Lep (leptin) - Rat Genome Database

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Gene: Lep (leptin) Rattus norvegicus
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Symbol: Lep
Name: leptin
RGD ID: 3000
Description: Enables hormone activity and peptide hormone receptor binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of metabolic process; and regulation of apoptotic process. Located in cytosol and extracellular space. Used to study several diseases, including alcohol dependence; glucose metabolism disease (multiple); liver disease (multiple); neurodegenerative disease (multiple); and short bowel syndrome. Biomarker of several diseases, including Huntington's disease; alcohol dependence; lipid metabolism disorder (multiple); liver disease (multiple); and obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin); PARTICIPATES IN energy homeostasis pathway; leptin system pathway; hypoxia inducible factor pathway; INTERACTS WITH (+)-catechin; (+)-taxifolin; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: OB; obese; obesity (murine homolog leptin); obesity factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Lepem5Mcwi ; Lepm1Kyo ; Lepem1Sage ; Lepem1
Genetic Models: SD-Lepem1 ; SS-Lepem5Mcwi ; SD-Lepem1Sage-/- ; SD-Lepem1Sage+/- ; W.F344-Lepm1Kyo ; F344-Lepm1Kyo
Is Marker For: Strains:   F344-Lepm1Kyo ; SD-Lepem1Narl
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,626,529 - 58,640,663 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl458,626,523 - 58,640,661 (+)EnsemblGRCr8
mRatBN7.2457,661,127 - 57,675,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl457,661,131 - 57,675,262 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx462,644,034 - 62,658,181 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0458,559,814 - 58,573,975 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0456,962,087 - 56,976,240 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0456,337,695 - 56,351,818 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,337,695 - 56,351,818 (+)Ensemblrn6Rnor6.0
Rnor_5.0456,085,079 - 56,099,209 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4455,943,837 - 55,945,938 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera452,770,132 - 52,784,148 (+)NCBICelera
RGSC_v3.1456,185,364 - 56,197,221 (+)NCBI
RH 3.4 Map4309.5RGD
Cytogenetic Map4q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISS)
abdominal obesity-metabolic syndrome 1  (ISS)
acute pancreatitis  (IEP)
acute promyelocytic leukemia  (ISO)
adult respiratory distress syndrome  (ISO)
alcohol dependence  (IDA,IEP,ISO)
alcoholic liver cirrhosis  (IDA)
Alzheimer's disease  (IDA,ISO)
asthma  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
bacterial pneumonia  (ISO)
Body Weight Changes  (IMP)
Brain Injuries  (IEP)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Cardiomegaly  (ISO)
Choroidal Neovascularization  (IEP)
Chronic Hepatitis C  (IEP)
chronic obstructive pulmonary disease  (ISO)
Colonic Neoplasms  (ISO)
congenital leptin deficiency  (ISO)
congestive heart failure  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
Dyslipidemias  (IEP)
End Stage Liver Disease  (IEP)
end stage renal disease  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (IDA,IMP,ISO)
Experimental Liver Cirrhosis  (IMP,ISO)
Experimental Mammary Neoplasms  (IEP)
familial hyperlipidemia  (IEP)
Female Infertility  (ISO)
Femoral Fractures  (IEP)
Fetal Growth Retardation  (IDA)
gastric ulcer  (ISO)
gestational diabetes  (ISO)
glucose intolerance  (IMP,ISO)
hepatocellular carcinoma  (IAGP,IEP)
hepatocellular clear cell carcinoma  (ISO)
Hepatomegaly  (ISO)
heroin dependence  (ISO)
Huntington's disease  (IEP)
Hypercapnia  (ISO)
Hypercholesterolemia  (IMP,ISO)
hyperglycemia  (ISO)
hyperinsulinism  (IMP,ISO)
Hyperphagia  (ISO)
Hyperplasia  (ISO)
hypertension  (IDA,ISO)
Hypertriglyceridemia  (IMP)
hypogonadism  (IDA,ISO)
Hypoventilation  (ISO)
Inflammation  (ISO)
Insulin Resistance  (IEP,IMP,ISO)
Kidney Reperfusion Injury  (IDA)
Knee Osteoarthritis  (ISO)
lipid metabolism disorder  (IEP)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO,ISS)
Metabolic Syndrome  (IEP,ISO)
morbid obesity  (ISO)
Myocardial Reperfusion Injury  (IEP)
Nerve Degeneration  (ISO)
obesity  (IDA,IEP,IMP,ISO,ISS)
obstructive sleep apnea  (ISO)
Oral Ulcer  (ISO)
osteoarthritis  (ISO)
osteoporosis  (IDA,IEP,ISO)
Parkinson's disease  (IDA)
Pneumococcal Pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
