Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Geraniin
go back to main search page
Accession:CHEBI:5328 term browser browse the term
Definition:A tannin that has formula C41H28O27.
Synonyms:related_synonym: Formula=C41H28O27;   InChI=1S/C41H28O27/c42-13-1-8(2-14(43)24(13)48)34(54)67-39-33-32-30(64-38(58)12-6-19(47)41(61)40(59,60)23(12)22-11(37(57)66-33)5-17(46)27(51)31(22)68-41)18(63-39)7-62-35(55)9-3-15(44)25(49)28(52)20(9)21-10(36(56)65-32)4-16(45)26(50)29(21)53/h1-6,18,23,30,32-33,39,42-46,48-53,59-61H,7H2/t18-,23+,30-,32+,33-,39+,41+/m1/s1;   InChIKey=JQQBXPCJFAKSPG-SVYIMCMUSA-N;   SMILES=Oc1cc(cc(O)c1O)C(=O)O[C@@H]1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)cc3C(=O)O[C@H]3[C@@H]2OC(=O)C2=CC(=O)[C@]4(O)Oc5c(O)c(O)cc(c5[C@H]2C4(O)O)C(=O)O[C@@H]13
 xref: CAS:60976-49-0;   KEGG:C10230;   KNApSAcK:C00002926
 xref_mesh: MESH:C024603


show annotations for term's descendants           Sort by:
Geraniin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACACA acetyl-CoA carboxylase alpha increases phosphorylation
multiple interactions		 ISO Geraniin results in increased phosphorylation of ACACA protein
STO 609 inhibits the reaction [Geraniin results in increased phosphorylation of ACACA protein]		 CTD PMID:36706894 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO Geraniin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of AKT1 protein] CTD PMID:27181634 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G BCL2 BCL2 apoptosis regulator increases phosphorylation EXP Geraniin results in increased phosphorylation of BCL2 protein CTD PMID:27097871 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 increases expression
multiple interactions		 ISO Geraniin results in increased expression of CAMKK2 protein
STO 609 inhibits the reaction [Geraniin results in increased expression of CAMKK2 protein]		 CTD PMID:36706894 NCBI chr12:121,237,692...121,297,819
Ensembl chr12:121,237,675...121,298,308 		JBrowse link
G CASP3 caspase 3 increases cleavage EXP Geraniin results in increased cleavage of CASP3 protein CTD PMID:27097871 PMID:28590547 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CEBPA CCAAT enhancer binding protein alpha increases expression
multiple interactions		 ISO Geraniin results in increased expression of CEBPA protein
STO 609 inhibits the reaction [Geraniin results in increased expression of CEBPA protein]		 CTD PMID:36706894 NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534 		JBrowse link
G FASN fatty acid synthase multiple interactions
decreases expression		 ISO STO 609 inhibits the reaction [Geraniin results in decreased expression of FASN protein] CTD PMID:36706894 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO Geraniin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein] CTD PMID:27181634 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO Geraniin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein] CTD PMID:27181634 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO Geraniin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein] CTD PMID:27181634 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation EXP Geraniin results in decreased phosphorylation of MAPK1 protein CTD PMID:31184425 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions
increases activity		 EXP SB 203580 inhibits the reaction [Geraniin results in increased activity of MAPK14 protein] CTD PMID:27097871 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation EXP Geraniin results in decreased phosphorylation of MAPK3 protein CTD PMID:31184425 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions		 EXP Geraniin results in decreased expression of MCL1 mRNA; Geraniin results in decreased expression of MCL1 protein
Geraniin inhibits the reaction [RELA protein binds to MCL1 promoter]		 CTD PMID:28590547 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions EXP Geraniin results in decreased expression of and results in decreased activity of MMP2 protein; U 0126 inhibits the reaction [Geraniin results in decreased expression of and results in decreased activity of MMP2 protein] CTD PMID:31184425 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Geraniin promotes the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of NFE2L2 protein] CTD PMID:27181634 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions
decreases phosphorylation		 ISO
EXP		 Geraniin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased degradation of NFKBIA protein]
Geraniin results in decreased phosphorylation of NFKBIA protein		 CTD PMID:27181634 PMID:28590547 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Geraniin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of and results in increased activity of NOS2 protein] CTD PMID:27181634 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP Geraniin results in increased cleavage of PARP1 protein CTD PMID:27097871 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma decreases expression
multiple interactions		 ISO Geraniin results in decreased expression of PPARG protein
STO 609 inhibits the reaction [Geraniin results in decreased expression of PPARG protein]		 CTD PMID:36706894 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PTK2 protein tyrosine kinase 2 decreases phosphorylation EXP Geraniin results in decreased phosphorylation of PTK2 protein CTD PMID:31184425 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation		 ISO
EXP		 Geraniin inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]
Geraniin inhibits the reaction [RELA protein binds to MCL1 promoter]
Geraniin results in decreased phosphorylation of RELA protein		 CTD PMID:27181634 PMID:28590547 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation EXP Geraniin results in decreased phosphorylation of SRC protein CTD PMID:31184425 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G TNF tumor necrosis factor decreases secretion
multiple interactions		 ISO Geraniin results in decreased secretion of TNF protein
Geraniin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]		 CTD PMID:12628509 PMID:27181634 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      application 25177
        pharmaceutical 24551
          drug 24548
            astringent 12086
              tannin 309
                Geraniin 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            organic molecule 25223
                              organic cyclic compound 24277
                                organic aromatic compound 23914
                                  phenols 21095
                                    polyphenol 10054
                                      tannin 309
                                        Geraniin 24
paths to the root