Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzo[a]pyrene-7,8-dione
go back to main search page
Accession:CHEBI:87752 term browser browse the term
Definition:An o-quinone resulting from the formal oxidation of both of the hydroxy groups of benzo[a]pyrene-cis-7,8-dihydrodiol. Benzo[a]pyrene-7,8-dione is a metabolite of the widespread carcinogen benzo[a]pyrene.
Synonyms:exact_synonym: benzo[pqr]tetraphene-7,8-dione
 related_synonym: BPQ;   BaP-7,8-dione;   Formula=C20H10O2;   InChI=1S/C20H10O2/c21-17-9-8-14-15-7-6-12-3-1-2-11-4-5-13(19(15)18(11)12)10-16(14)20(17)22/h1-10H;   InChIKey=CRYMJHJFLJAFNU-UHFFFAOYSA-N;   SMILES=C12=C3C4=CC=C1C=CC=C2C=CC3=C5C(=C4)C(C(C=C5)=O)=O;   benzo(a)pyrene-7,8-quinone
 xref: CAS:65199-11-3
 xref_mesh: MESH:C076588
 xref: PMID:15206904;   PMID:16962698;   PMID:19726680;   PMID:19916567;   PMID:22480306;   PMID:22782890;   PMID:23117049;   PMID:23587017;   PMID:24047243;   PMID:25616378;   PMID:8384091;   Reaxys:3551534


show annotations for term's descendants           Sort by:
benzo[a]pyrene-7,8-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor affects localization
multiple interactions		 EXP
ISO		 benzo(a)pyrene-7,8-dione affects the localization of AHR protein
AHR protein affects the reaction [benzo(a)pyrene-7,8-dione results in increased expression of CYP1A1 mRNA]		 CTD PMID:10706104 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 increases chemical synthesis
increases expression
affects chemical synthesis
multiple interactions		 EXP AKR1A1 protein results in increased chemical synthesis of benzo(a)pyrene-7,8-dione
benzo(a)pyrene-7,8-dione results in increased expression of AKR1A1 mRNA
AKR1A1 protein affects the chemical synthesis of benzo(a)pyrene-7,8-dione
[AKR1A1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione; AKR1A1 protein results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione; NAD promotes the reaction [AKR1A1 protein affects the chemical synthesis of benzo(a)pyrene-7,8-dione]		 CTD PMID:9973208 PMID:15720144 PMID:16411658 PMID:21910479 NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049 		JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B multiple interactions EXP [AKR1B1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284 		JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 multiple interactions EXP [AKR1B10 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412 		JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 multiple interactions
increases expression		 EXP [AKR1C1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione
benzo(a)pyrene-7,8-dione results in increased expression of AKR1C1 mRNA		 CTD PMID:9973208 PMID:21910479 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283 		JBrowse link
G AKR1C2 aldo-keto reductase family 1 member C2 multiple interactions EXP [AKR1C2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031 		JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 multiple interactions EXP [AKR1C3 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686 		JBrowse link
G AKR1C4 aldo-keto reductase family 1 member C4 multiple interactions EXP [AKR1C4 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr10:5,196,837...5,218,949
Ensembl chr10:5,195,462...5,218,949 		JBrowse link
G AKR7A2 aldo-keto reductase family 7 member A2 multiple interactions EXP [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in decreased abundance of Oxygen; [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in increased chemical synthesis of Hydrogen Peroxide; [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in increased chemical synthesis of Superoxides; [AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,303,965...19,312,144 		JBrowse link
G AKR7A3 aldo-keto reductase family 7 member A3 multiple interactions EXP [AKR7A3 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr 1:19,274,229...19,288,770
Ensembl chr 1:19,282,573...19,288,770 		JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator multiple interactions ISO ARNT protein affects the reaction [benzo(a)pyrene-7,8-dione results in increased expression of CYP1A1 mRNA] CTD PMID:10706104 NCBI chr 1:150,809,713...150,876,599
Ensembl chr 1:150,809,713...150,876,708 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression		 ISO
EXP		 AHR protein affects the reaction [benzo(a)pyrene-7,8-dione results in increased expression of CYP1A1 mRNA]; ARNT protein affects the reaction [benzo(a)pyrene-7,8-dione results in increased expression of CYP1A1 mRNA] CTD PMID:9973208 PMID:10706104 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions
increases expression		 EXP benzo(a)pyrene-7,8-dione results in increased expression of and results in increased activity of CYP1B1 protein
benzo(a)pyrene-7,8-dione results in increased expression of CYP1B1 mRNA		 CTD PMID:16411658 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression		 EXP alpha-Tocopherol inhibits the reaction [benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein]; Ascorbic Acid inhibits the reaction [benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein]
benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 mRNA; benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein		 CTD PMID:22053912 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO benzo(a)pyrene-7,8-dione results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:12213569 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO benzo(a)pyrene-7,8-dione results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:12213569 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 EXP benzo(a)pyrene-7,8-dione results in increased expression of NQO1 mRNA; benzo(a)pyrene-7,8-dione results in increased expression of NQO1 protein
[NQO1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione		 CTD PMID:21910479 PMID:22053912 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 increases metabolic processing EXP SULT1A1 protein results in increased metabolism of benzo(a)pyrene-7,8-dione CTD PMID:22782890 NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044 		JBrowse link
G SULT1A3 sulfotransferase family 1A member 3 increases metabolic processing EXP SULT1A3 protein results in increased metabolism of benzo(a)pyrene-7,8-dione CTD PMID:22782890 NCBI chr16:30,199,255...30,204,310
Ensembl chr16:30,199,228...30,204,310 		JBrowse link
G SULT1E1 sulfotransferase family 1E member 1 increases metabolic processing EXP SULT1E1 protein results in increased metabolism of benzo(a)pyrene-7,8-dione CTD PMID:22782890 NCBI chr 4:69,821,122...69,860,145
Ensembl chr 4:69,841,212...69,860,145 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26050
    role 25966
      biological role 25945
        aetiopathogenetic role 24606
          genotoxin 20130
            benzo[a]pyrene-7,8-dione 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 26050
    subatomic particle 26025
      composite particle 26025
        hadron 26025
          baryon 26025
            nucleon 26025
              atomic nucleus 26025
                atom 26025
                  main group element atom 25850
                    p-block element atom 25850
                      carbon group element atom 25447
                        carbon atom 25405
                          organic molecular entity 25405
                            heteroorganic entity 24782
                              organochalcogen compound 24395
                                organooxygen compound 24072
                                  carbonyl compound 23583
                                    ketone 19362
                                      cyclic ketone 16853
                                        quinone 9221
                                          orthoquinones 96
                                            benzo[a]pyrene-7,8-dione 20
paths to the root