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tetrahydrocurcumin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tetrahydrocurcumin
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Accession:CHEBI:67263 term browser browse the term
Definition:A beta-diketone that is curcumin in which both of the double bonds have been reduced to single bonds.
Synonyms:exact_synonym: 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
 related_synonym: 1,7-bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanedione;   Formula=C21H24O6;   InChI=1S/C21H24O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h5-6,9-12,24-25H,3-4,7-8,13H2,1-2H3;   InChIKey=LBTVHXHERHESKG-UHFFFAOYSA-N;   SMILES=COc1cc(CCC(=O)CC(=O)CCc2ccc(O)c(OC)c2)ccc1O
 xref: CAS:36062-04-1;   HMDB:HMDB0005789
 xref_mesh: MESH:C096277
 xref: MetaCyc:CPD-13315;   PMID:21116204;   PMID:21467222;   PMID:21887819;   PMID:21928294;   PMID:22072109;   PMID:22156377;   PMID:22212488;   PMID:22574459;   Reaxys:3485469


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tetrahydrocurcumin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy adenosylhomocysteinase affects expression ISO Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice RGD PMID:22212488 RGD:41410880 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO tetrahydrocurcumin inhibits the reaction [APP protein binds to APP protein] CTD PMID:19715544 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Cat catalase multiple interactions
affects expression
EXP
ISO
tetrahydrocurcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [Vincristine results in decreased expression of CAT protein]
tetrahydrocurcumin inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]
Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice
CTD
RGD
PMID:17076682 PMID:25869292 PMID:26102012 PMID:30423402 PMID:22212488 RGD:41410880 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA] CTD PMID:26102010 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 protein] CTD PMID:26102010 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression ISO tetrahydrocurcumin results in decreased expression of CYP2B10 mRNA CTD PMID:26102010 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein] CTD PMID:26102010 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein] CTD PMID:30423402 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:30423402 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein] CTD PMID:20696151 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein] CTD PMID:20696151 NCBI chr19:50,744,598...50,748,064
Ensembl chr19:33,834,403...33,838,231
JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein] CTD PMID:20696151 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of MMP2 protein] CTD PMID:25502771 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
affects expression
ISO tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of MMP9 protein]
Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice
CTD
RGD
PMID:25502771 PMID:22212488 RGD:41410880 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects expression ISO Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice RGD PMID:22212488 RGD:41410880 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 affects expression ISO Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice RGD PMID:22212488 RGD:41410880 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 protein] CTD PMID:25502771 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in decreased expression of NOS3 protein] CTD PMID:25502771 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO tetrahydrocurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
tetrahydrocurcumin results in decreased expression of PTGS2 mRNA
CTD PMID:18507010 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP tetrahydrocurcumin inhibits the reaction [Vincristine results in increased expression of TNF protein] CTD PMID:26102012 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        biochemical role 20261
          metabolite 20243
            tetrahydrocurcumin 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbon oxoacid 19150
                                    carboxylic acid 19147
                                      monocarboxylic acid 18300
                                        alpha,beta-unsaturated monocarboxylic acid 13607
                                          cinnamic acids 2560
                                            hydroxycinnamic acid 1419
                                              monohydroxycinnamic acid 1066
                                                ferulic acids 1029
                                                  ferulic acid 1029
                                                    trans-ferulic acid 979
                                                      curcumin 979
                                                        tetrahydrocurcumin 20
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