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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:orthoquinones
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Accession:CHEBI:25622 term browser browse the term
Definition:Any quinone in which the carbons of the two carbonyl groups in the quinone system are joined to each other by a single bond.
Synonyms:related_synonym: o-quinone;   o-quinones;   ortho-quinone;   ortho-quinones;   orthoquinone


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1,2-benzoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects localization
multiple interactions
ISO 2-benzoquinone affects the localization of AHR protein
[2-benzoquinone co-treated with 1,4-naphthoquinone] affects the localization of AHR protein
CTD PMID:26558468 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Alb albumin multiple interactions
affects binding
ISO
EXP
Benzene promotes the reaction [2-benzoquinone binds to ALB protein]
ALB protein binds to 2-benzoquinone
Benzene promotes the reaction [ALB protein binds to 2-benzoquinone]
CTD PMID:9826945, PMID:17366815 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
1,2-naphthoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization
ISO 1,2-naphthoquinone promotes the reaction [AHR protein binds to ARNT protein]; 1,2-naphthoquinone promotes the reaction [AHR protein binds to CYP1A1 enhancer]; AHR protein affects the reaction [1,2-naphthoquinone results in increased expression of CYP1A1 mRNA]
1,2-naphthoquinone results in increased expression of and affects the localization of AHR protein
1,2-naphthoquinone affects the localization of AHR protein
CTD PMID:26558468, PMID:27853106 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction ISO AKR1A1 protein results in increased reduction of 1,2-naphthoquinone CTD PMID:10510318 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases reduction ISO AKR1B1 protein results in increased reduction of 1,2-naphthoquinone CTD PMID:10510318 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 increases reduction ISO AKR7A2 protein results in increased reduction of 1,2-naphthoquinone CTD PMID:10510318 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G Alb albumin affects binding ISO 1,2-naphthoquinone binds to ALB protein CTD PMID:12385719 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases expression ISO 1,2-naphthoquinone results in increased expression of ALDH3A1 mRNA CTD PMID:26558468 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO 1,2-naphthoquinone promotes the reaction [AHR protein binds to ARNT protein] CTD PMID:26558468, PMID:27853106 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [1,2-naphthoquinone results in increased expression of CXCL8 mRNA]; CAT protein inhibits the reaction [1,2-naphthoquinone results in increased expression of PTGS2 mRNA]; CAT protein promotes the reaction [1,2-naphthoquinone results in increased expression of HMOX1 mRNA] CTD PMID:21997482 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO [S-Nitrosoglutathione binds to CBR1 protein] promotes the reaction [CBR1 protein results in increased metabolism of 1,2-naphthoquinone] CTD PMID:23295225 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO 1,2-naphthoquinone binds to and results in decreased activity of CREB1 protein CTD PMID:21530497 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO 1,2-naphthoquinone promotes the reaction [AHR protein binds to CYP1A1 enhancer]; 1,2-naphthoquinone promotes the reaction [POLR2A protein binds to CYP1A1 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [1,2-naphthoquinone results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [1,2-naphthoquinone results in increased expression of CYP1A1 mRNA] CTD PMID:26558468, PMID:26656082, PMID:27853106 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase increases metabolic processing
multiple interactions
ISO DCXR protein results in increased metabolism of 1,2-naphthoquinone
1,2-naphthoquinone inhibits the reaction [[[DCXR protein co-treated with NAD] results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin]
CTD PMID:28595002 NCBI chr10:109,906,119...109,909,696
Ensembl chr10:109,906,815...109,909,715
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of 1,2-naphthoquinone CTD PMID:24246760 NCBI chr 6:95,522,577...95,541,393
Ensembl chr 6:95,522,577...95,541,393
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO 1,2-naphthoquinone results in increased phosphorylation of and results in increased activity of EGFR protein CTD PMID:24067727 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases stability ISO 1,2-naphthoquinone results in increased stability of FOS protein CTD PMID:24067727 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases activity
affects binding
multiple interactions
ISO 1,2-naphthoquinone results in decreased activity of GAPDH protein
1,2-naphthoquinone binds to GAPDH protein
[Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone binds to GAPDH protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone results in decreased activity of GAPDH protein]
CTD PMID:21827172 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO CAT protein promotes the reaction [1,2-naphthoquinone results in increased expression of HMOX1 mRNA] CTD PMID:21997482 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO 1,2-naphthoquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of IKBKB protein] CTD PMID:21139339 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects response to substance
increases metabolic processing
ISO KEAP1 protein affects the susceptibility to 1,2-naphthoquinone
