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G
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Casp3
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caspase 3
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increases activity
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EXP
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Tetracaine results in increased activity of CASP3 protein
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CTD |
PMID:11981161 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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G
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Ccnd1
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cyclin D1
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multiple interactions decreases expression
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ISO
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HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCND1 protein]
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CTD |
PMID:34822839 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
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G
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Ccne1
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cyclin E1
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decreases expression multiple interactions
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ISO
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Tetracaine results in decreased expression of CCNE1 protein HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCNE1 protein]
|
CTD |
PMID:34822839 |
|
NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822
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G
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Cdk2
|
cyclin dependent kinase 2
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decreases phosphorylation multiple interactions
|
ISO
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Tetracaine results in decreased phosphorylation of CDK2 protein HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK2 protein]
|
CTD |
PMID:34822839 |
|
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878
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G
|
Cdk4
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cyclin-dependent kinase 4
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decreases phosphorylation
|
ISO
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Tetracaine results in decreased phosphorylation of CDK4 protein
|
CTD |
PMID:34822839 |
|
NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163
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G
|
Cdk6
|
cyclin-dependent kinase 6
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decreases phosphorylation multiple interactions
|
ISO
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Tetracaine results in decreased phosphorylation of CDK6 protein HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK6 protein]
|
CTD |
PMID:34822839 |
|
NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701
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G
|
Hnrnpa0
|
heterogeneous nuclear ribonucleoprotein A0
|
increases expression
|
ISO
|
Tetracaine results in increased expression of HNRNPA0 mRNA
|
CTD |
PMID:34822839 |
|
NCBI chr17:6,513,129...6,515,786
Ensembl chr17:6,512,629...6,516,127
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G
|
Hnrnpa1
|
heterogeneous nuclear ribonucleoprotein A1
|
decreases expression multiple interactions decreases response to substance
|
ISO
|
Tetracaine results in decreased expression of HNRNPA1 mRNA benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetracaine results in decreased expression of HNRNPA1 mRNA]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCND1 protein]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK2 protein]; Tetracaine results in decreased expression of and results in increased degradation of HNRNPA1 protein Tetracaine results in decreased expression of HNRNPA1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetracaine results in decreased expression of HNRNPA1 mRNA]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCND1 protein]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased expression of CCNE1 protein]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK2 protein]; HNRNPA1 protein inhibits the reaction [Tetracaine results in decreased phosphorylation of CDK6 protein]; Tetracaine results in decreased expression of and results in increased degradation of HNRNPA1 protein HNRNPA1 protein results in decreased susceptibility to Tetracaine
|
CTD |
PMID:34822839 |
|
NCBI chr 7:136,253,633...136,260,085
Ensembl chr 7:136,253,278...136,260,085
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G
|
Hnrnpa2b1
|
heterogeneous nuclear ribonucleoprotein A2/B1
|
decreases expression
|
ISO
|
Tetracaine results in decreased expression of HNRNPA2B1 mRNA
|
CTD |
PMID:34822839 |
|
NCBI chr 4:81,867,354...81,875,886
Ensembl chr 4:81,869,661...81,877,572
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G
|
Hnrnpc
|
heterogeneous nuclear ribonucleoprotein C
|
decreases expression increases expression
|
ISO
|
Tetracaine results in decreased expression of HNRNPC mRNA Tetracaine results in increased expression of HNRNPC mRNA
|
CTD |
PMID:34822839 |
|
NCBI chr15:27,253,098...27,282,779
Ensembl chr15:27,253,098...27,282,715
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G
|
Hrh1
|
histamine receptor H 1
|
affects binding multiple interactions
|
ISO
|
HRH1 protein binds to Tetracaine [HRH1 protein binds to Tetracaine] which results in increased import of Calcium
|
CTD |
PMID:32061592 |
|
NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248
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G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions increases phosphorylation
|
EXP
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2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]; Egtazic Acid promotes the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]
|
CTD |
PMID:11981161 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
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G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions increases phosphorylation
|
EXP
|
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]; Egtazic Acid promotes the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]
|
CTD |
PMID:11981161 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
G
|
Mapk8
|
mitogen-activated protein kinase 8
|
multiple interactions increases phosphorylation
|
EXP
|
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; Egtazic Acid inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]
|
CTD |
PMID:11981161 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
|
|
G
|
Mapk9
|
mitogen-activated protein kinase 9
|
multiple interactions increases phosphorylation
|
EXP
|
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; Egtazic Acid inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]
|
CTD |
PMID:11981161 |
|
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228
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G
|
Mmp2
|
matrix metallopeptidase 2
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decreases expression decreases activity
|
ISO
|
Tetracaine results in decreased expression of MMP2 mRNA Tetracaine results in decreased activity of MMP2 protein
|
CTD |
PMID:37806380 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
|
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G
|
Mmp9
|
matrix metallopeptidase 9
|
decreases expression decreases activity
|
ISO
|
Tetracaine results in decreased expression of MMP9 mRNA Tetracaine results in decreased activity of MMP9 protein
|
CTD |
PMID:37806380 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
|
|
G
|
Ryr1
|
ryanodine receptor 1
|
multiple interactions
|
ISO
|
Tetracaine inhibits the reaction [tetrabromobisphenol A results in increased activity of RYR1 protein]
|
CTD |
PMID:18329244 |
|
NCBI chr 1:93,420,078...93,551,305
Ensembl chr 1:93,420,078...93,551,305
|
|
G
|
Scn10a
|
sodium voltage-gated channel alpha subunit 10
|
multiple interactions
|
ISO EXP
|
Tetracaine inhibits the reaction [decamethrin results in increased activity of SCN10A protein]
|
CTD |
PMID:16325806 |
|
NCBI chr 8:128,228,424...128,340,749
Ensembl chr 8:128,228,424...128,340,298
|
|
G
|
Slc22a2
|
solute carrier family 22 member 2
|
multiple interactions
|
ISO
|
Tetracaine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
|
CTD |
PMID:21599003 |
|
NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
|
|
G
|
Timp2
|
TIMP metallopeptidase inhibitor 2
|
increases expression
|
ISO
|
Tetracaine results in increased expression of TIMP2 mRNA
|
CTD |
PMID:37806380 |
|
NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214
|
|
G
|
Trpv1
|
transient receptor potential cation channel, subfamily V, member 1
|
increases activity multiple interactions
|
EXP
|
Tetracaine results in increased activity of TRPV1 protein Tetracaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]
|
CTD |
PMID:15854744 PMID:18172555 |
|
NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021
|
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