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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:excipient
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Accession:CHEBI:75324 term browser browse the term
Definition:A generally pharmacologically inactive substance that is formulated with the active ingredient of a medication.
Synonyms:related_synonym: bulking agent;   bulking agents;   filler;   fillers
 xref: PMID:19709488;   PMID:21086329;   PMID:22707004;   PMID:22877709;   PMID:23450581;   PMID:23525964;   PMID:23657359;   Wikipedia:Excipient


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kaolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F11 coagulation factor XI decreases activity ISO Kaolin results in decreased activity of F11 protein CTD PMID:6604052 NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437 		JBrowse link
G F12 coagulation factor XII increases activity ISO Kaolin results in increased activity of F12 protein CTD PMID:6343536 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
tyloxapol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP tyloxapol results in decreased activity of ACHE protein CTD PMID:37749825 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Alb albumin multiple interactions
decreases expression		 ISO Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of ALB mRNA]; ferulic acid inhibits the reaction [tyloxapol results in decreased expression of ALB mRNA]; naringenin inhibits the reaction [tyloxapol results in decreased expression of ALB mRNA] CTD PMID:37076581 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Atg5 autophagy related 5 multiple interactions
decreases expression		 ISO Escin inhibits the reaction [tyloxapol results in decreased expression of ATG5 protein] CTD PMID:36905866 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg7 autophagy related 7 multiple interactions
decreases expression		 ISO Escin inhibits the reaction [tyloxapol results in decreased expression of ATG7 protein]; Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of ATG7 protein] CTD PMID:36905866 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Bche butyrylcholinesterase increases activity EXP tyloxapol results in increased activity of BCHE protein CTD PMID:37749825 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Becn1 beclin 1 decreases expression
multiple interactions		 ISO tyloxapol results in decreased expression of BECN1 protein
Escin inhibits the reaction [tyloxapol results in decreased expression of BECN1 protein]; Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of BECN1 protein]		 CTD PMID:36905866 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression
multiple interactions		 ISO tyloxapol results in decreased expression of GCLC protein
Escin inhibits the reaction [tyloxapol results in decreased expression of GCLC protein]; Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of GCLC protein]		 CTD PMID:36905866 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression		 ISO Escin inhibits the reaction [tyloxapol results in increased expression of GPT protein]; Fenofibrate inhibits the reaction [tyloxapol results in increased expression of GPT protein] CTD PMID:36905866 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP tyloxapol results in decreased activity of GSR protein CTD PMID:37749825 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO Fenofibrate inhibits the reaction [tyloxapol results in increased expression of IL6 mRNA]; ferulic acid inhibits the reaction [tyloxapol results in increased expression of IL6 mRNA]; naringenin inhibits the reaction [tyloxapol results in increased expression of IL6 mRNA] CTD PMID:37076581 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression
multiple interactions		 ISO tyloxapol results in increased expression of KEAP1 protein
Escin inhibits the reaction [tyloxapol results in increased expression of KEAP1 protein]; Fenofibrate inhibits the reaction [tyloxapol results in increased expression of KEAP1 protein]		 CTD PMID:36905866 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation		 ISO Escin inhibits the reaction [tyloxapol results in increased lipidation of MAP1LC3B protein]; Fenofibrate inhibits the reaction [tyloxapol results in increased lipidation of MAP1LC3B protein] CTD PMID:36905866 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Pon1 paraoxonase 1 decreases activity EXP tyloxapol results in decreased activity of PON1 protein CTD PMID:37749825 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions		 ISO tyloxapol results in decreased expression of PPARA protein
Escin inhibits the reaction [tyloxapol results in decreased expression of PPARA protein]		 CTD PMID:36905866 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions		 ISO tyloxapol results in increased expression of SQSTM1 protein
Escin inhibits the reaction [tyloxapol results in increased expression of SQSTM1 protein]; Fenofibrate inhibits the reaction [tyloxapol results in increased expression of SQSTM1 protein]		 CTD PMID:36905866 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions		 ISO tyloxapol results in increased expression of SREBF1 protein
Escin inhibits the reaction [tyloxapol results in increased expression of SREBF1 protein]; Fenofibrate inhibits the reaction [tyloxapol results in increased expression of SREBF1 protein]		 CTD PMID:36905866 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO tyloxapol results in increased expression of TNF mRNA
ferulic acid inhibits the reaction [tyloxapol results in increased expression of TNF mRNA]; naringenin inhibits the reaction [tyloxapol results in increased expression of TNF mRNA]		 CTD PMID:37076581 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 ISO ferulic acid inhibits the reaction [tyloxapol results in increased expression of VEGFA mRNA]; naringenin inhibits the reaction [tyloxapol results in increased expression of VEGFA mRNA] CTD PMID:37076581 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      application 19703
        excipient 20
          1,3-dioctanoylglycerol 0
          isomalt 0
          kaolin 2
          lactitol + 0
          tyloxapol 18
paths to the root