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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lenvatinib
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Accession:CHEBI:85994 term browser browse the term
Definition:A member of the class of quinolines that is the carboxamide of 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxylic acid. A multi-kinase inhibitor and orphan drug used (as its mesylate salt) for the treatment of various types of thyroid cancer that do not respond to radioiodine.
Synonyms:exact_synonym: 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide
 related_synonym: 4-(3-Chloro-4-(N'-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide;   E 7080;   E7080;   Formula=C21H19ClN4O4;   InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28);   InChIKey=WOSKHXYHFSIKNG-UHFFFAOYSA-N;   SMILES=C=1(C(=CC2=C(C1)N=CC=C2OC3=CC(=C(C=C3)NC(NC4CC4)=O)Cl)C(N)=O)OC;   UNII-EE083865G2
 xref: CAS:417716-92-8;   Drug_Central:4942;   KEGG:D09919
 xref_mesh: MESH:C531958
 xref: PDBeChem:LEV;   PMID:25240824;   PMID:25458359;   PMID:25589937;   PMID:25600977;   PMID:25616432;   PMID:25625428;   PMID:25671254;   PMID:25720434;   PMID:25795101;   PMID:25859118;   PMID:25913680;   PMID:25974026;   PMID:26008987;   PMID:26026266;   Reaxys:12096874;   Wikipedia:Lenvatinib
 cyclic_relationship: is_conjugate_base_of CHEBI:85998


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lenvatinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5f1a ATP synthase F1 subunit alpha affects expression EXP lenvatinib affects the expression of ATP5F1A protein CTD PMID:34019861 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Cat catalase decreases expression EXP lenvatinib results in decreased expression of CAT mRNA CTD PMID:34019861 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects expression EXP lenvatinib affects the expression of CDKN1A protein CTD PMID:34019861 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression EXP lenvatinib results in decreased expression of CPT1A mRNA CTD PMID:35788046 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression EXP
ISO		 lenvatinib results in decreased expression of CPT1B mRNA; lenvatinib results in decreased expression of CPT1B protein CTD PMID:35788046 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression EXP
ISO		 lenvatinib results in decreased expression of CPT2 mRNA; lenvatinib results in decreased expression of CPT2 protein CTD PMID:35788046 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Dnm1l dynamin 1-like increases expression EXP lenvatinib results in increased expression of DNM1L mRNA CTD PMID:34019861 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Fis1 fission, mitochondrial 1 increases expression EXP lenvatinib results in increased expression of FIS1 mRNA CTD PMID:34019861 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Lonp1 lon peptidase 1, mitochondrial decreases expression EXP lenvatinib results in decreased expression of LONP1 protein CTD PMID:34019861 NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 increases expression EXP lenvatinib results in increased expression of MAP3K5 mRNA CTD PMID:34019861 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression EXP lenvatinib results in increased expression of MAPK8 mRNA CTD PMID:34019861 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mfn1 mitofusin 1 affects expression EXP lenvatinib affects the expression of MFN1 mRNA CTD PMID:34019861 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640 		JBrowse link
G Mfn2 mitofusin 2 affects expression EXP lenvatinib affects the expression of MFN2 mRNA CTD PMID:34019861 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I affects expression
decreases expression		 EXP lenvatinib affects the expression of COX1 protein
lenvatinib results in decreased expression of COX1 protein		 CTD PMID:34019861 PMID:35788046 NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 affects expression EXP lenvatinib affects the expression of NDUFB8 protein CTD PMID:34019861 NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression EXP lenvatinib results in decreased expression of NFE2L2 mRNA CTD PMID:34019861 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nrf1 nuclear respiratory factor 1 affects expression EXP lenvatinib affects the expression of NRF1 mRNA CTD PMID:34019861 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase increases expression EXP lenvatinib results in increased expression of OPA1 mRNA CTD PMID:34019861 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B decreases expression EXP lenvatinib results in decreased expression of SDHB protein CTD PMID:34019861 PMID:35788046 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 decreases expression ISO
EXP		 lenvatinib results in decreased expression of SLC22A5 protein
lenvatinib results in decreased expression of SLC22A5 mRNA; lenvatinib results in decreased expression of SLC22A5 protein		 CTD PMID:35788046 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 decreases expression ISO
EXP		 lenvatinib results in decreased expression of SLC25A20 protein
lenvatinib results in decreased expression of SLC25A20 mRNA; lenvatinib results in decreased expression of SLC25A20 protein		 CTD PMID:35788046 NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP lenvatinib results in increased expression of SOD2 mRNA CTD PMID:34019861 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Ucp2 uncoupling protein 2 decreases expression EXP lenvatinib results in decreased expression of UCP2 mRNA; lenvatinib results in decreased expression of UCP2 protein CTD PMID:34019861 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 affects expression
decreases expression		 EXP lenvatinib affects the expression of UQCRC2 protein
lenvatinib results in decreased expression of UQCRC2 protein		 CTD PMID:34019861 PMID:35788046 NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453 		JBrowse link
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  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            antineoplastic agent 17817
              lenvatinib 24
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  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbon oxoacid 18654
                                    carboxylic acid 18651
                                      carboacyl group 17694
                                        univalent carboacyl group 17694
                                          carbamoyl group 17545
                                            carboxamide 17545
                                              monocarboxylic acid amide 15727
                                                urea 6223
                                                  ureas 6221
                                                    phenylureas 2620
                                                      lenvatinib 24
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