RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Osteoarthritis, Experimental
Accession: DOID:9004332
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Definition: Osteoarthritis that is induced in experimental animals by creating instability in joints through surgery or chemical treatment. It represents a progressive, degenerative joint disease resulting from biochemical changes and biomechanical stresses affecting articular cartilage.
Synonyms: primary_id: RDO:9000116
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Becn1
beclin 1
treatment
IEP
RGD
PMID:23589102
RGD:11561955
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Bmp4
bone morphogenetic protein 4
ISO
RGD
PMID:19404941
RGD:9068434
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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Casp3
caspase 3
treatment
IEP
RGD
PMID:29621761
RGD:13782275
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp6
caspase 6
treatment
IEP
RGD
PMID:29621761
RGD:13782275
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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Casp7
caspase 7
treatment
IEP
RGD
PMID:29621761
RGD:13782275
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp8
caspase 8
treatment
IEP
RGD
PMID:29621761
RGD:13782275
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Col1a1
collagen type I alpha 1 chain
treatment
IEP
RGD
PMID:25128628
RGD:11041187
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Ddr2
discoidin domain receptor tyrosine kinase 2
treatment
IEP
RGD
PMID:25975052
RGD:150429975
NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363
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Fgfr1
Fibroblast growth factor receptor 1
ISO
RGD
PMID:22833219
RGD:10402072
NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
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Flt1
Fms related receptor tyrosine kinase 1
ISO
RGD
PMID:23041435
RGD:10402106
NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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Hspa1a
heat shock protein family A (Hsp70) member 1A
treatment
IMP
RGD
PMID:16394269
RGD:10402538
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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Lrpap1
LDL receptor related protein associated protein 1
IEP
mRNA:decreased expression:knee
RGD
PMID:24754147
RGD:10412054
NCBI chr14:75,651,371...75,663,380
Ensembl chr14:75,651,376...75,665,414
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Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
treatment
IEP
RGD
PMID:23589102
RGD:11561955
NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
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Mapk3
mitogen activated protein kinase 3
IEP
RGD
PMID:29364174
RGD:13800565
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Ncam1
neural cell adhesion molecule 1
IEP
protein:decreased expression:skeletal joint
RGD
PMID:31742919
RGD:40924673
NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
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Serpinf1
serpin family F member 1
severity
ISO
RGD
PMID:28122611
RGD:27226703
NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
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Ulk1
unc-51 like autophagy activating kinase 1
treatment
IEP
RGD
PMID:23589102
RGD:11561955
NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
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