Lep (leptin) - Rat Genome Database

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Pathways
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Gene: Lep (leptin) Ictidomys tridecemlineatus
Analyze
Symbol: Lep
Name: leptin
RGD ID: 12679583
Description: ENCODES a protein that exhibits growth factor activity (ortholog); hormone activity (ortholog); peptide hormone receptor binding (ortholog); INVOLVED IN adipose tissue development (ortholog); aorta development (ortholog); bile acid metabolic process (ortholog); PARTICIPATES IN altered energy homeostasis pathway; altered leptin system pathway; energy homeostasis pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); abdominal obesity-metabolic syndrome 1 (ortholog); acute pancreatitis (ortholog); FOUND IN cytosol (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC101968976
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511854,282,689 - 54,287,494 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647915,394,966 - 15,411,334 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647915,394,966 - 15,411,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
abdominal obesity-metabolic syndrome 1  (ISO)
acute pancreatitis  (ISO)
acute promyelocytic leukemia  (ISO)
adult respiratory distress syndrome  (ISO)
alcohol dependence  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
asthma  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
bacterial pneumonia  (ISO)
Body Weight Changes  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colonic Neoplasms  (ISO)
congenital leptin deficiency  (ISO)
congestive heart failure  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
Dyslipidemias  (ISO)
End Stage Liver Disease  (ISO)
end stage renal disease  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial hyperlipidemia  (ISO)
Female Infertility  (ISO)
Femoral Fractures  (ISO)
Fetal Growth Retardation  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
glucose intolerance  (ISO)
hepatocellular carcinoma  (ISO)
hepatocellular clear cell carcinoma  (ISO)
Hepatomegaly  (ISO)
heroin dependence  (ISO)
Huntington's disease  (ISO)
Hypercapnia  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperphagia  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hypogonadism  (ISO)
Hypoventilation  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
Kidney Reperfusion Injury  (ISO)
Knee Osteoarthritis  (ISO)
lipid metabolism disorder  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
morbid obesity  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nerve Degeneration  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
Oral Ulcer  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
Parkinson's disease  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Pneumococcal Pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
Polydipsia  (ISO)
Polyuria  (ISO)
pre-eclampsia  (ISO)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
rhinitis  (ISO)
Sepsis  (ISO)
short bowel syndrome  (ISO)
Spinal Cord Injuries  (ISO)
steatotic liver disease  (ISO)
Tachycardia  (ISO)
type 2 diabetes mellitus  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (IEA,ISO)
adult feeding behavior  (IEA)
angiogenesis  (IEA)
aorta development  (IEA,ISO)
bile acid metabolic process  (IEA,ISO)
bone growth  (IEA)
bone mineralization involved in bone maturation  (ISO)
cardiac muscle hypertrophy  (ISO)
cellular response to insulin stimulus  (IEA,ISO)
cellular response to L-ascorbic acid  (ISO)
cellular response to leptin stimulus  (IEA)
cellular response to retinoic acid  (ISO)
central nervous system neuron development  (IEA,ISO)
cholesterol metabolic process  (IEA,ISO)
circadian rhythm  (ISO)
determination of adult lifespan  (IEA,ISO)
eating behavior  (IEA,ISO)
elastin metabolic process  (IEA,ISO)
energy homeostasis  (ISO)
energy reserve metabolic process  (IEA,ISO)
fatty acid beta-oxidation  (IEA,ISO)
fatty acid catabolic process  (ISO)
female pregnancy  (ISO)
glucose homeostasis  (IEA,ISO)
glucose metabolic process  (IEA,ISO)
glycerol biosynthetic process  (ISO)
hormone metabolic process  (IEA,ISO)
insulin secretion  (IEA,ISO)
intestinal absorption  (IEA)
intracellular signal transduction  (ISO)
leptin-mediated signaling pathway  (IEA,ISO)
leukocyte tethering or rolling  (ISO)
lipid metabolic process  (IEA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of appetite  (IEA)
negative regulation of appetite by leptin-mediated signaling pathway  (IEA)
negative regulation of autophagy  (IEA)
negative regulation of cartilage development  (ISO)
negative regulation of glucagon secretion  (IEA)
negative regulation of glucose import  (IEA)
negative regulation of glutamine transport  (ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of lipid storage  (ISO)
negative regulation of metabolic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of vasoconstriction  (ISO)
ovulation from ovarian follicle  (ISO)
phagocytosis  (IEA)
placenta development  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of cytokine production  (ISO)
positive regulation of developmental growth  (IEA)
positive regulation of fat cell apoptotic process  (ISO)
positive regulation of follicle-stimulating hormone secretion  (ISO)
positive regulation of hepatic stellate cell activation  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of interleukin-12 production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of luteinizing hormone secretion  (ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of monoatomic ion transport  (ISO)
positive regulation of myeloid cell differentiation  (ISO)
positive regulation of p38MAPK cascade  (IEA)
positive regulation of peroxisome proliferator activated receptor signaling pathway  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of protein import into nucleus  (IEA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IEA,ISO)
positive regulation of T cell proliferation  (IEA)
positive regulation of TOR signaling  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
prostaglandin secretion  (IEA)
regulation of angiogenesis  (IEA)
regulation of blood pressure  (ISO)
regulation of bone remodeling  (IEA)
regulation of brown fat cell differentiation  (IEA)
regulation of cell cycle  (IEA)
regulation of cytokine production involved in inflammatory response  (IEA)
regulation of endothelial cell proliferation  (IEA)
regulation of fat cell differentiation  (IEA,ISO)
regulation of gluconeogenesis  (IEA,ISO)
regulation of insulin secretion  (IEA,ISO)
regulation of intestinal cholesterol absorption  (IEA,ISO)
