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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-tyrosine
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Accession:CHEBI:17895 term browser browse the term
Definition:An optically active form of tyrosine having L-configuration.
Synonyms:related_synonym: (-)-alpha-amino-p-hydroxyhydrocinnamic acid;   (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid;   (S)-2-Amino-3-(p-hydroxyphenyl)propionic acid;   (S)-3-(p-Hydroxyphenyl)alanine;   (S)-Tyrosine;   (S)-alpha-amino-4-hydroxybenzenepropanoic acid;   4-hydroxy-L-phenylalanine;   Formula=C9H11NO3;   InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1;   InChIKey=OUYCCCASQSFEME-QMMMGPOBSA-N;   L-Tyrosin;   SMILES=N[C@@H](Cc1ccc(O)cc1)C(O)=O;   Tyr;   Tyrosine;   Y
 alt_id: CHEBI:13181;   CHEBI:21411;   CHEBI:46070;   CHEBI:46161;   CHEBI:6313
 xref: CAS:60-18-4;   DrugBank:DB00135;   Drug_Central:2786;   ECMDB:ECMDB00158;   Gmelin:50929;   HMDB:HMDB0000158;   KEGG:C00082;   KEGG:D00022;   KNApSAcK:C00001397;   MetaCyc:TYR;   PDBeChem:TYR;   PMID:15171683;   PMID:22360849;   PMID:22402312;   Reaxys:392441;   UM-BBD_compID:c0234;   Wikipedia:Tyrosine;   YMDB:YMDB00364
 cyclic_relationship: is_conjugate_acid_of CHEBI:32760;   is_conjugate_base_of CHEBI:32762;   is_enantiomer_of CHEBI:28479;   is_tautomer_of CHEBI:58315


show annotations for term's descendants           Sort by:
alpha-methyl-L-dopa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation
decreases activity		 ISO COMT protein results in increased methylation of Methyldopa
Methyldopa results in decreased activity of COMT protein		 CTD PMID:7053299 PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTA1 protein CTD PMID:8131222 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTM1 protein CTD PMID:8131222 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTP1 protein CTD PMID:8131222 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Prl prolactin increases expression
increases secretion		 ISO Methyldopa results in increased expression of PRL protein
Methyldopa results in increased secretion of PRL protein		 CTD PMID:1867878 PMID:7265421 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Ren renin decreases activity EXP Methyldopa results in decreased activity of REN protein CTD PMID:145319 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
Leu-enkephalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp3 dipeptidylpeptidase 3 increases cleavage
multiple interactions		 ISO DPP3 protein results in increased cleavage of Enkephalin, Leucine
spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]		 CTD PMID:10873616 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541 		JBrowse link
G Oprd1 opioid receptor, delta 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRD1 protein CTD PMID:26476280 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRM1 protein CTD PMID:26476280 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
maculosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of BAX protein] CTD PMID:34726822 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 protein] CTD PMID:34726822 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 mRNA]; maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of CASP3 protein] CTD PMID:34726822 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein] CTD PMID:34726822 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased activity of GSR protein] CTD PMID:34726822 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein modified form] CTD PMID:34726822 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein] CTD PMID:34726822 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 mRNA]; maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 protein] CTD PMID:34726822 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      application 19714
        pharmaceutical 19550
          drug 19550
            nutraceutical 13381
              L-tyrosine 17
                (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate 0
                Ala-Gly-Tyr 0
                Ala-Met-Asp-Tyr 0
                Ala-Tyr 0
                Ala-Val-Asp-Tyr 0
                Arg-Trp-Ser-Tyr 0
                Asn-Tyr 0
                Asp-Phe-Val-Tyr 0
                Asp-Tyr 0
                Cys-Met-Thr-Tyr 0
                DON-10-tyrosine 0
                Gln-Phe-Trp-Tyr 0
                Gln-Phe-Tyr 0
                Gln-Tyr 0
                Glu-Thr-Thr-Tyr 0
                Glu-Tyr 0
                Glu-Val-Thr-Leu-Tyr peptide residue 0
                Gly-Tyr 0
                Ile-Leu-Val-Tyr 0
                L-tyrosin-O(4)-yl group 0
                L-tyrosine derivative + 6
                L-tyrosine residue + 0
                L-tyrosine-d4 0
                L-tyrosino group 0
                L-tyrosinyl radical + 0
                L-tyrosinyl radical cation + 0
                L-tyrosyl group + 0
                Leu-Asp-Tyr 0
                Leu-Leu-Tyr 0
                Leu-Pro-Tyr 0
                Leu-Ser-Ser-Tyr 0
                Leu-Tyr 0
