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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3000
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lep
Name: leptin
Acc ID: CHEBI:50102
Term: N-methyl-N-nitrosourea
Definition: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.
Chemical ID: MESH:D008770
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lepincreases expressionISOLep (Mus musculus)6480464CTDMethylnitrosourea results in increased expression of LEP proteinPMID:16822543
Lepmultiple interactionsISOLep (Mus musculus)6480464CTDButylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]; Freund's Adjuvant inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]; IFNG protein inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein]PMID:16822543
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