GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Lep | increases expression | EXP | | 6480464 | CTD | Indomethacin results in increased expression of LEP protein | PMID:16280098 PMID:25051504 | Lep | multiple interactions | EXP | | 6480464 | CTD | BQ 610 inhibits the reaction [Indomethacin results in increased expression of LEP protein]; EDN1 protein promotes the reaction [Indomethacin results in increased expression of LEP protein]; LEP protein inhibits the reaction [Indomethacin results in decreased activity of GSR protein] | PMID:16280098 PMID:18181030 | Lep | multiple interactions | ISO | LEP (Homo sapiens) | 6480464 | CTD | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of LEP mRNA; [Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA; [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA; T 0070907 inhibits the reaction [[Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA]; T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA] | PMID:23086663 PMID:28628672 | |
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