                Leu-enkephalin 3
                Lys-Asp-Tyr 0
                Lys-Thr-Trp-Tyr 0
                Lys-Tyr 0
                Lys-Tyr-Glu 0
                Met-Tyr 0
                Met-enkephalin 0
                Phe-Tyr 0
                Phe-Tyr-Asp 0
                Ser-Tyr 0
                Thr-Pro-Tyr 0
                Thr-Tyr 0
                Tyr-Asn 0
                Tyr-Asp 0
                Tyr-Cys 0
                Tyr-FMDP 0
                Tyr-His 0
                Tyr-Ile-Leu 0
                Tyr-Pro 0
                Tyr-Ser 0
                Tyr-Thr 0
                Val-Tyr 0
                gamma-Glu-Tyr 0
                maculosin 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  carbon oxoacid 18675
                                    carboxylic acid 18672
                                      carboacyl group 17712
                                        univalent carboacyl group 17712
                                          formyl group 9052
                                            aldehyde 9052
                                              amino aldehyde 692
                                                L-tyrosinal 17
                                                  L-tyrosine 17
                                                    (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate 0
                                                    Ala-Gly-Tyr 0
                                                    Ala-Met-Asp-Tyr 0
                                                    Ala-Tyr 0
                                                    Ala-Val-Asp-Tyr 0
                                                    Arg-Trp-Ser-Tyr 0
                                                    Asn-Tyr 0
                                                    Asp-Phe-Val-Tyr 0
                                                    Asp-Tyr 0
                                                    Cys-Met-Thr-Tyr 0
                                                    DON-10-tyrosine 0
                                                    Gln-Phe-Trp-Tyr 0
                                                    Gln-Phe-Tyr 0
                                                    Gln-Tyr 0
                                                    Glu-Thr-Thr-Tyr 0
                                                    Glu-Tyr 0
                                                    Glu-Val-Thr-Leu-Tyr peptide residue 0
                                                    Gly-Tyr 0
                                                    Ile-Leu-Val-Tyr 0
                                                    L-tyrosin-O(4)-yl group 0
                                                    L-tyrosine derivative + 6
                                                    L-tyrosine residue + 0
                                                    L-tyrosine-d4 0
                                                    L-tyrosino group 0
                                                    L-tyrosinyl radical + 0
                                                    L-tyrosinyl radical cation + 0
                                                    L-tyrosyl group + 0
                                                    Leu-Asp-Tyr 0
                                                    Leu-Leu-Tyr 0
                                                    Leu-Pro-Tyr 0
                                                    Leu-Ser-Ser-Tyr 0
                                                    Leu-Tyr 0
                                                    Leu-enkephalin 3
                                                    Lys-Asp-Tyr 0
                                                    Lys-Thr-Trp-Tyr 0
                                                    Lys-Tyr 0
                                                    Lys-Tyr-Glu 0
                                                    Met-Tyr 0
                                                    Met-enkephalin 0
                                                    Phe-Tyr 0
                                                    Phe-Tyr-Asp 0
                                                    Ser-Tyr 0
                                                    Thr-Pro-Tyr 0
                                                    Thr-Tyr 0
                                                    Tyr-Asn 0
                                                    Tyr-Asp 0
                                                    Tyr-Cys 0
                                                    Tyr-FMDP 0
                                                    Tyr-His 0
                                                    Tyr-Ile-Leu 0
                                                    Tyr-Pro 0
                                                    Tyr-Ser 0
                                                    Tyr-Thr 0
                                                    Val-Tyr 0
                                                    gamma-Glu-Tyr 0
                                                    maculosin 8
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