GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304659
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arhgef2
Name: Rho/Rac guanine nucleotide exchange factor 2
Acc ID: CHEBI:77095
Term: flubendazole
Definition: A member of the class of mebendazole in which the benzoyl group is replaced by a p-fluorobenzoyl group. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections.
Chemical ID: MESH:C018945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13122266480464CTDflubendazole results in decreased expression of ARHGEF2 protein

PMID:30075109
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