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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetracaine
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Accession:CHEBI:9468 term browser browse the term
Definition:A benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia.
Synonyms:exact_synonym: 2-(dimethylamino)ethyl 4-(butylamino)benzoate
 related_synonym: 2-(Dimethylamino)ethyl p-(butylamino)benzoate;   Amethocaine;   Diaethylaminoaethanol ester der p-butylaminobenzoesaeure;   Formula=C15H24N2O2;   InChI=1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3;   InChIKey=GKCBAIGFKIBETG-UHFFFAOYSA-N;   SMILES=CCCCNc1ccc(cc1)C(=O)OCCN(C)C;   p-(butylamino)benzoic acid beta-(dimethylamino)ethyl ester;   p-Butylaminobenzoyl-2-dimethylaminoethanol;   tetracaina;   tetracainum
 alt_id: CHEBI:132027
 xref: CAS:94-24-6;   Drug_Central:2610;   KEGG:C07526;   KEGG:D00551;   LINCS:LSM-4633
 xref_mesh: MESH:D013748
 xref: PMID:25119673;   PMID:7567006;   PMID:7574001;   PMID:9989796;   Patent:US1889645;   Reaxys:2216051;   Wikipedia:Tetracaine


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tetracaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity EXP Tetracaine results in increased activity of CASP3 protein CTD PMID:11981161 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression 		ISO HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCND1 protein] CTD PMID:34822839 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccne1 cyclin E1 decreases expression
multiple interactions 		ISO Tetracaine results in decreased expression of CCNE1 protein
HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCNE1 protein] 		CTD PMID:34822839 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases phosphorylation
multiple interactions 		ISO Tetracaine results in decreased phosphorylation of CDK2 protein
HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK2 protein] 		CTD PMID:34822839 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases phosphorylation ISO Tetracaine results in decreased phosphorylation of CDK4 protein CTD PMID:34822839 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases phosphorylation
multiple interactions 		ISO Tetracaine results in decreased phosphorylation of CDK6 protein
HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK6 protein] 		CTD PMID:34822839 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701 		JBrowse link
G Hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 increases expression ISO Tetracaine results in increased expression of HNRNPA0 mRNA CTD PMID:34822839 NCBI chr17:6,513,129...6,515,786
Ensembl chr17:6,512,629...6,516,127 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 decreases expression
multiple interactions
decreases response to substance 		ISO Tetracaine results in decreased expression of HNRNPA1 mRNA
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetracaine results in decreased expression of HNRNPA1 mRNA]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCND1 protein]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK2 protein]; Tetracaine results in decreased expression of and results in increased degradation of HNRNPA1 protein
Tetracaine results in decreased expression of HNRNPA1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetracaine results in decreased expression of HNRNPA1 mRNA]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCND1 protein]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCNE1 protein]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK2 protein]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK6 protein]; Tetracaine results in decreased expression of and results in increased degradation of HNRNPA1 protein
HNRNPA1 protein results in decreased susceptibility to Tetracaine 		CTD PMID:34822839 NCBI chr 7:136,253,633...136,260,085
Ensembl chr 7:136,253,278...136,260,085 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression ISO Tetracaine results in decreased expression of HNRNPA2B1 mRNA CTD PMID:34822839 NCBI chr 4:81,867,354...81,875,886
Ensembl chr 4:81,869,661...81,877,572 		JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C decreases expression
increases expression 		ISO Tetracaine results in decreased expression of HNRNPC mRNA
Tetracaine results in increased expression of HNRNPC mRNA 		CTD PMID:34822839 NCBI chr15:27,253,098...27,282,779
Ensembl chr15:27,253,098...27,282,715 		JBrowse link
G Hrh1 histamine receptor H 1 affects binding
multiple interactions 		ISO HRH1 protein binds to Tetracaine
[HRH1 protein binds to Tetracaine] which results in increased import of Calcium 		CTD PMID:32061592 NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation 		EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]; Egtazic Acid promotes the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein] CTD PMID:11981161 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation 		EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]; Egtazic Acid promotes the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein] CTD PMID:11981161 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation 		EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; Egtazic Acid inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein] CTD PMID:11981161 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation 		EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; Egtazic Acid inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein] CTD PMID:11981161 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
decreases activity 		ISO Tetracaine results in decreased expression of MMP2 mRNA
Tetracaine results in decreased activity of MMP2 protein 		CTD PMID:37806380 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
decreases activity 		ISO Tetracaine results in decreased expression of MMP9 mRNA
Tetracaine results in decreased activity of MMP9 protein 		CTD PMID:37806380 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Ryr1 ryanodine receptor 1 multiple interactions ISO Tetracaine inhibits the reaction [tetrabromobisphenol A results in increased activity of RYR1 protein] CTD PMID:18329244 NCBI chr 1:93,420,078...93,551,305
Ensembl chr 1:93,420,078...93,551,305 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 multiple interactions ISO
EXP 		Tetracaine inhibits the reaction [decamethrin results in increased activity of SCN10A protein] CTD PMID:16325806 NCBI chr 8:128,228,424...128,340,749
Ensembl chr 8:128,228,424...128,340,298 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Tetracaine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO Tetracaine results in increased expression of TIMP2 mRNA CTD PMID:37806380 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity
multiple interactions 		EXP Tetracaine results in increased activity of TRPV1 protein
Tetracaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein] 		CTD PMID:15854744 PMID:18172555 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          drug 20416
            anaesthetic 12021
              local anaesthetic 7765
                tetracaine 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      aromatic carboxylic acid 14051
                                        benzoic acids 14017
                                          benzoate ester 5819
                                            tetracaine 22
paths to the root