1,2-naphthoquinone results in increased metabolism of KEAP1 protein
CTD PMID:21384861, PMID:25807370 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [1,2-naphthoquinone results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [1,2-naphthoquinone results in increased phosphorylation of MAPK1 protein] CTD PMID:24067727 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO 1,2-naphthoquinone results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [1,2-naphthoquinone results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [1,2-naphthoquinone results in increased phosphorylation of MAPK3 protein]
CTD PMID:24067727 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases activity
affects response to substance
ISO NFE2L2 protein promotes the reaction [sulforafan results in decreased susceptibility to 1,2-naphthoquinone]
1,2-naphthoquinone results in increased activity of NFE2L2 protein
[NFE2L2 affects the susceptibility to sulforafan] which affects the susceptibility to 1,2-naphthoquinone; NFE2L2 protein affects the susceptibility to 1,2-naphthoquinone
CTD PMID:19303893, PMID:20932822, PMID:21384861, PMID:21651925, PMID:25807370 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 1,2-naphthoquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:21139339 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 1,2-naphthoquinone inhibits the reaction [[lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide] CTD PMID:21139339 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases reduction
increases expression
ISO NQO1 protein results in increased reduction of 1,2-naphthoquinone
1,2-naphthoquinone results in increased expression of NQO1 mRNA
CTD PMID:21384861, PMID:26558468 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Polr2a RNA polymerase II subunit A multiple interactions ISO 1,2-naphthoquinone promotes the reaction [POLR2A protein binds to CYP1A1 protein] CTD PMID:26558468 NCBI chr10:56,339,277...56,364,888
Ensembl chr10:56,339,284...56,365,084
JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions ISO 1,2-naphthoquinone binds to and results in decreased activity of PRDX6 protein CTD PMID:22129745 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO 1,2-naphthoquinone results in increased expression of PTGS2 mRNA
CAT protein inhibits the reaction [1,2-naphthoquinone results in increased expression of PTGS2 mRNA]
CTD PMID:21997482 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 decreases activity ISO 1,2-naphthoquinone results in decreased activity of PTPN1 protein CTD PMID:24067727 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 1,2-naphthoquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased localization of and results in increased activity of RELA protein] CTD PMID:21139339 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions EXP [1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR1 mRNA; Capsaicin inhibits the reaction [[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR1 mRNA] CTD PMID:19399481 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Tacr2 tachykinin receptor 2 multiple interactions EXP [1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR2 mRNA; Capsaicin inhibits the reaction [[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR2 mRNA] CTD PMID:19399481 NCBI chr20:31,892,515...31,905,153
Ensembl chr20:31,892,515...31,905,153
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO 1,2-naphthoquinone binds to and results in decreased activity of TOP2A protein CTD PMID:22218491 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO 1,2-naphthoquinone results in increased activity of TRPA1 protein CTD PMID:21591660 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP [1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TRPV1 mRNA; Capsaicin inhibits the reaction [[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TRPV1 mRNA] CTD PMID:19399481 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity ISO 1,2-naphthoquinone results in increased activity of TRPV3 protein CTD PMID:29658714 NCBI chr10:59,829,755...59,863,780
Ensembl chr10:59,831,241...59,860,987
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions ISO 1,2-naphthoquinone results in increased metabolism of and results in decreased activity of UCHL1 protein; Glutathione inhibits the reaction [1,2-naphthoquinone results in increased metabolism of and results in decreased activity of UCHL1 protein] CTD PMID:24582816 NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973
JBrowse link
acenaphthoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of acenaphthenequinone CTD PMID:30926317 NCBI chr10:72,144,042...72,153,496
Ensembl chr10:72,144,042...72,153,375
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO acenaphthenequinone affects the localization of and results in increased expression of NFKB1 protein CTD PMID:17082565 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO [acenaphthenequinone results in increased chemical synthesis of Reactive Oxygen Species] which affects the expression of PTGS2 protein; Acetylcysteine inhibits the reaction [acenaphthenequinone results in increased expression of PTGS2 protein]; BAY 11-7085 inhibits the reaction [acenaphthenequinone results in increased expression of PTGS2 protein] CTD PMID:17082565 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [acenaphthenequinone results in increased expression of RELA protein]; acenaphthenequinone affects the localization of and results in increased expression of RELA protein; Acetylcysteine inhibits the reaction [acenaphthenequinone results in increased expression of RELA protein] CTD PMID:17082565, PMID:17925309 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