regulation of lipid biosynthetic process  (IEA,ISO)
regulation of lipoprotein lipid oxidation  (ISO)
regulation of metabolic process  (IEA,ISO)
regulation of natural killer cell activation  (IEA)
regulation of natural killer cell mediated cytotoxicity  (IEA)
regulation of natural killer cell proliferation  (IEA)
regulation of protein localization to nucleus  (IEA,ISO)
regulation of protein phosphorylation  (IEA)
regulation of steroid biosynthetic process  (IEA,ISO)
response to activity  (ISO)
response to dietary excess  (IEA,ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to hypoxia  (ISO)
response to insulin  (IEA,ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to vitamin E  (ISO)
sexual reproduction  (IEA)
signal transduction  (IEA)
T cell differentiation  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Lep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511854,282,689 - 54,287,494 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647915,394,966 - 15,411,334 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647915,394,966 - 15,411,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387128,241,278 - 128,257,629 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7128,241,278 - 128,257,629 (+)EnsemblGRCh38hg38GRCh38
GRCh377127,881,331 - 127,897,682 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367127,668,567 - 127,684,917 (+)NCBINCBI36Build 36hg18NCBI36
Build 347127,475,281 - 127,491,632NCBI
Celera7122,684,619 - 122,700,967 (+)NCBICelera
Cytogenetic Map7q32.1NCBI
HuRef7122,242,298 - 122,258,647 (+)NCBIHuRef
CHM1_17127,814,632 - 127,830,980 (+)NCBICHM1_1
T2T-CHM13v2.07129,552,743 - 129,569,093 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27127,264,455 - 127,280,803 (+)NCBI
Lep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39629,060,220 - 29,073,875 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl629,060,219 - 29,073,876 (+)EnsemblGRCm39 Ensembl
GRCm38629,060,221 - 29,073,876 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,060,220 - 29,073,877 (+)EnsemblGRCm38mm10GRCm38
MGSCv37629,010,221 - 29,023,876 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36629,010,231 - 29,023,886 (+)NCBIMGSCv36mm8
Celera629,063,769 - 29,077,429 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.3NCBI
Lep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,626,529 - 58,640,663 (+)NCBIGRCr8
mRatBN7.2457,661,127 - 57,675,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl457,661,131 - 57,675,262 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx462,644,034 - 62,658,181 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0458,559,814 - 58,573,975 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0456,962,087 - 56,976,240 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0456,337,695 - 56,351,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,337,695 - 56,351,818 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0456,085,079 - 56,099,209 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4455,943,837 - 55,945,938 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1456,185,364 - 56,197,221 (+)NCBI
Celera452,770,132 - 52,784,148 (+)NCBICelera
RH 3.4 Map4309.5RGD
Cytogenetic Map4q22NCBI
Lep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554799,274,516 - 9,279,472 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554799,266,604 - 9,276,568 (+)NCBIChiLan1.0ChiLan1.0
LEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26165,095,350 - 165,111,990 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1717,116,521 - 17,122,242 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07120,230,896 - 120,248,602 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17132,884,994 - 132,901,519 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7132,885,011 - 132,901,519 (+)Ensemblpanpan1.1panPan2
LEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,115,396 - 8,130,946 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,116,122 - 8,131,395 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha147,802,696 - 7,807,108 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0147,880,580 - 7,897,895 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl147,883,040 - 7,897,890 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1148,087,574 - 8,091,986 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0147,828,397 - 7,832,809 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0147,975,126 - 7,979,538 (-)NCBIUU_Cfam_GSD_1.0
LEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1820,106,868 - 20,123,323 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11820,106,867 - 20,124,071 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21821,200,988 - 21,231,275 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12197,056,913 - 97,071,161 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2197,057,529 - 97,071,220 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660426,335,426 - 6,349,076 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247837,708,588 - 7,721,727 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247837,708,820 - 7,721,610 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005319415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000029672   ⟹   ENSSTOP00000015183
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647915,394,966 - 15,411,334 (+)Ensembl
RefSeq Acc Id: XM_005319415   ⟹   XP_005319472
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511854,282,689 - 54,287,494 (+)NCBI
SpeTri2.0NW_00493647915,394,966 - 15,411,334 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005319472 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000015183.1
GenBank Protein KAG3277749 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005319472   ⟸   XM_005319415
- UniProtKB: I3MST8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000015183   ⟸   ENSSTOT00000029672


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000027970 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000029672.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  Leptin UniProtKB/TrEMBL
NCBI Gene Lep ENTREZGENE
PANTHER LEPTIN UniProtKB/TrEMBL
  PTHR11724 UniProtKB/TrEMBL
Pfam Leptin UniProtKB/TrEMBL
PIRSF Leptin UniProtKB/TrEMBL
PRINTS LEPTIN UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt I3MST8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-09 Lep  leptin  LOC101968976  leptin  Symbol and/or name change 5135510 APPROVED
2021-03-26 LOC101968976  leptin  Lep  leptin  Symbol and/or name change 5135510 APPROVED