMID:28671696   PMID:31239441   PMID:31969804  


Genomics

Comparative Map Data
Lzts1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39869,585,311 - 69,636,901 (-)NCBIGRCm39mm39
GRCm38869,132,659 - 69,184,249 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl869,132,669 - 69,184,225 (-)EnsemblGRCm38mm10GRCm38
MGSCv37871,659,402 - 71,664,852 (-)NCBIGRCm37mm9NCBIm37
MGSCv36872,064,492 - 72,069,942 (-)NCBImm8
Celera871,685,839 - 71,691,289 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
LZTS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl820,246,165 - 20,303,963 (-)EnsemblGRCh38hg38GRCh38
GRCh38820,246,165 - 20,303,963 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37820,103,676 - 20,161,474 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37820,103,676 - 20,161,492 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36820,147,956 - 20,157,083 (-)NCBINCBI36hg18NCBI36
Build 34820,147,956 - 20,157,083NCBI
Celera819,066,273 - 19,075,376 (-)NCBI
Cytogenetic Map8p21.3NCBI
HuRef818,643,682 - 18,652,790 (-)NCBIHuRef
CHM1_1820,305,442 - 20,314,568 (-)NCBICHM1_1
Lzts1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21620,542,756 - 20,598,204 (+)NCBI
Rnor_6.0 Ensembl1622,250,470 - 22,306,662 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01622,250,452 - 22,306,667 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01622,147,127 - 22,202,136 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41622,243,137 - 22,300,978 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11622,243,134 - 22,300,975 (+)NCBI
Celera1620,519,932 - 20,575,243 (+)NCBICelera
Cytogenetic Map16p14NCBI
Lzts1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540343,909,681 - 43,962,971 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540343,909,722 - 43,962,965 (-)NCBIChiLan1.0ChiLan1.0
LZTS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1816,418,501 - 16,476,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl816,418,496 - 16,476,111 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0819,471,361 - 19,529,437 (-)NCBIMhudiblu_PPA_v0panPan3
LZTS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2536,744,061 - 36,811,972 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12536,764,235 - 36,814,204 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lzts1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365554,330,878 - 4,384,883 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LZTS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl144,344,496 - 4,404,208 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1144,344,496 - 4,404,208 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2144,633,021 - 4,693,042 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LZTS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1818,315,243 - 18,377,492 (-)NCBI
ChlSab1.1 Ensembl818,315,130 - 18,324,345 (-)Ensembl
Lzts1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475815,956,300 - 16,006,174 (-)NCBI

Position Markers
D16Rat47  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38869,137,508 - 69,137,705UniSTSGRCm38
MGSCv37871,661,407 - 71,661,604UniSTSGRCm37
Celera871,687,844 - 71,688,041UniSTS
Cytogenetic Map8B3.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1321
Count of miRNA genes:632
Interacting mature miRNAs:768
Transcripts:ENSMUST00000037049, ENSMUST00000184061, ENSMUST00000184961, ENSMUST00000185176
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000037049   ⟹   ENSMUSP00000039397
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl869,135,503 - 69,140,953 (-)Ensembl
RefSeq Acc Id: ENSMUST00000181890
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl869,165,745 - 69,184,215 (-)Ensembl
RefSeq Acc Id: ENSMUST00000184961
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl869,182,160 - 69,184,205 (-)Ensembl
RefSeq Acc Id: ENSMUST00000185176   ⟹   ENSMUSP00000139117
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl869,132,669 - 69,184,225 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209353
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl869,179,728 - 69,182,230 (-)Ensembl
RefSeq Acc Id: NM_001370971   ⟹   NP_001357900
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39869,585,311 - 69,636,850 (-)NCBI
GRCm38869,132,659 - 69,184,198 (-)NCBI
Sequence:
RefSeq Acc Id: NM_199364   ⟹   NP_955396
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39869,585,311 - 69,636,850 (-)NCBI
GRCm38869,132,659 - 69,184,198 (-)NCBI
MGSCv37871,659,402 - 71,664,852 (-)RGD
Celera871,685,839 - 71,691,289 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509608   ⟹   XP_006509671
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39869,585,328 - 69,636,901 (-)NCBI
GRCm38869,134,495 - 69,184,249 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030243384   ⟹   XP_030099244
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39869,585,328 - 69,636,901 (-)NCBI
GRCm38869,134,495 - 69,184,249 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030243385   ⟹   XP_030099245
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39869,585,328 - 69,636,901 (-)NCBI
GRCm38869,134,495 - 69,184,249 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_955396   ⟸   NM_199364
- UniProtKB: P60853 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509671   ⟸   XM_006509608
- Peptide Label: isoform X1
- UniProtKB: P60853 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001357900   ⟸   NM_001370971
RefSeq Acc Id: XP_030099244   ⟸   XM_030243384
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030099245   ⟸   XM_030243385
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000139117   ⟸   ENSMUST00000185176
RefSeq Acc Id: ENSMUSP00000039397   ⟸   ENSMUST00000037049

Promoters
RGD ID:8667255
Promoter ID:EPDNEW_M11643
Type:initiation region
Name:AK138907_1
Description:n/a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38869,184,198 - 69,184,258EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2684762 AgrOrtholog
Ensembl Genes ENSMUSG00000036306 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000039397 UniProtKB/Swiss-Prot
  ENSMUSP00000139117 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000037049 UniProtKB/Swiss-Prot
  ENSMUST00000185176 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro LZTS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:211134 UniProtKB/Swiss-Prot
MGD MGI:2684762 ENTREZGENE
NCBI Gene 211134 ENTREZGENE
PANTHER PTHR19354:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lzts1 PhenoGen
UniProt A0PJT4_MOUSE UniProtKB/TrEMBL
  A1L146_MOUSE UniProtKB/TrEMBL
  LZTS1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2RTI1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-28 Lzts1  leucine zipper, putative tumor suppressor 1  Gm7677  predicted gene 7677  Data Merged 737654 PROVISIONAL