diagnostic agent - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	diagnostic agent	go back to main search page
Accession:	CHEBI:33295	browse the term
Definition:	A substance administered to aid diagnosis of a disease.
Synonyms:	related_synonym:	diagnostic aid

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Rat (785) Mouse (783) Human (808) Chinchilla (0) Bonobo (0) Dog (2) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (785)

2',7'-bis-(2-carboxyethyl)carboxyfluorescein

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 4

multiple interactions

Mefloquine inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily C member 5

increases export
multiple interactions

ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein
daidzein inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Quercetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; resveratrol inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; Silymarin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]; verlukast inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]

NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253

4-carboxy-TEMPO

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

myeloperoxidase

multiple interactions

tempo carboxylic acid inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

5(6)-carboxy-2',7'-dichlorofluorescein

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

affects transport
multiple interactions
increases export
increases transport

ABCC2 protein affects the transport of 5(6)-carboxy-2',7'-dichlorofluorescein
4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Ascorbic Acid inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]]; Ascorbic Acid promotes the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Benzbromarone inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Calcium deficiency inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; cyanoginosin LR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Cyclosporine inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin RR inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; microcystin-LF inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Probenecid inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Tobacco Smoke Pollution inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]
ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog
[ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein; ABCC2 gene mutant form inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein; Atorvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Fluvastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]

PMID:19326901 PMID:21240898 PMID:21341280 PMID:23562342 PMID:24907646 More...

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

multiple interactions
increases transport

[ABCC2 gene mutant form results in increased expression of ABCC3 protein] which results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein
Benzbromarone inhibits the reaction [ABCC3 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]

PMID:24907646 PMID:31348918

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 5

multiple interactions
increases uptake
increases transport

Benzbromarone inhibits the reaction [ABCC5 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC5 protein results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein

PMID:31348918 PMID:35066093

NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253

5-carboxyfluorescein

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 8

multiple interactions
increases transport

quercetin 3'-sulfate inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide analog inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

5-chloromethylfluorescein diacetate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

multiple interactions

ABCC2 protein affects the transport of [5-chloromethylfluorescein co-treated with Glutathione]

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

6-carboxyfluorescein

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

increases export

ABCC1 protein results in increased export of 6-carboxyfluorescein

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

affects export
multiple interactions

ABCC2 protein affects the export of 6-carboxyfluorescein
Probenecid inhibits the reaction [ABCC2 protein affects the export of 6-carboxyfluorescein]

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

solute carrier family 22 member 6

multiple interactions
increases uptake
increases import

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; Unithiol analog inhibits the reaction [SLC22A6 protein results in increased uptake of 6-carboxyfluorescein]

PMID:20237588 PMID:28629854

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

increases import
increases uptake
multiple interactions

SLC22A8 protein results in increased import of 6-carboxyfluorescein
SLC22A8 protein results in increased uptake of 6-carboxyfluorescein
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; 2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]; 3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Cadmium Chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; glutaric acid promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; lead chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; sodium arsenate promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Unithiol analog inhibits the reaction [SLC22A8 protein results in increased uptake of 6-carboxyfluorescein]

PMID:20237588 PMID:28629854

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

amidotrizoic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

multiple interactions
increases expression

telmisartan inhibits the reaction [Diatrizoate results in increased expression of AGT protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

Plant Extracts inhibits the reaction [Diatrizoate results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Diatrizoate co-treated with Iodine] results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

[Diatrizoate co-treated with Iodine] results in increased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

affects expression
multiple interactions
increases activity

Diatrizoate affects the expression of CASP3 protein
[Diatrizoate co-treated with Iodine] results in increased activity of CASP3 protein
telmisartan inhibits the reaction [Diatrizoate results in increased activity of CASP3 protein]

PMID:17173243 PMID:19452295 PMID:21036957

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

coagulation factor II, thrombin

multiple interactions

Diatrizoate inhibits the reaction [F2 protein binds to SERPINC1 protein]

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

forkhead box O1

decreases phosphorylation
multiple interactions

Diatrizoate results in decreased phosphorylation of FOXO1 protein
Plant Extracts inhibits the reaction [Diatrizoate results in decreased phosphorylation of FOXO1 protein]

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

forkhead box O3

affects phosphorylation

Diatrizoate affects the phosphorylation of FOXO3 protein

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

mitogen activated protein kinase 1

affects phosphorylation
multiple interactions

Diatrizoate affects the phosphorylation of MAPK1 protein
Plant Extracts affects the reaction [Diatrizoate affects the phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
affects phosphorylation

Plant Extracts affects the reaction [Diatrizoate affects the phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases phosphorylation

Diatrizoate results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

increases phosphorylation

Diatrizoate results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

Pim-1 proto-oncogene, serine/threonine kinase

decreases expression
multiple interactions

Diatrizoate results in decreased expression of PIM1 protein
Plant Extracts inhibits the reaction [Diatrizoate results in decreased expression of PIM1 protein]

NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174

G

RELA proto-oncogene, NF-kB subunit

increases phosphorylation

Diatrizoate results in increased phosphorylation of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

serpin family C member 1

multiple interactions

Diatrizoate inhibits the reaction [F2 protein binds to SERPINC1 protein]

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

signal transducer and activator of transcription 3

affects expression

Diatrizoate affects the expression of STAT3 protein modified form

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

barium sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

increases expression

Barium Sulfate results in increased expression of ALB mRNA

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

baculoviral IAP repeat-containing 5

increases expression

Barium Sulfate results in increased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

C-C motif chemokine ligand 11

increases expression

Barium Sulfate results in increased expression of CCL11 mRNA

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 2

increases secretion
increases expression

Barium Sulfate results in increased secretion of CCL2 protein
Barium Sulfate results in increased expression of CCL2 mRNA

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

affects expression

Barium Sulfate affects the expression of CCL20 mRNA

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 22

increases expression

Barium Sulfate results in increased expression of CCL22 mRNA

NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400

G

C-C motif chemokine ligand 24

increases expression

Barium Sulfate results in increased expression of CCL24 mRNA

NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893

G

C-C motif chemokine ligand 4

decreases expression

Barium Sulfate results in decreased expression of CCL4 mRNA

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 7

increases expression

Barium Sulfate results in increased expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

C-C motif chemokine receptor 2

increases expression

Barium Sulfate results in increased expression of CCR2 mRNA

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

CD40 ligand

decreases expression

Barium Sulfate results in decreased expression of CD40LG mRNA

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

C-X-C motif chemokine ligand 9

increases expression

Barium Sulfate results in increased expression of CXCL9 mRNA

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

C-X-C motif chemokine receptor 3

increases expression

Barium Sulfate results in increased expression of CXCR3 mRNA

NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969

G

cytochrome P450, family 4, subfamily a, polypeptide 1

increases expression

Barium Sulfate results in increased expression of CYP4A1 mRNA

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

G

cytochrome P450, family 4, subfamily a, polypeptide 2

increases expression

Barium Sulfate results in increased expression of CYP4A2 mRNA

NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165

G

cytochrome P450, family 4, subfamily a, polypeptide 3

increases expression

Barium Sulfate results in increased expression of CYP4A3 mRNA

NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463

G

cytochrome P450, family 4, subfamily f, polypeptide 1

increases expression

Barium Sulfate results in increased expression of CYP4F1 mRNA

NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046

G

cytochrome P450, family 4, subfamily f, polypeptide 4

increases expression

Barium Sulfate results in increased expression of CYP4F4 mRNA

NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506

G

cytochrome P450, family 4, subfamily f, polypeptide 6

increases expression

Barium Sulfate results in increased expression of CYP4F6 mRNA

NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782

G

exonuclease 1

affects expression

Barium Sulfate affects the expression of EXO1 mRNA

NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654

G

fatty acid binding protein 4

decreases expression

Barium Sulfate results in decreased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

hemoglobin alpha, adult chain 2

decreases expression

Barium Sulfate results in decreased expression of HBA1 mRNA

NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392

G

interleukin 2 receptor subunit beta

decreases expression

Barium Sulfate results in decreased expression of IL2RB mRNA

NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054

G

interleukin 6

increases expression

Barium Sulfate results in increased expression of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

keratin 1

increases expression

Barium Sulfate results in increased expression of KRT1 mRNA

NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844

G

DNA ligase 4

increases expression

Barium Sulfate results in increased expression of LIG4 mRNA

NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040

G

lactoperoxidase

increases expression

Barium Sulfate results in increased expression of LPO mRNA; Barium Sulfate results in increased expression of LPO protein

NCBI chr10:72,606,950...72,626,220
Ensembl chr10:72,606,944...72,626,535

G

matrix metallopeptidase 12

increases expression

Barium Sulfate results in increased expression of MMP12 mRNA; Barium Sulfate results in increased expression of MMP12 protein

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

G

mutY DNA glycosylase

increases expression

Barium Sulfate results in increased expression of MUTYH mRNA

NCBI chr 5:130,274,034...130,286,149
Ensembl chr 5:130,274,122...130,286,146

G

neuroglobin

decreases expression

Barium Sulfate results in decreased expression of NGB mRNA

NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830

G

NADPH oxidase organizer 1

increases expression

Barium Sulfate results in increased expression of NOXO1 mRNA

NCBI chr10:13,723,253...13,726,008
Ensembl chr10:13,721,473...13,726,061

G

opioid binding protein/cell adhesion molecule-like

increases expression

Barium Sulfate results in increased expression of OPCML mRNA

NCBI chr 8:26,788,988...27,304,551
Ensembl chr 8:26,192,841...27,300,620

G

platelet factor 4

increases expression

Barium Sulfate results in increased expression of PF4 mRNA

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

G

stearoyl-CoA desaturase

affects expression

Barium Sulfate affects the expression of SCD1 mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

transcription factor 21

decreases expression

Barium Sulfate results in decreased expression of TCF21 mRNA

NCBI chr 1:22,701,353...22,704,212
Ensembl chr 1:22,701,353...22,704,202

G

thrombospondin 2

increases expression

Barium Sulfate results in increased expression of THBS2 mRNA

NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789

G

DNA topoisomerase II alpha

increases expression

Barium Sulfate results in increased expression of TOP2A mRNA

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

thioredoxin interacting protein

decreases expression

Barium Sulfate results in decreased expression of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

X-ray repair cross complementing 2

increases expression

Barium Sulfate results in increased expression of XRCC2 mRNA

NCBI chr 4:9,423,873...9,502,980
Ensembl chr 4:9,423,898...9,442,482

ceruletide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

multiple interactions
increases expression

PTHLH protein promotes the reaction [Ceruletide results in increased expression of ACTA2 protein]; Shuangshen inhibits the reaction [Ceruletide results in increased expression of ACTA2 mRNA]; Shuangshen inhibits the reaction [Ceruletide results in increased expression of ACTA2 protein]
Ceruletide results in increased expression of ACTA2 mRNA; Ceruletide results in increased expression of ACTA2 protein

PMID:25035110 PMID:38113986

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adenosylhomocysteinase

decreases expression

Ceruletide results in decreased expression of AHCY protein

NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393

G

aldo-keto reductase family 1 member B1

increases expression

Ceruletide results in increased expression of AKR1B1 protein

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

AKT serine/threonine kinase 1

multiple interactions

(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

decreases expression

Ceruletide results in decreased expression of ALB protein modified form

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

activating transcription factor 4

multiple interactions

[2,2',4,4'-tetrabromodiphenyl ether co-treated with Ceruletide] results in increased expression of ATF4 protein

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

BCL2, apoptosis regulator

increases expression
multiple interactions

Ceruletide results in increased expression of BCL2 mRNA; Ceruletide results in increased expression of BCL2 protein
coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 protein]]; limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 mRNA]; limonin inhibits the reaction [Ceruletide results in increased expression of BCL2 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of BCL2 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bradykinin receptor B1

increases expression

Ceruletide results in increased expression of BDKRB1 mRNA

NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747

G

bradykinin receptor B2

increases expression

Ceruletide results in increased expression of BDKRB2 mRNA

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

bromodomain containing 4

multiple interactions

(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein

NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539

G

caspase 3

multiple interactions

[Glycodeoxycholic Acid co-treated with Ceruletide] results in decreased activity of CASP3 protein; Ceruletide results in increased cleavage of and results in increased activity of CASP3 protein

PMID:16339139 PMID:18832452

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

Ceruletide results in increased cleavage of and results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

Ceruletide results in increased cleavage of and results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

C-C motif chemokine ligand 2

multiple interactions
increases secretion
increases expression

coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein]]; limonin inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein]; PPARG affects the reaction [Ceruletide results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of CCL2 protein]; Rosiglitazone inhibits the reaction [Ceruletide results in increased expression of CCL2 mRNA]

PMID:17463185 PMID:21484880 PMID:34423886

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin D1

multiple interactions
increases expression

coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 protein]]; limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 mRNA]; limonin inhibits the reaction [Ceruletide results in increased expression of CCND1 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of CCND1 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of CCND1 protein]
Ceruletide results in increased expression of CCND1 mRNA; Ceruletide results in increased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

chaperonin containing TCP1 subunit 2

increases expression

Ceruletide results in increased expression of CCT2 protein

NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944

G

CCAAT/enhancer binding protein alpha

increases expression
multiple interactions

Ceruletide results in increased expression of CEBPA mRNA
[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPA protein; Dietary Fats promotes the reaction [Ceruletide results in increased expression of CEBPA mRNA]; Quercetin inhibits the reaction [[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPA protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of CEBPA mRNA]

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

CCAAT/enhancer binding protein beta

multiple interactions
increases expression

[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPB protein; Dietary Fats promotes the reaction [Ceruletide results in increased expression of CEBPB mRNA]; Quercetin inhibits the reaction [[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPB protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of CEBPB mRNA]

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

collagen type I alpha 1 chain

multiple interactions
increases expression

PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]
PTHLH protein inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]

PMID:22280800 PMID:25035110

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

cathepsin B

affects localization
multiple interactions

Ceruletide affects the localization of CTSB protein
sodium arsenite inhibits the reaction [Ceruletide affects the localization of CTSB protein]