benzo[a]pyrene-7,8-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects localization
multiple interactions
ISO benzo(a)pyrene-7,8-dione affects the localization of AHR protein
AHR protein affects the reaction [benzo(a)pyrene-7,8-dione results in increased expression of CYP1A1 mRNA]
CTD PMID:10706104 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases chemical synthesis
multiple interactions
affects chemical synthesis
increases expression
ISO AKR1A1 protein results in increased chemical synthesis of benzo(a)pyrene-7,8-dione
[AKR1A1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione; AKR1A1 protein results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione; NAD promotes the reaction [AKR1A1 protein affects the chemical synthesis of benzo(a)pyrene-7,8-dione]
benzo(a)pyrene-7,8-dione results in increased expression of AKR1A1 mRNA
CTD PMID:9973208, PMID:15720144, PMID:16411658, PMID:21910479 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions ISO [AKR1B1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO [AKR1B10 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 multiple interactions ISO [AKR1C4 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions ISO [AKR1C2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions ISO [AKR1C3 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 multiple interactions ISO [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in decreased abundance of Oxygen; [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in increased chemical synthesis of Hydrogen Peroxide; [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in increased chemical synthesis of Superoxides; [AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 multiple interactions ISO [AKR7A3 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione CTD PMID:21910479 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO ARNT protein affects the reaction [benzo(a)pyrene-7,8-dione results in increased expression of CYP1A1 mRNA] CTD PMID:10706104 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO AHR protein affects the reaction [benzo(a)pyrene-7,8-dione results in increased expression of CYP1A1 mRNA]; ARNT protein affects the reaction [benzo(a)pyrene-7,8-dione results in increased expression of CYP1A1 mRNA] CTD PMID:9973208, PMID:10706104 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO benzo(a)pyrene-7,8-dione results in increased expression of and results in increased activity of CYP1B1 protein
benzo(a)pyrene-7,8-dione results in increased expression of CYP1B1 mRNA
CTD PMID:16411658 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO alpha-Tocopherol inhibits the reaction [benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein]; Ascorbic Acid inhibits the reaction [benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein]
benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 mRNA; benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein
CTD PMID:22053912 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO benzo(a)pyrene-7,8-dione results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:12213569 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO benzo(a)pyrene-7,8-dione results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:12213569 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO benzo(a)pyrene-7,8-dione results in increased expression of NQO1 mRNA; benzo(a)pyrene-7,8-dione results in increased expression of NQO1 protein
[NQO1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione
CTD PMID:21910479, PMID:22053912 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases metabolic processing ISO SULT1A1 protein results in increased metabolism of benzo(a)pyrene-7,8-dione CTD PMID:22782890 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 increases metabolic processing ISO SULT1E1 protein results in increased metabolism of benzo(a)pyrene-7,8-dione CTD PMID:22782890 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
beta-lapachone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg7 autophagy related 7 affects response to substance ISO ATG7 protein affects the susceptibility to beta-lapachone CTD PMID:21035436 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Becn1 beclin 1 affects response to substance ISO BECN1 protein affects the susceptibility to beta-lapachone CTD PMID:21035436 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO beta-lapachone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; beta-lapachone inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO beta-lapachone affects the localization of and results in increased metabolism of MAP1LC3B protein CTD PMID:21035436 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases reduction ISO NQO1 protein results in increased reduction of beta-lapachone CTD PMID:24552538 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO beta-lapachone inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
dopachrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pomc proopiomelanocortin multiple interactions ISO [POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome; Quercetin analog inhibits the reaction [[POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome] CTD PMID:26586997 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Tyr tyrosinase multiple interactions ISO [POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome; Quercetin analog inhibits the reaction [[POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome] CTD PMID:26586997 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
