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Strain Registration

Strain: F344-Lepm1Kyo

Symbol: F344-Lepm1Kyo
Strain: F344-Lepm1
Substrain: Kyo
Full Name: F344 OB rat
RGD ID: 8549776
Citation ID: RRID:RGD_8549776
Ontology ID: RS:0003644
Alleles: Lepm1Kyo;   Lep
Also Known As: F344-Lepm1Kyo; F344 OB rat; NBRP Rat No: 0628; F344-Lep^[m1Kyo]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: Established by ENU mutagenesis in F344/NSlc rats. This strain has Lep missense mutation (Q92X).
Coat Color: albino
Inbred Generations: N10
Last Known Status: Live Animals (as of 2017-03-17)
Research Usage Diabetes Obesity
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2457,672,294 - 57,672,294RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0456,348,850 - 56,348,850RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0456,085,079 - 56,099,209RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4455,943,837 - 55,945,938RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver. Aizawa-Abe M, etal., Physiol Genomics. 2013 Sep 3;45(17):786-93. doi: 10.1152/physiolgenomics.00040.2013. Epub 2013 Jun 25.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Lepm1Kyo-var1 chr4 57672294 57672294 C T point_mutation mRatBN7.2
Lepm1Kyo-var1 chr4 56348850 56348850 C T point_mutation Rnor_6.0

Additional Information