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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Binge Drinking
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Accession:DOID:9006302 term browser browse the term
Definition:Drinking an excessive amount of ALCOHOLIC BEVERAGES in a short period of time.
Synonyms:primary_id: MESH:D063425;   RDO:0012117


show annotations for term's descendants           Sort by:
Binge Drinking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) ISO mRNA:altered exxpression:liver (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide ISO mRNA:altered exxpression:liver (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 3:138,121,217...138,138,444
Ensembl chr 3:138,121,227...138,136,653 		JBrowse link
G Bdnf brain derived neurotrophic factor ISO protein:altered expression:amygdala, pyriform cortex, bed nucleus of stria terminalis RGD PMID:23588198 RGD:405849391 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Car3 carbonic anhydrase 3 ISO associated with Alcoholic Liver Diseases;protein:decreased expression:liver RGD PMID:22545783 RGD:7495839 NCBI chr 3:14,928,598...14,937,441
Ensembl chr 3:14,928,572...14,937,583 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO mRNA:decreased expression:adenohypophysis RGD PMID:11045867 RGD:407431640 NCBI chr11:104,021,289...104,066,349
Ensembl chr11:104,023,681...104,066,349 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 IEP
ISO		 protein:increased expression, increased nitration
mRNA:altered exxpression:liver (rat)
associated with Alcoholic Liver Diseases;protein:increased expression:liver		 RGD PMID:25236742 PMID:25236742 PMID:29404485 PMID:23413777 PMID:22545783 RGD:14700891, RGD:14700891, RGD:14700911, RGD:405100715, RGD:7495839 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Dnmt1 DNA methyltransferase 1 IEP protein:increased expression:nucleus accumbens: RGD PMID:23423140 RGD:9588287 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184 		JBrowse link
G Drd1 dopamine receptor D1 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724 		JBrowse link
G Drd2 dopamine receptor D2 ISO mRNA:altered exxpression:spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Drd3 dopamine receptor D3 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295 		JBrowse link
G Drd4 dopamine receptor D4 susceptibility ISO DNA:repeats:exon:
mRNA:altered exxpression:spleen (rat)		 RGD PMID:19393859 PMID:23413777 RGD:401960068, RGD:405100715 NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377 		JBrowse link
G Efhd2 EF hand domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28397836 NCBI chr 4:141,585,453...141,602,231
Ensembl chr 4:141,585,453...141,602,231 		JBrowse link
G Fos FBJ osteosarcoma oncogene ISO protein:increased expression:prefrontal cortex RGD PMID:29407478 RGD:405295494 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr11:42,021,766...42,073,893
Ensembl chr11:42,021,766...42,073,757 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 5:71,115,735...71,253,192
Ensembl chr 5:71,114,940...71,253,192 		JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr  X:71,476,282...71,700,525
Ensembl chr  X:71,476,287...71,700,454 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha 6 ISO mRNA:altered exxpression:spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr11:42,197,264...42,211,977
Ensembl chr11:42,197,264...42,211,899 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor ISO protein:altered expression:amygdala, pyriform cortex, bed nucleus of stria terminalis RGD PMID:23298382 PMID:23588198 RGD:405849390, RGD:405849391 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO protein:decreased expression:liver RGD PMID:25864381 RGD:401827870 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO protein:decreased expression:serum RGD PMID:25864381 RGD:401827870 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Gpx4 glutathione peroxidase 4 ISO protein:decreased expression:liver RGD PMID:25864381 RGD:401827870 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273 		JBrowse link
G Grm2 glutamate receptor, metabotropic 2 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 9:106,521,733...106,533,308
Ensembl chr 9:106,520,294...106,533,281 		JBrowse link
G Grm5 glutamate receptor, metabotropic 5 ISO associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 7:87,233,212...87,784,271
Ensembl chr 7:87,233,376...87,784,115 		JBrowse link
G Mir125a microRNA 125a ISO RNA:decreased expression:neuron RGD PMID:27085842 RGD:26884454 NCBI chr17:18,051,074...18,051,141
Ensembl chr17:18,051,074...18,051,141 		JBrowse link
G Mir223 microRNA 223 ISO
IEP		 RNA:increased expression:serum
RNA:increased expression:serum, neutrophil,liver		 RGD PMID:27679493 PMID:27679493 RGD:21408575, RGD:21408575 NCBI chr  X:95,286,423...95,286,532
Ensembl chr  X:95,286,423...95,286,532 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 ameliorates IMP
IEP		 protein:decreased expression:central amygdaloid nucleus (mouse) RGD PMID:30647448 PMID:22218088 RGD:402463940, RGD:405096664 NCBI chr 8:67,149,595...67,159,452
Ensembl chr 8:67,149,844...67,159,444 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 treatment ISO RGD PMID:22500955 RGD:408361838 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Oprl1 opioid receptor-like 1 ISO RGD PMID:29197086 RGD:14348965 NCBI chr 2:181,356,585...181,362,778
Ensembl chr 2:181,356,809...181,362,778 		JBrowse link
G Per2 period circadian clock 2 ISO DNA, mRNA:hypermethylation, decreased expression:blood RGD PMID:30597578 RGD:405878075 NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046 		JBrowse link
G Pomc pro-opiomelanocortin-alpha ISO DNA, mRNA:hypermethylation, decreased expression:blood
mRNA:decreased expression:hypothalamus
protein:decreased expression:central amygdaloid nucleus, arcuate and paraventricular nucleus of hypothalamus		 RGD PMID:30597578 PMID:11045867 PMID:23792540 RGD:405878075, RGD:407431640, RGD:407571694 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Sirt1 sirtuin 1 ISO RGD PMID:24416161 RGD:9495933 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Slc23a2 solute carrier family 23 (nucleobase transporters), member 2 ISO RGD PMID:27085842 RGD:26884454 NCBI chr 2:131,894,416...131,987,287
Ensembl chr 2:131,894,416...131,987,028 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16225
    Chemically-Induced Disorders 1357
      substance-related disorder 673
        Alcohol-Related Disorders 374
          Binge Drinking 32
Path 2
Term Annotations click to browse term
  disease 16225
    disease of anatomical entity 15844
      nervous system disease 13766
        central nervous system disease 12282
          brain disease 11533
            disease of mental health 8313
              substance-related disorder 673
                Alcohol-Related Disorders 374
                  Binge Drinking 32
paths to the root