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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetracaine
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Accession:CHEBI:9468 term browser browse the term
Definition:A benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia.
Synonyms:exact_synonym: 2-(dimethylamino)ethyl 4-(butylamino)benzoate
 related_synonym: 2-(Dimethylamino)ethyl p-(butylamino)benzoate;   Amethocaine;   Diaethylaminoaethanol ester der p-butylaminobenzoesaeure;   Formula=C15H24N2O2;   InChI=1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3;   InChIKey=GKCBAIGFKIBETG-UHFFFAOYSA-N;   SMILES=CCCCNc1ccc(cc1)C(=O)OCCN(C)C;   p-(butylamino)benzoic acid beta-(dimethylamino)ethyl ester;   p-Butylaminobenzoyl-2-dimethylaminoethanol;   tetracaina;   tetracainum
 alt_id: CHEBI:132027
 xref: Beilstein:2216051;   CAS:94-24-6;   Drug_Central:2610;   KEGG:C07526;   KEGG:D00551;   LINCS:LSM-4633
 xref_mesh: MESH:D013748
 xref: PMID:25119673;   PMID:7567006;   PMID:7574001;   PMID:9989796;   Patent:US1889645;   Reaxys:2216051;   Wikipedia:Tetracaine


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tetracaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity EXP Tetracaine results in increased activity of CASP3 protein CTD PMID:11981161 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Hrh1 histamine receptor H 1 affects binding
multiple interactions		 ISO HRH1 protein binds to Tetracaine
[HRH1 protein binds to Tetracaine] which results in increased import of Calcium		 CTD PMID:32061592 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]; Egtazic Acid promotes the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein] CTD PMID:11981161 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]; Egtazic Acid promotes the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein] CTD PMID:11981161 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; Egtazic Acid inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein] CTD PMID:11981161 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation		 EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; Egtazic Acid inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein] CTD PMID:11981161 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Ryr1 ryanodine receptor 1 multiple interactions ISO Tetracaine inhibits the reaction [tetrabromobisphenol A results in increased activity of RYR1 protein] CTD PMID:18329244 NCBI chr 1:84,292,578...84,423,799
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 multiple interactions ISO
EXP		 Tetracaine inhibits the reaction [decamethrin results in increased activity of SCN10A protein] CTD PMID:16325806 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Tetracaine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity
multiple interactions		 EXP Tetracaine results in increased activity of TRPV1 protein
Tetracaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]		 CTD PMID:15854744 PMID:18172555 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      application 19477
        pharmaceutical 19327
          drug 19327
            anaesthetic 5985
              local anaesthetic 3088
                tetracaine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    p-block element atom 19710
                      carbon group element atom 19631
                        carbon atom 19621
                          organic molecular entity 19621
                            organic group 18730
                              organic divalent group 18721
                                organodiyl group 18721
                                  carbonyl group 18670
                                    carbonyl compound 18670
                                      carboxylic acid 18367
                                        aromatic carboxylic acid 11719
                                          benzoic acids 11692
                                            benzoate ester 5034
                                              tetracaine 10
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