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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3000
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lep
Name: leptin
Acc ID: CHEBI:28869
Term: menadione
Definition: A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.
Chemical ID: MESH:D024483
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lepincreases expressionISOLEP (Homo sapiens)6480464CTDVitamin K 3 results in increased expression of LEP mRNAPMID:16996477
Lepmultiple interactionsISOLEP (Homo sapiens)6480464CTD1,2-linoleoylphosphatidylcholine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]; S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]; SB 203580 inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]PMID:16996477
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