Polydipsia  (ISO)
Polyuria  (ISO)
pre-eclampsia  (IEP)
Prenatal Exposure Delayed Effects  (IEP)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IDA)
rhinitis  (ISO)
Sepsis  (IEP)
short bowel syndrome  (IDA)
Spinal Cord Injuries  (IEP)
steatotic liver disease  (IEP,ISO,ISS)
Tachycardia  (ISO)
type 2 diabetes mellitus  (IMP,ISO,ISS)
Ventricular Remodeling  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (EXP,ISO)
(S)-nicotine  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1,8-cineole  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrophenol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-amino-6-diazo-5-oxohexanoic acid  (ISO)
2-aminopurine  (ISO)
2-arachidonoylglycerol  (ISO)
2-deoxy-D-glucose  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methyl-4-chlorophenoxybutyric acid  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-aminobenzamide  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxybenzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (EXP)
AACOCF3  (ISO)
acarbose  (EXP)
acetaldehyde  (ISO)
acetylsalicylic acid  (EXP)
actinomycin D  (EXP)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
aldehydo-D-glucosamine 6-phosphate  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
allopurinol  (EXP)
alpha-Zearalanol  (EXP)
AM-251  (ISO)
Amibegron  (EXP)
amlodipine  (ISO)
ammonium chloride  (EXP)
anandamide  (ISO)
androst-4-ene-3,17-dione  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
apocynin  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (EXP,ISO)
atorvastatin calcium  (EXP)
ATP  (EXP)
Aurothioglucose  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
Bardoxolone methyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzyl parahydroxybenzoate  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
boron atom  (EXP)
BQ 123  (ISO)
bromodichloromethane  (ISO)
bucladesine  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
carbon nanotube  (ISO)
carvacrol  (EXP)
CCCP  (ISO)
cerulenin  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chlorohydrocarbon  (ISO)
chloroquine  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium atom  (EXP,ISO)
chrysin  (ISO)
cisplatin  (EXP)
clofibrate  (EXP,ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
conjugated linoleic acid  (ISO)
corn oil  (EXP)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP)
cyhalothrin  (EXP)
cyromazine  (EXP)
D-glucose  (EXP,ISO)
dantrolene  (EXP)
DDE  (ISO)
DDT  (ISO)
dehydroepiandrosterone  (EXP)
deoxycholic acid  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
diazoxide  (EXP)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
dibutylstannane  (ISO)
diethyl hydrogen phosphate  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diiodine  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
dipyridamole  (EXP)
disodium selenite  (ISO)
dobutamine  (ISO)
DPCPX  (EXP)
edelfosine  (ISO)
efavirenz  (ISO)
elemental boron  (EXP)
elemental selenium  (ISO)
Elemicin  (ISO)
enalapril  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
ethionamide  (EXP)
Ethyl icosapentate  (ISO)
ethylparaben  (ISO)
fenofibrate  (EXP,ISO)
fenoterol  (ISO)
fenvalerate  (EXP)
flufenamic acid  (ISO)
flutamide  (EXP)
fonofos  (ISO)
fructose  (EXP,ISO)
furan  (EXP)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
gemcitabine  (ISO)
gemfibrozil  (EXP)
genistein  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glycine  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
inulin  (EXP)
iodide salt  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
isoflavones  (EXP)
isoprenaline  (EXP,ISO)
isoscutellarein  (ISO)
isotretinoin  (EXP)
kaempferol  (ISO)
kainic acid  (ISO)
ketamine  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
lanthanum atom  (ISO)
lead(0)  (ISO)
Licarin A  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
loganin  (ISO)
lopinavir  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
mercury dichloride  (EXP,ISO)
metformin  (EXP,ISO)
methacholine chloride  (ISO)
methadone  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metronidazole  (ISO)
metyrapone  (EXP)
mevalonic acid  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (EXP,ISO)
morin  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naproxen  (EXP)
naringin  (EXP,ISO)
nelfinavir  (ISO)
neomycin  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nicotinic acid  (ISO)
nitric oxide  (ISO)
Nonylphenol  (ISO)
norwogonin  (ISO)
NS-398  (ISO)
