GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Lep | increases expression | EXP | | 25330351 | RGD | bis(2-ethylhexyl) phthalate increased expression of LEP in adipose tissue (rat) | | Lep | decreases expression | EXP | | 6480464 | CTD | Diethylhexyl Phthalate results in decreased expression of LEP protein | PMID:33309551 | Lep | multiple interactions | EXP | | 6480464 | CTD | [Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of LEP mRNA; [Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of LEP protein | PMID:33166671 | Lep | increases expression | ISO | Lep (Mus musculus) | 6480464 | CTD | Diethylhexyl Phthalate results in increased expression of LEP mRNA; Diethylhexyl Phthalate results in increased expression of LEP protein | PMID:22588786 PMID:35550907 | Lep | multiple interactions | ISO | Lep (Mus musculus) | 6480464 | CTD | [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased secretion of LEP protein; Diethylhexyl Phthalate results in decreased expression of and results in decreased secretion of LEP protein; PPARA gene mutant form inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of and results in decreased secretion of LEP protein] | PMID:29175711 PMID:30660623 | | ||||||||||||||||||||||
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