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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetracaine
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Accession:CHEBI:9468 term browser browse the term
Definition:A benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia.
Synonyms:exact_synonym: 2-(dimethylamino)ethyl 4-(butylamino)benzoate
 related_synonym: 2-(Dimethylamino)ethyl p-(butylamino)benzoate;   Amethocaine;   Diaethylaminoaethanol ester der p-butylaminobenzoesaeure;   Formula=C15H24N2O2;   InChI=1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3;   InChIKey=GKCBAIGFKIBETG-UHFFFAOYSA-N;   SMILES=CCCCNc1ccc(cc1)C(=O)OCCN(C)C;   p-(butylamino)benzoic acid beta-(dimethylamino)ethyl ester;   p-Butylaminobenzoyl-2-dimethylaminoethanol;   tetracaina;   tetracainum
 alt_id: CHEBI:132027
 xref: Beilstein:2216051;   CAS:94-24-6;   Drug_Central:2610;   KEGG:C07526;   KEGG:D00551;   LINCS:LSM-4633
 xref_mesh: MESH:D013748
 xref: PMID:25119673;   PMID:7567006;   PMID:7574001;   PMID:9989796;   Patent:US1889645;   Reaxys:2216051;   Wikipedia:Tetracaine


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tetracaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity EXP Tetracaine results in increased activity of CASP3 protein CTD PMID:11981161 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCND1 protein] CTD PMID:34822839 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 decreases expression
multiple interactions		 ISO Tetracaine results in decreased expression of CCNE1 protein
HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCNE1 protein]		 CTD PMID:34822839 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases phosphorylation
multiple interactions		 ISO Tetracaine results in decreased phosphorylation of CDK2 protein
HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK2 protein]		 CTD PMID:34822839 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases phosphorylation ISO Tetracaine results in decreased phosphorylation of CDK4 protein CTD PMID:34822839 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases phosphorylation
multiple interactions		 ISO Tetracaine results in decreased phosphorylation of CDK6 protein
HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK6 protein]		 CTD PMID:34822839 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 increases expression ISO Tetracaine results in increased expression of HNRNPA0 mRNA CTD PMID:34822839 NCBI chr17:6,507,728...6,510,385
Ensembl chr17:6,507,275...6,509,375 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 decreases expression
multiple interactions
decreases response to substance		 ISO Tetracaine results in decreased expression of HNRNPA1 mRNA
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetracaine results in decreased expression of HNRNPA1 mRNA]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCND1 protein]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK2 protein]; Tetracaine results in decreased expression of and results in increased degradation of HNRNPA1 protein
Tetracaine results in decreased expression of HNRNPA1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetracaine results in decreased expression of HNRNPA1 mRNA]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCND1 protein]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCNE1 protein]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK2 protein]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK6 protein]; Tetracaine results in decreased expression of and results in increased degradation of HNRNPA1 protein
HNRNPA1 protein results in decreased susceptibility to Tetracaine		 CTD PMID:34822839 NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression ISO Tetracaine results in decreased expression of HNRNPA2B1 mRNA CTD PMID:34822839 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249 		JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C decreases expression
increases expression		 ISO Tetracaine results in decreased expression of HNRNPC mRNA
Tetracaine results in increased expression of HNRNPC mRNA		 CTD PMID:34822839 NCBI chr15:24,779,593...24,809,213
Ensembl chr15:24,779,450...24,809,183 		JBrowse link
G Hrh1 histamine receptor H 1 affects binding
multiple interactions		 ISO HRH1 protein binds to Tetracaine
[HRH1 protein binds to Tetracaine] which results in increased import of Calcium		 CTD PMID:32061592 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]; Egtazic Acid promotes the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein] CTD PMID:11981161 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]; Egtazic Acid promotes the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein] CTD PMID:11981161 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; Egtazic Acid inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein] CTD PMID:11981161 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation		 EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; Egtazic Acid inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein] CTD PMID:11981161 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
decreases activity		 ISO Tetracaine results in decreased expression of MMP2 mRNA
Tetracaine results in decreased activity of MMP2 protein		 CTD PMID:37806380 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
decreases activity		 ISO Tetracaine results in decreased expression of MMP9 mRNA
Tetracaine results in decreased activity of MMP9 protein		 CTD PMID:37806380 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Ryr1 ryanodine receptor 1 multiple interactions ISO Tetracaine inhibits the reaction [tetrabromobisphenol A results in increased activity of RYR1 protein] CTD PMID:18329244 NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 multiple interactions ISO
EXP		 Tetracaine inhibits the reaction [decamethrin results in increased activity of SCN10A protein] CTD PMID:16325806 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Tetracaine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO Tetracaine results in increased expression of TIMP2 mRNA CTD PMID:37806380 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity
multiple interactions		 EXP Tetracaine results in increased activity of TRPV1 protein
Tetracaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]		 CTD PMID:15854744 PMID:18172555 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      application 19734
        pharmaceutical 19573
          drug 19573
            anaesthetic 11850
              local anaesthetic 7701
                tetracaine 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            heteroorganic entity 19558
                              organochalcogen compound 19317
                                organooxygen compound 19233
                                  carbon oxoacid 18695
                                    carboxylic acid 18692
                                      aromatic carboxylic acid 12706
                                        benzoic acids 12683
                                          benzoate ester 5736
                                            tetracaine 22
paths to the root