olanzapine  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
omaveloxolone  (ISO)
orlistat  (EXP,ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
perindopril  (EXP)
permethrin  (ISO)
phencyclidine  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phloretin  (ISO)
phlorizin  (ISO)
phosphatidylcholine  (ISO)
phosphoramidon  (EXP)
pioglitazone  (EXP)
piperine  (EXP)
pirimicarb  (EXP)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
pluronic P-123  (EXP)
Poloxamer  (EXP)
potassium dichromate  (ISO)
pravastatin  (ISO)
prochloraz  (ISO)
progesterone  (ISO)
propranolol  (EXP,ISO)
propylparaben  (ISO)
prostaglandin E2  (EXP)
Ptaquiloside  (ISO)
Pyridostigmine bromide  (ISO)
pyruvic acid  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
ramipril  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
reserpine  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rimonabant  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
roxarsone  (ISO)
ruthenium red  (ISO)
rutin  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
saquinavir  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium perchlorate  (EXP)
Sophocarpine  (EXP)
stavudine  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
sumatriptan  (EXP)
superoxide  (ISO)
tauroursodeoxycholic acid  (ISO)
terbufos  (ISO)
terbutaline  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thenoyltrifluoroacetone  (ISO)
thioacetamide  (EXP,ISO)
thiram  (EXP)
titanium dioxide  (ISO)
triazophos  (EXP)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triflumizole  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
U-73122  (ISO)
ursolic acid  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
wogonin  (ISO)
wortmannin  (ISO)
xanthone  (EXP)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc molecular entity  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase C activity  (ISO,ISS)
adipose tissue development  (ISO)
adult feeding behavior  (IEA,ISO,ISS)
alcohol metabolic process  (IEA)
angiogenesis  (IEA,ISO)
aorta development  (ISO)
bile acid metabolic process  (ISO)
bone growth  (IEA,ISO,ISS)
bone mineralization involved in bone maturation  (IDA)
cardiac muscle hypertrophy  (IDA)
cell surface receptor signaling pathway via JAK-STAT  (IEA,ISO)
cell surface receptor signaling pathway via STAT  (IEA,ISO)
cellular response to insulin stimulus  (ISO)
cellular response to L-ascorbic acid  (IEP)
cellular response to leptin stimulus  (IEA,ISO)
cellular response to retinoic acid  (IEP)
central nervous system neuron development  (ISO)
cholesterol metabolic process  (ISO)
circadian rhythm  (IEP)
determination of adult lifespan  (ISO)
eating behavior  (ISO)
elastin metabolic process  (ISO)
energy homeostasis  (IEA,ISO)
energy reserve metabolic process  (IBA,IDA)
fatty acid beta-oxidation  (ISO)
fatty acid catabolic process  (IDA,IEA)
female pregnancy  (IEP)
glucose homeostasis  (ISO)
glucose metabolic process  (ISO)
glycerol biosynthetic process  (IDA)
hormone metabolic process  (ISO)
insulin secretion  (ISO)
intestinal absorption  (IEA,ISO,ISS)
intracellular signal transduction  (IDA,TAS)
leptin-mediated signaling pathway  (IDA,IEA,ISO)
leukocyte tethering or rolling  (IDA)
lipid metabolic process  (IBA,ISO)
negative regulation of apoptotic process  (IDA)
negative regulation of appetite  (IEA,ISO,ISS)
negative regulation of appetite by leptin-mediated signaling pathway  (IBA,IDA)
negative regulation of autophagy  (IEA,ISO,ISS)
negative regulation of cartilage development  (IDA)
negative regulation of D-glucose import across plasma membrane  (IEA,ISO,ISS)
negative regulation of glucagon secretion  (IEA,ISO)
negative regulation of glutamine transport  (IMP)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of lipid storage  (IDA)
negative regulation of metabolic process  (IDA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of transport  (IEA)
negative regulation of vasoconstriction  (IDA)
ovulation from ovarian follicle  (IDA)
phagocytosis  (IDA,IEA,ISO,ISS)
placenta development  (IEA,ISO)
positive regulation of cell population proliferation  (IDA)
positive regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
positive regulation of cytokine production  (IEP)
positive regulation of developmental growth  (IEA,ISO)
positive regulation of fat cell apoptotic process  (IDA)
positive regulation of follicle-stimulating hormone secretion  (IEP)
positive regulation of hepatic stellate cell activation  (IDA)
