RGD Reference Report - Effects of the obese gene product on body weight regulation in ob/ob mice. - Rat Genome Database

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Effects of the obese gene product on body weight regulation in ob/ob mice.

Authors: Pelleymounter, MA  Cullen, MJ  Baker, MB  Hecht, R  Winters, D  Boone, T  Collins, F 
Citation: Pelleymounter MA, etal., Science. 1995 Jul 28;269(5223):540-3.
RGD ID: 2311134
Pubmed: PMID:7624776   (View Abstract at PubMed)

C57BL/6J mice with a mutation in the obese (ob) gene are obese, diabetic, and exhibit reduced activity, metabolism, and body temperature. Daily intraperitoneal injection of these mice with recombinant OB protein lowered their body weight, percent body fat, food intake, and serum concentrations of glucose and insulin. In addition, metabolic rate, body temperature, and activity levels were increased by this treatment. None of these parameters was altered beyond the level observed in lean controls, suggesting that the OB protein normalized the metabolic status of the ob/ob mice. Lean animals injected with OB protein maintained a smaller weight loss throughout the 28-day study and showed no changes in any of the metabolic parameters. These data suggest that the OB protein regulates body weight and fat deposition through effects on metabolism and appetite.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
obesity  ISOLep (Mus musculus)2311134; 2311134 RGD 
obesity  IMP 2311134 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Lep  (leptin)

Genes (Mus musculus)
Lep  (leptin)

Genes (Homo sapiens)
LEP  (leptin)


Additional Information