The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A polymeric compound resulting from the reaction of 4-(1,1,3,3-tetramethylbutyl)phenol with formaldehyde to give a chain in which 6-8 molecules are linked together by CH2 groups ortho to the phenolic hydroxy groups, which have then undergone reaction with oxirane to give polyoxyethyleneoxy moieties, Ar(OCH2CH2)xOH, where x = 8-10. A nonionic liquic polymer, it inhibits lipoprotein lipase and hence clearance of triglyceride from the plasma, so is used to induce hyperlipidaemia in test animals. Also used as a surfactant to aid liquefaction and removal of mucus- and pus-containing bronchopulmonary secretions.
Synonyms:
related_synonym:
4-(1,1,2,2-tetramethylbutyl)phenol polyer with formaldehyde and oxirane; Alevaire; Formula=(C2H4O)n.(C2H4O)n.(C17H26O2)n.(C2H4O)n.C29H44O2; Superinone; Triton A-20; Triton WR-1339; oxyethylated tertiary octylphenol formaldehyde polymer; p-(1,1,3,3-tetramethylbutyl)phenol polymer with ethylene oxide and formaldehyde; p-isooctylpolyoxyethylenenphenol formaldehyde polymer; tiloxapol; tyloxapolum; tyloxypal
Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of ALB mRNA]; ferulic acid inhibits the reaction [tyloxapol results in decreased expression of ALB mRNA]; naringenin inhibits the reaction [tyloxapol results in decreased expression of ALB mRNA]
Escin inhibits the reaction [tyloxapol results in decreased expression of ATG7 protein]; Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of ATG7 protein]
tyloxapol results in decreased expression of BECN1 protein Escin inhibits the reaction [tyloxapol results in decreased expression of BECN1 protein]; Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of BECN1 protein]
tyloxapol results in decreased expression of GCLC protein Escin inhibits the reaction [tyloxapol results in decreased expression of GCLC protein]; Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of GCLC protein]
Escin inhibits the reaction [tyloxapol results in increased expression of GPT protein]; Fenofibrate inhibits the reaction [tyloxapol results in increased expression of GPT protein]
Fenofibrate inhibits the reaction [tyloxapol results in increased expression of IL6 mRNA]; ferulic acid inhibits the reaction [tyloxapol results in increased expression of IL6 mRNA]; naringenin inhibits the reaction [tyloxapol results in increased expression of IL6 mRNA]
tyloxapol results in increased expression of KEAP1 protein Escin inhibits the reaction [tyloxapol results in increased expression of KEAP1 protein]; Fenofibrate inhibits the reaction [tyloxapol results in increased expression of KEAP1 protein]
Escin inhibits the reaction [tyloxapol results in increased lipidation of MAP1LC3B protein]; Fenofibrate inhibits the reaction [tyloxapol results in increased lipidation of MAP1LC3B protein]
tyloxapol results in increased expression of SQSTM1 protein Escin inhibits the reaction [tyloxapol results in increased expression of SQSTM1 protein]; Fenofibrate inhibits the reaction [tyloxapol results in increased expression of SQSTM1 protein]
tyloxapol results in increased expression of SREBF1 protein Escin inhibits the reaction [tyloxapol results in increased expression of SREBF1 protein]; Fenofibrate inhibits the reaction [tyloxapol results in increased expression of SREBF1 protein]
tyloxapol results in increased expression of TNF mRNA ferulic acid inhibits the reaction [tyloxapol results in increased expression of TNF mRNA]; naringenin inhibits the reaction [tyloxapol results in increased expression of TNF mRNA]
ferulic acid inhibits the reaction [tyloxapol results in increased expression of VEGFA mRNA]; naringenin inhibits the reaction [tyloxapol results in increased expression of VEGFA mRNA]
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