pyrroloquinoline quinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 increases expression EXP PQQ Cofactor results in increased expression of ACOX1 mRNA CTD PMID:25843018 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Atg12 autophagy related 12 multiple interactions ISO PQQ Cofactor inhibits the reaction [Doxorubicin results in increased expression of ATG12 protein] CTD PMID:31226464 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atg16l1 autophagy related 16-like 1 multiple interactions ISO PQQ Cofactor inhibits the reaction [Doxorubicin results in increased expression of ATG16L1 protein] CTD PMID:31226464 NCBI chr 9:94,879,876...94,915,231
Ensembl chr 9:94,879,745...94,915,228
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO PQQ Cofactor inhibits the reaction [Doxorubicin results in increased expression of ATG5 protein] CTD PMID:31226464 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO PQQ Cofactor inhibits the reaction [Doxorubicin results in increased expression of ATG7 protein] CTD PMID:31226464 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions EXP PQQ Cofactor inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ATM mRNA] CTD PMID:28115068 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO PQQ Cofactor inhibits the reaction [Rotenone affects the expression of BAX protein]; PQQ Cofactor inhibits the reaction [Rotenone results in increased expression of BAX protein]
PQQ Cofactor analog results in increased expression of BAX mRNA; PQQ Cofactor results in increased expression of BAX mRNA
CTD PMID:24755484, PMID:26276080, PMID:32068067 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO PQQ Cofactor inhibits the reaction [Rotenone affects the expression of BCL2 protein]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]
PQQ Cofactor analog results in decreased expression of BCL2 mRNA; PQQ Cofactor results in decreased expression of BCL2 mRNA
CTD PMID:24755484, PMID:26276080, PMID:32068067 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
EXP
ISO
PQQ Cofactor inhibits the reaction [Rotenone results in increased activity of CASP3 protein]
PQQ Cofactor analog results in increased cleavage of CASP3 protein; PQQ Cofactor results in increased cleavage of CASP3 protein
PQQ Cofactor inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]
CTD PMID:27108097, PMID:31226464, PMID:32068067 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO PQQ Cofactor inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein modified form] CTD PMID:31226464 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
increases activity
EXP PQQ Cofactor inhibits the reaction [Rotenone results in decreased activity of CAT protein]
PQQ Cofactor results in increased activity of CAT protein
CTD PMID:25843018 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO PQQ Cofactor inhibits the reaction [Rotenone results in increased expression of DIABLO protein] CTD PMID:26276080 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Fasn fatty acid synthase decreases expression EXP PQQ Cofactor results in decreased expression of FASN mRNA CTD PMID:25843018 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of GCLC mRNA] CTD PMID:26276080 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO PQQ Cofactor results in increased expression of GFAP mRNA CTD PMID:28578007 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of HMOX1 mRNA] CTD PMID:26276080 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions ISO PQQ Cofactor inhibits the reaction [Doxorubicin results in decreased expression of LAMP1 protein] CTD PMID:31226464 NCBI chr16:81,689,576...81,714,341
Ensembl chr16:81,689,335...81,714,419
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO PQQ Cofactor inhibits the reaction [Doxorubicin results in decreased expression of LAMP2 protein] CTD PMID:31226464 NCBI chr  X:124,722,628...124,766,079
Ensembl chr  X:124,722,628...124,766,044
JBrowse link
G Map2 microtubule-associated protein 2 decreases expression ISO PQQ Cofactor results in decreased expression of MAP2 mRNA CTD PMID:28578007 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Rotenone co-treated with PQQ Cofactor] results in increased phosphorylation of MAPK1 protein CTD PMID:24755484 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Rotenone co-treated with PQQ Cofactor] results in increased phosphorylation of MAPK3 protein CTD PMID:24755484 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I affects expression ISO PQQ Cofactor affects the expression of COX1 protein CTD PMID:28578007 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 multiple interactions
increases response to substance
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of NDUFS1 mRNA]]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of NDUFS1 mRNA]
NDUFS1 mRNA results in increased susceptibility to PQQ Cofactor
CTD PMID:24755484, PMID:26276080, PMID:27108097 NCBI chr 9:69,919,863...69,953,182
Ensembl chr 9:69,919,867...69,953,182
JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 multiple interactions EXP PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of NDUFS2 mRNA] CTD PMID:26276080 NCBI chr13:89,606,848...89,623,506
Ensembl chr13:89,606,840...89,619,398
JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 multiple interactions EXP PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of NDUFS3 mRNA] CTD PMID:26276080 NCBI chr 3:79,721,686...79,728,863
Ensembl chr 3:79,721,694...79,728,879
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 multiple interactions
increases response to substance
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of NDUFS4 mRNA]]; PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of NDUFS4 mRNA]