positive regulation of insulin receptor signaling pathway  (IDA)
positive regulation of interleukin-12 production  (IEA,ISO,ISS)
positive regulation of interleukin-6 production  (IEA,ISO,ISS)
positive regulation of interleukin-8 production  (IEA,ISO,ISS)
positive regulation of luteinizing hormone secretion  (IEP)
positive regulation of MAPK cascade  (IDA,IEA,ISO)
positive regulation of monoatomic ion transport  (IDA)
positive regulation of p38MAPK cascade  (IEA,ISO,ISS)
positive regulation of peroxisome proliferator activated receptor signaling pathway  (IDA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA,IEA,ISO,ISS)
positive regulation of protein import into nucleus  (IEA,ISO)
positive regulation of protein modification process  (IMP)
positive regulation of reactive oxygen species metabolic process  (IDA)
positive regulation of receptor signaling pathway via JAK-STAT  (IBA,IEA,IMP,ISO,ISS)
positive regulation of T cell proliferation  (IEA,ISO,ISS)
positive regulation of TOR signaling  (IEA,ISO,ISS)
positive regulation of tumor necrosis factor production  (IEA,ISO,ISS)
prostaglandin secretion  (IEA,ISO,ISS)
regulation of angiogenesis  (IEA,ISO,ISS)
regulation of blood pressure  (IDA)
regulation of bone remodeling  (IEA,ISO,ISS)
regulation of brown fat cell differentiation  (IEA,ISO,ISS)
regulation of catalytic activity  (ISO)
regulation of cell cycle  (IEA,ISO,ISS)
regulation of cytokine production involved in inflammatory response  (IEA,ISO,ISS)
regulation of endothelial cell proliferation  (IEA,ISO,ISS)
regulation of fat cell differentiation  (ISO)
regulation of gluconeogenesis  (ISO)
regulation of hormone secretion  (IEA)
regulation of insulin secretion  (ISO)
regulation of intestinal cholesterol absorption  (ISO)
regulation of lipid biosynthetic process  (ISO)
regulation of lipoprotein lipid oxidation  (IDA)
regulation of natural killer cell activation  (IEA,ISO,ISS)
regulation of natural killer cell mediated cytotoxicity  (IEA,ISO,ISS)
regulation of natural killer cell proliferation  (IEA,ISO,ISS)
regulation of nitric-oxide synthase activity  (ISO,ISS)
regulation of protein localization to nucleus  (ISO)
regulation of steroid biosynthetic process  (ISO)
response to activity  (IEP)
response to dietary excess  (IEA,IMP,ISO)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to hypoxia  (IEP)
response to insulin  (IBA,ISO)
response to nutrient  (IEP)
response to nutrient levels  (IEP)
response to vitamin E  (IEP)
signal transduction  (IEA)
T cell differentiation  (IEA,ISO,ISS)

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IDA)
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
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105. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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135. The polymorphism -2548G/A in leptin and severity of chronic obstructive pulmonary disease. Ye XW, etal., Int J Immunogenet. 2011 Feb;38(1):45-50. doi: 10.1111/j.1744-313X.2010.00968.x. Epub 2010 Sep 20.
136. Treatment of obesity hypoventilation syndrome and serum leptin. Yee BJ, etal., Respiration. 2006;73(2):209-12. Epub 2005 Sep 20.
137. Assessment of insulin sensitivity/resistance and their relations with leptin concentrations and anthropometric measures in a pregnant population with and without gestational diabetes mellitus. Yilmaz O, etal., J Diabetes Complications. 2009 Mar 6.
138. Adenovirus-mediated leptin expression normalises hypertension associated with diet-induced obesity. Zhang W, etal., J Neuroendocrinol. 2010 Mar;22(3):175-80. Epub 2010 Jan 5.
139. Propranolol Prevents Osteoporosis and up-regulates Leptin in Ovariectomized Rats. Zhang X, etal., Iran J Pharm Res. 2013 Summer;12(3):557-62.
140. A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Zhao AZ, etal., Nat Neurosci 2002 Aug;5(8):727-8.
141. Expression of leptin and its functional receptor on disc cells: contribution to cell proliferation. Zhao CQ, etal., Spine (Phila Pa 1976). 2008 Nov 1;33(23):E858-64.
142. The effect of di-2-ethylhexyl phthalate on inflammation and lipid metabolic disorder in rats. Zhou L, etal., Ecotoxicol Environ Saf. 2019 Apr 15;170:391-398. doi: 10.1016/j.ecoenv.2018.12.009. Epub 2018 Dec 11.
143. Effects of energy restriction and wheel running on mammary carcinogenesis and host systemic factors in a rat model. Zhu Z, etal., Cancer Prev Res (Phila). 2012 Mar;5(3):414-22. doi: 10.1158/1940-6207.CAPR-11-0454. Epub 2012 Jan 13.