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

C-X-C motif chemokine ligand 3

increases expression
multiple interactions

Ceruletide results in increased expression of CXCL1 mRNA
AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; AM 251 promotes the reaction [iodopravadoline inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]; HU 211 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; iodopravadoline inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; iodopravadoline promotes the reaction [AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]; PPARG affects the reaction [Ceruletide results in increased expression of CXCL1 mRNA]

PMID:17463185 PMID:17484889

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

DNA-damage inducible transcript 3

multiple interactions

[2,2',4,4'-tetrabromodiphenyl ether co-treated with Ceruletide] results in increased expression of DDIT3 protein

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dual specificity phosphatase 1

increases expression

Ceruletide results in increased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 10

increases expression

Ceruletide results in increased expression of DUSP10 mRNA

NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716

G

dual specificity phosphatase 6

increases expression

Ceruletide results in increased expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

[2,2',4,4'-tetrabromodiphenyl ether co-treated with Ceruletide] results in increased expression of and results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

endoplasmic reticulum to nucleus signaling 1

increases expression
multiple interactions

Ceruletide results in increased expression of ERN1 mRNA; Ceruletide results in increased expression of ERN1 protein
Dietary Fats promotes the reaction [Ceruletide results in increased expression of ERN1 mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of ERN1 protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of ERN1 mRNA]; Quercetin inhibits the reaction [Ceruletide results in increased expression of ERN1 protein]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

glutamate dehydrogenase 1

increases expression

Ceruletide results in increased expression of GLUD1 protein

NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957

G

glutamic--pyruvic transaminase

multiple interactions
increases expression

isoborneol inhibits the reaction [Ceruletide results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

heme oxygenase 1

increases expression
multiple interactions

Ceruletide results in increased expression of HMOX1 protein
coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein]]; limonin inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein H1

increases expression

Ceruletide results in increased expression of HNRNPH1 protein

NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846

G

heat shock protein family A (Hsp70) member 5

decreases expression

Ceruletide results in decreased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 8

decreases expression

Ceruletide results in decreased expression of HSPA8 protein

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

hypoxia up-regulated 1

increases expression

Ceruletide results in increased expression of HYOU1 protein

NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186

G

intercellular adhesion molecule 1

multiple interactions
increases expression

PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA]
rosiglitazone inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA]

PMID:17463185 PMID:25035110

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 10

multiple interactions

[resveratrol co-treated with Ceruletide] results in increased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

increases expression
increases secretion
multiple interactions

Ceruletide results in increased expression of IL1B mRNA; Ceruletide results in increased expression of IL1B protein
Ceruletide results in increased secretion of IL1B protein
coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]]; isoborneol inhibits the reaction [Ceruletide results in increased expression of IL1B protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]
Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL1B mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of IL1B protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of IL1B mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL1B mRNA]]; resveratrol inhibits the reaction [Ceruletide results in increased expression of IL1B protein]

PMID:14751415 PMID:21484880 PMID:24234420 PMID:26873426 PMID:33166053 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression
increases secretion
multiple interactions

Ceruletide results in increased expression of IL6 mRNA
Ceruletide results in increased secretion of IL6 protein
Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of IL6 protein]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]]
(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of IL6 protein]]; HU 211 inhibits the reaction [Ceruletide results in increased expression of IL6 protein]; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]]; isoborneol inhibits the reaction [Ceruletide results in increased expression of IL6 protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of IL6 protein]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of IL6 protein]; Shuangshen inhibits the reaction [Ceruletide results in increased expression of IL6 protein]
Ceruletide results in increased expression of IL6 mRNA; Ceruletide results in increased expression of IL6 protein
PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]

PMID:17484889 PMID:22280800 PMID:25035110 PMID:26390243 PMID:26873426 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Janus kinase 2

multiple interactions
increases expression

coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased expression of JAK2 protein]]; limonin inhibits the reaction [Ceruletide results in increased expression of JAK2 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased expression of JAK2 protein]

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Ceruletide results in increased expression of JUN mRNA
rosiglitazone inhibits the reaction [Ceruletide results in increased expression of JUN mRNA]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

KRAS proto-oncogene, GTPase

multiple interactions

(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]]

NCBI chr 4:178,185,418...178,218,484

G

mitogen-activated protein kinase 8

multiple interactions

[2,2',4,4'-tetrabromodiphenyl ether co-treated with Ceruletide] results in increased expression of and results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

microRNA 216a

increases expression

Ceruletide results in increased expression of MIR216A mRNA

NCBI chr14:102,524,105...102,524,210
Ensembl chr14:102,524,105...102,524,210

G

microRNA 216b

increases expression

Ceruletide results in increased expression of MIR216B mRNA

NCBI chr14:102,513,054...102,513,155
Ensembl chr14:102,513,054...102,513,155

G

microRNA 217

increases expression

Ceruletide results in increased expression of MIR217 mRNA

NCBI chr14:102,531,505...102,531,609
Ensembl chr14:102,531,505...102,531,609

G

myeloperoxidase

increases expression
increases activity
multiple interactions

Ceruletide results in increased expression of MPO protein
Ceruletide results in increased activity of MPO protein
HU 211 inhibits the reaction [Ceruletide results in increased expression of MPO protein]; isoborneol inhibits the reaction [Ceruletide results in increased activity of MPO protein]

PMID:17484889 PMID:33166053

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases expression

isoborneol inhibits the reaction [Ceruletide results in decreased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

increases degradation
multiple interactions

Ceruletide results in increased degradation of NFKBIA protein
sodium arsenite inhibits the reaction [Ceruletide results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

increases expression
multiple interactions

Ceruletide results in increased expression of NOS2 protein
isoborneol inhibits the reaction [Ceruletide results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

protein disulfide isomerase family A, member 4

increases expression

Ceruletide results in increased expression of PDIA4 protein

NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107

G

peroxisome proliferator-activated receptor gamma

multiple interactions

PPARG affects the reaction [Ceruletide results in increased expression of CCL2 mRNA]; PPARG affects the reaction [Ceruletide results in increased expression of CXCL1 mRNA]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

peroxiredoxin 2

increases expression

Ceruletide results in increased expression of PRDX2 protein

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

prostaglandin-endoperoxide synthase 2

increases expression

Ceruletide results in increased expression of PTGS2 mRNA; Ceruletide results in increased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone-like hormone

multiple interactions
affects response to substance
increases expression

PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA]; PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]
Ethanol results in increased susceptibility to [Ceruletide results in increased expression of PTHLH mRNA]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]
PTHLH protein affects the susceptibility to Ceruletide
Ceruletide results in increased expression of PTHLH mRNA; Ceruletide results in increased expression of PTHLH protein
PTHLH protein promotes the reaction [Ceruletide results in increased expression of ACTA2 protein]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]

PMID:22280800 PMID:25035110

NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases phosphorylation
increases expression

ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate inhibits the reaction [Ceruletide results in increased expression of RELA protein]; isoborneol inhibits the reaction [Ceruletide results in decreased phosphorylation of RELA protein]

PMID:22982818 PMID:33166053

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

receptor interacting serine/threonine kinase 1

increases cleavage

Ceruletide results in increased cleavage of RIPK1 protein

NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824

G

RuvB-like AAA ATPase 1

increases expression

Ceruletide results in increased expression of RUVBL1 protein

NCBI chr 4:120,932,486...120,967,400
Ensembl chr 4:120,932,417...121,029,384

G

serpin family F member 1

increases activity

cerulein increases activity of Serpinf1 protein in blood

RGD

NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646

G

SMAD family member 2

multiple interactions

[Shuangshen co-treated with Ceruletide] results in decreased expression of SMAD2 protein

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 3

increases expression
multiple interactions

Ceruletide results in increased expression of SMAD3 protein
Shuangshen inhibits the reaction [Ceruletide results in increased expression of SMAD3 protein]

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

superoxide dismutase 1

multiple interactions
decreases expression

isoborneol inhibits the reaction [Ceruletide results in decreased expression of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

signal transducer and activator of transcription 3

multiple interactions
increases phosphorylation

(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein; coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein]]; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]]; limonin inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [Ceruletide results in increased phosphorylation of STAT3 protein]

PMID:26390243 PMID:34423886

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

transforming growth factor, beta 1

multiple interactions
increases expression

Shuangshen inhibits the reaction [Ceruletide results in increased expression of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

increases expression
increases secretion
multiple interactions

Ceruletide results in increased expression of TNF mRNA; Ceruletide results in increased expression of TNF protein
Ceruletide results in increased secretion of TNF protein
coumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of TNF protein]]; isoborneol inhibits the reaction [Ceruletide results in increased expression of TNF protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of TNF protein]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of TNF protein]; Shuangshen inhibits the reaction [Ceruletide results in increased expression of TNF protein]
2-acetoxy-5-(2-4-(trifluoromethyl)phenethylamino)benzoic acid inhibits the reaction [[Ceruletide co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; [Ceruletide co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA; arsenic trioxide inhibits the reaction [Ceruletide results in increased expression of TNF mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of TNF mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of TNF protein]; Pentoxifylline inhibits the reaction [Ceruletide results in increased expression of TNF protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of TNF mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of TNF mRNA]]

PMID:10773043 PMID:17517186 PMID:22575522 PMID:26873426 PMID:33166053 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

triosephosphate isomerase 1

increases expression

Ceruletide results in increased expression of TPI1 protein

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

valosin-containing protein

decreases expression

Ceruletide results in decreased expression of VCP protein

NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571

G

X-box binding protein 1

increases expression
multiple interactions

Ceruletide results in increased expression of XBP1 mRNA alternative form; Ceruletide results in increased expression of XBP1 protein alternative form
Dietary Fats promotes the reaction [Ceruletide results in increased expression of XBP1 mRNA alternative form]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of XBP1 protein alternative form]; Quercetin inhibits the reaction [Ceruletide results in increased expression of XBP1 mRNA alternative form]; Quercetin inhibits the reaction [Ceruletide results in increased expression of XBP1 protein alternative form]

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

G

X-linked inhibitor of apoptosis

increases degradation

Ceruletide results in increased degradation of XIAP protein

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

corticotropin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine deaminase

increases activity

Adrenocorticotropic Hormone results in increased activity of ADA protein

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

calcitonin-related polypeptide alpha

increases abundance

CALCA protein results in increased abundance of Adrenocorticotropic Hormone

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

2',3'-cyclic nucleotide 3' phosphodiesterase

decreases activity

Adrenocorticotropic Hormone results in decreased activity of CNP protein

NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720

G

corticotropin releasing hormone

multiple interactions
increases secretion

Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]; Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]; E 4031 inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]]; Tetraethylammonium promotes the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

cytochrome P450, family 17, subfamily a, polypeptide 1

affects abundance

CYP17A1 protein affects the abundance of Adrenocorticotropic Hormone

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

growth hormone 1

multiple interactions

Adrenocorticotropic Hormone inhibits the reaction [INS protein results in increased secretion of GH1 protein]

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

5-hydroxytryptamine receptor 2A

multiple interactions
affects expression

Bupropion inhibits the reaction [Adrenocorticotropic Hormone affects the expression of HTR2A mRNA]

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

insulin 2

multiple interactions

Adrenocorticotropic Hormone inhibits the reaction [INS protein results in increased secretion of GH1 protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

nuclear receptor subfamily 3, group C, member 1

affects abundance

NR3C1 gene polymorphism affects the abundance of Adrenocorticotropic Hormone

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

protein phosphatase 1, regulatory (inhibitor) subunit 1B

multiple interactions

Cocaine promotes the reaction [PPP1R1B protein results in increased abundance of Adrenocorticotropic Hormone]

NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775

G

urocortin 2

increases abundance

UCN2 protein results in increased abundance of Adrenocorticotropic Hormone

NCBI chr 8:109,637,624...109,639,173
Ensembl chr 8:109,638,285...109,639,172

cosyntropin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hydroxysteroid 11-beta dehydrogenase 2

decreases expression

Cosyntropin results in decreased expression of HSD11B2 protein

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

creatinine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

basic helix-loop-helix ARNT like 1

increases abundance

BMAL1 gene mutant form results in increased abundance of Creatinine

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

collagen type II alpha 1 chain

multiple interactions

[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions
increases abundance

Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Creatinine]

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

leptin receptor

affects abundance
multiple interactions
increases abundance

LEPR affects the abundance of Creatinine
Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased abundance of Creatinine]; swietenine inhibits the reaction [LEPR gene mutant form results in increased abundance of Creatinine]

PMID:20567778 PMID:29988851 PMID:36066211

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

NFE2 like bZIP transcription factor 2

multiple interactions

[NFE2L2 protein affects the susceptibility to ochratoxin A] which results in increased abundance of Creatinine

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[SC 560 results in decreased activity of PTGS1 protein] which results in increased abundance of Creatinine

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

solute carrier family 47 member 1

multiple interactions

Creatinine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Creatinine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

superoxide dismutase 2

decreases abundance

SOD2 protein results in decreased abundance of Creatinine

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

desmopressin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aquaporin 2

increases expression
multiple interactions

Deamino Arginine Vasopressin results in increased expression of AQP2 mRNA; Deamino Arginine Vasopressin results in increased expression of AQP2 protein
Deamino Arginine Vasopressin inhibits the reaction [aluminum lactate results in decreased expression of AQP2 protein]; Deamino Arginine Vasopressin results in increased expression of and results in increased uptake of and results in increased ubiquitination of AQP2 protein
Lithium inhibits the reaction [Deamino Arginine Vasopressin results in increased expression of AQP2 mRNA]; Lithium inhibits the reaction [Deamino Arginine Vasopressin results in increased expression of AQP2 protein]

PMID:16495377 PMID:16675087 PMID:21734099

NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468

G

arginine vasopressin

multiple interactions

[Atrazine affects the metabolism of AVP protein] which results in increased abundance of Deamino Arginine Vasopressin

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

arginine vasopressin receptor 2

multiple interactions

[Deamino Arginine Vasopressin binds to and results in increased activity of AVPR2 protein] which results in decreased activity of 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid

PMID:1399968 PMID:15685210

NCBI chr X:151,633,501...151,636,155
Ensembl chr X:151,633,522...151,635,989

G

CF transmembrane conductance regulator

increases activity

Deamino Arginine Vasopressin results in increased activity of CFTR protein

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

cullin 5

increases expression

Deamino Arginine Vasopressin results in increased expression of CUL5 protein

NCBI chr 8:54,012,963...54,066,751
Ensembl chr 8:54,016,006...54,066,666

G

glycogen synthase kinase 3 beta

multiple interactions

GSK3B protein affects the reaction [Deamino Arginine Vasopressin results in increased abundance of Cyclic AMP]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

myosin light chain 9

increases phosphorylation
multiple interactions

Deamino Arginine Vasopressin results in increased phosphorylation of MYL9 protein
ML 7 inhibits the reaction [Deamino Arginine Vasopressin results in increased phosphorylation of MYL9 protein]

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

G

NEDD4 E3 ubiquitin protein ligase

increases expression

Deamino Arginine Vasopressin results in increased expression of NEDD4 protein

NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951

G

sodium channel epithelial 1 subunit beta

increases expression

Deamino Arginine Vasopressin results in increased expression of SCNN1B mRNA

NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451

G

sodium channel epithelial 1 subunit gamma

increases expression

Deamino Arginine Vasopressin results in increased expression of SCNN1G mRNA

NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816

G

von Willebrand factor

increases activity
increases secretion

Deamino Arginine Vasopressin results in increased activity of VWF protein
Deamino Arginine Vasopressin results in increased secretion of VWF protein

PMID:1837767 PMID:2738447 PMID:3259400

NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539

dimethyl sulfoxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

increases expression

Dimethyl Sulfoxide results in increased expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

ATP binding cassette subfamily B member 1A

affects expression

Dimethyl Sulfoxide affects the expression of ABCB1 mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

actin alpha 2, smooth muscle

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 protein; LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 mRNA]

PMID:11682029 PMID:35366062

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin, alpha, cardiac muscle 1

increases expression
decreases expression

Dimethyl Sulfoxide results in increased expression of ACTC1 mRNA
Dimethyl Sulfoxide results in decreased expression of ACTC1 mRNA

NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523

G

agouti related neuropeptide

affects expression

Dimethyl Sulfoxide affects the expression of AGRP mRNA

NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584

G

aryl hydrocarbon receptor

multiple interactions
increases expression
decreases expression

Dimethyl Sulfoxide promotes the reaction [AHR protein binds to CAD promoter]
Dimethyl Sulfoxide results in increased expression of AHR mRNA; Dimethyl Sulfoxide results in increased expression of AHR protein
AHR protein affects the reaction [Dimethyl Sulfoxide results in increased phosphorylation of MYL2 protein]; Dimethyl Sulfoxide promotes the reaction [AHR protein binds to AHR promoter]; Dimethyl Sulfoxide promotes the reaction [ARNT protein binds to AHR promoter]; Dimethyl Sulfoxide promotes the reaction [JDP2 protein binds to AHR promoter]; Dimethyl Sulfoxide promotes the reaction [NFE2L2 protein binds to AHR promoter]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [AHR protein binds to AHR promoter]]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [ARNT protein binds to AHR promoter]]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [JDP2 protein binds to AHR promoter]]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [NFE2L2 protein binds to AHR promoter]]; JDP2 protein affects the reaction [Dimethyl Sulfoxide results in increased expression of AHR mRNA]; JDP2 protein affects the reaction [Dimethyl Sulfoxide results in increased expression of AHR protein]
Dimethyl Sulfoxide results in decreased expression of AHR mRNA

PMID:16675542 PMID:22486318 PMID:33723743

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

activation-induced cytidine deaminase

affects expression

Dimethyl Sulfoxide affects the expression of AICDA mRNA

NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions
affects localization

Dimethyl Sulfoxide inhibits the reaction [Acetaminophen affects the localization of AIFM1 protein]
Dimethyl Sulfoxide affects the localization of AIFM1 protein

PMID:20423716 PMID:22535522

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

5'-aminolevulinate synthase 2

increases expression

Dimethyl Sulfoxide results in increased expression of ALAS2 mRNA

NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519

G

albumin

decreases expression
multiple interactions

Dimethyl Sulfoxide results in decreased expression of ALB mRNA
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of ALB mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased secretion of ALB protein
Dimethyl Sulfoxide results in decreased expression of ALB mRNA; Dimethyl Sulfoxide results in decreased expression of ALB protein

PMID:14757319 PMID:22105179 PMID:35366062

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

increases expression

Dimethyl Sulfoxide results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

apolipoprotein A1

increases expression
increases activity

Dimethyl Sulfoxide results in increased expression of APOA1 mRNA; Dimethyl Sulfoxide results in increased expression of APOA1 protein
Dimethyl Sulfoxide results in increased activity of APOA1 promoter

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein M

affects expression

Dimethyl Sulfoxide affects the expression of APOM mRNA

NCBI chr20:3,690,950...3,693,550
Ensembl chr20:3,688,413...3,693,550

G

aquaporin 1

increases expression

Dimethyl Sulfoxide results in increased expression of AQP1 mRNA

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

androgen receptor

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Androgens results in increased activity of AR protein]

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

Dimethyl Sulfoxide promotes the reaction [ARNT protein binds to CAD promoter]
Dimethyl Sulfoxide promotes the reaction [ARNT protein binds to AHR promoter]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [ARNT protein binds to AHR promoter]]

PMID:16675542 PMID:33723743

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

actin related protein 2/3 complex, subunit 4

affects expression

Dimethyl Sulfoxide affects the expression of ARPC4 mRNA

NCBI chr 4:146,522,255...146,532,784
Ensembl chr 4:146,522,176...146,532,785

G

activating transcription factor 3

increases expression

Dimethyl Sulfoxide results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATPase Na+/K+ transporting subunit alpha 2

increases expression

Dimethyl Sulfoxide results in increased expression of ATP1A2 mRNA

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATPase Na+/K+ transporting subunit beta 1

increases expression

Dimethyl Sulfoxide results in increased expression of ATP1B1 mRNA

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

G

ATPase Na+/K+ transporting subunit beta 3

increases expression

Dimethyl Sulfoxide results in increased expression of ATP1B3 mRNA

NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598

G

ATP synthase membrane subunit f

affects expression

Dimethyl Sulfoxide affects the expression of ATP5MF mRNA

NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236

G

BarH-like homeobox 2

affects expression

Dimethyl Sulfoxide affects the expression of BARHL2 mRNA

NCBI chr14:3,340,465...3,345,362
Ensembl chr14:3,340,465...3,345,353

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Dimethyl Sulfoxide results in increased expression of BAX mRNA
Dimethyl Sulfoxide results in increased expression of BAX protein
Quercetin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of BAX mRNA]

PMID:17652743 PMID:36305173

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Dimethyl Sulfoxide results in decreased expression of BCL2 protein
[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in decreased expression of BCL2 protein

PMID:36305173 PMID:37365769

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BEN domain containing 6

affects expression

Dimethyl Sulfoxide affects the expression of BEND6 mRNA

NCBI chr 9:36,081,033...36,135,309
Ensembl chr 9:36,081,484...36,135,228

G

BTG anti-proliferation factor 2

increases expression

Dimethyl Sulfoxide results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

similar to human chromosome 16 open reading frame 74

affects expression

Dimethyl Sulfoxide affects the expression of C16ORF74 mRNA

NCBI chr19:48,660,288...48,686,287
Ensembl chr19:48,660,288...48,686,349

G

simlar to human chromosome 19 open reading frame 81

affects expression

Dimethyl Sulfoxide affects the expression of C19ORF81 mRNA

NCBI chr 1:94,857,301...94,871,323
Ensembl chr 1:94,857,115...94,871,813

G

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

multiple interactions

Dimethyl Sulfoxide promotes the reaction [AHR protein binds to CAD promoter]; Dimethyl Sulfoxide promotes the reaction [ARNT protein binds to CAD promoter]; Dimethyl Sulfoxide promotes the reaction [ESR1 protein binds to CAD promoter]; Dimethyl Sulfoxide promotes the reaction [SP1 protein binds to CAD promoter]

NCBI chr 6:25,292,133...25,315,078
Ensembl chr 6:25,292,133...25,319,861

G

cell adhesion molecule 1

increases expression

Dimethyl Sulfoxide results in increased expression of CADM1 mRNA

NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833

G

caspase 3

multiple interactions
decreases expression
increases cleavage

[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide co-treated with 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine] results in increased expression of CASP3 protein; [lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in increased expression of CASP3 protein; Dimethyl Sulfoxide results in decreased cleavage of and results in decreased activity of CASP3 protein
Dimethyl Sulfoxide results in decreased expression of CASP3 protein
Dimethyl Sulfoxide results in increased cleavage of CASP3 protein

PMID:12370186 PMID:22535522 PMID:36305173 PMID:37365769

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Paraquat results in increased expression of CAT mRNA]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions
increases secretion
decreases expression

Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Dimethyl Sulfoxide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Dimethyl Sulfoxide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Dimethyl Sulfoxide inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Dimethyl Sulfoxide results in increased secretion of CCL2 protein]
Dimethyl Sulfoxide results in decreased expression of CCL2 mRNA
Dimethyl Sulfoxide inhibits the reaction [sodium arsenite results in increased expression of CCL2 mRNA]

PMID:10925121 PMID:14576080 PMID:15689417 PMID:17529908 PMID:21878375 More...

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 28

affects expression

Dimethyl Sulfoxide affects the expression of CCL28 mRNA

NCBI chr 2:51,601,354...51,625,999
Ensembl chr 2:51,601,331...51,625,997

G

C-C motif chemokine ligand 5

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased secretion of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

CD14 molecule

increases expression

Dimethyl Sulfoxide results in increased expression of CD14 protein

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD38 molecule

multiple interactions

Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CD38 mRNA]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CD38 mRNA]]

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

G

CD3 gamma subunit of T-cell receptor complex

affects expression

Dimethyl Sulfoxide affects the expression of CD3G mRNA

NCBI chr 8:45,280,797...45,287,271
Ensembl chr 8:45,281,204...45,287,147

G

CD59b molecule

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Asbestos, Crocidolite results in increased mutagenesis of CD59 gene]; Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in increased mutagenesis of CD59 gene]

PMID:12361925 PMID:15033018

NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847

G

cell division cycle 25B

decreases expression

Dimethyl Sulfoxide results in decreased expression of CDC25B mRNA

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

G

cadherin 1

increases expression
multiple interactions

Dimethyl Sulfoxide results in increased expression of CDH1 mRNA
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CDH1 mRNA

PMID:22193206 PMID:35366062

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of CDH2 mRNA

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

CEA cell adhesion molecule 19

affects expression

Dimethyl Sulfoxide affects the expression of CEACAM19 mRNA

NCBI chr 1:79,542,107...79,550,927
Ensembl chr 1:79,542,107...79,550,927

G

CCAAT/enhancer binding protein beta

increases expression

Dimethyl Sulfoxide results in increased expression of CEBPB mRNA

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

cilia and flagella associated protein 300

affects expression

Dimethyl Sulfoxide affects the expression of CFAP300 mRNA

NCBI chr 8:5,180,180...5,198,840
Ensembl chr 8:5,180,675...5,198,807

G

CASP8 and FADD-like apoptosis regulator

affects expression

Dimethyl Sulfoxide affects the expression of CFLAR mRNA

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

cell growth regulator with EF hand domain 1

affects expression

Dimethyl Sulfoxide affects the expression of CGREF1 mRNA

NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852

G

checkpoint kinase 2

affects expression

Dimethyl Sulfoxide affects the expression of CHEK2 mRNA

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

chemokine-like factor

affects expression

Dimethyl Sulfoxide affects the expression of CKLF mRNA

NCBI chr19:698,097...706,570
Ensembl chr19:698,033...706,570

G

claudin 6

multiple interactions
decreases methylation
increases expression

Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN6 mRNA]
Dimethyl Sulfoxide results in decreased methylation of CLDN6 promoter
Dimethyl Sulfoxide results in increased expression of CLDN6 mRNA

NCBI chr10:12,710,302...12,713,987
Ensembl chr10:12,709,960...12,715,973

G

claudin 8

increases expression

Dimethyl Sulfoxide results in increased expression of CLDN8 mRNA

NCBI chr11:27,875,857...27,878,106
Ensembl chr11:27,875,692...27,878,513

G

claudin 9

multiple interactions
increases expression
decreases methylation

Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN9 mRNA]
Dimethyl Sulfoxide results in increased expression of CLDN9 mRNA
Dimethyl Sulfoxide results in decreased methylation of CLDN9 promoter

NCBI chr10:12,714,137...12,715,568

G

ciliary neurotrophic factor

affects expression

Dimethyl Sulfoxide affects the expression of CNTF mRNA

NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877

G

collagen type XI alpha 1 chain

increases expression

Dimethyl Sulfoxide results in increased expression of COL11A1 mRNA

NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853

G

collagen type I alpha 1 chain

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in increased expression of COL1A1 protein]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of COL1A2 mRNA; LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of COL1A2 mRNA]

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type IV alpha 1 chain

increases expression

Dimethyl Sulfoxide results in increased expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

collagen type IV alpha 5 chain

increases expression

Dimethyl Sulfoxide results in increased expression of COL4A5 mRNA

NCBI chr X:105,118,762...105,322,699
Ensembl chr X:105,118,820...105,322,692

G

collagen type V alpha 1 chain

increases expression

Dimethyl Sulfoxide results in increased expression of COL5A1 mRNA

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

G

cytochrome c oxidase subunit 4i1

increases expression

Dimethyl Sulfoxide results in increased expression of COX4I1 protein

NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921

G

ceruloplasmin

increases expression

Dimethyl Sulfoxide results in increased expression of CP mRNA

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carboxypeptidase M

increases expression

Dimethyl Sulfoxide results in increased expression of CPM mRNA

NCBI chr 7:53,225,647...53,286,220
Ensembl chr 7:53,225,696...53,286,220

G

citrate synthase

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein]

