• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3000 Species: Rattus norvegicus RGD Object: Gene Symbol: Lep Name: leptin

Acc ID: CHEBI:22984 Term: calcium atom Definition: An alkaline earth metal atom that has formula Ca. CasRN: 7440-70-2 Chemical ID: MESH:D002118

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:69124	6480464	CTD	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [LEP protein results in increased transport of Calcium] 2-aminoethoxydiphenyl borate inhibits the reaction [LEP protein results in increased transport of Calcium] 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [LEP protein results in increased transport of Calcium] Calcium promotes the reaction [LEP protein results in increased transport of Calcium] Flufenamic Acid inhibits the reaction [LEP protein results in increased transport of Calcium] JAK2 protein promotes the reaction [LEP protein results in increased transport of Calcium] Lanthanum promotes the reaction [LEP protein results in increased transport of Calcium] LEP protein promotes the reaction [TRPC5 protein results in increased transport of Calcium] LEP protein promotes the reaction [TRPC4 protein results in increased transport of Calcium] wortmannin inhibits the reaction [LEP protein results in increased transport of Calcium] LEP protein promotes the reaction [TRPC1 protein results in increased transport of Calcium] edelfosine inhibits the reaction [LEP protein results in increased transport of Calcium]	PMID:20107083
increases transport	ISO	RGD:69124	6480464	CTD	LEP protein results in increased transport of Calcium	PMID:20107083
multiple interactions	ISO	RGD:69124	6480464	CTD	acetovanillone inhibits the reaction [LEP protein affects the abundance of Calcium] BQ 788 inhibits the reaction [LEP protein affects the abundance of Calcium] cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein affects the abundance of Calcium]	PMID:16380530
affects abundance	ISO	RGD:69124	6480464	CTD	LEP protein affects the abundance of Calcium	PMID:16380530
decreases abundance	ISO	RGD:69124	6480464	CTD	LEP protein results in decreased abundance of Calcium	PMID:14657008
affects expression	EXP		6480464	CTD	Calcium affects the expression of LEP mRNA	PMID:15913539
affects secretion	EXP		6480464	CTD	Calcium deficiency affects the secretion of LEP protein	PMID:10780946
multiple interactions	EXP		6480464	CTD	Calcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]	PMID:10780946