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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flubendazole
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Accession:CHEBI:77095 term browser browse the term
Definition:A member of the class of mebendazole in which the benzoyl group is replaced by a p-fluorobenzoyl group. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections.
Synonyms:exact_synonym: methyl [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate
 related_synonym: (5-(4-fluorobenzoyl)-1H-benzimidazole-2-yl)carbamic acid methyl ester;   Formula=C16H12FN3O3;   InChI=1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22);   InChIKey=CPEUVMUXAHMANV-UHFFFAOYSA-N;   Methyl N-(5-(p-fluorobenzoyl)-2-benzimidazolyl)carbamate;   R 17,889;   R 17899;   SMILES=COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c1ccc(F)cc1;   flubendazol;   flubendazolum;   methyl 5-(p-fluorobenzoyl)-2-benzimidazolecarbamate
 xref: CAS:31430-15-6;   Drug_Central:1186;   KEGG:D04200;   LINCS:LSM-5916
 xref_mesh: MESH:C018945
 xref: PMID:20348394;   PMID:20444026;   PMID:21609260;   PMID:22640491;   PMID:22717022;   PMID:23075539;   PMID:23287076;   PMID:23884106;   PMID:24297155;   PMID:3810656;   PMID:538808;   PMID:6126101;   PMID:7101714;   PMID:7212160;   Patent:DE2029637;   Patent:US3657267;   Reaxys:763480;   Wikipedia:Flubendazole


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flubendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 decreases expression ISO flubendazole results in decreased expression of ARHGEF2 protein CTD PMID:30075109 NCBI chr 2:187,964,100...188,022,847
Ensembl chr 2:187,977,008...188,021,377
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases phosphorylation ISO flubendazole results in increased phosphorylation of BCL2 protein CTD PMID:32652169 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases phosphorylation ISO flubendazole results in increased phosphorylation of BCL2L1 protein CTD PMID:32652169 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO flubendazole results in increased cleavage of CASP3 protein
BAY 11-7085 affects the reaction [flubendazole results in increased cleavage of CASP3 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein]; benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein]; Cyclosporine inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein]
CTD PMID:32652169 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein] CTD PMID:30075109 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30075109 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO flubendazole results in increased activity of MAPK8 protein CTD PMID:32652169 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases phosphorylation ISO flubendazole results in increased phosphorylation of MCL1 protein CTD PMID:32652169 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO flubendazole results in increased expression of PMAIP1 protein CTD PMID:32652169 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression ISO flubendazole results in decreased expression of PTK2 protein CTD PMID:30075109 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO flubendazole results in decreased expression of RAC1 protein CTD PMID:30075109 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity
multiple interactions
ISO flubendazole results in increased activity of RELA protein
4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine affects the reaction [flubendazole results in increased activity of RELA protein]; BAY 11-7085 affects the reaction [flubendazole results in increased activity of RELA protein]
CTD PMID:32652169 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO flubendazole results in decreased expression of RHOA protein CTD PMID:30075109 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30075109 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tp53 tumor protein p53 increases activity ISO flubendazole results in increased activity of TP53 protein CTD PMID:32652169 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      biological role 19732
        aetiopathogenetic role 18987
          teratogenic agent 15895
            flubendazole 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic group 18631
                              organic divalent group 18622
                                organodiyl group 18622
                                  carbonyl group 18537
                                    carbonyl compound 18537
                                      carboxylic ester 15539
                                        carbamate ester 7445
                                          flubendazole 15
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