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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chronic Cerebral Hypoperfusion
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Accession:DOID:9007970 term browser browse the term
Definition:A major factor contributing to cognitive decline in age-related neurological disorders. Such a decrease in cerebral blood flow has been associated with Alzheimer disease and vascular dementia.
Synonyms:exact_synonym: CCH
 primary_id: RDO:9000062


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Chronic Cerebral Hypoperfusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 IEP protein:decreased expression:hippocampus RGD PMID:22639386 RGD:11541085 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Apoe apolipoprotein E IEP protein:increased expression:cerebral cortex, synapse RGD PMID:28620701 RGD:13703133 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G App amyloid beta precursor protein IEP protein:increased expression:cerebral white matter: RGD PMID:11743996 RGD:10054250 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bace1 beta-secretase 1 IEP protein:increased expression:hippocampus RGD PMID:28683457 RGD:13782142 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like IEP mRNA:increased expression:hippocampus RGD PMID:24072673 RGD:10402542 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803 		JBrowse link
G Dag1 dystroglycan 1 IEP RGD PMID:21192954 RGD:11541061 NCBI chr 8:108,890,926...108,955,611
Ensembl chr 8:108,890,929...108,952,325 		JBrowse link
G Fth1 ferritin heavy chain 1 IEP protein:increased expression:hippocampus RGD PMID:22639386 RGD:11541085 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 treatment IDA RGD PMID:16645134 RGD:10401930 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 IEP RGD PMID:24838625 RGD:9686415 NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774 		JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 IEP RGD PMID:24838625 RGD:9686415 NCBI chr 7:9,969,801...9,988,839
Ensembl chr 7:9,970,368...9,988,841 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP protein:increased expression:hippocampus RGD PMID:24072673 RGD:10402542 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO protein:hyperphosphorylation:brain: RGD PMID:24371084 RGD:10412307 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO protein:hyperphosphorylation:corpus callosum, endothelial cell, astrocyte: RGD PMID:24371084 RGD:10412307 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 IEP protein:increased expression:dentate gyrus RGD PMID:17931356 RGD:10412049 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847 		JBrowse link
G Nos3 nitric oxide synthase 3 IMP RGD PMID:15703700 RGD:13824977 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nox1 NADPH oxidase 1 ameliorates IMP RGD PMID:24294978 RGD:329955573 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Tfrc transferrin receptor IEP protein:increased expression:hippocampus RGD PMID:22639386 RGD:11541085 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    Pathological Conditions, Signs and Symptoms 13343
      Pathologic Processes 7990
        ischemia 1500
          brain ischemia 641
            Chronic Cerebral Hypoperfusion 17
Path 2
Term Annotations click to browse term
  disease 18969
    disease of anatomical entity 18249
      nervous system disease 14090
        central nervous system disease 12430
          brain disease 11668
            cerebrovascular disease 1000
              brain ischemia 641
                Chronic Cerebral Hypoperfusion 17
paths to the root