NDUFS4 mRNA results in increased susceptibility to PQQ Cofactor
CTD PMID:24755484, PMID:26276080, PMID:27108097 NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO PQQ Cofactor results in increased expression of NRF1 mRNA CTD PMID:28578007 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO PQQ Cofactor analog results in decreased expression of and results in increased cleavage of PARP1 protein; PQQ Cofactor results in decreased expression of and results in increased cleavage of PARP1 protein CTD PMID:32068067 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression
EXP
ISO
PQQ Cofactor promotes the reaction [Rotenone results in increased expression of PPARGC1A mRNA]
PQQ Cofactor results in increased expression of PPARGC1A mRNA
CTD PMID:25843018, PMID:28578007 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A increases expression ISO PQQ Cofactor results in increased expression of SDHA protein CTD PMID:28578007 NCBI chr 1:31,545,631...31,570,601
Ensembl chr 1:31,545,631...31,570,601
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of SLC18A2 protein] CTD PMID:26276080 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Sod2 superoxide dismutase 2 increases activity
multiple interactions
EXP PQQ Cofactor results in increased activity of SOD2 protein
PQQ Cofactor inhibits the reaction [Rotenone results in decreased activity of SOD2 protein]
CTD PMID:25843018 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression
decreases expression
EXP
ISO
PQQ Cofactor results in increased expression of TFAM mRNA
PQQ Cofactor results in decreased expression of TFAM mRNA
CTD PMID:25843018, PMID:28578007 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP PQQ Cofactor inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:26276080, PMID:27108097 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 multiple interactions ISO PQQ Cofactor inhibits the reaction [Doxorubicin results in decreased expression of TOMM20 protein] CTD PMID:31226464 NCBI chr19:59,863,421...59,873,411
Ensembl chr19:59,863,421...59,873,411
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    chemical entity 19791
      group 19698
        inorganic group 19168
          oxo group 18404
            organic oxo compound 18404
              carbonyl compound 18404
                ketone 16152
                  cyclic ketone 13818
                    quinone 8334
                      orthoquinones 84
                        1,2-benzoquinones + 2
                        1,2-naphthoquinones + 37
                        12-demethylmultiorthoquinone 0
                        3-bromo-beta-lapachone 0
                        6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylic acid 0
                        Carbamazepine-o-quinone 0
                        acenaphthoquinone 4
                        benzo[a]pyrene-7,8-dione 18
                        beta-lapachone 6
                        betanidin quinone 0
                        cysteine tryptophylquinone + 0
                        dibenzo[1,4]dioxine-2,3-dione 0
                        dopachrome + 2
                        estra-1(10),4-diene-2,3,17-trione 0
                        estra-1,5(10)-diene-3,4,17-trione 0
                        indole-5,6-quinone 0
                        laccaridione A 0
                        laccaridione B 0
                        multiorthoquinone 0
                        nocardione A 0
                        phanquone 0
                        pyrroloquinoline quinone 35
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18508
                              organic divalent group 18501
                                organodiyl group 18501
                                  carbonyl group 18404
                                    carbonyl compound 18404
                                      ketone 16152
                                        cyclic ketone 13818
                                          quinone 8334
                                            orthoquinones 84
                                              1,2-benzoquinones + 2
                                              1,2-naphthoquinones + 37
                                              12-demethylmultiorthoquinone 0
                                              3-bromo-beta-lapachone 0
                                              6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylic acid 0
                                              Carbamazepine-o-quinone 0
                                              acenaphthoquinone 4
                                              benzo[a]pyrene-7,8-dione 18
                                              beta-lapachone 6
                                              betanidin quinone 0
                                              cysteine tryptophylquinone + 0
                                              dibenzo[1,4]dioxine-2,3-dione 0
                                              dopachrome + 2
                                              estra-1(10),4-diene-2,3,17-trione 0
                                              estra-1,5(10)-diene-3,4,17-trione 0
                                              indole-5,6-quinone 0
                                              laccaridione A 0
                                              laccaridione B 0
                                              multiorthoquinone 0
                                              nocardione A 0
                                              phanquone 0
                                              pyrroloquinoline quinone 35
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.