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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3000
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lep
Name: leptin
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lepincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of LEP proteinPMID:17379010
Lepmultiple interactionsEXP 6480464CTDBezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein]; Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein]PMID:17379010 PMID:17621560
Lepdecreases expressionISOLep (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of LEP mRNAPMID:12057914
Lepincreases expressionISOLep (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of LEP mRNAPMID:12057914
Lepmultiple interactionsISOLEP (Homo sapiens)6480464CTD[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of LEP proteinPMID:18437699
Lepmultiple interactionsISOLep (Mus musculus)6480464CTD[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein; TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein]PMID:21327618
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