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

colony stimulating factor 1 receptor

increases expression

Dimethyl Sulfoxide results in increased expression of CSF1R mRNA

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

centriolar satellite-associated tubulin polyglutamylase complex regulator 1

affects expression

Dimethyl Sulfoxide affects the expression of CSTPP1 mRNA

NCBI chr 3:77,247,393...77,416,307
Ensembl chr 3:77,248,375...77,416,274

G

cystathionine gamma-lyase

affects expression

Dimethyl Sulfoxide affects the expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

catenin beta 1

increases expression

Dimethyl Sulfoxide results in increased expression of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cutA divalent cation tolerance homolog

affects expression

Dimethyl Sulfoxide affects the expression of CUTA mRNA

NCBI chr20:5,022,956...5,024,580
Ensembl chr20:5,022,956...5,024,552

G

C-X-C motif chemokine ligand 14

affects expression

Dimethyl Sulfoxide affects the expression of CXCL14 mRNA

NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839

G

CXXC finger protein 4

affects expression

Dimethyl Sulfoxide affects the expression of CXXC4 mRNA

NCBI chr 2:222,664,148...222,689,365
Ensembl chr 2:222,664,771...222,689,365

G

cytochrome P450, family 11, subfamily b, polypeptide 3

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [adrenocorticotropin zinc results in decreased expression of CYP11B2 mRNA]; Dimethyl Sulfoxide promotes the reaction [adrenocorticotropin zinc results in decreased activity of CYP11B2 protein]

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 1, subfamily a, polypeptide 1

affects expression
multiple interactions
increases expression

Dimethyl Sulfoxide affects the expression of CYP1A1 mRNA
JDP2 protein affects the reaction [Dimethyl Sulfoxide results in increased expression of CYP1A1 protein]
Dimethyl Sulfoxide results in increased expression of CYP1A1; Dimethyl Sulfoxide results in increased expression of CYP1A1 protein
Dimethyl Sulfoxide results in increased expression of CYP1A1 mRNA; Dimethyl Sulfoxide results in increased expression of CYP1A1 protein
Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]]

PMID:12147272 PMID:12843640 PMID:22486318 PMID:31096615 PMID:33723743

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects expression
increases expression
multiple interactions

Dimethyl Sulfoxide affects the expression of CYP1A2 mRNA
Dimethyl Sulfoxide results in increased expression of CYP1A2 mRNA
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP1A2 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP1A2 protein; [hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP1A2

PMID:12843640 PMID:18347083 PMID:30262279 PMID:35366062

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

affects expression
increases expression

Dimethyl Sulfoxide affects the expression of CYP1B1 mRNA
Dimethyl Sulfoxide results in increased expression of CYP1B1 protein

PMID:12843640 PMID:33723743

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 27, subfamily a, polypeptide 1

multiple interactions

Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CYP27A1 mRNA]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of CYP27A1 mRNA]]

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily a, polypeptide 2

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline]

NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin]

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
multiple interactions

Dimethyl Sulfoxide results in increased expression of CYP2B6 mRNA; Dimethyl Sulfoxide results in increased expression of CYP2B6 protein
[Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2B10 protein; NR1I3 gene mutant form inhibits the reaction [[Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2B10 protein]
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP2B6 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP2B6 protein

PMID:20371638 PMID:30262279 PMID:31096615 PMID:35366062

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily c, polypeptide 24

multiple interactions

[Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2C55 mRNA; [Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2C55 protein; NR1I3 gene mutant form inhibits the reaction [[Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2C55 mRNA]; NR1I3 gene mutant form inhibits the reaction [[Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2C55 protein]

NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [CYP2C6 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP2C19 protein

PMID:19858067 PMID:35366062

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 2

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]

NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]; Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

affects expression
increases expression
increases activity
multiple interactions

Dimethyl Sulfoxide affects the expression of CYP2E1 mRNA
Dimethyl Sulfoxide results in increased expression of CYP2E1 protein
Dimethyl Sulfoxide results in increased activity of CYP2E1 protein
Dimethyl Sulfoxide binds to and results in increased expression of CYP2E1 protein; Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]; Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein results in increased metabolism of methylformamide]
Dimethyl Sulfoxide results in increased expression of CYP2E1 mRNA; Dimethyl Sulfoxide results in increased expression of CYP2E1 protein
Dimethyl Sulfoxide inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]; Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]]

PMID:1538706 PMID:3113478 PMID:3337723 PMID:8074729 PMID:9143349 More...

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
affects expression
increases expression

Dimethyl Sulfoxide inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline]
Dimethyl Sulfoxide affects the expression of CYP3A4 mRNA
Dimethyl Sulfoxide results in increased expression of CYP3A4 mRNA; Dimethyl Sulfoxide results in increased expression of CYP3A4 protein
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP3A4 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP3A4 protein; [Dimethyl Sulfoxide results in increased susceptibility to Rifampin] which results in increased expression of CYP3A4 mRNA; [hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP3A4; Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; PRMT1 protein affects the reaction [[Dimethyl Sulfoxide results in increased susceptibility to Rifampin] which results in increased expression of CYP3A4 mRNA]; PRMT1 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; trichostatin A affects the reaction [Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]

PMID:12843640 PMID:18347083 PMID:19858067 PMID:30262279 PMID:31096615 More...

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline]

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

affects expression

Dimethyl Sulfoxide affects the expression of CYP3A5 mRNA

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450 family 7 subfamily A member 1

increases expression

DMSO increases expression of Cyp7a1 mRNA in rat liver; reaction inhibited by INT-767

RGD

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cysteine rich tail 1

affects expression

Dimethyl Sulfoxide affects the expression of CYSRT1 mRNA

NCBI chr 3:8,054,195...8,057,846
Ensembl chr 3:8,053,482...8,059,721

G

DNA-damage inducible transcript 3

increases expression

Dimethyl Sulfoxide results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEPP autophagy regulator 1

affects expression

Dimethyl Sulfoxide affects the expression of DEPP1 mRNA

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

DNA fragmentation factor subunit alpha

increases cleavage

Dimethyl Sulfoxide results in increased cleavage of DFFA protein

NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633

G

DNA methyltransferase 1-associated protein 1

affects expression

Dimethyl Sulfoxide affects the expression of DMAP1 mRNA

NCBI chr 5:131,143,726...131,151,760
Ensembl chr 5:131,143,729...131,151,742

G

DnaJ heat shock protein family (Hsp40) member B5

increases expression

Dimethyl Sulfoxide results in increased expression of DNAJB5 mRNA

NCBI chr 5:57,176,840...57,186,067
Ensembl chr 5:57,176,845...57,185,490

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

Dimethyl Sulfoxide results in increased expression of DNAJB9 mRNA

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

DNA methyltransferase 1

decreases expression

Dimethyl Sulfoxide results in decreased expression of DNMT1 protein

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

dual specificity phosphatase 1

increases expression

Dimethyl Sulfoxide results in increased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

ELL associated factor 2

affects expression

Dimethyl Sulfoxide affects the expression of EAF2 mRNA

NCBI chr11:63,960,200...64,004,610
Ensembl chr11:63,960,200...64,004,610

G

endothelin 2

decreases expression

Dimethyl Sulfoxide results in decreased expression of EDN2 mRNA

NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814

G

endothelin receptor type A

multiple interactions

[Dimethyl Sulfoxide co-treated with Cycloheximide] results in decreased expression of EDNRA mRNA; [Dimethyl Sulfoxide co-treated with Cycloheximide] results in decreased expression of EDNRA protein; [Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA mRNA; [Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA protein

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

endothelin receptor type B

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter promotes the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter promotes the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]]; Cycloheximide inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; Cycloheximide inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; Dactinomycin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; Dactinomycin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; pyrazolanthrone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; pyrazolanthrone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; wedelolactone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; wedelolactone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]
Dimethyl Sulfoxide results in increased expression of EDNRB mRNA; Dimethyl Sulfoxide results in increased expression of EDNRB protein

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

EEF1A lysine methyltransferase 1

affects expression

Dimethyl Sulfoxide affects the expression of EEF1AKMT1 mRNA

NCBI chr15:31,694,284...31,711,367
Ensembl chr15:31,694,292...31,711,336

G

EGF containing fibulin extracellular matrix protein 1

increases expression

Dimethyl Sulfoxide results in increased expression of EFEMP1 mRNA

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018

G

early growth response 1

increases expression

Dimethyl Sulfoxide results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 4E binding protein 1

increases phosphorylation
multiple interactions

Dimethyl Sulfoxide results in increased phosphorylation of EIF4EBP1 protein
[Mechlorethamine co-treated with Dimethyl Sulfoxide] results in increased phosphorylation of EIF4EBP1 protein; Mechlorethamine inhibits the reaction [Dimethyl Sulfoxide results in increased phosphorylation of EIF4EBP1 protein]

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

eukaryotic translation initiation factor 4, gamma 2

increases expression

Dimethyl Sulfoxide results in increased expression of EIF4G2 protein

NCBI chr 1:165,181,433...165,193,583
Ensembl chr 1:165,181,434...165,193,588

G

epithelial membrane protein 1

increases expression

Dimethyl Sulfoxide results in increased expression of EMP1 mRNA

NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904

G

endonuclease G

affects localization

Dimethyl Sulfoxide affects the localization of ENDOG protein

NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

decreases expression

Dimethyl Sulfoxide results in decreased expression of ENPP2 protein

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

epididymal peptidase inhibitor

affects expression

Dimethyl Sulfoxide affects the expression of EPPIN mRNA

NCBI chr 3:153,312,396...153,319,310
Ensembl chr 3:153,312,396...153,319,310

G

estrogen receptor 1

multiple interactions

Dimethyl Sulfoxide promotes the reaction [ESR1 protein binds to CAD promoter]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

eva-1 homolog B

affects expression

Dimethyl Sulfoxide affects the expression of EVA1B mRNA

NCBI chr 5:138,427,088...138,429,602
Ensembl chr 5:138,427,151...138,432,433

G

Fas cell surface death receptor

increases expression

Dimethyl Sulfoxide results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

decreases expression

Dimethyl Sulfoxide results in decreased expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

F-box and leucine-rich repeat protein 21

affects expression

Dimethyl Sulfoxide affects the expression of FBXL21P mRNA

NCBI chr17:8,060,412...8,077,415
Ensembl chr17:8,060,414...8,073,359

G

fibrinogen gamma chain

increases expression

Dimethyl Sulfoxide results in increased expression of FGG mRNA; Dimethyl Sulfoxide results in increased expression of FGG protein

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

filamin C

increases expression

Dimethyl Sulfoxide results in increased expression of FLNC mRNA

NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844

G

fragile X messenger ribonucleoprotein 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein]

NCBI chr X:147,240,239...147,278,057
Ensembl chr X:147,240,301...147,278,050

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Dimethyl Sulfoxide results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box A2

decreases expression

Dimethyl Sulfoxide results in decreased expression of FOXA2 mRNA

NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326

G

fibroblast growth factor receptor substrate 3

affects expression

Dimethyl Sulfoxide affects the expression of FRS3 mRNA

NCBI chr 9:13,288,559...13,297,285
Ensembl chr 9:13,288,667...13,295,382

G

glutamate decarboxylase 1

increases expression

Dimethyl Sulfoxide results in increased expression of GAD1 mRNA

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

growth arrest and DNA-damage-inducible, alpha

affects expression

Dimethyl Sulfoxide affects the expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

growth arrest and DNA-damage-inducible, gamma

increases expression

Dimethyl Sulfoxide results in increased expression of GADD45G mRNA

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

G

glyceraldehyde-3-phosphate dehydrogenase

affects expression

Dimethyl Sulfoxide affects the expression of GAPDH mRNA

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

GATA binding protein 4

decreases expression
increases expression

Dimethyl Sulfoxide results in decreased expression of GATA4 mRNA
Dimethyl Sulfoxide results in increased expression of GATA4 mRNA

NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636

G

GATA binding protein 6

decreases expression

Dimethyl Sulfoxide results in decreased expression of GATA6 mRNA

NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532

G

gap junction protein, alpha 1

increases expression

Dimethyl Sulfoxide results in increased expression of GJA1 mRNA

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, beta 1

increases expression

Dimethyl Sulfoxide results in increased expression of GJB1 mRNA

NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925

G

gap junction protein, beta 2

increases expression

Dimethyl Sulfoxide results in increased expression of GJB2 mRNA

NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177

G

glycosyltransferase 8 domain containing 1

affects expression

Dimethyl Sulfoxide affects the expression of GLT8D1 mRNA

NCBI chr16:6,192,269...6,207,227
Ensembl chr16:6,192,300...6,207,229

G

G protein subunit gamma 3

affects expression

Dimethyl Sulfoxide affects the expression of GNG3 mRNA

NCBI chr 1:205,731,837...205,733,603
Ensembl chr 1:205,731,837...205,733,603

G

G protein-coupled bile acid receptor 1

decreases expression

DMSO decreases expression of Gpbar1 protein in rat liver; reaction inhibited by INT-767

RGD

NCBI chr 9:75,860,758...75,863,260
Ensembl chr 9:75,860,677...75,863,168

G

G protein-coupled receptor 75

affects expression

Dimethyl Sulfoxide affects the expression of GPR75 mRNA

NCBI chr14:104,609,542...104,618,885
Ensembl chr14:104,611,089...104,620,370

G

glutamic--pyruvic transaminase

multiple interactions

[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in increased expression of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

granulin precursor

increases expression

Dimethyl Sulfoxide results in increased expression of GRN mRNA

NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775

G

glutathione S-transferase alpha 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in decreased expression of GSTA1 protein]

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase kappa 1

affects expression

Dimethyl Sulfoxide affects the expression of GSTK1 mRNA

NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292

G

glutathione S-transferase mu 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in decreased expression of GSTM1 protein]

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

increases expression

Dimethyl Sulfoxide results in increased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase pi 1

increases expression

Dimethyl Sulfoxide results in increased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

H2B clustered histone 6

affects expression

Dimethyl Sulfoxide affects the expression of H2BC6 mRNA

NCBI chr17:41,520,775...41,521,238

G

H3.4 histone, cluster member

multiple interactions
decreases methylation

[Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H3-4 protein modified form binds to TGM2 gene]; Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased acetylation of H3-4 protein]
Dimethyl Sulfoxide results in decreased methylation of H3-4 protein