Additional References at PubMed
PMID:7657834   PMID:7733988   PMID:7794258   PMID:8589726   PMID:8607798   PMID:9732873   PMID:10592285   PMID:10660043   PMID:10742101   PMID:10802666   PMID:11068878   PMID:11387233  
PMID:11460888   PMID:11803578   PMID:11830177   PMID:11853868   PMID:11880274   PMID:11883944   PMID:11934674   PMID:11960027   PMID:12021059   PMID:12033496   PMID:12060569   PMID:12093446  
PMID:12114517   PMID:12177191   PMID:12226142   PMID:12364559   PMID:12372004   PMID:12385894   PMID:12433965   PMID:12467652   PMID:12504075   PMID:12521924   PMID:12540597   PMID:12540600  
PMID:12573803   PMID:12619866   PMID:12660872   PMID:12660883   PMID:12702488   PMID:12704794   PMID:12736159   PMID:12810558   PMID:12815040   PMID:12829630   PMID:12865257   PMID:12925742  
PMID:12928006   PMID:12933650   PMID:12958061   PMID:12959975   PMID:14576185   PMID:14592417   PMID:14605003   PMID:14688445   PMID:14709837   PMID:14711457   PMID:14715713   PMID:14732484  
PMID:14747284   PMID:14993217   PMID:14993225   PMID:15044184   PMID:15059958   PMID:15081399   PMID:15280541   PMID:15292470   PMID:15304210   PMID:15304373   PMID:15322334   PMID:15331383  
PMID:15381111   PMID:15388782   PMID:15389880   PMID:15449734   PMID:15473134   PMID:15475485   PMID:15498885   PMID:15500001   PMID:15572209   PMID:15572849   PMID:15582724   PMID:15590268  
PMID:15679864   PMID:15687408   PMID:15717845   PMID:15721267   PMID:15727948   PMID:15731403   PMID:15741239   PMID:15742403   PMID:15746250   PMID:15746256   PMID:15798949   PMID:15845621  
PMID:15899045   PMID:15905318   PMID:15955812   PMID:15995171   PMID:16046456   PMID:16092054   PMID:16125533   PMID:16141392   PMID:16144736   PMID:16166199   PMID:16180331   PMID:16195403  
PMID:16203737   PMID:16210420   PMID:16238463   PMID:16321456   PMID:16328017   PMID:16330326   PMID:16339207   PMID:16343770   PMID:16403782   PMID:16413128   PMID:16443671   PMID:16455789  
PMID:16457907   PMID:16513828   PMID:16553787   PMID:16604086   PMID:16627588   PMID:16718624   PMID:16825198   PMID:16914228   PMID:16950545   PMID:16964413   PMID:16965293   PMID:16988073  
PMID:17023527   PMID:17038325   PMID:17038553   PMID:17038557   PMID:17085442   PMID:17093945   PMID:17170237   PMID:17194747   PMID:17220191   PMID:17268854   PMID:17273787   PMID:17280591  
PMID:17303662   PMID:17303663   PMID:17318810   PMID:17321040   PMID:17344214   PMID:17355316   PMID:17356529   PMID:17363621   PMID:17419800   PMID:17433256   PMID:17453686   PMID:17481674  
PMID:17495032   PMID:17562852   PMID:17565119   PMID:17595338   PMID:17610413   PMID:17669377   PMID:17693256   PMID:17957153   PMID:17974623   PMID:17991727   PMID:17992637   PMID:18006472  
PMID:18006626   PMID:18063139   PMID:18063686   PMID:18096657   PMID:18097472   PMID:18155694   PMID:18176912   PMID:18178314   PMID:18179777   PMID:18191822   PMID:18197581   PMID:18210329  
PMID:18296272   PMID:18310448   PMID:18367451   PMID:18401831   PMID:18458326   PMID:18468410   PMID:18516053   PMID:18535786   PMID:18556346   PMID:18568952   PMID:18587446   PMID:18588949  
PMID:18665796   PMID:18669592   PMID:18719678   PMID:18924245   PMID:19000372   PMID:19011998   PMID:19020290   PMID:19084046   PMID:19103999   PMID:19127349   PMID:19139561   PMID:19158409  
PMID:19179437   PMID:19224154   PMID:19276673   PMID:19372589   PMID:19386920   PMID:19390347   PMID:19391127   PMID:19403617   PMID:19539991   PMID:19591986   PMID:19633450   PMID:19671839  
PMID:19688109   PMID:19709655   PMID:19728324   PMID:19876773   PMID:19877509   PMID:19887391   PMID:19888448   PMID:19910644   PMID:19940076   PMID:20036647   PMID:20067107   PMID:20094971  
PMID:20226796   PMID:20307649   PMID:20385158   PMID:20412389   PMID:20541607   PMID:20584107   PMID:20620997   PMID:20668022   PMID:20668029   PMID:20731748   PMID:20838752   PMID:20952387  
PMID:20960110   PMID:21059361   PMID:21141565   PMID:21158112   PMID:21234744   PMID:21239630   PMID:21255014   PMID:21257164   PMID:21270124   PMID:21304902   PMID:21334429   PMID:21340571  
PMID:21378499   PMID:21418127   PMID:21512961   PMID:21544068   PMID:21557150   PMID:21607623   PMID:21771332   PMID:21777028   PMID:22033902   PMID:22115950   PMID:22133515   PMID:22210233  
PMID:22253420   PMID:22372349   PMID:22374757   PMID:22459287   PMID:22610169   PMID:22638834   PMID:22645452   PMID:22653842   PMID:22751689   PMID:22773379   PMID:22927639   PMID:22956308  
