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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:iodixanol
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Accession:CHEBI:31705 term browser browse the term
Definition:A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography.
Synonyms:exact_synonym: 5,5'-[(2-hydroxypropane-1,3-diyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide]
 related_synonym: 5,5'-((2-hydroxytrimethylene)bis(acetylimino))bis(N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide);   Formula=C35H44I6N6O15;   InChI=1S/C35H44I6N6O15/c1-13(52)46(30-26(38)20(32(59)42-3-15(54)9-48)24(36)21(27(30)39)33(60)43-4-16(55)10-49)7-19(58)8-47(14(2)53)31-28(40)22(34(61)44-5-17(56)11-50)25(37)23(29(31)41)35(62)45-6-18(57)12-51/h15-19,48-51,54-58H,3-12H2,1-2H3,(H,42,59)(H,43,60)(H,44,61)(H,45,62);   InChIKey=NBQNWMBBSKPBAY-UHFFFAOYSA-N;   SMILES=CC(=O)N(CC(O)CN(C(C)=O)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I;   iodixanolum
 xref: Beilstein:7245697;   CAS:92339-11-2;   DrugBank:DB01249;   Drug_Central:3302;   KEGG:D01474;   LINCS:LSM-4960
 xref_mesh: MESH:C044834
 xref: Wikipedia:Iodixanol


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iodixanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO iodixanol results in increased phosphorylation of AKT1 protein CTD PMID:34774977 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO iodixanol results in increased expression of CCL2 protein CTD PMID:34774977 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO iodixanol results in increased expression of CCL3 protein CTD PMID:34774977 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO iodixanol results in increased expression of CCL7 protein CTD PMID:34774977 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO iodixanol results in increased expression of CXCL10 protein CTD PMID:34774977 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Edn1 endothelin 1 increases expression EXP iodixanol results in increased expression of EDN1 protein CTD PMID:21354280 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in decreased expression of GCLM mRNA CTD PMID:29860548 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP iodixanol results in increased expression of HAVCR1 mRNA CTD PMID:19104440 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions
increases secretion		 ISO trigonelline inhibits the reaction [iodixanol results in increased secretion of HEXB protein] CTD PMID:34774977 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of HMGB1 protein CTD PMID:29860548 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 EXP iodixanol results in increased expression of HMOX1 mRNA
[Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of HMOX1 mRNA		 CTD PMID:19104440 PMID:29860548 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression EXP iodixanol results in decreased expression of NOS2 protein CTD PMID:21354280 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of PINK1 protein CTD PMID:29860548 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Plcg1 phospholipase C, gamma 1 increases phosphorylation
multiple interactions		 ISO iodixanol results in increased phosphorylation of PLCG1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [iodixanol results in increased phosphorylation of PLCG1 protein]; trigonelline inhibits the reaction [iodixanol results in increased phosphorylation of PLCG1 protein]		 CTD PMID:34774977 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of PRKN protein CTD PMID:29860548 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP iodixanol inhibits the reaction [[Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein] CTD PMID:29860548 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO iodixanol results in increased expression of VEGFA protein CTD PMID:34774977 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      application 19668
        pharmaceutical 19508
          diagnostic agent 783
            diagnostic imaging agent 574
              radioopaque medium 185
                iodixanol 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    p-block element atom 19796
                      p-block molecular entity 19796
                        carbon group molecular entity 19741
                          organic molecular entity 19737
                            heteroorganic entity 19495
                              organohalogen compound 18533
                                organoiodine compound 2401
                                  iodixanol 17
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