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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-Solamarine
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Accession:CHEBI:172847 term browser browse the term
Synonyms:exact_synonym: (2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-5-hydroxy-6-(hydroxymethyl)-2-[(1S,2S,4S,5'S,6S,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-piperidine]-16-yl]oxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol
 related_synonym: Formula=C45H73NO16;   InChI=1S/C45H73NO16/c1-19-8-13-45(46-16-19)20(2)30-27(62-45)15-26-24-7-6-22-14-23(9-11-43(22,4)25(24)10-12-44(26,30)5)57-42-39(61-40-36(54)34(52)31(49)21(3)56-40)38(33(51)29(18-48)59-42)60-41-37(55)35(53)32(50)28(17-47)58-41/h6,19-21,23-42,46-55H,7-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27-,28+,29+,30-,31-,32+,33-,34+,35-,36+,37+,38-,39+,40-,41-,42+,43-,44-,45-/m0/s1;   InChIKey=QCTMYNGDIBTNSK-AQZQQWEISA-N;   SMILES=O1[C@@]2([C@@]([C@@]3([C@]([C@]4([C@](CC3)([C@@]5(C(=CC4)C[C@@H](O[C@@H]6O[C@@H]([C@H](O)[C@H](O[C@@H]7O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)CO)[C@H]6O[C@@H]8O[C@H]([C@H](O)[C@@H](O)[C@H]8O)C)CO)CC5)C)[H])[H])(C2)[H])C)([C@@H]([C@@]19NC[C@H](CC9)C)C)[H])[H]
 xref: CAS:20318-30-3;   Chemspider:32697914
 xref_mesh: MESH:C026608


show annotations for term's descendants           Sort by:
alpha-Solamarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of BAD mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of BAD protein] CTD PMID:35350913 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of BCL2L1 mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of BCL2L1 protein] CTD PMID:35350913 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of BDNF protein] CTD PMID:35350913 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in increased cleavage of CASP3 protein]; alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of CASP3 mRNA] CTD PMID:35350913 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of CREB1 protein] CTD PMID:35350913 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of DLG4 protein] CTD PMID:35350913 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of and affects the localization of FOXO3 protein]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of FOXO3 protein] CTD PMID:35350913 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of GCLC protein] CTD PMID:35350913 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of GCLM mRNA] CTD PMID:35350913 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of HMGB1 mRNA] CTD PMID:35350913 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of HMOX1 mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of HMOX1 protein] CTD PMID:35350913 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of IL1B mRNA] CTD PMID:35350913 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of NQO1 mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of NQO1 protein] CTD PMID:35350913 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased phosphorylation of NTRK2 protein] CTD PMID:35350913 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Prrx1 paired related homeobox 1 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of PRRX1 protein] CTD PMID:35350913 NCBI chr13:75,600,777...75,671,896
Ensembl chr13:75,601,706...75,670,866 		JBrowse link
G Sypl1 synaptophysin-like 1 multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of SYPL1 protein] CTD PMID:35350913 NCBI chr 6:49,565,111...49,585,205
Ensembl chr 6:49,565,154...49,585,330 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of TNF mRNA] CTD PMID:35350913 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          metabolite 19484
            saponin 486
              steroid saponin 358
                alpha-Solamarine 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbohydrates and carbohydrate derivatives 15270
                                    carbohydrate 15270
                                      carbohydrate derivative 14278
                                        glycosyl compound 13035
                                          glycoside 11818
                                            saponin 486
                                              steroid saponin 358
                                                alpha-Solamarine 17
paths to the root