PMID:22958918   PMID:22967108   PMID:22982569   PMID:22995391   PMID:23056516   PMID:23064363   PMID:23093703   PMID:23129112   PMID:23172699   PMID:23201827   PMID:23211513   PMID:23264212  
PMID:23413430   PMID:23418591   PMID:23506735   PMID:23506793   PMID:23525184   PMID:23535030   PMID:23544111   PMID:23576026   PMID:23579487   PMID:23669042   PMID:23724144   PMID:23782941  
PMID:23825665   PMID:23936817   PMID:24007473   PMID:24026073   PMID:24039946   PMID:24063596   PMID:24100028   PMID:24184591   PMID:24239717   PMID:24243000   PMID:24243887   PMID:24340098  
PMID:24361011   PMID:24446159   PMID:24467741   PMID:24495350   PMID:24498181   PMID:24499246   PMID:24561183   PMID:24662007   PMID:24787748   PMID:24913911   PMID:24926823   PMID:25001932  
PMID:25060689   PMID:25065280   PMID:25205242   PMID:25260611   PMID:25330951   PMID:25398524   PMID:25561025   PMID:25575055   PMID:25583546   PMID:25645057   PMID:25722014   PMID:25793389  
PMID:25797953   PMID:25833759   PMID:25846408   PMID:25935421   PMID:25979360   PMID:25981175   PMID:26017929   PMID:26122392   PMID:26496899   PMID:26506851   PMID:26529250   PMID:26538454  
PMID:26676252   PMID:26731409   PMID:26751999   PMID:26780438   PMID:26846568   PMID:26907996   PMID:26982498   PMID:27037668   PMID:27222924   PMID:27378381   PMID:27534878   PMID:27623562  
PMID:27629888   PMID:27751931   PMID:27827305   PMID:27923787   PMID:27923809   PMID:28069950   PMID:28097455   PMID:28112679   PMID:28179125   PMID:28276709   PMID:28407241   PMID:28407664  
PMID:28627582   PMID:28677772   PMID:28759941   PMID:28797891   PMID:28877872   PMID:28957383   PMID:29044801   PMID:29241183   PMID:29254298   PMID:29294325   PMID:29519872   PMID:29568885  
PMID:29849871   PMID:30019195   PMID:30206280   PMID:30311938   PMID:30424542   PMID:31077169   PMID:31222048   PMID:31306448   PMID:31708912   PMID:31840160   PMID:32127397   PMID:32149734  
PMID:32840013   PMID:33352624   PMID:33396616   PMID:33431976   PMID:33799501   PMID:34121590   PMID:34717752   PMID:34830465   PMID:35806240   PMID:37769981   PMID:38442503  


Genomics

Comparative Map Data
Lep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,626,529 - 58,640,663 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl458,626,523 - 58,640,661 (+)EnsemblGRCr8
mRatBN7.2457,661,127 - 57,675,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl457,661,131 - 57,675,262 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx462,644,034 - 62,658,181 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0458,559,814 - 58,573,975 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0456,962,087 - 56,976,240 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0456,337,695 - 56,351,818 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,337,695 - 56,351,818 (+)Ensemblrn6Rnor6.0
Rnor_5.0456,085,079 - 56,099,209 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4455,943,837 - 55,945,938 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera452,770,132 - 52,784,148 (+)NCBICelera
RGSC_v3.1456,185,364 - 56,197,221 (+)NCBI
RH 3.4 Map4309.5RGD
Cytogenetic Map4q22NCBI
LEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387128,241,278 - 128,257,629 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7128,241,278 - 128,257,629 (+)Ensemblhg38GRCh38
GRCh377127,881,331 - 127,897,682 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367127,668,567 - 127,684,917 (+)NCBIBuild 36Build 36hg18NCBI36
Build 347127,475,281 - 127,491,632NCBI
Celera7122,684,619 - 122,700,967 (+)NCBICelera
Cytogenetic Map7q32.1NCBI
HuRef7122,242,298 - 122,258,647 (+)NCBIHuRef
CHM1_17127,814,632 - 127,830,980 (+)NCBICHM1_1
T2T-CHM13v2.07129,552,743 - 129,569,093 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27127,264,455 - 127,280,803 (+)NCBI
Lep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39629,060,220 - 29,073,875 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl629,060,219 - 29,073,876 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38629,060,221 - 29,073,876 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,060,220 - 29,073,877 (+)Ensemblmm10GRCm38
MGSCv37629,010,221 - 29,023,876 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36629,010,231 - 29,023,886 (+)NCBIMGSCv36mm8
Celera629,063,769 - 29,077,429 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.3NCBI