NCBI chr10:43,740,702...43,741,262

G

H1.3 linker histone, cluster member

affects expression

Dimethyl Sulfoxide affects the expression of H1-3 mRNA

NCBI chr17:41,551,524...41,552,303
Ensembl chr17:41,529,667...41,552,334

G

heart and neural crest derivatives expressed 1

decreases expression
increases expression

Dimethyl Sulfoxide results in decreased expression of HAND1 mRNA
Dimethyl Sulfoxide results in increased expression of HAND1 mRNA

NCBI chr10:42,006,646...42,009,213
Ensembl chr10:42,006,651...42,009,213

G

hemoglobin subunit beta

increases expression

Dimethyl Sulfoxide results in increased expression of HBB mRNA

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

hydroxycarboxylic acid receptor 1

affects expression

Dimethyl Sulfoxide affects the expression of HCAR1 mRNA

NCBI chr12:32,710,680...32,713,934
Ensembl chr12:32,711,027...32,712,082

G

HEXIM P-TEFb complex subunit 1

increases expression

Dimethyl Sulfoxide results in increased expression of HEXIM1 mRNA; Dimethyl Sulfoxide results in increased expression of HEXIM1 protein

NCBI chr10:88,062,808...88,064,920
Ensembl chr10:88,062,803...88,066,189

G

hypoxia inducible factor 1 subunit alpha

increases expression

Dimethyl Sulfoxide results in increased expression of HIF1A mRNA

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

histone cluster 1 H2a family member I like 1

affects expression

Dimethyl Sulfoxide affects the expression of H3C6 mRNA

NCBI chr17:41,568,181...41,569,093
Ensembl chr17:41,568,471...41,569,109

G

histone cluster 1 H2A family like 1

affects expression

Dimethyl Sulfoxide affects the expression of H2AC6 mRNA

NCBI chr17:42,707,954...42,708,420

G

heme oxygenase 1

decreases expression
multiple interactions
increases expression

Dimethyl Sulfoxide results in decreased expression of HMOX1 protein
[Dimethyl Sulfoxide co-treated with resveratrol] inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; Dimethyl Sulfoxide inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]
Dimethyl Sulfoxide results in increased expression of HMOX1 mRNA

PMID:15689417 PMID:22118543 PMID:22193206 PMID:26497626 PMID:36305173

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

haptoglobin

increases expression

Dimethyl Sulfoxide results in increased expression of HP mRNA; Dimethyl Sulfoxide results in increased expression of HP protein

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

hypoxanthine phosphoribosyltransferase 1

decreases expression

Dimethyl Sulfoxide results in decreased expression of HPRT1 mRNA

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

HRas proto-oncogene, GTPase

affects expression

Dimethyl Sulfoxide affects the expression of HRAS mRNA

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

heat shock protein family A (Hsp70) member 1A

increases expression

Dimethyl Sulfoxide results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

intercellular adhesion molecule 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [beryllium sulfate results in increased secretion of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

immediate early response 2

increases expression

Dimethyl Sulfoxide results in increased expression of IER2 mRNA

NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211

G

interferon gamma

multiple interactions

[Dimethyl Sulfoxide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA; Dimethyl Sulfoxide inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased secretion of CCL5 protein]; Dimethyl Sulfoxide inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased secretion of IL6 protein]

PMID:21878375 PMID:29594315

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon gamma receptor 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of IFNGR1 mRNA]

NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785

G

intraflagellar transport 81

affects expression

Dimethyl Sulfoxide affects the expression of IFT81 mRNA

NCBI chr12:33,957,744...34,037,164
Ensembl chr12:33,957,806...34,037,057

G

interleukin 1 alpha

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of IL1A mRNA]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
decreases expression

Dimethyl Sulfoxide inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased secretion of CCL5 protein]; Dimethyl Sulfoxide inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased secretion of IL6 protein]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of IFNGR1 mRNA]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of IL1A mRNA]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of IL1B mRNA]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of NFKB2 mRNA]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of NFKBIA mRNA]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]
[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in increased expression of IL1B protein
Dimethyl Sulfoxide results in decreased expression of IL1B mRNA

PMID:21878375 PMID:29594315 PMID:37365769

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor type 1

decreases expression

Dimethyl Sulfoxide results in decreased expression of IL1R1 mRNA

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 2

multiple interactions

[Dimethyl Sulfoxide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 23 subunit alpha

affects expression

Dimethyl Sulfoxide affects the expression of IL23A mRNA

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

G

interleukin 6

multiple interactions
decreases secretion

Dimethyl Sulfoxide inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased secretion of IL6 protein]; Dimethyl Sulfoxide inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of IL6 mRNA]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]
Dimethyl Sulfoxide results in decreased secretion of IL6 protein
[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in increased expression of IL6 protein; Dimethyl Sulfoxide inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA]

PMID:9378980 PMID:10022265 PMID:15689417 PMID:21878375 PMID:24296301 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

immunity-related GTPase M

affects expression

Dimethyl Sulfoxide affects the expression of IRGM mRNA

NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578

G

ISG15 ubiquitin-like modifier

affects expression

Dimethyl Sulfoxide affects the expression of ISG15 mRNA

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

integrin subunit alpha M

multiple interactions
increases expression

[Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of ITGAM protein; Dexamethasone inhibits the reaction [Dimethyl Sulfoxide results in increased expression of ITGAM protein]; Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of ITGAM protein]

PMID:7909661 PMID:15964820 PMID:16617325 PMID:22118543 PMID:26330309

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit alpha X

multiple interactions

Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of ITGAX protein]

NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698

G

integrin subunit beta 2

multiple interactions

Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of ITGB2 protein]

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

Jun dimerization protein 2

multiple interactions

Dimethyl Sulfoxide promotes the reaction [JDP2 protein binds to AHR promoter]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [AHR protein binds to AHR promoter]]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [ARNT protein binds to AHR promoter]]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [JDP2 protein binds to AHR promoter]]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [NFE2L2 protein binds to AHR promoter]]; JDP2 protein affects the reaction [Dimethyl Sulfoxide results in increased expression of AHR mRNA]; JDP2 protein affects the reaction [Dimethyl Sulfoxide results in increased expression of AHR protein]; JDP2 protein affects the reaction [Dimethyl Sulfoxide results in increased expression of CYP1A1 protein]

NCBI chr 6:105,261,619...105,302,386
Ensembl chr 6:105,261,373...105,301,485

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Dimethyl Sulfoxide results in increased expression of JUN mRNA
Dimethyl Sulfoxide inhibits the reaction [Paraquat results in increased expression of JUN mRNA]

PMID:7662713 PMID:22193206

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

KLF transcription factor 2

increases expression

Dimethyl Sulfoxide results in increased expression of KLF2 mRNA

NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944

G

KLF transcription factor 4

increases expression

Dimethyl Sulfoxide results in increased expression of KLF4 mRNA

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

kelch-like family member 41

affects expression

Dimethyl Sulfoxide affects the expression of KLHL41 mRNA

NCBI chr 3:54,434,291...54,447,415
Ensembl chr 3:54,434,234...54,449,222

G

keratin 15

decreases expression

Dimethyl Sulfoxide results in decreased expression of KRT15 mRNA

NCBI chr10:85,066,797...85,070,614
Ensembl chr10:85,066,802...85,171,799

G

keratin 18

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of KRT18 mRNA

NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166

G

laminin subunit alpha 1

increases expression

Dimethyl Sulfoxide results in increased expression of LAMA1 mRNA

NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478

G

laminin subunit beta 2

increases expression

Dimethyl Sulfoxide results in increased expression of LAMB2 mRNA

NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549

G

lactate dehydrogenase C

affects expression

Dimethyl Sulfoxide affects the expression of LDHC mRNA

NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378

G

galectin 1

affects expression

Dimethyl Sulfoxide affects the expression of LGALS1 mRNA

NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345

G

LLGL scribble cell polarity complex component 2

affects expression

Dimethyl Sulfoxide affects the expression of LLGL2 mRNA

NCBI chr10:101,050,978...101,086,527
Ensembl chr10:101,051,408...101,086,525

G

leucine rich repeat containing 4

affects expression

Dimethyl Sulfoxide affects the expression of LRRC4 mRNA

NCBI chr 4:57,433,518...57,437,114
Ensembl chr 4:57,433,428...57,437,911

G

LYR motif containing 9

affects expression

Dimethyl Sulfoxide affects the expression of LYRM9 mRNA

NCBI chr10:63,725,718...63,739,772
Ensembl chr10:63,725,743...63,739,772

G

mitogen activated protein kinase kinase 1

increases expression
multiple interactions

Dimethyl Sulfoxide results in increased expression of MAP2K1 mRNA
cucurbitacin IIa inhibits the reaction [Dimethyl Sulfoxide results in increased expression of MAP2K1 mRNA]

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

multiple interactions
increases expression

cucurbitacin IIa inhibits the reaction [Dimethyl Sulfoxide results in increased expression of MAP2K2 mRNA]

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions
decreases activity

Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in increased activity of MAP3K5 protein]
Dimethyl Sulfoxide results in decreased activity of MAP3K5 protein

NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800

G

mitogen activated protein kinase 3

affects expression
multiple interactions
increases expression

Dimethyl Sulfoxide affects the expression of MAPK3 mRNA
cucurbitacin IIa inhibits the reaction [Dimethyl Sulfoxide results in increased expression of MAPK3 mRNA]

PMID:24834073 PMID:31265865

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

methionine adenosyltransferase 1A

increases activity

Dimethyl Sulfoxide results in increased activity of MAT1A protein

NCBI chr16:16,983,084...17,001,284
Ensembl chr16:16,983,022...17,001,274

G

methionine adenosyltransferase 2A

increases activity

Dimethyl Sulfoxide results in increased activity of MAT2A protein

NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493

G

melanocortin 1 receptor

affects expression

Dimethyl Sulfoxide affects the expression of MC1R mRNA

NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192

G

myocyte enhancer factor 2C

increases expression
decreases expression

Dimethyl Sulfoxide results in increased expression of MEF2C mRNA
Dimethyl Sulfoxide results in decreased expression of MEF2C mRNA

NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880

G

methyltransferase like 26

affects expression

Dimethyl Sulfoxide affects the expression of METTL26 mRNA

NCBI chr10:14,894,574...14,908,067
Ensembl chr10:14,894,581...14,905,851

G

microfibril associated protein 5

affects expression

Dimethyl Sulfoxide affects the expression of MFAP5 mRNA

NCBI chr 4:155,727,925...155,750,458
Ensembl chr 4:155,727,925...155,750,458

G

microRNA 320a

multiple interactions

dimethyl sulfoxide promotes the reaction [ischemia-reperfusion injury increases expression of Mir320a miRNA in nucleus]

RGD

NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473

G

matrix metallopeptidase 1

increases expression

Dimethyl Sulfoxide results in increased expression of MMP1 mRNA; Dimethyl Sulfoxide results in increased expression of MMP1 protein

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 13

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of MMP13 mRNA

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

multiple interactions
increases expression

[Dimethyl Sulfoxide co-treated with resveratrol] inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]
Dimethyl Sulfoxide results in increased expression of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions
increases expression

[Dimethyl Sulfoxide co-treated with resveratrol] inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Dimethyl Sulfoxide inhibits the reaction [Ethanol results in increased activity of MMP9 protein]
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of MMP9 mRNA
Dimethyl Sulfoxide results in increased expression of MMP9 protein

PMID:17603938 PMID:26497626 PMID:35366062

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

increases secretion
increases expression
multiple interactions

Dimethyl Sulfoxide results in increased secretion of MPO protein
Dimethyl Sulfoxide results in increased expression of MPO mRNA
[Irinotecan co-treated with Dimethyl Sulfoxide] results in increased activity of MPO protein; [Tetradecanoylphorbol Acetate co-treated with Dimethyl Sulfoxide] results in increased activity of MPO protein; GSK484 inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Dimethyl Sulfoxide] results in increased activity of MPO protein]; Irinotecan promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Dimethyl Sulfoxide] results in increased activity of MPO protein]; phenethyl isothiocyanate inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Dimethyl Sulfoxide] results in increased activity of MPO protein]; Tetradecanoylphorbol Acetate promotes the reaction [Dimethyl Sulfoxide results in increased expression of MPO mRNA]

PMID:21633126 PMID:38341106

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mitochondrial ribosomal protein L43

affects expression

Dimethyl Sulfoxide affects the expression of MRPL43 mRNA

NCBI chr 1:243,866,848...243,868,285
Ensembl chr 1:243,866,931...243,868,281

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

murinoglobulin 2

increases expression

Dimethyl Sulfoxide results in increased expression of PZP mRNA; Dimethyl Sulfoxide results in increased expression of PZP protein

NCBI chr 4:155,164,061...155,236,894
Ensembl chr 4:155,164,011...155,236,475

G

matrix remodeling associated 8

increases expression

Dimethyl Sulfoxide results in increased expression of MXRA8 mRNA

NCBI chr 5:166,448,919...166,453,645
Ensembl chr 5:166,449,154...166,453,636

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

Dimethyl Sulfoxide results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin light chain 2

increases phosphorylation
multiple interactions

Dimethyl Sulfoxide results in increased phosphorylation of MYL2 protein
AHR protein affects the reaction [Dimethyl Sulfoxide results in increased phosphorylation of MYL2 protein]

NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983

G

myosin IG

increases expression

Dimethyl Sulfoxide results in increased expression of MYO1G mRNA

NCBI chr14:81,386,701...81,401,843
Ensembl chr14:81,386,701...81,401,843

G

Nanog homeobox

decreases expression

Dimethyl Sulfoxide results in decreased expression of NANOG mRNA

NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116

G

neurofilament heavy chain

decreases expression

Dimethyl Sulfoxide results in decreased expression of NEFH mRNA

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

nestin

decreases expression

Dimethyl Sulfoxide results in decreased expression of NES mRNA

NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression
affects response to substance
decreases expression

[Dimethyl Sulfoxide co-treated with resveratrol] inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]
Dimethyl Sulfoxide results in increased expression of NFE2L2 protein modified form
NFE2L2 protein affects the susceptibility to Dimethyl Sulfoxide
dimethyl sulfoxide promotes the reaction [ischemia-reperfusion injury increases expression of Nfe2l2 protein in nucleus]
Dimethyl Sulfoxide promotes the reaction [NFE2L2 protein binds to AHR promoter]; JDP2 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [NFE2L2 protein binds to AHR promoter]]
Dimethyl Sulfoxide results in decreased expression of NFE2L2 protein

