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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3000
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lep
Name: leptin
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lepmultiple interactionsEXP 6480464CTD[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein; morin analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein]; Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein]PMID:24854284
Lepmultiple interactionsISOLep (Mus musculus)6480464CTD[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein; [Streptozocin co-treated with Dietary Fats] results in decreased expression of LEP protein; Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein]; Omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of LEP protein]PMID:29988851 PMID:32410268
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