Lep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554799,274,516 - 9,279,472 (+)Ensembl
ChiLan1.0NW_0049554799,266,604 - 9,276,568 (+)NCBIChiLan1.0ChiLan1.0
LEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26165,095,350 - 165,111,990 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1717,116,521 - 17,122,242 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07120,230,896 - 120,248,602 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17132,884,994 - 132,901,519 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7132,885,011 - 132,901,519 (+)EnsemblpanPan2panpan1.1
LEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,115,396 - 8,130,946 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,116,122 - 8,131,395 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha147,802,696 - 7,807,108 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0147,880,580 - 7,897,895 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl147,883,040 - 7,897,890 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1148,087,574 - 8,091,986 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0147,828,397 - 7,832,809 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0147,975,126 - 7,979,538 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511854,282,689 - 54,287,494 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647915,394,966 - 15,411,334 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647915,394,966 - 15,411,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1820,106,868 - 20,123,323 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11820,106,867 - 20,124,071 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21821,200,988 - 21,231,275 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12197,056,913 - 97,071,161 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2197,057,529 - 97,071,220 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660426,335,426 - 6,349,076 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247837,708,588 - 7,721,727 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247837,708,820 - 7,721,610 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lep
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16110,485,308 - 110,499,224 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lep
71 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:471
Count of miRNA genes:263
Interacting mature miRNAs:330
Transcripts:ENSRNOT00000071926
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41564430960644309Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42786220462997402Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat

Markers in Region
PMC21729P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2457,672,228 - 57,672,419 (+)MAPPERmRatBN7.2
Rnor_6.0456,348,785 - 56,348,975NCBIRnor6.0
Rnor_5.0456,096,176 - 56,096,366UniSTSRnor5.0
RGSC_v3.4455,945,637 - 55,945,827UniSTSRGSC3.4
Celera452,781,115 - 52,781,305UniSTS
Cytogenetic Map4q22UniSTS
RH94808  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2457,672,559 - 57,672,658 (+)MAPPERmRatBN7.2
Rnor_6.0456,349,116 - 56,349,214NCBIRnor6.0
Rnor_5.0456,096,507 - 56,096,605UniSTSRnor5.0
RGSC_v3.4455,945,968 - 55,946,066UniSTSRGSC3.4
Celera452,781,446 - 52,781,544UniSTS
RH 3.4 Map4309.5UniSTS
Cytogenetic Map4q22UniSTS
Lep  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,479,601 - 46,480,909 (+)MAPPERmRatBN7.2
Rnor_6.0850,477,430 - 50,478,737NCBIRnor6.0
Rnor_5.0849,103,749 - 49,105,056UniSTSRnor5.0
Celera846,061,659 - 46,062,966UniSTS
Cytogenetic Map4q22UniSTS
LEP-3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2457,670,569 - 57,672,217 (+)MAPPERmRatBN7.2
Rnor_6.0456,347,126 - 56,348,773NCBIRnor6.0
Rnor_5.0456,094,517 - 56,096,164UniSTSRnor5.0
RGSC_v3.4455,943,978 - 55,945,625UniSTSRGSC3.4
Celera452,779,456 - 52,781,103UniSTS
Cytogenetic Map4q22UniSTS


Related Rat Strains
The following Strains have been annotated to Lep
F344-Lepm1Kyo     SD-Lepem1Narl    


Genetic Models
This gene Lep is modified in the following models/strains:
SD-Lepem1     SS-Lepem5Mcwi     SD-Lepem1Sage-/-     SD-Lepem1Sage+/-     W.F344-Lepm1Kyo     F344-Lepm1Kyo    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 26 51 47 47 16 22 16 6 161 80 11 23 47 52 31 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000071926   ⟹   ENSRNOP00000066184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl458,626,523 - 58,640,661 (+)Ensembl
mRatBN7.2 Ensembl457,661,131 - 57,675,262 (+)Ensembl