CTD
RGD

PMID:26497626 PMID:32023790 PMID:33723743 PMID:36305173 PMID:31089916

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 2

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of NFKB2 mRNA]

NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213

G

NFKB inhibitor alpha

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of NFKBIA mRNA]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

N-myc (and STAT) interactor

affects expression

Dimethyl Sulfoxide affects the expression of NMI mRNA

NCBI chr 3:36,415,607...36,439,716
Ensembl chr 3:36,415,607...36,439,498

G

nicotinamide riboside kinase 1

affects expression

Dimethyl Sulfoxide affects the expression of NMRK1 mRNA

NCBI chr 1:216,049,350...216,076,792
Ensembl chr 1:216,049,437...216,076,791

G

nitric oxide synthase 2

decreases expression

Dimethyl Sulfoxide results in decreased expression of NOS2 mRNA

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 3

increases expression

Dimethyl Sulfoxide results in increased expression of NOTCH3 mRNA

NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025

G

NAD(P)H quinone dehydrogenase 1

increases expression

Dimethyl Sulfoxide results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group H, member 4

decreases expression

DMSO decreases expression of Nr1h4 mRNA and protein in rat liver; reaction inhibited by INT-767

RGD

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

NR1I3 gene mutant form inhibits the reaction [[Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2B10 protein]; NR1I3 gene mutant form inhibits the reaction [[Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2C55 mRNA]; NR1I3 gene mutant form inhibits the reaction [[Phenobarbital co-treated with Dimethyl Sulfoxide] results in increased expression of CYP2C55 protein]

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nudix hydrolase 1

affects expression

Dimethyl Sulfoxide affects the expression of NUDT1 mRNA

NCBI chr12:14,302,514...14,309,559
Ensembl chr12:14,302,694...14,305,826

G

occludin

increases expression

Dimethyl Sulfoxide results in increased expression of OCLN mRNA

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

ornithine decarboxylase 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Paraquat results in increased activity of ODC1 protein]

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

orosomucoid 1

increases expression

Dimethyl Sulfoxide results in increased expression of ORM1 mRNA; Dimethyl Sulfoxide results in increased expression of ORM1 protein

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

osteocrin

affects expression

Dimethyl Sulfoxide affects the expression of OSTN mRNA

NCBI chr11:73,442,167...73,478,498
Ensembl chr11:73,442,487...73,468,603

G

purinergic receptor P2X 7

multiple interactions

[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in increased expression of P2RX7 protein

NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619

G

peptidyl arginine deiminase 4

multiple interactions
increases expression

Calcimycin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of PADI4 protein]; Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of PADI4 mRNA]

PMID:15964820 PMID:29425503

NCBI chr 5:153,041,351...153,074,412
Ensembl chr 5:153,041,352...153,074,362

G

par-6 family cell polarity regulator alpha

affects expression

Dimethyl Sulfoxide affects the expression of PARD6A mRNA

NCBI chr19:33,589,531...33,591,900
Ensembl chr19:33,589,542...33,591,900

G

poly (ADP-ribose) polymerase 1

increases cleavage

Dimethyl Sulfoxide results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

programmed cell death 4

increases expression

Dimethyl Sulfoxide results in increased expression of PDCD4 protein

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

PHD finger protein 6

affects expression

Dimethyl Sulfoxide affects the expression of PHF6 mRNA

NCBI chr X:132,656,658...132,699,720
Ensembl chr X:132,656,672...132,699,127

G

phosphoinositide kinase, FYVE-type zinc finger containing

affects expression

Dimethyl Sulfoxide affects the expression of PIKFYVE mRNA

NCBI chr 9:66,563,747...66,657,873
Ensembl chr 9:66,563,727...66,657,868

G

pejvakin

affects expression

Dimethyl Sulfoxide affects the expression of PJVK mRNA

NCBI chr 3:61,594,644...61,605,051
Ensembl chr 3:61,596,641...61,605,045

G

phospholipase A2 group IIA

decreases expression

Dimethyl Sulfoxide results in decreased expression of PLA2G2A mRNA

NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014

G

pleckstrin homology and FYVE domain containing 1

affects expression

Dimethyl Sulfoxide affects the expression of PLEKHF1 mRNA

NCBI chr 1:90,908,304...90,915,862
Ensembl chr 1:90,904,742...90,915,820

G

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

increases expression

Dimethyl Sulfoxide results in increased expression of PLOD2 mRNA

NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255

G

proopiomelanocortin

decreases expression

Dimethyl Sulfoxide results in decreased expression of POMC protein

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

cytochrome p450 oxidoreductase

multiple interactions
decreases activity

Dimethyl Sulfoxide inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]
Dimethyl Sulfoxide results in decreased activity of POR protein
Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]; Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Dimethyl Sulfoxide promotes the reaction [Hemin results in decreased activity of POR protein]; Hemin promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; Hemin promotes the reaction [Dimethyl Sulfoxide results in decreased activity of POR protein]

PMID:11368792 PMID:21215309

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

protection of telomeres 1

multiple interactions

2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [[Dimethyl Sulfoxide co-treated with Tretinoin] results in increased expression of POT1 mRNA]; 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [[Dimethyl Sulfoxide co-treated with Tretinoin] results in increased expression of POT1 mRNA]; [Dimethyl Sulfoxide co-treated with Tretinoin] results in increased expression of POT1 mRNA

NCBI chr 4:54,205,330...54,263,137
Ensembl chr 4:54,205,332...54,263,042

G

POU class 5 homeobox 1

affects expression

Dimethyl Sulfoxide affects the expression of POU5F1 mRNA

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator activated receptor alpha

decreases expression

Dimethyl Sulfoxide results in decreased expression of PPARA mRNA

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

decreases expression

Dimethyl Sulfoxide results in decreased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

polyglutamine binding protein 1

affects expression

Dimethyl Sulfoxide affects the expression of PQBP1 mRNA

NCBI chr X:14,603,516...14,608,091
Ensembl chr X:14,603,539...14,608,087

G

protein arginine methyltransferase 1

multiple interactions

PRMT1 protein affects the reaction [[Dimethyl Sulfoxide results in increased susceptibility to Rifampin] which results in increased expression of CYP3A4 mRNA]; PRMT1 protein affects the reaction [Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]

NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345

G

peripherin

affects expression

Dimethyl Sulfoxide affects the expression of PRPH mRNA

NCBI chr 7:130,218,149...130,222,136
Ensembl chr 7:130,218,357...130,222,136

G

prostaglandin-endoperoxide synthase 1

decreases expression

Dimethyl Sulfoxide results in decreased expression of PTGS1 mRNA

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
[Dimethyl Sulfoxide co-treated with resveratrol] inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
Dimethyl Sulfoxide results in increased expression of PTGS2 protein

PMID:21878375 PMID:26497626

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

peroxidasin

increases expression

Dimethyl Sulfoxide results in increased expression of PXDN mRNA

NCBI chr 6:46,580,749...46,658,345
Ensembl chr 6:46,580,761...46,658,345

G

RAB3C, member RAS oncogene family

affects expression

Dimethyl Sulfoxide affects the expression of RAB3C mRNA

NCBI chr 2:41,627,720...41,843,541
Ensembl chr 2:41,627,720...41,843,749

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

[cucurbitacin IIa co-treated with Dimethyl Sulfoxide] results in increased expression of RAF1 mRNA

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in increased expression of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

reelin

increases expression

Dimethyl Sulfoxide results in increased expression of RELN mRNA

NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211

G

regulatory factor X3

affects expression

Dimethyl Sulfoxide affects the expression of RFX3 mRNA

NCBI chr 1:225,449,872...225,709,622
Ensembl chr 1:225,456,187...225,709,402

G

ribonuclease A family member 4

affects expression

Dimethyl Sulfoxide affects the expression of RNASE4 mRNA

NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117

G

ring finger protein 152

affects expression

Dimethyl Sulfoxide affects the expression of RNF152 mRNA

NCBI chr13:21,324,039...21,403,405
Ensembl chr13:21,323,824...21,403,113

G

ribosomal protein S6

multiple interactions
increases phosphorylation
affects phosphorylation

[Dimethyl Sulfoxide co-treated with Mechlorethamine] results in increased phosphorylation of RPS6 protein; Mechlorethamine inhibits the reaction [Dimethyl Sulfoxide results in increased phosphorylation of RPS6 protein]
Mechlorethamine affects the reaction [Dimethyl Sulfoxide affects the phosphorylation of RPS6 protein]

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

RT1 class II, locus Da

decreases expression

Dimethyl Sulfoxide results in decreased expression of HLA-DRA mRNA

NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455

G

retinoid X receptor alpha

increases expression
affects response to substance

Dimethyl Sulfoxide results in increased expression of RXRA mRNA; Dimethyl Sulfoxide results in increased expression of RXRA protein
RXRA protein affects the susceptibility to Dimethyl Sulfoxide

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

retinoid X receptor gamma

decreases expression

Dimethyl Sulfoxide results in decreased expression of RXRG protein

NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167

G

S100 calcium binding protein A13

affects expression

Dimethyl Sulfoxide affects the expression of S100A13 mRNA

NCBI chr 2:175,999,439...176,005,933

G

S100 calcium binding protein A8

increases expression

Dimethyl Sulfoxide results in increased expression of S100A8 mRNA

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein A9

increases expression

Dimethyl Sulfoxide results in increased expression of S100A9 mRNA

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

succinate dehydrogenase complex assembly factor 4

affects expression

Dimethyl Sulfoxide affects the expression of SDHAF4 mRNA

NCBI chr 9:26,408,332...26,416,478

G

selenium binding protein 1

increases abundance

SELENBP1 gene mutant form results in increased abundance of Dimethyl Sulfoxide

NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594

G

stress-associated endoplasmic reticulum protein family member 2

affects expression

Dimethyl Sulfoxide affects the expression of SERP2 mRNA

NCBI chr15:51,879,882...51,903,958
Ensembl chr15:51,879,877...51,904,785

G

solute carrier family 24 member 2

increases expression

Dimethyl Sulfoxide results in increased expression of SLC24A2 mRNA

NCBI chr 5:101,497,916...101,741,840
Ensembl chr 5:101,502,278...101,739,337

G

solute carrier family 24 member 4

increases expression

Dimethyl Sulfoxide results in increased expression of SLC24A4 mRNA

NCBI chr 6:121,279,590...121,419,811
Ensembl chr 6:121,280,031...121,414,949

G

solute carrier family 2 member 6

affects expression

Dimethyl Sulfoxide affects the expression of SLC2A6 mRNA

NCBI chr 3:10,348,395...10,355,208
Ensembl chr 3:10,348,395...10,355,208

G

solute carrier family 35, member E4

affects expression

Dimethyl Sulfoxide affects the expression of SLC35E4 mRNA

NCBI chr14:78,803,320...78,810,186
Ensembl chr14:78,803,323...78,810,241

G

SMAD family member 2

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SMAD2 protein modified form

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 3

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SMAD3 protein modified form

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

SMAD family member 4

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SMAD4 protein

NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438

G

snail family transcriptional repressor 1

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SNAI1 mRNA

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SNAI2 mRNA

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

sorting nexin 15

affects expression

Dimethyl Sulfoxide affects the expression of SNX15 mRNA

NCBI chr 1:203,417,029...203,426,173
Ensembl chr 1:203,417,029...203,426,247

G

superoxide dismutase 3

increases expression

Dimethyl Sulfoxide results in increased expression of SOD3 mRNA

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

sorbitol dehydrogenase

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Carbon Tetrachloride results in increased activity of SORD protein]

NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133

G

SRY-box transcription factor 17

decreases expression

Dimethyl Sulfoxide results in decreased expression of SOX17 mRNA

NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228

G

Sp1 transcription factor

multiple interactions

Dimethyl Sulfoxide promotes the reaction [SP1 protein binds to CAD promoter]

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

serine peptidase inhibitor, Kazal type 2

affects expression

Dimethyl Sulfoxide affects the expression of SPINK2 mRNA

NCBI chr14:30,967,682...30,974,326
Ensembl chr14:30,967,714...30,974,326

G

sterol regulatory element binding transcription factor 1

increases expression

DMSO increases expression of Srebf1 mRNA in rat liver; reaction inhibited by INT-767

RGD

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

sulfiredoxin 1

increases expression

Dimethyl Sulfoxide results in increased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

SH3 and cysteine rich domain 3

affects expression

Dimethyl Sulfoxide affects the expression of STAC3 mRNA

NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589

G

signal transducer and activator of transcription 3

multiple interactions

[cucurbitacin IIa co-treated with Dimethyl Sulfoxide] results in increased expression of STAT3 mRNA

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

sulfotransferase family 1A member 1

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]; Dimethyl Sulfoxide inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol]

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

small ubiquitin-like modifier 1

affects expression

Dimethyl Sulfoxide affects the expression of SUMO1 mRNA

NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761

G

synaptonemal complex central element protein 2

affects expression

Dimethyl Sulfoxide affects the expression of SYCE2 mRNA

NCBI chr19:23,266,236...23,291,265
Ensembl chr19:23,268,869...23,300,980

G

taste receptor, type 2, member 116

affects expression

Dimethyl Sulfoxide affects the expression of TAS2R14 mRNA

NCBI chr 4:166,266,984...166,267,958
Ensembl chr 4:166,266,984...166,267,958

G

TatD DNase domain containing 1

affects expression

Dimethyl Sulfoxide affects the expression of TATDN1 mRNA

NCBI chr 7:90,449,979...90,481,000
Ensembl chr 7:90,441,079...90,481,133

G

telomerase RNA component

multiple interactions

2,4,5,2',4',5'-hexachlorobiphenyl affects the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of TERC mRNA]; 3,4,5,3',4'-pentachlorobiphenyl affects the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of TERC mRNA]; [Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of TERC mRNA

NCBI chr 2:112,815,654...112,816,041

G

telomeric repeat binding factor 1

multiple interactions

2,4,5,2',4',5'-hexachlorobiphenyl affects the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of TERF1 mRNA]; 3,4,5,3',4'-pentachlorobiphenyl affects the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of TERF1 mRNA]; [Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of TERF1 mRNA

NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340

G

telomeric repeat binding factor 2

multiple interactions

[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Dimethyl Sulfoxide co-treated with Tretinoin] results in decreased expression of TERF2 mRNA; [Tretinoin co-treated with Dimethyl Sulfoxide] results in increased expression of TERF2 mRNA

NCBI chr19:34,976,963...35,005,813
Ensembl chr19:34,977,471...35,005,819

G

telomerase reverse transcriptase

decreases expression
multiple interactions

Dimethyl Sulfoxide results in decreased expression of TERT mRNA
2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased activity of TERT protein]; 3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased expression of TERT mRNA]; 3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased activity of TERT protein]; [Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased activity of TERT protein; [Tretinoin co-treated with Dimethyl Sulfoxide] results in decreased expression of TERT mRNA

PMID:16180984 PMID:26330309

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

transferrin

increases expression

Dimethyl Sulfoxide results in increased expression of TF mRNA

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

tissue factor pathway inhibitor

affects expression

Dimethyl Sulfoxide affects the expression of TFPI mRNA

NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880

G

transforming growth factor, beta 1

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased abundance of Adenosine Triphosphate; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of ALB mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CDH1 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP1A2 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP1A2 protein; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP2B6 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP2B6 protein; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP2C19 protein; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP2C9 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP2C9 protein; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP3A4 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP3A4 protein; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of KRT18 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of MMP13 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of MMP9 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased secretion of ALB protein; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 protein; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of CDH2 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of COL1A2 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SMAD2 protein modified form; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SMAD3 protein modified form; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SMAD4 protein; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SNAI1 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of SNAI2 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of TIMP1 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of TIMP2 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of VIM mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ZEB1 mRNA; [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ZEB2 mRNA; LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ACTA2 mRNA]; LY-2157299 inhibits the reaction [[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of COL1A2 mRNA]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transglutaminase 2

multiple interactions

[Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H3-4 protein modified form binds to TGM2 gene]; [Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H4C16 protein modified form binds to TGM2 gene]; Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of TGM2 mRNA]; Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of TGM2 protein]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of TGM2 mRNA]]

NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981

G

TIMP metallopeptidase inhibitor 1

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in increased expression of TIMP2 protein]
[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of TIMP2 mRNA

PMID:11682029 PMID:35366062

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

TIR domain containing adaptor protein

affects expression

Dimethyl Sulfoxide affects the expression of TIRAP mRNA

NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432

G

tight junction protein 1

increases expression

Dimethyl Sulfoxide results in increased expression of TJP1 mRNA

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

transmembrane protein 121

affects expression

Dimethyl Sulfoxide affects the expression of TMEM121 mRNA

NCBI chr 6:132,262,182...132,265,797
Ensembl chr 6:132,262,176...132,265,914

G

transmembrane protein 134

affects expression

Dimethyl Sulfoxide affects the expression of TMEM134 mRNA

NCBI chr 1:201,419,225...201,424,778
Ensembl chr 1:201,419,264...201,431,411

G

transmembrane protein 150C

affects expression

Dimethyl Sulfoxide affects the expression of TMEM150C mRNA

NCBI chr14:9,454,999...9,525,300
Ensembl chr14:9,508,515...9,525,298

G

transmembrane protein 266

affects expression

Dimethyl Sulfoxide affects the expression of TMEM266 mRNA

NCBI chr 8:55,707,122...55,820,692
Ensembl chr 8:55,707,122...55,820,692

G

tumor necrosis factor

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased secretion of CCL5 protein]; Dimethyl Sulfoxide inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased secretion of IL6 protein]; Dimethyl Sulfoxide inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
[lipopolysaccharide, E coli O55-B5 co-treated with Dimethyl Sulfoxide] results in increased expression of TNF protein; Dimethyl Sulfoxide inhibits the reaction [Asbestos, Crocidolite results in increased secretion of TNF protein]; Dimethyl Sulfoxide inhibits the reaction [ferrous sulfate promotes the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]]
Dimethyl Sulfoxide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Ethanol promotes the reaction [Hydroxamic Acids analog promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]]]; Hydroxamic Acids analog promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]; Hydroxamic Acids analog promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]]

PMID:7539275 PMID:14576080 PMID:21878375 PMID:22319556 PMID:37365769

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 12A

increases expression

Dimethyl Sulfoxide results in increased expression of TNFRSF12A mRNA

NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045

G

TNF receptor superfamily member 1A

multiple interactions

Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFRSF1A protein]; Dimethyl Sulfoxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFRSF1A protein]

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

translocase of outer mitochondrial membrane 5

affects expression

Dimethyl Sulfoxide affects the expression of TOMM5 mRNA

NCBI chr 5:59,362,360...59,365,191
Ensembl chr 5:59,362,240...59,365,269

G

tropomyosin 3

increases expression

Dimethyl Sulfoxide results in increased expression of TPM3 mRNA

NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013

G

transformer 2 beta

increases expression

Dimethyl Sulfoxide results in increased expression of TRA2B mRNA

NCBI chr11:78,788,880...78,807,252
Ensembl chr11:78,788,884...78,807,249

G

tribbles pseudokinase 3

increases expression

Dimethyl Sulfoxide results in increased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

G

TSC22 domain family, member 3

affects expression

Dimethyl Sulfoxide affects the expression of TSC22D3 mRNA

NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861

G

t-SNARE domain containing 1

affects expression

Dimethyl Sulfoxide affects the expression of TSNARE1 mRNA

NCBI chr 7:106,226,056...106,407,308

G

tubulin, beta 3 class III

decreases expression

Dimethyl Sulfoxide results in decreased expression of TUBB3 mRNA

NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243

G

U2 small nuclear RNA auxiliary factor 1-like 4

affects expression

Dimethyl Sulfoxide affects the expression of U2AF1L4 mRNA

NCBI chr 1:85,816,268...85,818,462
Ensembl chr 1:85,815,101...85,818,462

G

ubiquitin-conjugating enzyme E2C

affects expression

Dimethyl Sulfoxide affects the expression of UBE2C mRNA

NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339

G

UFM1-specific peptidase 1

affects expression

Dimethyl Sulfoxide affects the expression of UFSP1 mRNA

NCBI chr12:19,406,133...19,407,147
Ensembl chr12:19,406,142...19,407,195

G

UDP glucuronosyltransferase family 1 member A6

affects expression

Dimethyl Sulfoxide affects the expression of UGT1A6 mRNA

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

affects expression

Dimethyl Sulfoxide affects the expression of UGT1A9 mRNA

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

uroplakin 3B

affects expression

Dimethyl Sulfoxide affects the expression of UPK3B mRNA

NCBI chr12:20,630,231...20,637,634
Ensembl chr12:20,631,525...20,637,724

G

urotensin 2 receptor

affects expression

Dimethyl Sulfoxide affects the expression of UTS2R mRNA

NCBI chr10:106,438,092...106,439,252
Ensembl chr10:106,438,092...106,439,252

G

vimentin

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of VIM mRNA

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

vomeronasal 1 receptor 10

affects expression

Dimethyl Sulfoxide affects the expression of VN1R2 mRNA

NCBI chr 1:60,064,704...60,065,639
Ensembl chr 1:60,064,501...60,082,218

G

WAPL cohesin release factor

increases expression

Dimethyl Sulfoxide results in increased expression of WAPL mRNA

NCBI chr16:10,005,520...10,075,270
Ensembl chr16:10,004,941...10,073,510

G

Wnt family member 11

affects expression

Dimethyl Sulfoxide affects the expression of WNT11 mRNA

NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294

G

zinc finger E-box binding homeobox 1

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ZEB1 mRNA

NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214

G

zinc finger E-box binding homeobox 2

multiple interactions

[Dimethyl Sulfoxide co-treated with TGFB1 protein] results in increased expression of ZEB2 mRNA

NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157

G

zinc finger protein 36

affects expression

Dimethyl Sulfoxide affects the expression of ZFP36 mRNA

NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564

edrophonium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
decreases activity

Edrophonium binds to and results in decreased activity of ACHE protein; Edrophonium inhibits the reaction [asoxime chloride inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of ACHE protein]]; Edrophonium inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Edrophonium inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Edrophonium promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]
Edrophonium results in decreased activity of ACHE protein

PMID:25522658 PMID:27297626

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

butyrylcholinesterase

multiple interactions

Edrophonium binds to and results in decreased activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

ferric ammonium citrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aconitase 1

increases activity
decreases activity

ferric ammonium citrate results in increased activity of ACO1 protein
ferric ammonium citrate results in decreased activity of ACO1 protein

PMID:11054110 PMID:18073202

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

aconitase 2

multiple interactions
increases activity

ferric ammonium citrate inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein]; ferric ammonium citrate inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
ferric ammonium citrate results in increased activity of ACO2 protein

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

acid phosphatase 5, tartrate resistant

increases expression
multiple interactions

ferric ammonium citrate results in increased expression of ACP5 protein
Silybin inhibits the reaction [ferric ammonium citrate results in increased expression of ACP5 protein]

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

AKT serine/threonine kinase 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions

ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

alkaline phosphatase, biomineralization associated

multiple interactions

ferric ammonium citrate results in decreased expression of and results in decreased activity of ALPL protein; Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of and results in decreased activity of ALPL protein]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

annexin A3

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ANXA3 protein]

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

G

Rho GDP dissociation inhibitor alpha

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ARHGDIA protein]

NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023

G

beclin 1

multiple interactions

[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of BECN1 protein; [Hydrogen Peroxide co-treated with [ferric ammonium citrate results in increased abundance of Iron]] results in increased expression of BECN1 protein; BECN1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; BECN1 protein affects the reaction [Hydrogen Peroxide inhibits the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

bone morphogenetic protein 6

multiple interactions

ferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]; ferric ammonium citrate inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

caspase 3

increases cleavage
multiple interactions

ferric ammonium citrate results in increased cleavage of CASP3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; Deferoxamine inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; DNM1L protein mutant form inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]

PMID:17191120 PMID:26318285 PMID:27481217

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

ferric ammonium citrate inhibits the reaction [2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased expression of CDKN1A protein]
ferric ammonium citrate results in increased expression of CDKN1A protein

PMID:12807743 PMID:38483099

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

increases expression

ferric ammonium citrate results in increased expression of CDKN2A protein

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

collagen type I alpha 1 chain

decreases expression

ferric ammonium citrate results in decreased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

dynamin 1-like

multiple interactions
decreases phosphorylation

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Cyclosporine inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Deferoxamine inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; DNM1L protein mutant form inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]; ferric ammonium citrate results in decreased phosphorylation of and affects the localization of DNM1L protein; N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]; Tacrolimus inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]

PMID:26318285 PMID:27481217

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

endoplasmic reticulum protein 29

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of ERP29 protein]

NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376

G

coagulation factor III, tissue factor

increases expression
multiple interactions

ferric ammonium citrate results in increased expression of F3 mRNA
Deferoxamine inhibits the reaction [ferric ammonium citrate results in increased expression of F3 mRNA]

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

ferritin heavy chain 1

multiple interactions
increases expression

ferric ammonium citrate promotes the reaction [Palmitic Acid results in increased expression of FTH1 protein]
ferric ammonium citrate results in increased expression of FTH1 protein

PMID:32283200 PMID:38483099

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

ferritin light chain 1

multiple interactions
increases expression

[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of FTL mRNA
ferric ammonium citrate results in increased expression of FTL protein
ferric ammonium citrate results in increased expression of FTL1 protein
ferric ammonium citrate results in increased expression of FTL1 mRNA
SLC40A1 protein inhibits the reaction [ferric ammonium citrate results in increased expression of FTL1 mRNA]

PMID:12393473 PMID:19913091 PMID:38483099

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725

G

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of GAPDH protein]

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

galactosidase, beta 1

increases expression

ferric ammonium citrate results in increased expression of GLB1 protein

NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127

G

glyoxalase 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of GLO1 protein]

NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649

G

H2A.X variant histone

increases expression

ferric ammonium citrate results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

hepcidin antimicrobial peptide

multiple interactions
decreases expression

Deferoxamine promotes the reaction [ferric ammonium citrate results in decreased expression of HAMP mRNA]; ferric ammonium citrate affects the reaction [Deferoxamine inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]]; ferric ammonium citrate inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

heme oxygenase 1

increases expression
multiple interactions

ferric ammonium citrate results in increased expression of HMOX1 protein
[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HMOX1 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [ferric ammonium citrate results in increased expression of HMOX1 protein]

PMID:12393473 PMID:16439612

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of HSPA1A protein]

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1 like

multiple interactions

[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA1L mRNA

NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571

G

heat shock protein family A (Hsp70) member 9

multiple interactions

[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of HSPA9 mRNA

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

heat shock protein family D (Hsp60) member 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of HSPD1 protein]

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

interleukin 1 beta

multiple interactions

ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of IL6 mRNA]; ferric ammonium citrate inhibits the reaction [Ozone results in increased secretion of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; Thapsigargin inhibits the reaction [ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin 2

multiple interactions

ferric ammonium citrate inhibits the reaction [Palmitic Acid inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

iron responsive element binding protein 2

decreases expression
decreases activity

ferric ammonium citrate results in decreased expression of IREB2 protein
ferric ammonium citrate results in decreased activity of IREB2 protein

PMID:11054110 PMID:17469137 PMID:18073202

NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611

G

lipocalin 2

multiple interactions

ferric ammonium citrate inhibits the reaction [bathophenanthroline disulfonic acid results in decreased expression of LCN2 protein]

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein; BECN1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; BECN1 protein affects the reaction [Hydrogen Peroxide inhibits the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; Hydrogen Peroxide inhibits the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; Hydrogen Peroxide inhibits the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; olaparib promotes the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; PARP1 protein affects the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK1 protein
ferric ammonium citrate results in increased phosphorylation of MAPK1 protein

PMID:17191120 PMID:25858758

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

increases phosphorylation

ferric ammonium citrate results in increased phosphorylation of MAPK14 protein

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK3 protein
ferric ammonium citrate results in increased phosphorylation of MAPK3 protein

PMID:17191120 PMID:25858758

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitochondrial ribosomal protein S9

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of MRPS9 protein]

