RGD Reference Report - Neural cell adhesion molecule regulates chondrocyte hypertrophy in chondrogenic differentiation and experimental osteoarthritis. - Rat Genome Database

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Neural cell adhesion molecule regulates chondrocyte hypertrophy in chondrogenic differentiation and experimental osteoarthritis.

Authors: Cheng, Bin-Feng  Lian, Jun-Jiang  Yang, Hai-Jie  Wang, Lei  Yu, Hao-Heng  Bi, Jia-Jia  Gao, Yao-Xin  Chen, Su-Juan  Wang, Mian  Feng, Zhi-Wei 
Citation: Cheng BF, etal., Stem Cells Transl Med. 2020 Feb;9(2):273-283. doi: 10.1002/sctm.19-0190. Epub 2019 Nov 19.
RGD ID: 40924673
Pubmed: PMID:31742919   (View Abstract at PubMed)
PMCID: PMC6988767   (View Article at PubMed Central)
DOI: DOI:10.1002/sctm.19-0190   (Journal Full-text)

Chondrocyte hypertrophy-like change is an important pathological process of osteoarthritis (OA), but the mechanism remains largely unknown. Neural cell adhesion molecule (NCAM) is highly expressed and involved in the chondrocyte differentiation of mesenchymal stem cells (MSCs). In this study, we found that NCAM deficiency accelerates chondrocyte hypertrophy in articular cartilage and growth plate of OA mice. NCAM deficiency leads to hypertrophic chondrocyte differentiation in both murine MSCs and chondrogenic cells, in which extracellular signal-regulated kinase (ERK) signaling plays an important role. Moreover, NCAM expression is downregulated in an interleukin-1β-stimulated OA cellular model and monosodium iodoacetate-induced OA rats. Overexpression of NCAM substantially inhibits hypertrophic differentiation in the OA cellular model. In conclusion, NCAM could inhibit hypertrophic chondrocyte differentiation of MSCs by inhibiting ERK signaling and reduce chondrocyte hypertrophy in experimental OA model, suggesting the potential utility of NCAM as a novel therapeutic target for alleviating chondrocyte hypertrophy of OA.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NCAM1HumanOsteoarthritis, Experimental  ISONcam1 (Rattus norvegicus)protein:decreased expression:skeletal jointRGD 
Ncam1RatOsteoarthritis, Experimental  IEP protein:decreased expression:skeletal jointRGD 
Ncam1MouseOsteoarthritis, Experimental  ISONcam1 (Rattus norvegicus)protein:decreased expression:skeletal jointRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ncam1  (neural cell adhesion molecule 1)

Genes (Mus musculus)
Ncam1  (neural cell adhesion molecule 1)

Genes (Homo sapiens)
NCAM1  (neural cell adhesion molecule 1)


Additional Information