Rnor_6.0 Ensembl456,337,695 - 56,351,818 (+)Ensembl
RefSeq Acc Id: NM_013076   ⟹   NP_037208
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,626,538 - 58,640,661 (+)NCBI
mRatBN7.2457,661,131 - 57,675,262 (+)NCBI
Rnor_6.0456,337,695 - 56,351,818 (+)NCBI
Rnor_5.0456,085,079 - 56,099,209 (+)NCBI
RGSC_v3.4455,943,837 - 55,945,938 (+)RGD
Celera452,770,132 - 52,784,148 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107126   ⟹   XP_038963054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,626,529 - 58,640,663 (+)NCBI
mRatBN7.2457,661,127 - 57,675,262 (+)NCBI
RefSeq Acc Id: NP_037208   ⟸   NM_013076
- Peptide Label: precursor
- UniProtKB: P50596 (UniProtKB/Swiss-Prot),   A6IEB6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066184   ⟸   ENSRNOT00000071926
RefSeq Acc Id: XP_038963054   ⟸   XM_039107126
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50596-F1-model_v2 AlphaFold P50596 1-167 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3000 AgrOrtholog
BioCyc Gene G2FUF-45408 BioCyc
Ensembl Genes ENSRNOG00000045797 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071926 ENTREZGENE
  ENSRNOT00000071926.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  Leptin UniProtKB/Swiss-Prot
KEGG Report rno:25608 UniProtKB/Swiss-Prot
NCBI Gene 25608 ENTREZGENE
PANTHER LEPTIN UniProtKB/Swiss-Prot
  PTHR11724 UniProtKB/Swiss-Prot
Pfam Leptin UniProtKB/Swiss-Prot
PharmGKB LEP RGD
PhenoGen Lep PhenoGen
PIRSF Leptin UniProtKB/Swiss-Prot
PRINTS LEPTIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000045797 RatGTEx
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A0A1C9CJH3_RAT UniProtKB/TrEMBL
  A6IEB6 ENTREZGENE, UniProtKB/TrEMBL
  LEP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Lep  leptin      Symbol and Name status set to approved 70586 APPROVED
2001-07-23 Lep  leptin      Name withdrawn 67952 WITHDRAWN
2001-07-23 Lep  leptin      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-06-26 Lep  leptin      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-06-26 Lep  Obesity (murine homolog, leptin)      Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_drugs cilostamide, a Pde3b inhibitor blocks inhibitory effect on food intake 625547
gene_expression produced by adipose tissues 625675
gene_expression higher expression in heterozygous (Fa/fa) than homozygous lean rats 625532
gene_expression expressed in the adipose tissues 625675
gene_function adipocyte-derived peptide hormone 625547
gene_function adipocyte-derived peptide hormone 625675
gene_function peptide hormone 625675
gene_mutations_overexpression high dosage increase the arterial pressure and heart rate 625675
gene_other change in levels may be directly linked to fa mutation in Zucker rats 625532
gene_other leptin resistance may involve attenuation of either the anorexic or energy expenditure response to leptin 625675
gene_pathway activates Jak-Stat pathway and phosphatidyl inositol 3-kinase (PI3K)-regulated phosphodiesterase 3B(PDE3B)-cyclic AMP (PI3K-PDE3B-cAMP) pathway 625547
gene_process involved in energy homeostasis 61790
gene_process may have a role in the inhibition of neuropeptideY/agouti-related protein neurons and activation of pro-opiomelanocortin/cocaine- and amphetamine regulated transcript neurons 61790
gene_process causes feeding inhibition through induction of PI3K, Pde3b activity and decreasing cAMP in hypothalamus 625547
gene_process infusion induces nitric oxide-mediated vasodilation in aortic and mesenteric arteries 625675
gene_process inhibits the ANG-II ( angiotensin II)-induced fast contractions in the endothelium-denuded aortic rings in Wistar rats 625675
gene_process acts in the signaling mechanism to control body fat 625675
gene_process leptin-induced leptin resistance was associated with persistent elevation in hypothalamic phosphorylated signal transducer and activator of transcription-3 (STAT3); curator note 625675
gene_process stimulates leukemic cell growth 729241
gene_process high dosage increase the arterial pressure and heart rate, infusion induces nitric oxide-mediated vasodilation in aortic and mesenteric arteries 625675
gene_regulation mRNA expression significantly increased in adipose cells from obese (fa/fa) compared to lean (Fa/fa) rat 625532
gene_regulation expression of mRNA is decreased by a fat pad specific vagotomy 625675
gene_regulation produced by the adipose tissues 625675