NCBI chr 9:45,113,554...45,172,375
Ensembl chr 9:45,113,554...45,172,375

G

metallothionein 2A

multiple interactions

[ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

nuclear receptor coactivator 4

multiple interactions

ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased expression of NCOA4 protein]

NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641

G

nitric oxide synthase 2

multiple interactions

[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA; Acetylcysteine inhibits the reaction [[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

O-GlcNAcase

multiple interactions

ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of OGA protein]

NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359

G

prolyl 4-hydroxylase subunit alpha 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of P4HA1 protein]

NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786

G

poly (ADP-ribose) polymerase 1

multiple interactions

[ferric ammonium citrate results in increased abundance of Iron] which results in decreased expression of PARP1 protein; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein]; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; PARP1 protein affects the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in decreased expression of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

pyruvate dehydrogenase E1 subunit beta

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PDHB protein]

NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500

G

phosphoglycerate kinase 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PGK1 protein]

NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418

G

peripheral myelin protein 22

multiple interactions

[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of PMP22 mRNA

NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714

G

peptidylprolyl isomerase A

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PPIA protein]

NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

receptor for activated C kinase 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of RACK1 protein]

NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975

G

RUNX family transcription factor 2

multiple interactions
decreases expression

Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of RUNX2 protein]

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

sirtuin 1

multiple interactions
decreases expression

[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein; olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein]; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in decreased expression of PARP1 protein]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]
Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of SIRT1 protein]

PMID:34826546 PMID:36087815

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 11 member 1

increases expression

ferric ammonium citrate results in increased expression of SLC11A1 mRNA

NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101

G

solute carrier family 11 member 2

increases expression

ferric ammonium citrate results in increased expression of SLC11A2 mRNA

NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145

G

solute carrier family 40 member 1

increases expression
multiple interactions

ferric ammonium citrate results in increased expression of SLC40A1 mRNA
SLC40A1 protein inhibits the reaction [ferric ammonium citrate results in increased expression of FTL1 mRNA]

NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481

G

superoxide dismutase 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of SOD1 mRNA]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
decreases expression

Silybin inhibits the reaction [ferric ammonium citrate results in decreased expression of SOD2 protein]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

transferrin

multiple interactions

ferric ammonium citrate inhibits the reaction [TF protein results in increased uptake of Iron]

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transferrin receptor 2

decreases expression

ferric ammonium citrate results in decreased expression of TFR2 protein

NCBI chr12:19,107,673...19,124,622
Ensembl chr12:19,107,673...19,124,591

G

transferrin receptor

decreases expression
multiple interactions

ferric ammonium citrate results in decreased expression of TFRC mRNA; ferric ammonium citrate results in decreased expression of TFRC protein
[ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of TFRC mRNA

PMID:11054110 PMID:12393473 PMID:16760464 PMID:18073202 PMID:25633564

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

tumor necrosis factor

multiple interactions

ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases expression

ferric ammonium citrate results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TPD52 like 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of TPD52L1 protein]

NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109

G

voltage-dependent anion channel 2

multiple interactions

ferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of VDAC2 protein]

NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553

G

X-box binding protein 1

multiple interactions

ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased expression of XBP1 protein]

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

fluorescein (lactone form)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

[CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein; Tranylcypromine inhibits the reaction [[CYP2C19 protein results in increased metabolism of dibenzylfluorescein] which results in increased chemical synthesis of Fluorescein]

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Fluorescein results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

solute carrier family 22 member 6

multiple interactions

Fluorescein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier organic anion transporter family member 1B2

increases uptake
multiple interactions

SLCO1B3 protein results in increased uptake of Fluorescein
bisphenol A inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; bisphenol F promotes the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; Probenecid inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]; tetrabromobisphenol A inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein]

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

solute carrier organic anion transporter family, member 3a1

increases uptake
multiple interactions

SLCO3A1 protein results in increased uptake of Fluorescein
Cyclosporine promotes the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]; simvastatin acid affects the reaction [SLCO3A1 protein results in increased uptake of Fluorescein]

NCBI chr 1:128,106,232...128,388,043
Ensembl chr 1:128,106,228...128,387,925

fluorescein 5-isothiocyanate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 7

affects binding

Fluorescein-5-isothiocyanate binds to ABCB7 protein

NCBI chr X:69,295,598...69,436,775
Ensembl chr X:69,295,552...69,436,858

G

aldo-keto reductase family 1, member C2

increases expression

Fluorescein-5-isothiocyanate results in increased expression of AKR1C2 mRNA

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

annexin A4

affects binding

Fluorescein-5-isothiocyanate binds to ANXA4 protein

NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161

G

Rho GTPase activating protein 6

affects binding

Fluorescein-5-isothiocyanate binds to ARHGAP6 protein

NCBI chr X:24,953,464...25,490,003
Ensembl chr X:24,953,464...25,488,663

G

5-azacytidine induced 2

affects binding

Fluorescein-5-isothiocyanate binds to AZI2 protein

NCBI chr 8:117,773,248...117,797,844
Ensembl chr 8:117,773,279...117,797,847

G

capping actin protein of muscle Z-line subunit beta

affects binding

Fluorescein-5-isothiocyanate binds to CAPZB protein

NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409

G

CD109 molecule

affects binding

Fluorescein-5-isothiocyanate binds to CD109 protein

NCBI chr 8:79,454,480...79,569,195
Ensembl chr 8:79,454,480...79,569,194

G

CD180 molecule

affects binding

Fluorescein-5-isothiocyanate binds to CD180 protein

NCBI chr 2:33,855,940...33,870,046
Ensembl chr 2:33,855,991...33,899,936

G

CD86 molecule

increases expression

Fluorescein-5-isothiocyanate results in increased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

CD93 molecule

affects binding

Fluorescein-5-isothiocyanate binds to CD93 protein

NCBI chr 3:135,891,859...135,898,378
Ensembl chr 3:135,891,859...135,898,378

G

cell division cycle 20

affects binding

Fluorescein-5-isothiocyanate binds to CDC20 protein

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

COPI coat complex subunit alpha

affects binding

Fluorescein-5-isothiocyanate binds to COPA protein

NCBI chr13:84,546,483...84,586,879
Ensembl chr13:84,545,943...84,586,874

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

Fluorescein-5-isothiocyanate results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

DDB1 and CUL4 associated factor 4

affects binding

Fluorescein-5-isothiocyanate binds to DCAF4 protein

NCBI chr 6:103,154,847...103,180,992
Ensembl chr 6:103,154,867...103,180,982

G

DOT1 like histone lysine methyltransferase

affects binding

Fluorescein-5-isothiocyanate binds to DOT1L protein

NCBI chr 7:8,918,764...8,959,474
Ensembl chr 7:8,917,786...8,956,475

G

elaC ribonuclease Z 1

affects binding

Fluorescein-5-isothiocyanate binds to ELAC1 protein

NCBI chr18:67,321,231...67,341,358
Ensembl chr18:67,323,583...67,340,936

G

ectonucleotide pyrophosphatase/phosphodiesterase 7

affects binding

Fluorescein-5-isothiocyanate binds to ENPP7 protein

NCBI chr10:104,242,169...104,247,185
Ensembl chr10:104,242,223...104,246,589

G

fibronectin leucine rich transmembrane protein 3

affects binding

Fluorescein-5-isothiocyanate binds to FLRT3 protein

NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841

G

fibronectin 1

affects binding

Fluorescein-5-isothiocyanate binds to FN1 protein

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

heme oxygenase 1

increases expression
multiple interactions

Fluorescein-5-isothiocyanate results in increased expression of HMOX1 protein
[Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 5

affects binding

Fluorescein-5-isothiocyanate binds to HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 9

affects binding

Fluorescein-5-isothiocyanate binds to HSPA9 protein

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

interferon gamma

multiple interactions

[Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein; [Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IFNG protein; [Fluorescein-5-isothiocyanate co-treated with tricaproin] results in increased secretion of IFNG protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein

PMID:29198882 PMID:36870414

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

inhibitor of nuclear factor kappa B kinase subunit beta

affects binding

Fluorescein-5-isothiocyanate binds to IKBKB protein

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

IKAROS family zinc finger 4

affects binding

Fluorescein-5-isothiocyanate binds to IKZF4 protein

NCBI chr 7:1,063,283...1,102,940
Ensembl chr 7:1,056,890...1,084,341

G

interleukin 17A

multiple interactions

[Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IL17A protein

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 17 receptor E

affects binding

Fluorescein-5-isothiocyanate binds to IL17RE protein

NCBI chr 4:146,604,547...146,618,206
Ensembl chr 4:146,605,526...146,618,206

G

interleukin 31 receptor A

affects binding

Fluorescein-5-isothiocyanate binds to IL31RA protein

NCBI chr 2:44,118,748...44,189,943
Ensembl chr 2:44,122,624...44,183,767

G

interleukin 4

multiple interactions
increases expression

[Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; [dibutyrylglycerol analog co-treated with Fluorescein-5-isothiocyanate] affects the secretion of IL4 protein; [Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IL4 protein; [Fluorescein-5-isothiocyanate co-treated with tricaproin] results in increased secretion of IL4 protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]]

PMID:27871981 PMID:29198882 PMID:36870414

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

Ly6/Plaur domain containing 3

affects binding

Fluorescein-5-isothiocyanate binds to LYPD3 protein

NCBI chr 1:80,226,449...80,230,901
Ensembl chr 1:80,226,449...80,230,901

G

MAF bZIP transcription factor F

increases expression

Fluorescein-5-isothiocyanate results in increased expression of MAFF mRNA

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

mitogen-activated protein kinase kinase kinase 20

affects binding

Fluorescein-5-isothiocyanate binds to MAP3K20 protein

NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK1 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK1 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK3 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK3 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK8 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation

Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK9 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

metallothionein 2A

increases expression

Fluorescein-5-isothiocyanate results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

myosin binding protein C1

affects binding

Fluorescein-5-isothiocyanate binds to MYBPC1 protein

NCBI chr 7:22,930,350...23,015,981
Ensembl chr 7:22,930,350...23,015,957

G

NFE2 like bZIP transcription factor 2

multiple interactions

[Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

Fluorescein-5-isothiocyanate results in increased expression of NQO1 mRNA
Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein
diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]]

PMID:20491607 PMID:27871981

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

phospholipase C, epsilon 1

affects binding

Fluorescein-5-isothiocyanate binds to PLCE1 protein

NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438

G

periostin

affects binding

Fluorescein-5-isothiocyanate binds to POSTN protein

NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099

G

PPARG related coactivator 1

affects binding

Fluorescein-5-isothiocyanate binds to PPRC1 protein

NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587

G

protein kinase C, beta

increases expression

Fluorescein-5-isothiocyanate results in increased expression of PRKCB protein

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

pleckstrin and Sec7 domain containing 4

affects binding

Fluorescein-5-isothiocyanate binds to PSD4 protein

NCBI chr 3:7,137,069...7,173,571
Ensembl chr 3:7,137,155...7,173,571

G

proteasome 26S subunit, non-ATPase 14

affects binding

Fluorescein-5-isothiocyanate binds to PSMD14 protein

NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein; Melatonin inhibits the reaction [[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

sodium voltage-gated channel alpha subunit 5

affects binding

Fluorescein-5-isothiocyanate binds to SCN5A protein

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

G

SKI family transcriptional corepressor 1

affects binding

Fluorescein-5-isothiocyanate binds to SKOR1 protein

NCBI chr 8:63,599,153...63,609,727
Ensembl chr 8:63,599,165...63,607,756

G

solute carrier family 10 member 1

multiple interactions
increases uptake

Taurocholic Acid promotes the reaction [SLC10A1 protein results in increased uptake of Fluorescein-5-isothiocyanate]

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 38, member 10

affects binding

Fluorescein-5-isothiocyanate binds to SLC38A10 protein

NCBI chr10:105,386,836...105,436,636
Ensembl chr10:105,386,836...105,436,636

G

signal transducer and activator of transcription 3

multiple interactions
increases phosphorylation

diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 5A

multiple interactions
increases phosphorylation

diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]]

NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866

G

signal transducer and activator of transcription 6

increases phosphorylation
multiple interactions

Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]]

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

transient receptor potential cation channel, subfamily A, member 1

affects binding

Fluorescein-5-isothiocyanate binds to TRPA1 protein

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

thymic stromal lymphopoietin

increases expression
multiple interactions

Fluorescein-5-isothiocyanate results in increased expression of TSLP protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]]

NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548

G

thioredoxin 1

increases expression

Fluorescein-5-isothiocyanate results in increased expression of TXN mRNA

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

ubiquitin specific peptidase 3

affects binding

Fluorescein-5-isothiocyanate binds to USP3 protein

NCBI chr 8:67,078,249...67,154,109
Ensembl chr 8:67,079,927...67,154,111

gadobutrol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

decreases expression

gadobutrol results in decreased expression of ADIPOQ mRNA

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

fatty acid binding protein 4

decreases expression

gadobutrol results in decreased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

peroxisome proliferator-activated receptor gamma

decreases expression

gadobutrol results in decreased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

gadodiamide hydrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

decreases expression

gadodiamide results in decreased expression of ADIPOQ mRNA; gadodiamide results in decreased expression of ADIPOQ protein

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions

gadodiamide results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 1 family, member A1

increases expression

gadodiamide results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

ankyrin repeat domain 22

increases expression

gadodiamide results in increased expression of ANKRD22 mRNA

NCBI chr 1:231,639,035...231,670,537
Ensembl chr 1:231,639,314...231,670,381

G

ATM serine/threonine kinase

increases expression

gadodiamide results in increased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase phospholipid transporting 8B1

increases expression

gadodiamide results in increased expression of ATP8B1 mRNA

NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396

G

C-C motif chemokine ligand 2

increases expression
increases secretion

gadodiamide results in increased expression of CCL2 mRNA
gadodiamide results in increased expression of CCL2 mRNA; gadodiamide results in increased expression of CCL2 protein
gadodiamide results in increased secretion of CCL2 protein

PMID:20938346 PMID:20959327

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 4

increases expression

gadodiamide results in increased expression of CCL4 protein

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 7

increases expression

gadodiamide results in increased expression of CCL7 protein

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

centrosomal protein 15

increases expression

gadodiamide results in increased expression of CEP15 mRNA

NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838